nach oben

European Archives of Oto-Rhino-Laryngology

07.04.2024 | Laryngology

Diagnostic and prognostic nomograms for laryngeal carcinoma patients with lung metastasis: a SEER-based study

verfasst von: Wanxi Qu, Zhaohui Qin, Li Cui, Shiwang Yuan, Nan Yao, Ji Ma, Jiaying Lu, Jiang Wang, Minhan Wang, Yuanhu Yao

Erschienen in: European Archives of Oto-Rhino-Laryngology

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To establish two nomograms to quantify the risk of lung metastasis (LM) in laryngeal carcinoma (LC) and predict the overall survival of LC patients with LM.

Methods

Totally 9515 LC patients diagnosed histologically from 2000 to 2019 were collected from the Surveillance, Epidemiology, and End Results database. The independent diagnostic factors for LM in LC patients and prognostic factors for LC patients with LM were identified by logistic and Cox regression analysis, respectively. Nomograms were established based on regression coefficients and evaluated by receiver operating characteristic curve, calibration curves, and decision curve analysis.

Results

Patients with supraglottis, higher pathological grade, higher N stage, and distant metastasis (bone, brain, or liver) were more likely to have LM (P < 0.05). Chemotherapy, surgery and radiotherapy were independent factors of the overall survival of LC patients with LM (P < 0.05). The area under curve of diagnostic nomogram were 0.834 and 0.816 in the training and validation cohort respectively. For the prognostic nomogram, the area under curves of 1-, 2-, and 3-years were 0.735, 0.734, and 0.709 in the training cohort and 0.705, 0.803, and 0.809 in the validation cohort. The calibration curves and decision curve analysis indicated good performance of the nomograms.

Conclusion

Distant metastasis (bone, brain, or liver) and N stage should be considered for prediction of LM in LC patients. Chemotherapy is the most significant influencing prognostic factor improving the survival of LC patients with LM. Two nomograms may benefit for providing better precautionary measures and treatment decision.

Karatzanis AD, Psychogios G, Waldfahrer F, Kapsreiter M, Zenk J, Velegrakis GA et al (2014) Management of locally advanced laryngeal cancer. J Otolaryngol Head Neck Surg 43:4. https://doi.org/10.1186/1916-0216-43-4CrossRefPubMedPubMedCentral

Megwalu UC, Sikora AG (2014) Survival outcomes in advanced laryngeal cancer. JAMA Otolaryngol Head Neck Surg 140:855–860. https://doi.org/10.1001/jamaoto.2014.1671CrossRefPubMed

Pan Y, Hong Y, Liang Z, Zhuang W (2019) Survival analysis of distant metastasis of laryngeal carcinoma: analysis based on SEER database. Eur Arch Otorhinolaryngol 276:193–201. https://doi.org/10.1007/s00405-018-5244-5CrossRefPubMed

Yang W, Mei X, Zhou Y, Su R, Lei W, Zheng S et al (2021) Risk factors and survival outcomes of laryngeal squamous cell carcinoma patients with lung metastasis: a population-based study. Auris Nasus Larynx 48:723–730. https://doi.org/10.1016/j.anl.2020.11.009CrossRefPubMed

Chiesa-Estomba CM, Lechien JR, Ayad T, Calvo-Henriquez C, Gonzalez-Garcia JA, Sistiaga-Suarez JA et al (2021) Clinical and histopathological risk factors for distant metastasis in head and neck cancer patients. Acta Otorhinolaryngol Ital 41:6–17. https://doi.org/10.14639/0392-100X-N0879CrossRefPubMedPubMedCentral

Duprez F, Berwouts D, De Neve W, Bonte K, Boterberg T, Deron P et al (2017) Distant metastases in head and neck cancer. Head Neck 39:1733–1743. https://doi.org/10.1002/hed.24687CrossRefPubMed

Kjems J, Zukauskaite R, Johansen J, Eriksen JG, Lassen P, Andersen E et al (2021) Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study. Acta Oncol 60:1472–1480. https://doi.org/10.1080/0284186X.2021.1959056CrossRefPubMed

Pfister DG, Spencer S, Adelstein D, Adkins D, Anzai Y, Brizel DM et al (2020) Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 18:873–898. https://doi.org/10.6004/jnccn.2020.0031CrossRefPubMed

Bianco FJ Jr (2006) Nomograms and medicine. Eur Urol 50:884–886. https://doi.org/10.1016/j.eururo.2006.07.043CrossRefPubMed

10.

Ju J, Wang J, Ma C, Li Y, Zhao Z, Gao T et al (2016) Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients. Oncotarget 7:51059–51068. https://doi.org/10.18632/oncotarget.10595CrossRefPubMedPubMedCentral

11.

Dedivitis RA, Denardin OV, Castro MA, Pfuetzenreiter EG Jr (2009) Risk factors for distant metastasis in head and neck cancer. Rev Col Bras Cir 36:478–481. https://doi.org/10.1590/s0100-69912009000600003CrossRefPubMed

12.

Shen W, Sakamoto N, Yang L (2015) Cancer-specific mortality and competing mortality in patients with head and neck squamous cell carcinoma: a competing risk analysis. Ann Surg Oncol 22:264–271. https://doi.org/10.1245/s10434-014-3951-8CrossRefPubMed

13.

Ferlito A, Shaha AR, Silver CE, Rinaldo A, Mondin V (2001) Incidence and sites of distant metastases from head and neck cancer. ORL J Otorhinolaryngol Relat Spec 63:202–207. https://doi.org/10.1159/000055740CrossRefPubMed

14.

Li X, Di B, Shang Y, Zhou Y, Cheng J, He Z (2009) Clinicopathologic risk factors for distant metastases from head and neck squamous cell carcinomas. Eur J Surg Oncol 35:1348–1353. https://doi.org/10.1016/j.ejso.2009.06.010CrossRefPubMed

15.

Lee DH, Kim MJ, Roh JL, Kim SB, Choi SH, Nam SY et al (2012) Distant metastases and survival prediction in head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 147:870–875. https://doi.org/10.1177/0194599812447048CrossRefPubMed

16.

Mutlu V, Ucuncu H, Altas E, Aktan B (2014) The relationship between the localization, size, stage and histopathology of the primary laryngeal tumor with neck metastasis. Eurasian J Med 46:1–7. https://doi.org/10.5152/eajm.2014.01CrossRefPubMedPubMedCentral

17.

Yamagata K, Onizawa K, Otsuka Y, Yoshida H (2008) Treatment for lung metastasis from head and neck squamous cell carcinoma: a preliminary study of docetaxel. Oral Maxillofac Surg 12:13–18. https://doi.org/10.1007/s10006-008-0100-1CrossRefPubMed

18.

Olsen KD (2010) Reexamining the treatment of advanced laryngeal cancer. Head Neck 32:1–7. https://doi.org/10.1002/hed.21294CrossRefPubMed

19.

Young ER, Diakos E, Khalid-Raja M, Mehanna H (2015) Resection of subsequent pulmonary metastases from treated head and neck squamous cell carcinoma: systematic review and meta-analysis. Clin Otolaryngol 40:208–218. https://doi.org/10.1111/coa.12348CrossRefPubMed

20.

Florescu C, Thariat J (2014) Local ablative treatments of oligometastases from head and neck carcinomas. Crit Rev Oncol Hematol 91:47–63. https://doi.org/10.1016/j.critrevonc.2014.01.004CrossRefPubMed

21.

Patel TD, Marchiano E, Chin OY, Kilic S, Eloy JA, Baredes S et al (2016) Utility of surgery/radiotherapy in distant metastatic head and neck squamous cell carcinoma: a population-based approach. Otolaryngol Head Neck Surg 154:868–874. https://doi.org/10.1177/0194599815627637CrossRefPubMed

22.

Zhu RQ, Zhang YM, Luo XY, Shen WY, Zhu HY (2022) A novel nomogram and risk classification system for predicting overall survival in head and neck squamous cell cancer with distant metastasis at initial diagnosis. Eur Arch Otorhinolaryngol. https://doi.org/10.1007/s00405-022-07716-wCrossRefPubMed

23.

Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF (2017) An update on larynx cancer. CA Cancer J Clin 67:31–50. https://doi.org/10.3322/caac.21386CrossRefPubMed

24.

Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C et al (2016) Long-term results of a multicenter randomized phase III trial of induction chemotherapy with cisplatin, 5-fluorouracil, +/- docetaxel for larynx preservation. J Natl Cancer Inst. https://doi.org/10.1093/jnci/djv368CrossRefPubMed

25.

Janoray G, Pointreau Y, Alfonsi M, Sire C, Geoffrois L, de Raucourt D et al (2020) Induction chemotherapy followed by cisplatin or cetuximab concomitant to radiotherapy for laryngeal/hypopharyngeal cancer: long-term results of the TREMPLIN randomised GORTEC trial. Eur J Cancer 133:86–93. https://doi.org/10.1016/j.ejca.2020.04.009CrossRefPubMed

26.

Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S et al (2008) Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 359:1116–1127. https://doi.org/10.1056/NEJMoa0802656CrossRefPubMed

27.

Okamoto I, Sato H, Tsukahara K (2020) Overall survival and PD-L1 expression in patients with recurrent or metastatic head and neck cancer treated with nivolumab. Auris Nasus Larynx 47:676–686. https://doi.org/10.1016/j.anl.2020.04.001CrossRefPubMed

28.

Pasalic D, Betancourt-Cuellar SL, Taku N, Ludmir EB, Lu Y, Allen PK et al (2020) Outcomes and toxicities following stereotactic ablative radiotherapy for pulmonary metastases in patients with primary head and neck cancer. Head Neck 42:1939–1953. https://doi.org/10.1002/hed.26117CrossRefPubMedPubMedCentral

29.

Yilmaz T, Hosal S, Ozyar E, Akyol F, Gursel B (2005) Post-operative radiotherapy in advanced laryngeal cancer: effect on local and regional recurrence, distant metastases and second primaries. J Laryngol Otol 119:784–790. https://doi.org/10.1258/002221505774481183CrossRefPubMed

30.

Lahoz Zamarro MT, Galve Royo F, Martinez Subias J, Laguia PM (2001) Distant metastases in patients with advance laryngeal carcinoma. Acta Otorrinolaringol Esp 52:307–311. https://doi.org/10.1016/s0001-6519(01)78212-xCrossRefPubMed

31.

Brouwer J, Bree R, Hoekstra OS, Langendijk JA, Castelijns JA, Leemans CR (2005) Screening for distant metastases in patients with head and neck cancer: what is the current clinical practice? Clin Otolaryngol 30:438–443. https://doi.org/10.1111/j.1365-2273.2005.01068.xCrossRefPubMed

32.

Imre A, Pinar E, Dincer E, Ozkul Y, Aslan H, Songu M et al (2016) Lymph node density in node-positive laryngeal carcinoma: analysis of prognostic value for survival. Otolaryngol Head Neck Surg 155:797–804. https://doi.org/10.1177/0194599816652371CrossRefPubMed

33.

Adibi M, Kenney PA, Thomas AZ, Borregales LD, Nogueras-Gonzalez GM, Wang X et al (2016) Prediction of pulmonary metastasis in renal cell carcinoma patients with indeterminate pulmonary nodules. Eur Urol 69:352–360. https://doi.org/10.1016/j.eururo.2015.08.053CrossRefPubMed

34.

Chen S, Li X, Liang Y, Lu X, Huang Y, Zhu J et al (2022) Short-term prognosis for hepatocellular carcinoma patients with lung metastasis: a retrospective cohort study based on the SEER database. Medicine (Baltimore) 101:e31399. https://doi.org/10.1097/MD.0000000000031399CrossRefPubMed

35.

Liu LL, Sun JD, Xiang ZL (2022) Survival nomograms for colorectal carcinoma patients with lung metastasis and lung-only metastasis, based on the SEER database and a single-center external validation cohort. BMC Gastroenterol 22:446. https://doi.org/10.1186/s12876-022-02547-9CrossRefPubMedPubMedCentral

Titel: Diagnostic and prognostic nomograms for laryngeal carcinoma patients with lung metastasis: a SEER-based study
verfasst von: Wanxi Qu
Zhaohui Qin
Li Cui
Shiwang Yuan
Nan Yao
Ji Ma
Jiaying Lu
Jiang Wang
Minhan Wang
Yuanhu Yao
Publikationsdatum: 07.04.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-024-08608-x

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Diagnostic and prognostic nomograms for laryngeal carcinoma patients with lung metastasis: a SEER-based study

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet HNO

Akuter Schwindel: Wann lohnt sich eine MRT?

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Update HNO

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Neu im Fachgebiet HNO

Akuter Schwindel: Wann lohnt sich eine MRT?

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Update HNO