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Inflammation Research

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01.07.2012 | Original Research Paper

Inflammation–hemostasis relationship in infected malnourished mice: modulatory effect of Lactobacillus casei CRL 431

verfasst von: Hortensia Zelaya, Cecilia Haro, Jonathan Laiño, Susana Alvarez, Graciela Agüero

Erschienen in: Inflammation Research | Ausgabe 7/2012

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Abstract

Objective and design

The coagulation system is considered part of the defense machinery, but its excessive activation can lead to additional damage. We studied the effects of oral administration of Lactobacillus casei CRL 431—a probiotic bacterium—on the activation of coagulation and the relationship with inflammatory parameters during a respiratory infection in malnourished mice.

Materials and methods

Malnourished Swiss albino mice were nourished with a balanced commercial diet (BCD) for 7 days or BCD with L. casei for the last 2 days (BCD + Lc). BCD, BCD + Lc, malnourished (MNC) and well-nourished controls (WNC) were infected with Streptococcus pneumoniae. Blood and bronchoalveolar lavage samples were obtained at different times post-infection.

Results and conclusions

Malnutrition altered most of the evaluated parameters before and after infection. The repletion diet with supplemental L. casei was the most effective in limiting coagulation activation and normalizing coagulation inhibition mechanisms. These findings will help develop further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.

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Titel: Inflammation–hemostasis relationship in infected malnourished mice: modulatory effect of Lactobacillus casei CRL 431
verfasst von: Hortensia Zelaya
Cecilia Haro
Jonathan Laiño
Susana Alvarez
Graciela Agüero
Publikationsdatum: 01.07.2012
Verlag: SP Birkhäuser Verlag Basel
Erschienen in: Inflammation Research / Ausgabe 7/2012
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-012-0472-4

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Abstract

Objective and design

Materials and methods

Results and conclusions

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