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European Journal of Applied Physiology

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20.06.2021 | Original Article

Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults

verfasst von: Xi Li, Tianyu Han, Xu Zou, Han Zhang, Wenpin Feng, Han Wang, Yulin Shen, Li Zhang, Guoliang Fang

Erschienen in: European Journal of Applied Physiology | Ausgabe 10/2021

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Abstract

Purpose

To compare the effects of 12-week high-intensity interval training (HIIT) and vigorous-intensity continuous training (VICT) on cognitive function, physical fitness, VO₂max, serum neurotransmitters and neurotrophic factors in overweight and obese elderly individuals.

Methods

Twenty-nine physically inactive older adults (18 males and 11 females) with a mean age of 64.8 ± 3.9 years were randomly divided into a control group (CON, n = 9), an HIIT group (4 × 3 min at 90% VO₂max interspersed with 3 min at 60% VO₂max, n = 10) and a VICT group (25 min at 70% VO₂max, n = 10) and submitted to 12 weeks of training. Cognitive function questionnaires, physical fitness, VO₂max, serum neurotransmitters and neurotrophic factors were determined at baseline and post training.

Results

Twelve weeks of HIIT and VICT improved the VO₂max (4.19 ± 2.21 and 1.84 ± 1.63 mL/kg/min, respectively, p = 0.005), sit-and-reach distance (8.7 ± 3.0 and 7.8 ± 3.8 cm, p = 0.033), choice reaction time (− 0.115 ± 0.15 and − 0.09 ± 0.15 s, p = 0.004) and one-leg stand time (4.4 ± 3.4 and 4.2 ± 4.0 s, p < 0.001) of the elderly participants. The serum concentrations of brain-derived neurotrophic factor (375.5 ± 247.9 and 227.0 ± 137.1 pg/ml, p = 0.006), nerve growth factor (33.9 ± 16.7 and 23.3 ± 14.5 pg/ml, p = 0.037), neurotrophin-3 (24.2 ± 9.33 and 16.3 ± 5.91 pg/ml, p = 0.006) and neurotrophin-4 (10.4 ± 3.8 and 7.8 ± 5.0 pg/ml, p = 0.029) increased significantly in the HIIT and VICT groups after training. In addition, compared to VICT, HIIT significantly increased VO₂max and the serum neurotrophin-3 concentration. Serum concentrations of the neurotransmitters acetylcholine, dopamine and serotonin trended upward with training. No significant change was observed in the cognitive function questionnaire scores (p > 0.05).

Conclusion

HIIT is suitable for elderly adults and is more effective than VICT for improving VO₂max and serum neurotrophin-3 concentrations.

Chinese Clinical Trial Registry number

No. ChiCTR1900022315, date of registration: 4 April 2019

Adamson SB, Lorimer R, Cobley JN, Babraj JA (2014) Extremely short-duration high-intensity training substantially improves the physical function and self-reported health status of elderly adults. J Am Geriatr Soc 62(7):1380–1381PubMedCrossRef

Afzalpour ME, Chadorneshin HT, Foadoddini M, Eivari HA (2015) Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain. Physiol Behav 147:78–83PubMedCrossRef

Angadi SS, Mookadam F, Lee CD, Tucker WJ, Haykowsky MJ, Gaesser GA (2015) High-intensity interval training vs moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: a pilot study. J Appl Physiol 119(6):753–758PubMedCrossRef

Angevaren M, Vanhees L, Wendel-Vos W, Verhaar HJ, Aufdemkampe G, Aleman A, Verschuren WM (2007) Intensity, but not duration, of physical activities is related to cognitive function. Eur J Cardiovasc Prev Rehabil 14(6):825–830PubMedCrossRef

Angevaren M, Aufdemkampe G, Verhaar H, Aleman A, Vanhees L (2008) Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD005381.pub3CrossRefPubMed

Angevaren M, Vanhees L, Nooyens AC, Wendel-Vos CW, Verschuren WM (2010) Physical activity and 5-year cognitive decline in the Doetinchem cohort study. Ann Epidemiol 20(6):473–479PubMedCrossRef

Astrand I, Astrand P, Hallbäck I, Kilbom A (1973) Reduction in maximal oxygen uptake with age. J Appl Physiol 35(5):649–654PubMedCrossRef

Bailey SJ, Wilkerson DP, DiMenna FJ, Jones AM (2009) Influence of repeated sprint training on pulmonary O₂ uptake and muscle deoxygenation kinetics in humans. J Appl Physiol 106(6):1875–1887PubMedCrossRef

Batacan RB, Duncan MJ, Dalbo VJ, Tucker PS, Fenning AS (2017) Effects of high-intensity interval training on cardiometabolic health: a systematic review and meta-analysis of intervention studies. Br J Sports Med 51(6):494–503PubMedCrossRef

Benda NM, Seeger JP, Stevens GG, Hijmans-Kersten BT, van Dijk AP, Bellersen L, Lamfers EJ, Hopman MT, Thijssen DH (2015) Effects of high-intensity interval training versus continuous training on physical fitness, cardiovascular function and quality of life in heart failure patients. PLoS ONE. https://doi.org/10.1371/journal.pone.0141256CrossRefPubMedPubMedCentral

Bohannon RW (2008) Hand-grip dynamometry predicts future outcomes in aging adults. J Geriatr Phys Ther 31(1):3–10PubMedCrossRef

Bolduc V, Thorin-Trescases N, Thorin E (2013) Endothelium-dependent control of cerebrovascular functions through age: exercise for healthy cerebrovascular aging. Am J Physiol Heart Circ Physiol 305(5):H620–H633PubMedCrossRef

Buchheit M, Laursen PB (2013) High-intensity interval training, solutions to the programming puzzle. Sports Med 43(10):927–954PubMedCrossRef

Burgomaster KA, Howarth KR, Phillips SM, Rakobowchuk M, MacDonald MJ, McGee SL, Gibala MJ (2008) Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol 586(1):151–160PubMedCrossRef

Cassidy S, Thoma C, Houghton D, Trenell MI (2017) High-intensity interval training: a review of its impact on glucose control and cardiometabolic health. Diabetologia 60(1):7–23PubMedCrossRef

Chen KL, Xu Y, Chu AQ, Ding D, Liang XN, Nasreddine ZS, Dong Q, Hong Z, Zhao QH, Guo QH (2016) Validation of the Chinese version of Montreal cognitive assessment basic for screening mild cognitive impairment. J Am Geriatr Soc 64(12):e285–e290PubMedCrossRef

Cholerton B, Baker LD, Craft S (2011) Insulin resistance and pathological brain ageing. Diabet Med 28(12):1463–1475PubMedCrossRef

Cocks M, Shaw CS, Shepherd SO, Fisher JP, Ranasinghe AM, Barker TA, Tipton KD, Wagenmakers AJ (2013) Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males. J Physiol 591(3):641–656PubMedCrossRef

Coetsee C, Terblanche E (2017) Cerebral oxygenation during cortical activation: the differential influence of three exercise training modalities. A randomized controlled trial. Eur J Appl Physiol 117(8):1617–1627PubMedCrossRef

Cohen J (1969) Statistical power analysis for the behavioral sciences. Academic Press, New York

Cohen J (1973) Eta-squared and partial eta-squared in fixed factor ANOVA designs. Educ Psychol Measur 33(1):107–112CrossRef

Cohen J (1992) A power primer. Psychol Bull 112(1):155PubMedCrossRef

Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R, McAuley E, Elavsky S, Marquez DX, Hu L, Kramer AF (2006) Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci 61(11):1166–1170PubMedCrossRef

Costigan SA, Eather N, Plotnikoff RC, Hillman CH, Lubans DR (2016) High-intensity interval training on cognitive and mental health in adolescents. Med Sci Sports Exerc 48(10):1985–1993PubMedCrossRef

Daussin FN, Zoll J, Dufour SP, Ponsot E, Lonsdorfer-Wolf E, Doutreleau S, Mettauer B, Piquard F, Geny B, Richard R (2008) Effect of interval versus continuous training on cardiorespiratory and mitochondrial functions: relationship to aerobic performance improvements in sedentary subjects. Am J Physiol Regul Integr Comp Physiol 295(1):R264–R272PubMedCrossRef

Dykiert D, Der G, Starr JM, Deary IJ (2012) Age differences in intra-individual variability in simple and choice reaction time: systematic review and meta-analysis. PLoS ONE 7(10):e45759PubMedPubMedCentralCrossRef

Ellingsen Ø, Halle M, Conraads V, Støylen A, Dalen H, Delagardelle C, Larsen A-I, Hole T, Mezzani A, Van Craenenbroeck EM (2017) High-intensity interval training in patients with heart failure with reduced ejection fraction. Circulation 135(9):839–849PubMedPubMedCentralCrossRef

Erickson K, Kramer AF (2009) Aerobic exercise effects on cognitive and neural plasticity in older adults. Br J Sports Med 43(1):22–24PubMedCrossRef

Esfarjani F, Laursen PB (2007) Manipulating high-intensity interval training: effects on VO2max, the lactate threshold and 3000 m running performance in moderately trained males. J Sci Med Sport 10(1):27–35PubMedCrossRef

Fang G, Zhao J, Li P, Li L, Yu T, Yang X, He Z, Tian Y (2017) Long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats. Sci Bull 62(11):755–757CrossRef

Gajewski PD, Falkenstein M (2016) Physical activity and neurocognitive functioning in aging-a condensed updated review. Eur Rev Aging Phys Act 13(1):1–7PubMedPubMedCentralCrossRef

Gao Y, Zhao Y, Pan J, Yang L, Huang T, Feng X, Li C, Liang S, Zhou D, Liu C (2014) Treadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways. Brain Res 1585:83–90PubMedCrossRef

Gormley SE, Swain DP, High R, Spina RJ, Dowling EA, Kotipalli US, Gandrakota R (2008) Effect of intensity of aerobic training on VO2max. Med Sci Sports Exerc 40(7):1336–1343PubMedCrossRef

Hawkins SA, Wiswell RA (2003) Rate and mechanism of maximal oxygen consumption decline with aging. Sports Med 33(12):877–888PubMedCrossRef

Hayes SM, Forman DE, Verfaellie M (2016) Cardiorespiratory fitness is associated with cognitive performance in older but not younger adults. J Gerontol B Psychol Sci Soc Sci 71(3):474–482PubMedCrossRef

Heyn P, Abreu BC, Ottenbacher KJ (2004) The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil 85(10):1694–1704PubMedCrossRef

Hillman CH, Erickson KI, Kramer AF (2008) Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci 9(1):58PubMedCrossRef

Hwang C-L, Yoo J-K, Kim H-K, Hwang M-H, Handberg EM, Petersen JW, Christou DD (2016) Novel all-extremity high-intensity interval training improves aerobic fitness, cardiac function and insulin resistance in healthy older adults. Exp Gerontol 82:112–119PubMedPubMedCentralCrossRef

Keating CJ, Montilla JÁP, Román PÁL, del Castillo RM (2020) Comparison of high-intensity interval training to moderate-intensity continuous training in older adults: a systematic review. J Aging Phys Act 1(aop):1–10

Kennedy G, Hardman RJ, Macpherson H, Scholey AB, Pipingas A (2017) How does exercise reduce the rate of age-associated cognitive decline? A review of potential mechanisms. J Alzheimers Dis 55(1):1–18PubMedCrossRef

Kirk-Sanchez NJ, McGough EL (2014) Physical exercise and cognitive performance in the elderly: current perspectives. Clin Interv Aging 9:51PubMed

Lemmink KA, Kemper HC, Greef MH, Rispens P, Stevens M (2003) The validity of the sit-and-reach test and the modified sit-and-reach test in middle-aged to older men and women. Res Q Exerc Sport 74(3):331–336PubMedCrossRef

Li R, Wu Y, Jiang D (2016) NT-3 attenuates the growth of human neuron cells through the ERK pathway. Cytotechnology 68(4):659–664PubMedCrossRef

Marosi K, Mattson MP (2014) BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab 25(2):89–98PubMedCrossRef

Meneses A (2013) 5-HT systems: emergent targets for memory formation and memory alterations. Rev Neurosci 24(6):629–664PubMedCrossRef

Miksys SL, Tyndale RF (2010) Neurodegenerative diseases: a growing challenge. Clin Pharmacol Ther 88(4):427–430. https://doi.org/10.1038/clpt.2010.198CrossRefPubMed

Milanović Z, Sporiš G, Weston M (2015) Effectiveness of high-intensity interval training (HIT) and continuous endurance training for VO2max improvements: a systematic review and meta-analysis of controlled trials. Sports Med 45(10):1469–1481PubMedCrossRef

Mulero J, Zafrilla P, Martinez-Cacha A (2011) Oxidative stress, frailty and cognitive decline. J Nutr Health Aging 15(9):756–760PubMedCrossRef

Muscari A, Giannoni C, Pierpaoli L, Berzigotti A, Maietta P, Foschi E, Ravaioli C, Poggiopollini G, Bianchi G, Magalotti D (2010) Chronic endurance exercise training prevents aging-related cognitive decline in healthy older adults: a randomized controlled trial. Int J Geriatr Psychiatry 25(10):1055–1064PubMedCrossRef

Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(4):695–699PubMedCrossRef

Nettiksimmons J, Simonsick EM, Harris T, Satterfield S, Rosano C, Yaffe K (2014) The associations between serum brain-derived neurotrophic factor, potential confounders, and cognitive decline: a longitudinal study. PLoS ONE 9(3):e91339PubMedPubMedCentralCrossRef

Paillard T, Rolland Y, de Souto BP (2015) Protective effects of physical exercise in Alzheimer’s disease and Parkinson’s disease: a narrative review. J Clin Neurol 11(3):212–219PubMedPubMedCentralCrossRef

Peruyero F, Zapata J, Pastor D, Cervelló E (2017) The acute effects of exercise intensity on inhibitory cognitive control in adolescents. Front Psychol 8:921PubMedPubMedCentralCrossRef

Radák Z, Kaneko T, Tahara S, Nakamoto H, Pucsok J, Sasvári M, Nyakas C, Goto S (2001) Regular exercise improves cognitive function and decreases oxidative damage in rat brain. Neurochem Int 38(1):17–23PubMedCrossRef

Reddy PH (2009) Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer’s disease. Exp Neurol 218(2):286–292PubMedPubMedCentralCrossRef

Reed JL, Keast M-L, Beanlands RA, Blais AZ, Clarke AE, Pipe AL, Tulloch HE (2019) The effects of aerobic interval training and moderate-to-vigorous intensity continuous exercise on mental and physical health in women with heart disease. Eur J Prev Cardiol 26(2):211–214PubMedCrossRef

Schliebs R, Arendt T (2011) The cholinergic system in aging and neuronal degeneration. Behav Brain Res 221(2):555–563PubMedCrossRef

Simen AA, Bordner KA, Martin MP, Moy LA, Barry LC (2011) Cognitive dysfunction with aging and the role of inflammation. Ther Adv Chronic Dis 2(3):175–195PubMedPubMedCentralCrossRef

Siuda J, Patalong-Ogiewa M, Żmuda W, Targosz-Gajniak M, Niewiadomska E, Matuszek I, Jędrzejowska-Szypułka H, Rudzińska-Bar M (2017) Cognitive impairment and BDNF serum levels. Neurol Neurochir Pol 51(1):24–32PubMedCrossRef

Terrando N, Eriksson LI, Kyu Ryu J, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M (2011) Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol 70(6):986–995PubMedPubMedCentralCrossRef

Tian Y, Jiang C, Wang M, Cai R, Zhang Y, He Z, Wang H, Wu D, Wang F, Liu X (2016) BMI, leisure-time physical activity, and physical fitness in adults in China: results from a series of national surveys, 2000–14. Lancet Diabetes Endocrinol 4(6):487–497PubMedCrossRef

Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, Hashimoto T (2016) Greater impact of acute high-intensity interval exercise on post-exercise executive function compared to moderate-intensity continuous exercise. Physiol Behav 155:224–230PubMedCrossRef

Valdez G, Tapia JC, Kang H, Clemenson GD, Gage F, Lichtman JW, Sanes JR (2010) Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise. Proc Natl Acad Sci 107(33):14863–14868PubMedPubMedCentralCrossRef

Vaynman S, Ying Z, Gomez-Pinilla F (2007) The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function. Neuroscience 144(3):825–833PubMedCrossRef

Villafaina S, Giménez-Guervós Pérez MJ, Fuentes-García JP (2020) Comparative effects of high-intensity interval training vs moderate-intensity continuous training in phase iii of a tennis-based cardiac rehabilitation program: a Pilot Randomized Controlled Trial. Sustainability 12(10):4134CrossRef

Wang X, Wang W, Li L, Perry G, Lee H-G (1842) Zhu X (2014) Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease. Biochim Biophys Acta Mol Basis Dis BBA 8:1240–1247

Wang S, Chen L, Zhang L, Huang C, Xiu Y, Wang F, Zhou C, Luo Y, Xiao Q, Tang Y (2015) Effects of long-term exercise on spatial learning, memory ability, and cortical capillaries in aged rats. Med Sci Monit 21:945PubMedPubMedCentralCrossRef

Wärnberg J, Gomez-Martinez S, Romeo J, Díaz LE, Marcos A (2009) Nutrition, inflammation, and cognitive function. Ann N Y Acad Sci 1153(1):164–175PubMedCrossRef

Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM (2013) Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab 18(5):649–659PubMedPubMedCentralCrossRef

Wyckelsma VL, Levinger I, McKenna MJ, Formosa LE, Ryan MT, Petersen AC, Anderson MJ, Murphy RM (2017) Preservation of skeletal muscle mitochondrial content in older adults: relationship between mitochondria, fibre type and high-intensity exercise training. J Physiol 595(11):3345–3359PubMedPubMedCentralCrossRef

Xu Y, Yan J, Zhou P, Li J, Gao H, Xia Y, Wang Q (2012) Neurotransmitter receptors and cognitive dysfunction in Alzheimer’s disease and Parkinson’s disease. Prog Neurobiol 97(1):1–13PubMedPubMedCentralCrossRef

Zhang H (1988) Psychological, measurement in China. Int J Psychol 23(1–6):101–117CrossRef

Titel: Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults
verfasst von: Xi Li
Tianyu Han
Xu Zou
Han Zhang
Wenpin Feng
Han Wang
Yulin Shen
Li Zhang
Guoliang Fang
Publikationsdatum: 20.06.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 10/2021
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-021-04746-w

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Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults

Abstract

Purpose

Methods

Results

Conclusion

Chinese Clinical Trial Registry number

Neu im Fachgebiet Arbeitsmedizin

Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

Wie hat sich die Lebenserwartung ohne funktionelle Einschränkungen in Deutschland entwickelt? Eine Analyse mit Daten des Deutschen Alterssurveys (DEAS)

Hitzeschutz im Fokus der hessischen Betreuungs- und Pflegeaufsicht

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Chinese Clinical Trial Registry number

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