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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 3/2011

01.06.2011

Genetics of Rhinosinusitis

verfasst von: Leandra Mfuna-Endam, Yuan Zhang, Martin Y. Desrosiers

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 3/2011

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Abstract

Suggestion for a potential genetic basis to chronic rhinosinusitis (CRS) is afforded by degree of inheritability suggested from family and twin studies, existence of CRS in simple mendelian diseases, and development of sinusitis as part of the phenotype of certain gene “knockout” murine models. Genetic association studies are expected to identify novel genes associated with CRS and suggest novel mechanisms implicated in disease development. Although these studies are subject to methodologic difficulties, associations of CRS and polymorphisms in more than 30 genes have been published, with single nucleotide polymorphisms in 3 (IL1A, TNFA, AOAH) replicated. While the individual risk conferred by these single nucleotide polymorphisms remains modest, taken as a group, they suggest an important implication of pathways of innate immune recognition and in regulation of downstream signaling in the development of CRS. In a demonstration of these techniques’ potential to identify new targets for research, the authors present a functional investigation of LAMB1, the top-rated gene from a pooling-based genome-wide association study of CRS. Upregulation of gene expression in LAMB1 and associated laminin genes in primary epithelial cells from CRS patients implicates the extracellular matrix in development of CRS and offers a new avenue for further study.
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Metadaten
Titel
Genetics of Rhinosinusitis
verfasst von
Leandra Mfuna-Endam
Yuan Zhang
Martin Y. Desrosiers
Publikationsdatum
01.06.2011
Verlag
Current Science Inc.
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 3/2011
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-011-0189-4

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