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Head and Neck Pathology

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28.11.2023 | Research

Evaluation of Diagnostic Significance of Salivary miRNA-184 and miRNA-21 in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

verfasst von: Aarushi Garg, Aadithya B. Urs, Bidhan Chandra Koner, Jeyaseelan Augustine, Sameer Ahmad Guru

Erschienen in: Head and Neck Pathology | Ausgabe 4/2023

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Abstract

Background

Altered levels of miRNAs might affect the pathogenesis of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). This study evaluated the diagnostic potential of salivary miRNA-21 and miRNA-184 in OSCC and OPMD.

Methods

We recruited a total of 90 subjects including OSCC, OPMD, and healthy controls. RNA was isolated from the saliva samples of the study subjects. Expression of miRNA-21 and miRNA-184 was analyzed using qRT-PCR. Their levels were compared and the diagnostic cut-off was determined using the ROC curve.

Results

There was a significant increase in miRNA-21 and a decrease in miRNA-184 in OSCC and OPMD as compared to healthy controls (p < 0.001). Levels of salivary miRNA-21 and miRNA-184 can differentiate OSCC and OPMD from controls and premalignant conditions from malignant conditions.

Conclusion

Salivary miRNA-21 and miRNA-184 may be beneficial for the early detection of OSCC and OPMD. Also, saliva can be used for detecting neoplastic transformation of oral mucosa since it is non-invasive and easily accessible.

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Titel: Evaluation of Diagnostic Significance of Salivary miRNA-184 and miRNA-21 in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders
verfasst von: Aarushi Garg
Aadithya B. Urs
Bidhan Chandra Koner
Jeyaseelan Augustine
Sameer Ahmad Guru
Publikationsdatum: 28.11.2023
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 4/2023
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-023-01600-7

Springer Medizin

Evaluation of Diagnostic Significance of Salivary miRNA-184 and miRNA-21 in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Abstract

Background

Methods

Results

Conclusion

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

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