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Inflammation Research
Erschienen in: Inflammation Research 3/2017

07.12.2016 | Original Research Paper

Genetic polymorphisms of IL-18 rs1946518 and IL-1β rs16944 are associated with prognosis and survival of acute myeloid leukemia

verfasst von: Hong Wang, Mingqiang Hua, Shukang Wang, Jie Yu, Chen Chen, Xueyun Zhao, Chen Zhang, Chaoqin Zhong, Ruiqing Wang, Na He, Ming Hou, Daoxin Ma

Erschienen in: Inflammation Research | Ausgabe 3/2017

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Abstract

Background

Though the pathogenesis of AML is still unknown, accumulating evidence revealed that immune response plays a vital part in it. NLRP3 inflammasome as a component of immune system has been found related to several cancers. The single nucleotide polymorphisms (SNPs) of NLRP3 inflammasome genes may be related to pathogenesis and prognosis of AML.

Methods and results

We determined polymorphisms of NLRP3 (rs35829419), CARD8 (rs2043211), IL-1β (rs16944), IL-18 (rs1946518) and NF-κB −94 ins/del ATTG in de novo AML patients to find out whether they play roles in the susceptibility and severity of AML. In our study, 383 AML cases and 300 randomly selected healthy individuals were examined for the polymorphisms and expression of NLRP3 genes. IL-1β (rs16944) polymorphism in different risk AML subgroups was found statistically different, with more GA genotype in favorable-risk cytogenetics group. We also demonstrated that the bone marrow blasts of patients carrying IL-18 (rs1946518) GG or GT genotype were higher than patients of TT genotype. IL-18 plasma level of patients with IL-18 (rs1946518) GT or TT genotype was higher than GG genotype. Moreover, the GT genotype of IL-18 (rs1946518) led to statistically poorer AML-specific survival.

Conclusion

IL-1β (rs16944) and IL-18 (rs1946518) may be served as potential predictors for AML.
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Metadaten
Titel
Genetic polymorphisms of IL-18 rs1946518 and IL-1β rs16944 are associated with prognosis and survival of acute myeloid leukemia
verfasst von
Hong Wang
Mingqiang Hua
Shukang Wang
Jie Yu
Chen Chen
Xueyun Zhao
Chen Zhang
Chaoqin Zhong
Ruiqing Wang
Na He
Ming Hou
Daoxin Ma
Publikationsdatum
07.12.2016
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 3/2017
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-016-1012-4

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