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Erschienen in:

2020 | Frühgeburten | OriginalPaper | Buchkapitel

6. Rezidivierende Spontanaborte

verfasst von : Kilian Vomstein

Erschienen in: Therapiehandbuch Gynäkologie und Geburtshilfe

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Habituelle Aborte (RSA) sind von der WHO definiert als 3 oder mehr konsekutive spontane Fehlgeburten vor der 22. SSW und betreffen ca. 1–3 % aller Paare im reproduktionsfähigen Alter. Eine Reihe an Risikofaktoren wie genetische Auffälligkeiten, Veränderungen in der Hämostase und anatomische Ursachen sind im Rahmen der Abklärung etabliert. Trotz intensiver Diagnostik bleibt bei fast 50 % der Patientinnen die Ursache ungeklärt. Die Behandlung von Paaren mit habituellen Aborten stellt für jeden Frauenarzt eine besondere Herausforderung dar und bedarf einer intensiven Betreuung. Das Kapitel fasst die Ursachen und therapeutischen Möglichkeiten zusammen und orientiert sich an den Empfehlungen der nationalen und internationalen Leitlinien.

Abbas AK, Murphy KM, Sher A (1996) Functional diversity of helper T lymphocytes. Nature 383(6603):787–793PubMedCrossRef

Abramson J, Stagnaro-Green A (2001) Thyroid antibodies and fetal loss: an evolving story. Thyroid 11(1):57–63PubMedCrossRef

Aluvihare VR, Kallikourdis M, Betz AG (2004) Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol 5(3):266–271PubMedCrossRef

Ammon Avalos L, Galindo C, Li DK (2012) A systematic review to calculate background miscarriage rates using life table analysis. Birth Defects Res A Clin Mol Teratol 94(6):417–423PubMedCrossRef

Ata B, Tan SL, Shehata F, Holzer H, Buckett W (2011) A systematic review of intravenous immunoglobulin for treatment of unexplained recurrent miscarriage. Fertil Steril 95(3):1080–1085PubMedCrossRef

Bashiri A, Ratzon R, Amar S, Serjienko R, Mazor M, Shoham-Vardi I (2012) Two vs. three or more primary recurrent pregnancy losses – are there any differences in epidemiologic characteristics and index pregnancy outcome? J Perinat Med 40(4):365–371PubMedCrossRef

Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO (2012) VTE, thrombophilia, antithrombotic therapy, and pregnancy: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest 141(2 Suppl):e691S–e736SPubMedPubMedCentralCrossRef

Beaman KD, Ntrivalas E, Mallers TM, Jaiswal MK, Kwak-Kim J, Gilman-Sachs A (2012) Immune etiology of recurrent pregnancy loss and its diagnosis. Am J Reprod Immunol 67(4):319–325PubMedCrossRef

Beer AE, Kwak JY, Ruiz JE (1996) Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in vitro fertilization cycles. Am J Reprod Immunol 35(4):376–382PubMedCrossRef

Benhadi N, Wiersinga WM, Reitsma JB, Vrijkotte TG, Bonsel GJ (2009) Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death. Eur J Endocrinol 160(6):985–991PubMedCrossRef

Beydoun H, Saftlas AF (2005) Association of human leucocyte antigen sharing with recurrent spontaneous abortions. Tissue Antigens 65(2):123–135PubMedCrossRef

Billington WD (2003) The immunological problem of pregnancy: 50 years with the hope of progress. A tribute to Peter Medawar. J Reprod Immunol 60(1):1–11PubMedCrossRef

Bohlmann MK, von Wolff M, Luedders DW, Beuter-Winkler P, Diedrich K, Hornemann A, Strowitzki T (2010) Hysteroscopic findings in women with two and with more than two first-trimester miscarriages are not significantly different. Reprod Biomed Online 21(2):230–236PubMedCrossRef

Bohlmann MK, Baumann K, Bauersachs R (2011) Thromboembolische Erkrankungen in Schwangerschaft und Wochenbett. Der Gynäkologe 44(7):533–537CrossRef

Boue J, Bou A, Lazar P (1975) Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions. Teratology 12(1):11–26PubMedCrossRef

Bouet P-E, El Hachem H, Monceau E, Gariépy G, Kadoch I-J, Sylvestre C (2016) Chronic endometritis in women with recurrent pregnancy loss and recurrent implantation failure: prevalence and role of office hysteroscopy and immunohistochemistry in diagnosis. Fertil Steril 105(1):106–110PubMedCrossRef

Branch DW, Gibson M, Silver RM (2010) Clinical practice. Recurrent miscarriage. N Engl J Med 363(18):1740–1747PubMedCrossRef

Bulmer JN, Morrison L, Longfellow M, Ritson A, Pace D (1991) Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studies. Hum Reprod 6(6):791–798PubMedCrossRef

Bulmer JN, Williams PJ, Lash GE (2010) Immune cells in the placental bed. Int J Dev Biol 54(2–3):281–294PubMedCrossRef

Carp HJ, Shoenfeld Y (2007) Recurrent spontaneous abortions in antiphospholipid syndrome: natural killer cells – an additional mechanism in a multi factorial process. Rheumatology (Oxford) 46(10):1517–1519CrossRef

Carrington B, Sacks G, Regan L (2005) Recurrent miscarriage: pathophysiology and outcome. Curr Opin Obstet Gynecol 17(6):591–597PubMedCrossRef

Casini ML, Rossi F, Agostini R, Unfer V (2006) Effects of the position of fibroids on fertility. Gynecol Endocrinol 22(2):106–109PubMedCrossRef

Chen X, Mariee N, Jiang L, Liu Y, Wang CC, Li TC, Laird S (2017) Measurement of uterine natural killer cell percentage in the periimplantation endometrium from fertile women and women with recurrent reproductive failure: establishment of a reference range. Am J Obstet Gynecol 217(6):680 e681–680 e686CrossRef

Chen Y-q, Fang R-l, Luo Y-n, Luo C-q (2016) Analysis of the diagnostic value of CD138 for chronic endometritis, the risk factors for the pathogenesis of chronic endometritis and the effect of chronic endometritis on pregnancy: a cohort study. BMC Women’s Health 16(1):60PubMedPubMedCentralCrossRef

Christiansen OB (1996) A fresh look at the causes and treatments of recurrent miscarriage, especially its immunological aspects. Hum Reprod Update 2(4):271–293PubMedCrossRef

Christiansen OB (2006) Evidence-based investigations and treatments of recurrent pregnancy loss. Curr Opin Obstet Gynecol 18(3):304–312PubMedCrossRef

Christiansen OB, Steffensen R, Nielsen HS, Varming K (2008) Multifactorial etiology of recurrent miscarriage and its scientific and clinical implications. Gynecol Obstet Invest 66(4):257–267PubMedCrossRef

Christiansen OB, Larsen EC, Egerup P, Lunoee L, Egestad L, Nielsen HS (2015) Intravenous immunoglobulin treatment for secondary recurrent miscarriage: a randomised, double-blind, placebo-controlled trial. BJOG 122(4):500–508PubMedCrossRef

Clark DA, Coulam CB, Daya S, Chaouat G (2001) Unexplained sporadic and recurrent miscarrage in the new millennium: a critical analysis of immune mechanisms and treatments. Hum Reprod Update 7(5):501–511PubMedCrossRef

Clifford K, Flanagan AM, Regan L (1999) Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study. Hum Reprod 14(11):2727–2730PubMedCrossRef

Cohn DM, Goddijn M, Middeldorp S, Korevaar JC, Dawood F, Farquharson RG (2010) Recurrent miscarriage and antiphospholipid antibodies: prognosis of subsequent pregnancy. J Thromb Haemost 8(10):2208–2213PubMedCrossRef

Coomarasamy A, Williams H, Truchanowicz E, Seed PT, Small R, Quenby S, Gupta P, Dawood F, Koot YE, Bender Atik R, Bloemenkamp KW, Brady R, Briley AL, Cavallaro R, Cheong YC, Chu JJ, Eapen A, Ewies A, Hoek A, Kaaijk EM, Koks CA, Li TC, MacLean M, Mol BW, Moore J, Ross JA, Sharpe L, Stewart J, Vaithilingam N, Farquharson RG, Kilby MD, Khalaf Y, Goddijn M, Regan L, Rai R (2015) A randomized trial of progesterone in women with recurrent miscarriages. N Engl J Med 373(22):2141–2148PubMedCrossRef

Coomarasamy A, Devall AJ, Cheed V, Harb H, Middleton LJ, Gallos ID, Williams H, Eapen AK, Roberts T, Ogwulu CC, Goranitis I, Daniels JP, Ahmed A, Bender-Atik R, Bhatia K, Bottomley C, Brewin J, Choudhary M, Crosfill F, Deb S, Duncan WC, Ewer A, Hinshaw K, Holland T, Izzat F, Johns J, Kriedt K, Lumsden MA, Manda P, Norman JE, Nunes N, Overton CE, Quenby S, Rao S, Ross J, Shahid A, Underwood M, Vaithilingam N, Watkins L, Wykes C, Horne A, Jurkovic D (2019) A randomized trial of progesterone in women with bleeding in early pregnancy. N Engl J Med 380(19):1815–1824PubMedCrossRef

Craig LB, Ke RW, Kutteh WH (2002) Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss. Fertil Steril 78(3):487–490PubMedCrossRef

Dakhly DM, Bayoumi YA, Sharkawy M, Gad Allah SH, Hassan MA, Gouda HM, Hashem AT, Hatem DL, Ahmed MF, El-Khayat W (2016) Intralipid supplementation in women with recurrent spontaneous abortion and elevated levels of natural killer cells. Int J Gynaecol Obstet 135(3):324–327PubMedCrossRef

De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, Eastman CJ, Lazarus JH, Luton D, Mandel SJ, Mestman J, Rovet J, Sullivan S (2012) Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 97(8):2543–2565PubMedCrossRef

De Stefano V, Chiusolo P, Paciaroni K, Leone G (1998) Epidemiology of factor V Leiden: clinical implications. Semin Thromb Hemost 24(4):367–379PubMedCrossRef

Devi Wold AS, Pham N, Arici A (2006) Anatomic factors in recurrent pregnancy loss. Semin Reprod Med 24(1):25–32PubMedCrossRef

Eiben B, Bartels I, Bahr-Porsch S, Borgmann S, Gatz G, Gellert G, Goebel R, Hammans W, Hentemann M, Osmers R et al (1990) Cytogenetic analysis of 750 spontaneous abortions with the direct-preparation method of chorionic villi and its implications for studying genetic causes of pregnancy wastage. Am J Hum Genet 47(4):656–663PubMedPubMedCentral

El Hachem H, Crepaux V, May-Panloup P, Descamps P, Legendre G, Bouet P-E (2017) Recurrent pregnancy loss: current perspectives. International Journal of Women’s Health 9:331–345PubMedPubMedCentralCrossRef

Empson M, Lassere M, Craig JC, Scott JR (2002) Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet Gynecol 99(1):135–144PubMed

Ensom MH, Stephenson MD (2011) A two-center study on the pharmacokinetics of intravenous immunoglobulin before and during pregnancy in healthy women with poor obstetrical histories. Hum Reprod 26(9):2283–2288PubMedPubMedCentralCrossRef

Ford HB, Schust DJ (2009) Recurrent pregnancy loss: etiology, diagnosis, and therapy. Rev Obstet Gynecol 2(2):76–83PubMedPubMedCentral

Granato D, Blum S, Rossle C, Le Boucher J, Malnoe A, Dutot G (2000) Effects of parenteral lipid emulsions with different fatty acid composition on immune cell functions in vitro. JPEN J Parenter Enteral Nutr 24(2):113–118PubMedCrossRef

Greene MF, Hare JW, Cloherty JP, Benacerraf BR, Soeldner JS (1989) First-trimester hemoglobin A1 and risk for major malformation and spontaneous abortion in diabetic pregnancy. Teratology 39(3):225–231PubMedCrossRef

Greenwood SM, Moran JJ (1981) Chronic endometritis: morphologic and clinical observations. Obstet Gynecol 58(2):176–184PubMed

Grimbizis GF, Camus M, Tarlatzis BC, Bontis JN, Devroey P (2001) Clinical implications of uterine malformations and hysteroscopic treatment results. Hum Reprod Update 7(2):161–174PubMedCrossRef

Guerin LR, Prins JR, Robertson SA (2009) Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update 15(5):517–535PubMedPubMedCentralCrossRef

Hadziselimovic F, Geneto R, Buser M (2007) Celiac disease, pregnancy, small for gestational age: role of extravillous trophoblast. Fetal Pediatr Pathol 26(3):125–134PubMedCrossRef

Haider S, Knofler M (2009) Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 30(2):111–123PubMedCrossRef

Hiby SE, Walker JJ, O’Shaughnessy KM, Redman CW, Carrington M, Trowsdale J, Moffett A (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 200(8):957–965PubMedPubMedCentralCrossRef

Hooker AB, Lemmers M, Thurkow AL, Heymans MW, Opmeer BC, Brolmann HA, Mol BW, Huirne JA (2014) Systematic review and meta-analysis of intrauterine adhesions after miscarriage: prevalence, risk factors and long-term reproductive outcome. Hum Reprod Update 20(2):262–278PubMedCrossRef

Hughes GR (2011) Hughes syndrome (the antiphospholipid syndrome): a disease of our time. Inflammopharmacology 19(2):69–73PubMedCrossRef

James A, B.-O. Committee on Practice (2011) Practice bulletin no. 123: thromboembolism in pregnancy. Obstet Gynecol 118(3):718–729CrossRef

Jin LP, Chen QY, Zhang T, Guo PF, Li DJ (2009) The CD4+ CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clin Immunol 133(3):402–410PubMedCrossRef

Johnston-MacAnanny EB, Hartnett J, Engmann LL, Nulsen JC, Sanders MM, Benadiva CA (2010) Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization. Fertil Steril 93(2):437–441PubMedCrossRef

Kannar V, Lingaiah HK, Sunita V (2012) Evaluation of endometrium for chronic endometritis by using syndecan-1 in abnormal uterine bleeding. J Lab Physicians 4(2):69PubMedPubMedCentralCrossRef

King K, Smith S, Chapman M, Sacks G (2010) Detailed analysis of peripheral blood natural killer (NK) cells in women with recurrent miscarriage. Hum Reprod 25(1):52–58PubMedCrossRef

Kitaya K (2011) Prevalence of chronic endometritis in recurrent miscarriages. Fertil Steril 95(3):1156–1158PubMedCrossRef

Kuon RJ, Vomstein K, Weber M, Muller F, Seitz C, Wallwiener S, Strowitzki T, Schleussner E, Markert UR, Daniel V, Toth B (2017a) The „killer cell story“ in recurrent miscarriage: association between activated peripheral lymphocytes and uterine natural killer cells. J Reprod Immunol 119:9–14PubMedCrossRef

Kuon RJ, Weber M, Heger J, Santillan I, Vomstein K, Bar C, Strowitzki T, Markert UR, Toth B (2017b) Uterine natural killer cells in patients with idiopathic recurrent miscarriage. Am J Reprod Immunol 78(4):e12721CrossRef

Kwak JY, Beaman KD, Gilman-Sachs A, Ruiz JE, Schewitz D, Beer AE (1995) Up-regulated expression of CD56+, CD56+/CD16+, and CD19+ cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am J Reprod Immunol 34(2):93–99PubMedCrossRef

Kwiatek M, Geca T, Krzyzanowski A, Malec A, Kwasniewska A (2015) Peripheral dendritic cells and CD4+ CD25+ Foxp3+ regulatory T cells in the first trimester of normal pregnancy and in women with recurrent miscarriage. PLoS ONE 10(5):e0124747PubMedPubMedCentralCrossRef

Laird SM, Mariee N, Wei L, Li TC (2011) Measurements of CD56+ cells in peripheral blood and endometrium by flow cytometry and immunohistochemical staining in situ. Hum Reprod 26(6):1331–1337PubMedCrossRef

Lash GE, Bulmer JN (2011) Do uterine natural killer (uNK) cells contribute to female reproductive disorders? J Reprod Immunol 88(2):156–164PubMedCrossRef

Lash GE, Bulmer JN, Li TC, Innes BA, Mariee N, Patel G, Sanderson J, Quenby S, Laird SM (2016) Standardisation of uterine natural killer (uNK) cell measurements in the endometrium of women with recurrent reproductive failure. J Reprod Immunol 116:50–59PubMedCrossRef

Li TC, Makris M, Tomsu M, Tuckerman E, Laird S (2002) Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update 8(5):463–481PubMedCrossRef

Lissalde-Lavigne G, Fabbro-Peray P, Mares P, Gris JC (2006) More on: factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first intended pregnancy: the matched case-control „NOHA First“ study. J Thromb Haemost 4(7):1640–1642PubMedCrossRef

Mak A, Cheung MW, Cheak AA, Ho RC (2010) Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression. Rheumatology (Oxford) 49(2):281–288CrossRef

Manyonda I, Sinthamoney E, Belli AM (2004) Controversies and challenges in the modern management of uterine fibroids. BJOG 111(2):95–102PubMedCrossRef

Marik PE, Plante LA (2008) Venous thromboembolic disease and pregnancy. N Engl J Med 359(19):2025–2033PubMedCrossRef

McQueen DB, Bernardi LA, Stephenson MD (2014) Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise. Fertil Steril 101(4):1026–1030PubMedCrossRef

McQueen DB, Perfetto CO, Hazard FK, Lathi RB (2015) Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss. Fertil Steril 104(4):927–931PubMedCrossRef

Medawar PB (1953) Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol 7:320–338

Meuleman T, Lashley LE, Dekkers OM, van Lith JM, Claas FH, Bloemenkamp KW (2015) HLA associations and HLA sharing in recurrent miscarriage: a systematic review and meta-analysis. Hum Immunol 76(5):362–373PubMedCrossRef

Meza-Espinoza JP, Anguiano LO, Rivera H (2008) Chromosomal abnormalities in couples with reproductive disorders. Gynecol Obstet Invest 66(4):237–240PubMedCrossRef

Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, de Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4(2):295–306PubMedCrossRef

Moffett A, Colucci F (2014) Uterine NK cells: active regulators at the maternal-fetal interface. J Clin Invest 124(5):1872–1879PubMedPubMedCentralCrossRef

Moffett A, Shreeve N (2015) First do no harm: uterine natural killer (NK) cells in assisted reproduction. Hum Reprod 30(7):1519–1525PubMedPubMedCentralCrossRef

Nawroth F, Bohlmann M, Gillessen-Kaesbach G, Rogenhofer N, Tempfer C, Wischmann T, von Wolff M, Würfel W, Toth B (2017) Habituelle Aborte. Der Gynäkologe 50(7):533–545CrossRef

Negro R, Mestman JH (2011) Thyroid disease in pregnancy. Best Pract Res Clin Endocrinol Metab 25(6):927–943PubMedCrossRef

Nelson DB, Casey BM, McIntire DD, Cunningham FG (2014) Subsequent pregnancy outcomes in women previously diagnosed with subclinical hypothyroidism. Am J Perinatol 31(1):77–84PubMed

Ntrivalas EI, Bowser CR, Kwak-Kim J, Beaman KD, Gilman-Sachs A (2005) Expression of killer immunoglobulin-like receptors on peripheral blood NK cell subsets of women with recurrent spontaneous abortions or implantation failures. Am J Reprod Immunol 53(5):215–221PubMedCrossRef

Ogasawara M, Aoki K, Okada S, Suzumori K (2000) Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 73(2):300–304PubMedCrossRef

Park HJ, Kim YS, Yoon TK, Lee WS (2016) Chronic endometritis and infertility. Clin Exp Reprod Med 43(4):185PubMedPubMedCentralCrossRef

Perricone C, de Carolis C, Perricone R (2012) Pregnancy and autoimmunity: a common problem. Best Pract Res Clin Rheumatol 26(1):47–60PubMedCrossRef

Practice Committee of the American Society for Reproductive Medicine (2012) Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril 98(5):1103–1111CrossRef

Practice Committee of the American Society for Reproductive Medicine (2015) Current clinical irrelevance of luteal phase deficiency: a committee opinion. Fertil Steril 103(4):e27–e32CrossRef

Pritchard AM, Hendrix PW, Paidas MJ (2016) Hereditary thrombophilia and recurrent pregnancy loss. Clin Obstet Gynecol 59(3):487–497PubMedCrossRef

Quenby S, Vince G, Farquharson R, Aplin J (2002) Recurrent miscarriage: a defect in nature’s quality control? Hum Reprod 17(8):1959–1963PubMedCrossRef

Quenby S, Kalumbi C, Bates M, Farquharson R, Vince G (2005) Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage. Fertil Steril 84(4):980–984PubMedCrossRef

Raga F, Casan EM, Bonilla-Musoles F (2009) Expression of vascular endothelial growth factor receptors in the endometrium of septate uterus. Fertil Steril 92(3):1085–1090PubMedCrossRef

Reid JG, Simpson NA, Walker RG, Economidou O, Shillito J, Gooi HC, Duffy SR, Walker JJ (2001) The carriage of pro-inflammatory cytokine gene polymorphisms in recurrent pregnancy loss. Am J Reprod Immunol 45(1):35–40PubMedCrossRef

Rey E, Kahn SR, David M, Shrier I (2003) Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 361(9361):901–908PubMedCrossRef

Robertson MJ, Ritz J (1990) Biology and clinical relevance of human natural killer cells. Blood 76(12):2421–2438PubMedCrossRef

Robson A, Harris LK, Innes BA, Lash GE, Aljunaidy MM, Aplin JD, Baker PN, Robson SC, Bulmer JN (2012) Uterine natural killer cells initiate spiral artery remodeling in human pregnancy. FASEB J 26(12):4876–4885PubMedCrossRef

Rodger MA, Betancourt MT, Clark P, Lindqvist PG, Dizon-Townson D, Said J, Seligsohn U, Carrier M, Salomon O, Greer IA (2010) The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. PLoS Med 7(6):e1000292PubMedPubMedCentralCrossRef

Romero R, Espinoza J, Mazor M (2004) Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil Steril 82(4):799–804PubMedCrossRef

Rotterdam EA-SPCWG (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81(1):19–25CrossRef

Roussev RG, Ng SC, Coulam CB (2007) Natural killer cell functional activity suppression by intravenous immunoglobulin, intralipid and soluble human leukocyte antigen-G. Am J Reprod Immunol 57(4):262–269PubMedCrossRef

Roussev RG, Acacio B, Ng SC, Coulam CB (2008) Duration of intralipid’s suppressive effect on NK cell’s functional activity. Am J Reprod Immunol 60(3):258–263PubMedCrossRef

Roussev RG, Dons’koi BV, Stamatkin C, Ramu S, Chernyshov VP, Coulam CB, Barnea ER (2013) Preimplantation factor inhibits circulating natural killer cell cytotoxicity and reduces CD69 expression: implications for recurrent pregnancy loss therapy. Reprod Biomed Online 26(1):79–87PubMedCrossRef

Salim R, Regan L, Woelfer B, Backos M, Jurkovic D (2003) A comparative study of the morphology of congenital uterine anomalies in women with and without a history of recurrent first trimester miscarriage. Hum Reprod 18(1):162–166PubMedCrossRef

Saravelos SH, Yan J, Rehmani H, Li TC (2011) The prevalence and impact of fibroids and their treatment on the outcome of pregnancy in women with recurrent miscarriage. Hum Reprod 26(12):3274–3279PubMedCrossRef

Seshadri S, Sunkara SK (2014) Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis. Hum Reprod Update 20(3):429–438PubMedCrossRef

Shakhar K, Ben-Eliyahu S, Loewenthal R, Rosenne E, Carp H (2003) Differences in number and activity of peripheral natural killer cells in primary versus secondary recurrent miscarriage. Fertil Steril 80(2):368–375PubMedCrossRef

Shapira E, Ratzon R, Shoham-Vardi I, Serjienko R, Mazor M, Bashiri A (2012) Primary vs. secondary recurrent pregnancy loss – epidemiological characteristics, etiology, and next pregnancy outcome. J Perinat Med 40(4):389–396PubMedCrossRef

Stephenson MD, Kutteh WH, Purkiss S, Librach C, Schultz P, Houlihan E, Liao C (2010) Intravenous immunoglobulin and idiopathic secondary recurrent miscarriage: a multicentered randomized placebo-controlled trial. Hum Reprod 25(9):2203–2209PubMedPubMedCentralCrossRef

Sugiura-Ogasawara M, Ozaki Y, Katano K, Suzumori N, Mizutani E (2011) Uterine anomaly and recurrent pregnancy loss. Semin Reprod Med 29(6):514–521PubMedCrossRef

Tan WK, Lim SK, Tan LK, Bauptista D (2012) Does low-molecular-weight heparin improve live birth rates in pregnant women with thrombophilic disorders? A systematic review. Singapore Med J 53(10):659–663PubMed

Tersigni C, Castellani R, de Waure C, Fattorossi A, De Spirito M, Gasbarrini A, Scambia G, Di Simone N (2014) Celiac disease and reproductive disorders: meta-analysis of epidemiologic associations and potential pathogenic mechanisms. Hum Reprod Update 20(4):582–593PubMedCrossRef

Toth B (Hrsg) (2017) Fehlgeburten Totgeburten Frühgeburten: Ursachen, Prävention und Therapie. Springer, Berlin

Toth B, Jeschke U, Rogenhofer N, Scholz C, Wurfel W, Thaler CJ, Makrigiannakis A (2010) Recurrent miscarriage: current concepts in diagnosis and treatment. J Reprod Immunol 85(1):25–32PubMedCrossRef

Toth B, Wurfel W, Bohlmann M, Zschocke J, Rudnik-Schoneborn S, Nawroth F, Schleussner E, Rogenhofer N, Wischmann T, von Wolff M, Hancke K, von Otte S, Kuon R, Feil K, Tempfer C (2018) Recurrent miscarriage: diagnostic and therapeutic procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry Number 015/050). Geburtshilfe Frauenheilkd 78(4):364–381PubMedPubMedCentralCrossRef

Tursi A, Giorgetti G, Brandimarte G, Elisei W (2008) Effect of gluten-free diet on pregnancy outcome in celiac disease patients with recurrent miscarriages. Dig Dis Sci 53(11):2925–2928PubMedCrossRef

Vanky E, Stridsklev S, Heimstad R, Romundstad P, Skogoy K, Kleggetveit O, Hjelle S, von Brandis P, Eikeland T, Flo K, Berg KF, Bunford G, Lund A, Bjerke C, Almas I, Berg AH, Danielson A, Lahmami G, Carlsen SM (2010) Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study. J Clin Endocrinol Metab 95(12):E448–E455PubMedCrossRef

Wang X, Chen C, Wang L, Chen D, Guang W, French J (2003) Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study. Fertil Steril 79(3):577–584PubMedCrossRef

Warburton D, Kline J, Stein Z, Hutzler M, Chin A, Hassold T (1987) Does the karyotype of a spontaneous abortion predict the karyotype of a subsequent abortion? Evidence from 273 women with two karyotyped spontaneous abortions. Am J Hum Genet 41(3):465–483PubMedPubMedCentral

Wegmann TG, Lin H, Guilbert L, Mosmann TR (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 14(7):353–356PubMedCrossRef

WHO (1977) Who: recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths. Acta Obstet Gynecol Scand 56(3):247–253

Winger EE, Reed JL (2008) Treatment with tumor necrosis factor inhibitors and intravenous immunoglobulin improves live birth rates in women with recurrent spontaneous abortion. Am J Reprod Immunol 60(1):8–16PubMedCrossRef

Ziakas PD, Pavlou M, Voulgarelis M (2010) Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss: a systematic review and meta-analysis. Obstet Gynecol 115(6):1256–1262PubMedCrossRef

Zolghadri J, Momtahan M, Aminian K, Ghaffarpasand F, Tavana Z (2011) The value of hysteroscopy in diagnosis of chronic endometritis in patients with unexplained recurrent spontaneous abortion. Eur J Obstet Gynecol and Reprod Biol 155(2):217–220CrossRef

Titel: Rezidivierende Spontanaborte
verfasst von: Kilian Vomstein
Verlag: Springer Berlin Heidelberg
Buch: Therapiehandbuch Gynäkologie und Geburtshilfe
Print ISBN: 978-3-662-59808-5

Electronic ISBN: 978-3-662-59809-2

Copyright-Jahr: 2020
DOI: https://doi.org/10.1007/978-3-662-59809-2_6

Update Gynäkologie

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Springer Medizin

6. Rezidivierende Spontanaborte

Zusammenfassung

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hirsutismus bei PCOS: Laser- und Lichttherapien helfen

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Update Gynäkologie

Springer Medizin

Zusammenfassung

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Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hirsutismus bei PCOS: Laser- und Lichttherapien helfen

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Update Gynäkologie