Maternal psychological distress, education, household income, and congenital heart defects: a prospective cohort study from the Japan environment and children’s study
verfasst von:
Yasuaki Saijo, Eiji Yoshioka, Yukihiro Sato, Hiroshi Azuma, Yusuke Tanahashi, Yoshiya Ito, Sumitaka Kobayashi, Machiko Minatoya, Yu Ait Bamai, Keiko Yamazaki, Sachiko Itoh, Chihiro Miyashita, Atsuko Ikeda-Araki, Reiko Kishi, the Japan Environment and Children’s Study (JECS) Group
The influence of maternal psychological distress on infant congenital heart defects (CHDs) has not been thoroughly investigated. Furthermore, there have been no reports on the combined effect of maternal psychological distress and socioeconomic status on infant CHDs. This study aimed to examine whether maternal psychological distress, socioeconomic status, and their combinations were associated with CHD.
Methods
We conducted a prospective cohort study using data from the Japan Environment and Children’s Study, which recruited pregnant women between 2011 and 2014. Maternal psychological distress was evaluated using the Kessler Psychological Distress Scale in the first trimester, while maternal education and household income were evaluated in the second and third trimesters. The outcome of infant CHD was determined using the medical records at 1 month of age and/or at birth. Crude- and confounder-adjusted logistic regression analyses were performed to evaluate the association between maternal psychological distress and education and household income on infant CHD.
Results
A total of 93,643 pairs of mothers and infants were analyzed, with 1.1% of infants having CHDs. Maternal psychological distress had a significantly higher odds ratio in the crude analysis but not in the adjusted analysis, while maternal education and household income were statistically insignificant. In the analysis of the combination variable of lowest education and psychological distress, the P for trend was statistically significant in the crude and multivariate model excluding anti-depressant medication, but the significance disappeared in the full model (P = 0.050).
Conclusions
The combination of maternal psychological distress and lower education may be a possible indicator of infant CHD.
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Abkürzungen
CHD
Congenital heart defects
JECS
Japan Environment and Children’s Study
EDC
Education
K6
6-Item Psychological Distress Scale
OR
Odds ratio
CI
Confidence interval
Background
Congenital heart defects (CHDs) are the most common non-chromosomal congenital disorders [1] and develop in 0.8 to 1.2% of newborns [2‐4]. Although CHD-related mortality has dramatically decreased due to the significant improvements in diagnostics, percutaneous interventions, surgery, and medication, enabling most children to reach adulthood [3], it remains the leading cause of mortality from congenital anomalies and results in a heavy global disease burden [4, 5].
A meta-analysis published in 2014 reported that lower maternal socioeconomic status was slightly associated with increased risk of infant CHDs, while lower maternal education and household income had significantly higher relative risks of 1.11 and 1.05 for infant CHDs, respectively [6]. Furthermore, recent case–control studies have also reported a significant risk of maternal lower education for CHD [7, 8]. A lower socioeconomic status is associated with common mental disorders [9, 10], and the association between anti-depressant use during pregnancy and CHD has been reported in a meta-analysis [11]. Concerning actual depressive symptoms, a case–control study in China reported that depressive symptoms during pregnancy were related to a significantly increased odds ratio (OR) for infant CHDs [12]. However, the diagnosis of depression in a UK cohort and depressive symptoms in a Northern Ireland case–control study was not related to infant CHDs [8, 13].
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Thus, whether maternal psychological distress, including depressive symptoms, is a risk factor for CHD has not been fully investigated, and there have been no reports on the combined effects of maternal education, income, and maternal psychological distress on CHD. Further, to our knowledge, there have been no Japanese reports investigating maternal education, income, and maternal psychological distress on CHD risk after adjusting for confounders. This study aimed to examine whether maternal psychological stress, education, household income, and their combinations affected infant CHD using the birth cohort data from the Japan Environment and Children’s Study (JECS) [14, 15].
Methods
Participants
The JECS is a nationwide Japanese prospective birth cohort study aiming to identify the environmental factors affecting children’s health and development and is considered to be relatively free of selection bias and representative of the pregnant population in Japan [14, 15]. To cover all the geographical areas of Japan, pregnant women were recruited from 15 Regional Centers (Hokkaido, Miyagi, Fukushima, Chiba, Kanagawa, Koshin, Toyama, Aichi, Kyoto, Osaka, Hyogo, Tottori, Kochi, Fukuoka, and South Kyushu/Okinawa). Baseline recruitment was performed in collaboration with local governments and healthcare providers to maximize representativeness. The children were then followed up until 13 years from birth.
Between January 2011 and March 2014, 103,060 pregnant women in the early stages of pregnancy were recruited. Excluding the pregnancies in the same woman, the study involved 97,413 singleton pregnancies. In our study, we excluded 3,561 pregnancies with a birth status of miscarriage or stillbirth. Of the remaining 93,852 births, which included only the first infant among those with multiple births, those diagnosed with chromosomal abnormalities (n = 209), based on their medical records at birth and 1 month, were excluded. Thus, the final number of participants was 93,643 infants (Fig. 1). Specifically, we used the jecs-ta-20190930 dataset from the JECS, registered in the University Hospital Medical Information Network (UMIN) 000,030,786 (UMIN Clinical Trials Registry, 15/01/2018).
Fig. 1
Flowchart of the study. * Only the first infants of multiple births are included
×
Ethics statement
The JECS protocol was approved by the Institutional Review Board on Epidemiological Studies of the Ministry of the Environment and by the ethics committees of all participating institutions. This was also conducted in accordance with the Declaration of Helsinki and other nationally valid regulations. Written informed consent was obtained from all participants.
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Outcomes
Infant CHD diagnosed in the medical records at 1 month of age and/or at birth was defined as the outcome. In the sensitivity analyses, the medical records were checked if the caregivers answered positively to the diagnosis of CHD after birth among the infants’ siblings in the 2-year questionnaire. If CHDs were confirmed in the medical records, we defined them as 2-year CHD-positive in the sensitivity analysis.
Maternal and education, household income, and psychological distress
Socioeconomic status in this study was determined by the mothers’ educational attainment and household income. During pregnancy, questionnaires were distributed to the enrolled mothers during the first (T1; if the participation was delayed, it was distributed during the second/third trimester) and second/third trimesters (T2). The latter included questions about the mothers’ educational attainment, categorized as ≤ 9 years (EDC1: junior high school), 10 to ≤ 12 years (EDC2: high school), 13–15 years (EDC3: technical junior college, technical/vocational college, or associate degree), or ≥ 16 years (EDC4: bachelor’s degree or postgraduate degree). The T2 questionnaire also included questions on household income, categorized as ≤ 199, 200–399, 400–599, 600–799, 800–999, and ≥ 1000 thousand yen. Meanwhile, maternal psychological distress was assessed using the Japanese version of the Kessler 6-Item Psychological Distress Scale (K6) in the T1 questionnaire [16, 17], with a K6 score of > 13 points indicating positive maternal psychological distress [18, 19].
The other independent variables
Based on previous studies [7‐10, 12, 13], the following were selected as covariates: maternal age at delivery, pregnancy body mass index (BMI), paternal education, marital status, mother’s alcohol habit, mother and father’s smoking habits, parity, infant sex, plurality, fertility treatment, hypertensive disorder during pregnancy, thyroid diseases during pregnancy, diabetes mellitus/gestational diabetes during pregnancy, folic acid supplementation at early pregnancy, anti-depressant use at early pregnancy, and mother’s CHDs.
The T1 questionnaire included questions regarding the mother’s birthday, marital status, smoking habit (along with the father’s), folic acid supplementation, anti-depressant use, and history of CHDs. Marital status was classified as married or unmarried, including divorced or bereaved. Smoking habit was categorized as never smoked/quitting smoking before pregnancy or quitting smoking/continued smoking during pregnancy. Folic acid supplementation and anti-depressant use were defined as positive if these were taken between pregnancy perception and 12 weeks of gestation. Lastly, if the mothers responded positively to the query about a previous CHD diagnosis, they were considered positive for CHDs.
On the other hand, the T2 questionnaire inquired about the mothers’ drinking habits. Nondrinkers included those with no history of alcohol intake and those quitting before pregnancy, while drinkers including those currently drinking or quitting during pregnancy.
The following information was also collected from the medical records: infant birth date, plurality, parity, mode of pregnancy (spontaneous, ovulation induction through medication, or artificial insemination/in vitro fertilization), hypertension (hypertension before or during pregnancy), thyroid disease, diabetes mellitus (diabetes mellitus before or during pregnancy), and height and pre-pregnancy weight, from which the BMI was calculated. The mother’s age at infant birth was calculated using her and the infant’s birth dates.
Statistical analysis
Fisher’s exact test was used to analyze the associations between infant CHD, maternal education, household income, and maternal psychological distress.
For participants with missing data (1.9%), the information was replaced using multiple imputations (25 imputed datasets) based on the assumption that data were missing at random. The imputation model included all the variables analyzed in Fisher’s exact test and the K6 raw score, dichotomized to K6 ≥ 13 or not. Using the imputed datasets, the crude OR of each variable for infant CHD was calculated.
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Next, we conducted multivariable logistic regression analyses to estimate the ORs for infant CHD with 95% confidence intervals (95% CIs). First, psychological distress, maternal education, and household income were introduced separately (crude model). In model 1, the three variables were introduced, along with age, pre-pregnancy BMI, father education, marital status, mother drinking habit, mother smoking, paternal smoking, plurality, infant sex, mode of pregnancy, hypertensive disorder, thyroid diseases, diabetes, and folic acid supplementation. Despite the varying reports on anti-depressants being possible mediators of depression [8, 20‐23], model 2 was constructed using all the model 1 variables and anti-depressant use.
Then, we constructed the combination variable of the mothers’ lowest education (EDC1) and psychological distress. Lower household income was not included as a combination variable because it had no significant protective OR. We then analyzed the crude and adjusted OR of the combination variable, and the trend P values were calculated using it as an integer variable. P values for the interaction term between the mothers’ lowest education (EDC1) and psychological distress were also analyzed.
As mentioned above, 2-year CHD data was available, but this was restricted to the participants who had answered the 2-year questionnaire (N = 80,468), which may have been biased towards the participants with higher education, higher household income, and lower psychological distress tended to respond to the 2-year questionnaire (Supplemental Table 1). Therefore, in the first sensitivity analysis, 2-year CHD positivity was added to the original CHDs positive outcome, but in the second sensitivity analysis, it was deleted from the original outcome negative.
Two-sided P-values of < 0.05 were considered statistically significant. All analyses were conducted using Stata statistical software version 16.0 for Windows (StataCorp, College Station, TX, USA).
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Results
CHD had a prevalence of 1.1% (Table 1). Among maternal education, household income, and psychological distress, only psychological distress had a statistically significant relationship with infant CHDs in the pairwise deletion analyses (Supplemental Table 2).
Table 1
Characteristics of the study population (N = 93,643)
Number
Percent
Mother’s age at delivery
-24
9,378
10.0
25–29
25,755
27.5
30–34
33,022
35.3
35–39
21,159
22.6
40-
4,318
4.6
Missing
11
0.0
Pre-pregnancy BMI
-18.4
14,652
15.7
18.5–24.9
68,683
73.4
25-
10,180
10.9
Missing
128
0.1
Mother’s education
EDC1
4,389
4.7
EDC2
28,664
30.6
EDC3
38,499
41.1
EDC4
19,910
21.3
Missing
2,181
2.3
Father’s education
EDC1
6,546
7.0
EDC2
33,325
35.6
EDC3
20,512
21.9
EDC4
30,481
32.6
Missing
2,779
3.0
Household income (10 thousand yen/year)
-199
4,820
5.2
200–399
29,378
31.4
400–599
28,177
30.1
600–799
13,642
14.6
800–999
5,677
6.1
1000-
3,652
3.9
Missing
8,297
8.9
Marital status
Married
87,804
93.8
Unmarried, divorced or bereavement
4,189
4.5
Missing
1,650
1.8
Mother’s alcohol intake
Non-drinker
45,632
48.7
Drinker during early pregnancy
45,604
48.7
Missing
2,407
2.6
Mother’s smoking status
Non-, ex-smoker
74,878
80.0
Smoker during pregnancy
16,840
18.0
Missing
1,925
2.1
Father’s smoking status
Non-, ex-smoker
45,760
48.9
Smoker during pregnancy
44,594
47.6
Missing
3,289
3.5
Plurality
Singleton
92,738
99.0
Multiplet
905
1.0
Parity
0
38,925
41.6
1
34,151
36.5
> 2
18,183
19.4
Missing
2,384
2.6
Infant’s sex
Boy
45,587
48.7
Girl
48,038
51.3
Missing
18
0.0
Fertility treatment
Spontaneous
86,724
92.6
Ovulation induction through medication
2,598
2.8
Artificial insemination or in vitro Fertilization
3,816
4.1
Missing
505
0.5
Hypertensive disorder during pregnancy
No
88,703
94.7
Yes
3,397
3.6
Missing
1,543
1.7
Thyroid diseases during pregnancy
No
90,362
96.5
Yes
1,244
1.3
Missing
2,037
2.2
Diabetes mellitus during pregnancy/gestational diabetes
No
89,160
95.2
Yes
2,940
3.1
Missing
1,543
1.7
Folic acid supplementation at early pregnancy
No
66,290
70.8
Yes
25,585
27.3
Missing
1,768
1.9
Anti-depressant use
No
91,651
97.9
Yes
224
0.2
Missing
1,768
1.9
Congenital heart diseases in the mother
No
92,119
98.4
Yes
289
0.3
Missing
1,235
1.3
Psychological distress in the mother
No
88,072
94.1
Yes
3,231
3.5
Missing
2,340
2.5
CHD (outcome) in the siblings
Negative
92,641
98.9
Positive
1,002
1.1
EDC1: junior high school, EDC2: high school, EDC3: technical junior college, technical/vocational college, or EDC4: associate degree bachelor’s degree or postgraduate degree
After multiple imputations in the crude logistic regressions, psychological distress had a significantly higher OR (OR 1.39; 95% CI, 1.03–1.87), while maternal education and household income were statistically insignificant. However, in models 1 and 2, the significance of psychological distress became dismissible (Model 1: OR 1.32; 95% CI, 0.98–1.79; Model2: OR 1.31; 95% CI, 0.97–1.77) (Table 2).
Table 2
Crude and adjusted ORs of maternal education, psychological distress, and household income (Multiple imputation, N = 93,643)
Crude
Model 1
Model 2
Proportiona
OR
95%CI
P
OR
95%CI
P
OR
95%CI
P
Mother’s education
EDC1
4.9%
1.24
0.92
-
1.67
0.160
1.09
0.76
-
1.54
0.645
1.08
0.76
-
1.54
0.656
EDC2
31.5%
0.99
0.83
-
1.19
0.927
0.90
0.73
-
1.11
0.334
0.90
0.73
-
1.11
0.332
EDC3
42.0%
1.00
0.84
-
1.18
0.998
0.96
0.80
-
1.15
0.667
0.96
0.80
-
1.15
0.668
EDC4
21.7%
1.00
1.00
1.00
Household income (10 thousand yen/year)
-199
5.9%
0.98
0.66
-
1.45
0.915
0.93
0.61
-
1.41
0.721
0.93
0.61
-
1.41
0.718
200–399
35.0%
0.91
0.67
-
1.24
0.542
0.93
0.67
-
1.28
0.652
0.93
0.67
-
1.28
0.650
400–599
32.7%
0.86
0.63
-
1.17
0.334
0.89
0.65
-
1.22
0.466
0.89
0.65
-
1.22
0.467
600–799
15.7%
0.85
0.61
-
1.20
0.360
0.88
0.63
-
1.24
0.462
0.88
0.63
-
1.24
0.464
800–999
6.5%
0.72
0.48
-
1.08
0.116
0.74
0.50
-
1.11
0.148
0.74
0.50
-
1.11
0.148
1000-
4.2%
1.00
1.00
1.00
Mother’s psychological distress
No
96.4%
1.00
1.00
1.00
Yes
3.6%
1.39
1.03
-
1.87
0.029
1.32
0.98
-
1.79
0.066
1.31
0.97
-
1.77
0.080
EDC1: junior high school, EDC2: high school, EDC3: technical junior college, technical/vocational college, or EDC4: associate degree bachelor’s degree or postgraduate degree
aMean proportion of each category in the imputed 25 datasets
Model 1: All listed variables, maternal age, mother BMI, father education, marital status, mother drinking habit, mother smoking, paternal smoking, parity, infant sex, plurality, fertility treatment, hypertensive disorder during pregnancy, thyroid diseases during pregnancy, diabetes mellitus/gestational diabetes during pregnancy, folic acid supplementation during early pregnancy, and mother congenital heart diseases are introduced
Model 2: All variables in Model 1 and anti-depressant use are introduced
In the analysis of the combination variable of maternal psychological distress and lowest education (EDC1), the first and second combinations had no statistical significance, but the trend for p was statistically significant (crude: p = 0.011, Model 1; P = 0.043). However, its significance diminished in Model 2 (p = 0.050) (Table 3, ORs of the combination of EDC1 and psychological distress are shown in Supplemental Table 3). P values for the interaction term between EDC1 and psychological distress had no statistical significance.
Table 3
Adjusted ORs of number of maternal education and psychological distress for CHDs (Multiple imputation, 93,643)
Crude
Model 1
Model 2
Proportiona
OR
95%CI
P
P for trend
OR
95%CI
P
P for trend
OR
95%CI
P
P for trend
Number of positiveb
0
92.0%
1.00
0.011
1.00
0.043
1.00
0.050
1
7.6%
1.25
1.00
-
1.55
0.052
1.20
0.95
-
1.52
0.123
1.20
0.95
-
1.51
0.135
2
0.4%
2.02
0.97
-
4.24
0.062
1.87
0.88
-
3.99
0.103
1.83
0.86
-
3.91
0.117
P for interaction term
0.563
0.573
0.589
aMean proportion of each category in the imputed 25 datasets
bNumber of mother junior high school or psychological distress positive
Model 1: All listed variables, maternal age, mother BMI, household income father education, marital status, mother drinking habit, mother smoking, paternal smoking, parity, infant sex, plurality, fertility treatment, hypertensive disorder during pregnancy, thyroid diseases during pregnancy, diabetes mellitus/gestational diabetes during pregnancy, folic acid supplementation during early pregnancy, and mother congenital heart diseases are introduced
Model 2: All variables in Model 1 and anti-depressant use are introduced
P for trend: The number of positives (0–2) was introduced into the model
P for interaction term: Mothers’ lowest education (EDC1), psychological distress, and their interaction term were introduced into the model
In the first sensitivity analysis where the 2-year CHDs positive were added to the original outcome positive, psychological distress had a significantly higher OR only in the crude analysis (OR 1.30; 95% CI, 1.00–1.69) (Supplemental Table 4). A similar result was observed in the second sensitivity analysis where the 2-year CHDs positive were deleted from the original outcome negative (OR 1.39; 95% CI, 1.03–1.87) (Supplemental Table 5). Regarding the combination variable of psychological distress and lowest education, the significant trend for p disappeared in the first sensitivity analysis (Supplemental Table 6) but was still significant in crude and model 1 in the second sensitivity analysis (Supplemental Table 7).
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Discussions
In this prospective birth cohort study, the crude analysis showed that only maternal psychological distress had a significantly higher OR for infant CHDs in the crude analysis, while lower education in mothers and lower household income were unexpectedly insignificant. Further, the combination variable of maternal psychological distress and lowest education had significant trend p values in the crude analysis and Model 1 but not in Model 2.
As previously mentioned, the meta-analysis published in 2014 reported that lower maternal education and household income had significantly higher relative risks for infant CHDs at 1.11 and 1.05, respectively [6]. While the relative risk of household income was significant, its effect size was negligible relative to maternal education. The protective results of higher household income in the present study may be due to the minimal effect size. Furthermore, household income did not necessarily reflect the lifetime socioeconomic status for relatively young women. Education was related to favorable dietary intake patterns among pregnant Japanese women, but the household income was not [24].
In our current study, maternal education had no significant result with the point estimation of crude OR 1.24. Although its OR was higher than household income in the meta-analysis [6], the significance of the relatively low effect size may not be detected due to the lack of statistical power. Moreover, socioeconomic effects on CHDs in developed countries were smaller compared to developing countries [6], and it has been reported that socioeconomic differences affected mortality, morbidity, and risk factors in Japan to a lesser degree than in the US or Europe [25].
A Chinese case–control study found that prenatal depressive symptoms had significantly increased OR (1.94) for CHD. However, the symptoms were evaluated using the Zung Self-Rating Depression Scale after birth, leading to recall bias [12]. Meanwhile, in the UK cohort, diagnosis of depression without anti-depressant use during the first trimester had no significant OR (1.10). Similarly, a case–control study conducted in Northern Ireland reported that having symptoms of “feeling down, depressed or hopeless” within the past month at 10–12 weeks of gestation had no significant OR (1.20) [8, 13]. In the present study, psychological distress had a significant OR on crude analysis, but this became negligible in the adjusted models. The K6 scores in our study could not be directly compared with the previous studies’ because this test evaluates psychological distress and does not focus on depression only [17‐19], and the evaluation of depression varied across the studies. However, psychological distress, if present, seemed to have a minor effect on infant CHD.
The combination variable of maternal psychological distress and lowest education (EDC1) had significant trend P values in the crude analysis and Model 1, but both had no statistically significant ORs (2.02, 95% confidence interval: 0.97—4.24) in the crude analysis. Because the effect size of the crude model was relatively large, the combination may identify high-risk pregnancies for infant CHD. The significance of trend p disappeared in Model 2, and the mediation effect of anti-depressants may influence the significance of dilution, although it seemed to be weak [8].
There were doctor-diagnosed child CHDs beyond 2 years among the participants who answered the 2-year age questionnaire, who tended to have a higher socioeconomic status and a lower prevalence of psychological distress [26]. Therefore, to negate this possible bias, we performed two sensitivity analyses. The first analysis included the 2-year CHDs positive and the original CHDs positive outcome, which was almost slightly diluted, as expected. On the other hand, in the second sensitivity analysis, several p values decreased slightly when the 2-year CHDs positive were deleted from the outcome negative. In the main analysis, the relationships were mostly biased to null because the diagnosis of CHDs seemed to result in the nondifferential misclassification of the binary outcomes [27]. Therefore, we believe that the crude effects of psychological distress and the combination variable are small but significant.
Although lower maternal education had no significant effect on infant CHD, the combined effect of maternal psychological distress and lowest education had a significantly increased OR. Therefore, stress and depression screening should be provided for early-stage pregnant women. Education on preventive measures including the use of folate supplementation, minimization of infectious-disease exposure, avoidance of organic solvents, and avoidance of alcohol, tobacco, and illicit drugs [28] may be useful for pregnant women with lower education and psychological distress.
There were several limitations to our present study. First, we did not have adequate statistical power to investigate the weak relationships. For instance, assuming that the non-exposure groups had an average CHD incidence (1.07%), the statistical power to obtain ORs of 1.3 for ECD1 (reference: ECD4) and maternal psychological distress would be 46% and 43%, respectively. Second, our results may not be generalized to other countries due to differences in the educational systems, rates of entering higher educational institutions, and the prevalence of maternal psychological distress. Third, prenatal diagnosis of CHD may affect maternal psychological distress [29]. However, its effect during the first trimester might be limited because the fetal CHDs were mainly diagnosed after 18 to 20 gestational weeks [30], and 80% of the T1 questionnaires were submitted within 20 gestational weeks. Fourth, the severity of CHD was not considered in the analyses. Fifth, although we measured maternal psychological distress using the questionnaire, we did not evaluate specific depressive symptoms.
Conclusions
The crude analysis in this prospective birth cohort study showed that maternal psychological distress in the first trimester was related to infant CHDs. Meanwhile, the multivariate analysis showed the maternal psychological distress and lowest education were also related. The combination of maternal psychological distress and lowest education may be a possible indicator of infant CHD.
Acknowledgements
We would like to express our gratitude to all the participants of the JECS and all the staff members involved in data collection.
Consortia the Japan Environment and Children’s Study (JECS) Group
5Nagoya City University, Nagoya, Japan. 6National Institute for Environmental Studies, Tsukuba, Japan. 7National Center for Child Health and Development, Tokyo, Japan. 8Tohoku University, Sendai, Japan. 9Fukushima Medical University, Fukushima, Japan. 10Chiba University, Chiba, Japan. 11Yokohama City University, Yokohama, Japan. 12University of Yamanashi, Chuo, Japan. 13University of Toyama, Toyama, Japan. 14Kyoto University, Kyoto, Japan. 15Osaka University, Suita, Japan. 16Hyogo College of Medicine, Nishinomiya, Japan. 17Tottori University, Yonago, Japan. 18Kochi University, Nankoku, Japan. 19University of Occupational and Environmental Health, Kitakyushu, Japan. 20Kumamoto University, Kumamoto, Japan)
Declarations
Ethics approval and consent to participate
The JECS protocol was approved by the Institutional Review Board on Epidemiological Studies of the Ministry of the Environment and by the ethics committees of all the participating institutions, i.e., the National Institute for Environmental Studies, the National Center for Child Health and Development, Hokkaido University, Sapporo Medical University, Asahikawa Medical University, Japanese Red Cross Hokkaido College of Nursing, Tohoku University, Fukushima Medical University, Chiba University, Yokohama City University, University of Yamanashi, Shinshu University, University of Toyama, Nagoya City University, Kyoto University, Doshisha University, Osaka University, Osaka Medical Center and Research Institute for Maternal and Child Health, Hyogo College of Medicine, Tottori University, Kochi University, University of Occupational and Environmental University, Kyushu University, Kumamoto University, University of Miyazaki, and University of the Ryukyus. The JECS was conducted in accordance with the Declaration of Helsinki and other nationally valid regulations. Written informed consent was obtained from all participating mothers and fathers.
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
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Maternal psychological distress, education, household income, and congenital heart defects: a prospective cohort study from the Japan environment and children’s study
verfasst von
Yasuaki Saijo Eiji Yoshioka Yukihiro Sato Hiroshi Azuma Yusuke Tanahashi Yoshiya Ito Sumitaka Kobayashi Machiko Minatoya Yu Ait Bamai Keiko Yamazaki Sachiko Itoh Chihiro Miyashita Atsuko Ikeda-Araki Reiko Kishi the Japan Environment and Children’s Study (JECS) Group
Trastuzumab deruxtecan scheint auch jenseits von Lungenkrebs gut gegen solide Tumoren mit HER2-Mutationen zu wirken. Dafür sprechen die Daten einer offenen Pan-Tumor-Studie.
Frauen mit lokalem oder metastasiertem Brustkrebs, die Statine einnehmen, haben eine niedrigere krebsspezifische Mortalität als Patientinnen, die dies nicht tun, legen neue Daten aus den USA nahe.
Welche Antibiotika darf man bei unkomplizierter Zystitis verwenden und wovon sollte man die Finger lassen? Welche pflanzlichen Präparate können helfen? Was taugt der zugelassene Impfstoff? Antworten vom Koordinator der frisch überarbeiteten S3-Leitlinie, Prof. Florian Wagenlehner.
Das Risiko, nach einem Gestationsdiabetes einen Typ-2-Diabetes zu entwickeln, hängt nicht nur von der Zahl, sondern auch von der Reihenfolge der betroffenen Schwangerschaften ab.
Update Gynäkologie
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