nach oben

19.02.2024 | Original Article

Decreased retinal vascular density is associated with cognitive impairment in CADASIL: an optical coherence tomography angiography study

verfasst von: Yu Guo, Jianchen Hao, Ruilin Zhu, Li Bai, Yong Shan, Yunchuang Sun, Fan Li, Wei Zhang, Zhaoxia Wang, Liu Yang, Yun Yuan, Chen Ling

Erschienen in: Neurological Sciences

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This study aimed to assess alterations in retinal vascular density in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients using optical coherence tomography angiography (OCTA) and investigate their association with MRI and cognitive features.

Methods

Twenty-five patients with CADASIL and forty healthy controls were evaluated by Cirrus HD-OCT 5000 with AngioPlex OCTA to determine changes in macular retinal vasculature. Retinal vasculature parameters between two groups were compared. The MRI lesion burden and neuropsychological scales were also examined in patients. The association between OCTA parameters and MRI/cognitive features was evaluated using partial Spearman rank correlation.

Results

The vessel density and perfusion density of whole image in macular region (vessel density: t = − 2.834, p = 0.005; perfusion density: t = − 2.691, p = 0.007) were significantly decreased in patients with CADASIL. Moreover, vessel density of whole image in macular region was negatively associated with Fazekas scores (ρ = − 0.457; p = 0.025) and the number of lacunar infractions (ρ = − 0.425, p = 0.038) after adjustment for age. Decreased macular vessel density and perfusion density of whole image were also associated with MoCA scores (vessel density: ρ = 0.542, p = 0.006; perfusion density: ρ = 0.478, p = 0.018) and other domain-specific neuropsychological tests (p < 0.05) after adjustment for age.

Conclusion

Decreased retinal vascular density was associated with increased MRI lesion burden and cognitive impairment in patients with CADASIL. Our findings suggest that the degree of retinal vascular involvement, as demonstrated by OCTA, may be consistent with the severity of MRI lesions and the degree of cognitive impairment in patients.

Nur mit Berechtigung zugänglich

Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, Alamowitch S, Domenga V, Cécillion M, Marechal E, Maciazek J, Vayssiere C, Cruaud C, Cabanis EA, Ruchoux MM, Weissenbach J, Bach JF, Bousser MG, Tournier-Lasserve E (1996) Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 383:707–710. https://doi.org/10.1038/383707a0ADSCrossRefPubMed

Yamamoto Y, Craggs LJ, Watanabe A, Booth T, Attems J, Low RW, Oakley AE, Kalaria RN (2013) Brain microvascular accumulation and distribution of the NOTCH3 ectodomain and granular osmiophilic material in CADASIL. J Neuropathol Exp Neurol 72:416–431. https://doi.org/10.1097/NEN.0b013e31829020b5CrossRefPubMed

Brice S, Jabouley A, Reyes S, Machado C, Rogan C, Dias-Gastellier N, Chabriat H, du Montcel ST (2020) Modeling the cognitive trajectory in CADASIL. J Alzheimer’s Dis : JAD 77:291–300. https://doi.org/10.3233/jad-200310CrossRefPubMed

Roine S, Harju M, Kivelä TT, Pöyhönen M, Nikoskelainen E, Tuisku S, Kalimo H, Viitanen M, Summanen PA (2006) Ophthalmologic findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a cross-sectional study. Ophthalmology 113:1411–1417. https://doi.org/10.1016/j.ophtha.2006.03.030CrossRefPubMed

Patton N, Aslam T, Macgillivray T, Pattie A, Deary IJ, Dhillon B (2005) Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat 206:319–348. https://doi.org/10.1111/j.1469-7580.2005.00395.xCrossRefPubMedPubMedCentral

Parisi V, Pierelli F, Malandrini A, Carrera P, Olzi D, Gregori D, Restuccia R, Parisi L, Fattapposta F (2000) Visual electrophysiological responses in subjects with cerebral autosomal arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Clin Neurophysiol 111:1582–1588CrossRefPubMed

Parisi V, Pierelli F, Fattapposta F, Bianco F, Parisi L, Restuccia R, Malandrini A, Ferrari M, Carrera P (2003) Early visual function impairment in CADASIL. Neurology 60:2008–2010CrossRefPubMed

Parisi V, Pierelli F, Coppola G, Restuccia R, Ferrazzoli D, Scassa C, Bianco F, Parisi L, Fattapposta F (2007) Reduction of optic nerve fiber layer thickness in CADASIL. Eur J Neurol 14:627–631CrossRefPubMed

Haritoglou C, Rudolph G, Hoops JP, Opherk C, Kampik A, Dichgans M (2004) Retinal vascular abnormalities in CADASIL. Neurology 62:1202–1205. https://doi.org/10.1212/01.wnl.0000118296.16326.e1CrossRefPubMed

10.

Fang X-J, Yu M, Wu Y, Zhang Z-H, Wang W-W, Wang Z-X, Yuan Y (2017) Study of enhanced depth imaging optical coherence tomography in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Chin Med J 130:1042–1048. https://doi.org/10.4103/0366-6999.204935CrossRefPubMedPubMedCentral

11.

Liu Y, Wu Y, Xie S, Luan X-h, Yuan Y (2008) Retinal arterial abnormalities correlate with brain white matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy. Clin Experiment Ophthalmol 36:532–536. https://doi.org/10.1111/j.1442-9071.2008.01825.xCrossRefPubMed

12.

de Carlo TE, Romano A, Waheed NK, Duker JS (2015) A review of optical coherence tomography angiography (OCTA). Int J Retina Vitreous 1:5. https://doi.org/10.1186/s40942-015-0005-8CrossRefPubMedPubMedCentral

13.

Roberta F, Arturo C, Maurizio F (2022) Optical coherence tomography angiography of central serous chorioretinopathy: quantitative evaluation of the vascular pattern and capillary flow density. Graefe’s Arch Clin Exp Ophthalmol = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie 260:1015–1024. https://doi.org/10.1007/s00417-021-05306-wCrossRef

14.

Carta A, Farci R, Galantuomo MS, Fossarello M (2022) X-linked retinoschisis: OCT-angiography in two brothers from a four-generation family with a p.Arg197Cys pathogenic variant in the gene. Eur J Ophthalmol 33:NP109-NP114. https://doi.org/10.1177/11206721221136315

15.

Farci R, Carta A, Cocco E, Frau J, Fossarello M, Diaz G (2020) Optical coherence tomography angiography in multiple sclerosis: a cross-sectional study. PLoS One 15:e0236090. https://doi.org/10.1371/journal.pone.0236090CrossRefPubMedPubMedCentral

16.

Wang X, Wei Q, Wu X, Cao S, Chen C, Zhang J, Yan Y, Geng Z, Tian Y, Wang K (2021) The vessel density of the superficial retinal capillary plexus as a new biomarker in cerebral small vessel disease: an optical coherence tomography angiography study. Neurol Sci: Off J Italian Neurol Soc Italian Soc Clin Neurophysiol 42:3615–3624. https://doi.org/10.1007/s10072-021-05038-zCrossRef

17.

Fu W, Zhou X, Wang M, Li P, Hou J, Gao P, Wang J (2022) Fundus changes evaluated by OCTA in patients with cerebral small vessel disease and their correlations: a cross-sectional study. Front Neurol 13:843198. https://doi.org/10.3389/fneur.2022.843198CrossRefPubMedPubMedCentral

18.

Wu J, Zhang X, Azhati G, Li T, Xu G, Liu F (2020) Retinal microvascular attenuation in mental cognitive impairment and Alzheimer’s disease by optical coherence tomography angiography. Acta Ophthalmol (Copenh) 98:e781–e787. https://doi.org/10.1111/aos.14381CrossRef

19.

Li Y, Wang X, Zhang Y, Zhang P, He C, Li R, Wang L, Zhang H, Zhang Y (2022) Retinal microvascular impairment in Parkinson’s disease with cognitive dysfunction. Parkinsonism Relat Disord 98:27–31. https://doi.org/10.1016/j.parkreldis.2022.03.008CrossRefPubMed

20.

Fickweiler W, Wolfson EA, Paniagua SM, Yu MG, Adam A, Bahnam V, Sampani K, Wu IH, Musen G, Aiello LP, Shah H, Sun JK, King GL (2021) Association of cognitive function and retinal neural and vascular structure in type 1 diabetes. J Clin Endocrinol Metab 106:1139–1149. https://doi.org/10.1210/clinem/dgaa921CrossRefPubMed

21.

Yang K, Cui L, Chen X, Yang C, Zheng J, Zhu X, Xiao Y, Su B, Li C, Shi K, Lu F, Qu J, Li M (2022) Decreased vessel density in retinal capillary plexus and thinner ganglion cell complex associated with cognitive impairment. Front Aging Neurosci 14:872466. https://doi.org/10.3389/fnagi.2022.872466CrossRefPubMedPubMedCentral

22.

Yang K, Shen B, Li D-K, Wang Y, Zhao J, Zhao J, Yu W-B, Liu Z-Y, Tang Y-L, Liu F-T, Yu H, Wang J, Guo Q-H, Wu J-J (2018) Cognitive characteristics in Chinese non-demented PD patients based on gender difference. Transl Neurodegener 7:16. https://doi.org/10.1186/s40035-018-0120-1CrossRefPubMedPubMedCentral

23.

Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O’Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw F-E, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Rv O, Pantoni L, Speck O, Stephan BCM, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M (2013) Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 12:822–838. https://doi.org/10.1016/S1474-4422(13)70124-8CrossRefPubMedPubMedCentral

24.

Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA (1987) MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 149:351–356. https://doi.org/10.2214/ajr.149.2.351CrossRefPubMed

25.

Ling C, Zhang Z, Wu Y, Fang X, Kong Q, Zhang W, Wang Z, Yang Q, Yuan Y (2019) Reduced venous oxygen saturation associates with increased dependence of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a 7.0-T magnetic resonance imaging study. Stroke 50:3128–3134. https://doi.org/10.1161/strokeaha.119.026376CrossRefPubMed

26.

Garcia-Medina JJ, Rubio-Velazquez E, Lopez-Bernal MD, Parraga-Muñoz D, Perez-Martinez A, Pinazo-Duran MD, Del-Rio-Vellosillo M (2020) Optical coherence tomography angiography of macula and optic nerve in autism spectrum disorder: a pilot study. J Clin Med 9:3123. https://doi.org/10.3390/jcm9103123

27.

Nelis P, Kleffner I, Burg MC, Clemens CR, Alnawaiseh M, Motte J, Marziniak M, Eter N, Alten F (2018) OCT-angiography reveals reduced vessel density in the deep retinal plexus of CADASIL patients. Sci Rep 8:8148. https://doi.org/10.1038/s41598-018-26475-5ADSCrossRefPubMedPubMedCentral

28.

Tsokolas G, Tsaousis KT, Diakonis VF, Matsou A, Tyradellis S (2020) Optical coherence tomography angiography in neurodegenerative diseases: a review. Eye and brain 12:73–87. https://doi.org/10.2147/eb.S193026CrossRefPubMedPubMedCentral

29.

Sun C, Wu Y, Ling C, Xie Z, Sun Y, Xie Z, Li Z, Fang X, Kong Q, An J, Wang B, Zhuo Y, Zhang W, Wang Z, Yuan Y, Zhang Z (2022) Reduced blood flow velocity in lenticulostriate arteries of patients with CADASIL assessed by PC-MRA at 7T. J Neurol Neurosurg Psychiatry 93:451–452. https://doi.org/10.1136/jnnp-2021-326258CrossRefPubMed

30.

Yu D-Y, Cringle SJ, Yu PK, Balaratnasingam C, Mehnert A, Sarunic MV, An D, Su E-N (2019) Retinal capillary perfusion: spatial and temporal heterogeneity. Prog Retin Eye Res 70:23–54. https://doi.org/10.1016/j.preteyeres.2019.01.001CrossRefPubMed

31.

Wei W, Li Y, Xie Z, Deegan AJ, Wang RK (2019) Spatial and temporal heterogeneities of capillary hemodynamics and its functional coupling during neural activation. IEEE Trans Med Imaging 38:1295–1303. https://doi.org/10.1109/TMI.2018.2883244CrossRefPubMed

32.

Chan G, Balaratnasingam C, Yu PK, Morgan WH, McAllister IL, Cringle SJ, Yu D-Y (2013) Quantitative changes in perifoveal capillary networks in patients with vascular comorbidities. Invest Ophthalmol Vis Sci 54:5175–5185. https://doi.org/10.1167/iovs.13-11945CrossRefPubMed

33.

Lin C-W, Yang Z-W, Chen C-H, Cheng Y-W, Tang S-C, Jeng J-S (2022) Reduced macular vessel density and inner retinal thickness correlate with the severity of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). PLoS One 17:e0268572. https://doi.org/10.1371/journal.pone.0268572CrossRefPubMedPubMedCentral

34.

Yoon SP, Grewal DS, Thompson AC, Polascik BW, Dunn C, Burke JR, Fekrat S (2019) Retinal microvascular and neurodegenerative changes in Alzheimer’s disease and mild cognitive impairment compared with control participants. Ophthalmol Retina 3:489–499. https://doi.org/10.1016/j.oret.2019.02.002CrossRefPubMedPubMedCentral

35.

Li Z-B, Lin Z-J, Li N, Yu H, Wu Y-L, Shen X (2021) Evaluation of retinal and choroidal changes in patients with Alzheimer’s type dementia using optical coherence tomography angiography. Int J Ophthalmol 14:860–868. https://doi.org/10.18240/ijo.2021.06.11CrossRefPubMedPubMedCentral

36.

Bulut M, Kurtuluş F, Gözkaya O, Erol MK, Cengiz A, Akıdan M, Yaman A (2018) Evaluation of optical coherence tomography angiographic findings in Alzheimer’s type dementia. Br J Ophthalmol 102:233–237. https://doi.org/10.1136/bjophthalmol-2017-310476CrossRefPubMed

37.

Ban S, Wang H, Wang M, Xu S, Qin Z, Su J, Du X, Liu J-R (2019) Diffuse tract damage in CADASIL is correlated with global cognitive impairment. Eur Neurol 81:294–301. https://doi.org/10.1159/000501612CrossRefPubMed

38.

Taniguchi A, Shindo A, Tabei KI, Onodera O, Ando Y, Urabe T, Kimura K, Kitagawa K, Miyamoto Y, Takegami M, Ihara M, Mizuta I, Mizuno T, Tomimoto H (2022) Imaging characteristics for predicting cognitive impairment in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Front Aging Neurosci 14:876437. https://doi.org/10.3389/fnagi.2022.876437CrossRefPubMedPubMedCentral

Titel: Decreased retinal vascular density is associated with cognitive impairment in CADASIL: an optical coherence tomography angiography study
verfasst von: Yu Guo
Jianchen Hao
Ruilin Zhu
Li Bai
Yong Shan
Yunchuang Sun
Fan Li
Wei Zhang
Zhaoxia Wang
Liu Yang
Yun Yuan
Chen Ling
Publikationsdatum: 19.02.2024
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-024-07390-2

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Bluttest erkennt Parkinson schon zehn Jahre vor der Diagnose

10.05.2024 Parkinson-Krankheit Nachrichten

Ein Bluttest kann abnorm aggregiertes Alpha-Synuclein bei einigen Menschen schon zehn Jahre vor Beginn der motorischen Parkinsonsymptome nachweisen. Mit einem solchen Test lassen sich möglicherweise Prodromalstadien erfassen und die Betroffenen früher behandeln.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Wartezeit nicht kürzer, aber Arbeit flexibler

Psychotherapie Medizin aktuell

Fünf Jahren nach der Neugestaltung der Psychotherapie-Richtlinie wurden jetzt die Effekte der vorgenommenen Änderungen ausgewertet. Das Hauptziel der Novellierung war eine kürzere Wartezeit auf Therapieplätze. Dieses Ziel wurde nicht erreicht, es gab jedoch positive Auswirkungen auf andere Bereiche.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen