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01.12.2024 | Review

Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets

verfasst von: Talita de Carvalho Kimura, Reydson Alcides de Lima-Souza, Tayná Figueiredo Maciel, Luiz Paulo Kowalski, Cláudia Malheiros Coutinho‑Camillo, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano

Erschienen in: Head and Neck Pathology | Ausgabe 1/2024

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Abstract

Background

Salivary gland carcinomas (SGCs) are a rare group of malignant neoplasms of the head and neck region. MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been associated with the control biological process and oncogenic mechanism by the regulation of gene expression at the post-transcriptional level. Recent evidence has suggested that miRNA expression may play a role in the tumorigenesis and carcinogenesis process in SGCs.

Methods

This review provides a comprehensive literature review of the role of miRNAs expression in SGCs focusing on the diagnostic, prognostic, and therapeutic applications.

Results

In this review, numerous dysregulated miRNAs have demonstrated an oncogenic and suppressor role in SGCs.

Conclusion

In the future, these miRNAs may eventually constitute useful diagnostic and prognostic biomarkers that may lead to a better understanding of SGCs oncogenesis. Additionally, the development of therapeutic agents based on miRNAs may be a promising target in SGC treatment.

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Titel: Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets
verfasst von: Talita de Carvalho Kimura
Reydson Alcides de Lima-Souza
Tayná Figueiredo Maciel
Luiz Paulo Kowalski
Cláudia Malheiros Coutinho‑Camillo
Erika Said Abu Egal
Albina Altemani
Fernanda Viviane Mariano
Publikationsdatum: 01.12.2024
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 1/2024
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-023-01603-4

Springer Medizin

Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets

Abstract

Background

Methods

Results

Conclusion

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

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