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29.11.2021 | Original Article

Daily symptom associations for urinary urgency and anxiety, depression and stress in women with overactive bladder

verfasst von: Allen A. Mehr, Karl J. Kreder, Susan K. Lutgendorf, Patrick Ten Eyck, Emma S. Greimann, Catherine S. Bradley

Erschienen in: International Urogynecology Journal | Ausgabe 4/2022

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Abstract

Introduction and hypothesis

Women with overactive bladder (OAB) report psychological distress, anxiety and depression, but short-term associations between these symptoms are poorly studied. Our objectives were to study daily associations between OAB symptoms and psychological symptoms and test whether these associations were stable when reassessed after 3 months. We hypothesized that OAB symptoms are positively associated with anxiety and depression symptoms over a short-term (daily) basis.

Methods

Female patients with OAB [bothersome urgency and/or urgency urinary incontinence (UUI)] assessed OAB and mood symptoms at baseline and 3 months using a 3-day bladder diary and visual analog scale (VAS) ratings (0–100 mm) for anxiety, depression and stress. Daily OAB and mood symptom associations were tested using Spearman correlations. Generalized estimating equation (GEE) models tested associations between daily urgency scores and each psychological rating adjusting for covariates, time and a time-symptom interaction term.

Results

Participants (n = 69) had mean (SD) age 63.3 (13.4) years. Baseline diary outcomes [median (IQR)/day] included day voids 8 (7–11), nocturia 0 (0–1), UUI episodes 1 (0–3) and urgency score 1.75 (1–2.25). Anxiety and depression diagnoses (dx) and treatment (tx) were common (anxiety dx 30.4%, tx 21.7%; depression dx 47.8%, tx 37.7%), but daily anxiety, depression and stress ratings were low [median (IQR) mm 10 (3–35), 5 (1–16), and 16 (4–39), respectively]. Daily urgency scores correlated with anxiety (r = 0.30–0.40, days 1–3, p ≤ 0.01 for all), depression (r = 0.24–0.35, p ≤ 0.05 all) and stress (r = 0.27–0.34, p ≤ 0.03 all). GEE models indicated no significant change in these associations between baseline and 3 months, and OAB treatment did not impact the associations.

Conclusions

Urgency scores were positively associated with same-day ratings of anxiety, depression and stress in OAB patients.

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Titel: Daily symptom associations for urinary urgency and anxiety, depression and stress in women with overactive bladder
verfasst von: Allen A. Mehr
Karl J. Kreder
Susan K. Lutgendorf
Patrick Ten Eyck
Emma S. Greimann
Catherine S. Bradley
Publikationsdatum: 29.11.2021
Verlag: Springer International Publishing
Erschienen in: International Urogynecology Journal / Ausgabe 4/2022
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-021-05033-0

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Daily symptom associations for urinary urgency and anxiety, depression and stress in women with overactive bladder