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01.06.2010 | Original Research Paper

Extramedullary hematopoiesis is dysregulated in histamine-free histidine decarboxylase knockout (HDC^−/−) mice

verfasst von: Zsuzsanna Horváth, Éva Pállinger, Győző Horváth, Ivett Jelinek, Gizella Veszely, József Fűrész, András Falus, Edit I. Buzás

Erschienen in: Inflammation Research | Ausgabe 6/2010

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Abstract

Objective and design

In this study we investigated the role of histamine on the extramedullary hematopoiesis.

Methods

Male histidine decarboxylase knockout (HDC^−/−) mice and wild-type mice were used (n = 5/group). Groups of mice received sublethal total-body gamma irradiation at a single dose of 4 Gy. Spleen cells were studied at different time points post-irradiation by flow cytometry, colony forming unit (CFU) assay, and real-time PCR. For statistical analysis Student’s t test, ANOVA, and Holm-Sidak post-hoc test were used.

Results

By day 14 after irradiation, spleen cell counts increased almost eightfold in wild-type and not even fourfold in HDC^−/− mice (P < 0.01). The proliferative capacity and interleukin-3 signaling of stem cells were impaired in HDC^−/− mice. STAT5 mRNA expression was decreased in granulocyte-myeloid colonies by 72.9 ± 8.6% (P < 0.001), compared to the wild-type.

Conclusions

The absence of histamine adversely affects splenic hematopoiesis via direct and indirect mechanisms.

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Titel: Extramedullary hematopoiesis is dysregulated in histamine-free histidine decarboxylase knockout (HDC−/−) mice
verfasst von: Zsuzsanna Horváth
Éva Pállinger
Győző Horváth
Ivett Jelinek
Gizella Veszely
József Fűrész
András Falus
Edit I. Buzás
Publikationsdatum: 01.06.2010
Verlag: SP Birkhäuser Verlag Basel
Erschienen in: Inflammation Research / Ausgabe 6/2010
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-009-0114-7

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Abstract

Objective and design

Methods

Results

Conclusions

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