Erschienen in:
30.10.2017 | Short Communication
Insulin-like growth factor-6 (IGFBP-6) stimulates neutrophil oxidative burst, degranulation and chemotaxis
verfasst von:
Massimo Conese, Susanna D’Oria, Stefano Castellani, Rosa Trotta, Pasqualina Montemurro, Arcangelo Liso
Erschienen in:
Inflammation Research
|
Ausgabe 2/2018
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Abstract
The aim of this study was to understand whether insulin-like growth factor-binding protein-6 (IGFBP-6) has functional effects on neutrophils, in particular when they cross epithelium during inflammation. We found that IGFBP-6 increased ROS production (cytofluorimetry), degranulation of primary and tertiary granules (ELISA) and transmigration through the epithelial monolayer. No priming by IGFBP-6 on neutrophils stimulated by either PMA or fMLP was observed. IGFBP-6 is an agonist of neutrophils’ functions, most likely when these cells have been already activated by other stimuli.