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01.05.2011 | Review

Impact of smoking on inflammation: overview of molecular mechanisms

verfasst von: R. B. Gonçalves, R. D. Coletta, K. G. Silvério, L. Benevides, M. Z. Casati, J. S. da Silva, F. H. Nociti Jr.

Erschienen in: Inflammation Research | Ausgabe 5/2011

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Abstract

Background

Inflammation is a critical component of normal tissue repair, as well as being fundamental to the body’s defense against infection. Environmental factors, such as smoking, have been reported to modify the host response and hence modify inflammation progression, severity and outcome. Therefore, a comprehensive understanding of the molecular mechanisms by which smoking affects inflammation is vital for preventive and therapeutic strategies on a clinical level.

Aim

The purpose of the present article is to review the potential biological mechanisms by which smoking affects inflammation, emphasizing recent developments.

Results

Smoking is reported to effect a number of biological mediators of inflammation through its effect on immune-inflammatory cells, leading to an immunosuppressant state. Recent evidence strongly suggests that the molecular mechanisms behind the modulation of inflammation by smoking mainly involve the nuclear factor-kappa B (NF-kB) family, through the activation of both an inhibitor of IkB kinase (IKK)-dependent and -independent pathway. In addition to NF-kB activation, a number of transcriptional factors including GATA, PAX5 and Smad 3/4, have also been implicated.

Conclusion

Multiple mechanisms may be responsible for the association of smoking and inflammation, and the identification of potential therapeutic targets should guide future research.

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Titel: Impact of smoking on inflammation: overview of molecular mechanisms
verfasst von: R. B. Gonçalves
R. D. Coletta
K. G. Silvério
L. Benevides
M. Z. Casati
J. S. da Silva
F. H. Nociti Jr.
Publikationsdatum: 01.05.2011
Verlag: SP Birkhäuser Verlag Basel
Erschienen in: Inflammation Research / Ausgabe 5/2011
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-011-0308-7

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Lactoferrin inhibits the inflammatory and angiogenic activation of bovine aortic endothelial cells

Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation

Black tea polyphenol theaflavin suppresses LPS-induced ICAM-1 and VCAM-1 expression via blockage of NF-κB and JNK activation in intestinal epithelial cells

Cross-linking of CD137 ligand modulates immune responses of thioglycollate-elicited mouse peritoneal macrophages

Non-invasive screening of progressive joint defects in the Type II collagen-induced arthritis animal model using radiographic paw images