Skip to main content
Erschienen in: Archives of Gynecology and Obstetrics 5/2012

01.11.2012 | General Gynecology

MR imaging evaluation of fibroid clearance following open myomectomy for massive/multiple symptomatic fibroids

verfasst von: Nevin T. Wijesekera, Giovanni Mauri, Sahana Gupta, Anna-Maria Belli, Isaac T. Manyonda

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2012

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To evaluate the technical success of total fibroid clearance at open myomectomy for massive and/or multiple symptomatic fibroids using MR imaging (MRI) as the imaging modality.

Methods

The study group comprised 27 women [mean age 37.4 ± 6.9 years (range 27–53)] who underwent open myomectomy for the treatment of massive/multiple symptomatic fibroids at our institution between January 2009 and April 2010. Myomectomy was performed with the intention of achieving complete fibroid clearance. Pre- and postmyomectomy MRI was performed to assess changes in uterine volume and fibroid burden. Periprocedural data (including blood loss and complications) and relief of clinical symptoms at follow-up were also recorded.

Results

The mean time to MRI and clinical follow-up was 10 months (range 6–15 months). The mean uterine volume premyomectomy was 795 ± 580 cc and postmyomectomy was 123 ± 70 cc (p < 0.001). The mean percentage reduction in uterine volume was 80.3 % (range 43.0–98.1 %). Of the 10/27 (37.0 %) women with residual fibroids at follow-up: 7 patients had fibroids measuring up to 1 cc in volume, 3 patients had fibroids measuring up to 6 cc. Postoperative adnexal seromas were observed in 6/27 (22.2 %) patients. The clinical success rates of myomectomy amongst the 22/27 (81 %) responders were: 73 % for menorrhagia, 64 % for pain, and 36–64 % for mass-related symptoms.

Conclusions

Using MRI, we have confirmed that open myomectomy can achieve total or near-total fibroid clearance in the majority of patients with massive and/or multiple fibroids.
Literatur
1.
Zurück zum Zitat van der Kooij SM, Hehenkamp WJ, Volkers NA et al (2010) Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial. Am J Obstet Gynecol 203:105.e1-13PubMed van der Kooij SM, Hehenkamp WJ, Volkers NA et al (2010) Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial. Am J Obstet Gynecol 203:105.e1-13PubMed
2.
Zurück zum Zitat Smeets AJ, Nijenhuis RJ, van Rooij WJ et al (2010) Uterine artery embolization in patients with a large fibroid burden: long-term clinical and MR follow-up. Cardiovasc Intervent Radiol 33:943–948PubMedCrossRef Smeets AJ, Nijenhuis RJ, van Rooij WJ et al (2010) Uterine artery embolization in patients with a large fibroid burden: long-term clinical and MR follow-up. Cardiovasc Intervent Radiol 33:943–948PubMedCrossRef
3.
Zurück zum Zitat Berkane N, Moutafoff-Borie C (2010) Impact of previous uterine artery embolization on fertility. Curr Opin Obstet Gynecol 22:242–247PubMedCrossRef Berkane N, Moutafoff-Borie C (2010) Impact of previous uterine artery embolization on fertility. Curr Opin Obstet Gynecol 22:242–247PubMedCrossRef
4.
Zurück zum Zitat Taylor A, Sharma M, Tsirkas P et al (2005) Surgical and radiological management of uterine fibroids—a UK survey of current consultant practice. Acta Obstet Gynecol Scand 84:478–482PubMed Taylor A, Sharma M, Tsirkas P et al (2005) Surgical and radiological management of uterine fibroids—a UK survey of current consultant practice. Acta Obstet Gynecol Scand 84:478–482PubMed
5.
Zurück zum Zitat Tulandi T, Murray C, Guralnick M (1993) Adhesion formation and reproductive outcome after myomectomy and second look laparoscopy. Obstet Gynecol 82:213–215PubMed Tulandi T, Murray C, Guralnick M (1993) Adhesion formation and reproductive outcome after myomectomy and second look laparoscopy. Obstet Gynecol 82:213–215PubMed
6.
Zurück zum Zitat Thompson LB, Reed SD, McCrummen BK et al (2006) Leiomyoma characteristics and risk of subsequent surgery after myomectomy. Int J Gynaecol Obstet 95:138–143PubMedCrossRef Thompson LB, Reed SD, McCrummen BK et al (2006) Leiomyoma characteristics and risk of subsequent surgery after myomectomy. Int J Gynaecol Obstet 95:138–143PubMedCrossRef
7.
Zurück zum Zitat Tsuji S, Takahashi K, Imaoka I et al (2006) MRI evaluation of the uterine structure after myomectomy. Gynecol Obstet Invest 61:106–110PubMedCrossRef Tsuji S, Takahashi K, Imaoka I et al (2006) MRI evaluation of the uterine structure after myomectomy. Gynecol Obstet Invest 61:106–110PubMedCrossRef
8.
Zurück zum Zitat Manyonda IT, Bratby M, Horst JS et al (2011) Uterine artery embolization versus myomectomy: impact on quality of life-results of the FUME (Fibroids of the Uterus: Myomectomy versus Embolization) trial. Cardiovasc Intervent Radiol Jul 20 [Epub ahead of print] Manyonda IT, Bratby M, Horst JS et al (2011) Uterine artery embolization versus myomectomy: impact on quality of life-results of the FUME (Fibroids of the Uterus: Myomectomy versus Embolization) trial. Cardiovasc Intervent Radiol Jul 20 [Epub ahead of print]
9.
Zurück zum Zitat Peddada SD, Laughlin SK, Miner K et al (2008) Growth of uterine leiomyomata among premenopausal black and white women. Proc Natl Acad Sci USA 105:19887–19892PubMedCrossRef Peddada SD, Laughlin SK, Miner K et al (2008) Growth of uterine leiomyomata among premenopausal black and white women. Proc Natl Acad Sci USA 105:19887–19892PubMedCrossRef
10.
Zurück zum Zitat Mukhopadhaya N, De Silva C, Manyonda IT (2008) Conventional myomectomy. Best Pract Res Clin Obstet Gynaecol 22:677–705PubMedCrossRef Mukhopadhaya N, De Silva C, Manyonda IT (2008) Conventional myomectomy. Best Pract Res Clin Obstet Gynaecol 22:677–705PubMedCrossRef
11.
Zurück zum Zitat Byrne H, Miskry T, Gomez CM (2009) Using vasopressin for myomectomy. Obstet Gynecol 114:169–170PubMed Byrne H, Miskry T, Gomez CM (2009) Using vasopressin for myomectomy. Obstet Gynecol 114:169–170PubMed
12.
Zurück zum Zitat Parthipun AA, Taylor J, Manyonda I et al (2010) Does size really matter? Analysis of the effect of large fibroids and uterine volumes on complication rates of uterine artery embolisation. Cardiovasc Intervent Radiol 33:955–959PubMedCrossRef Parthipun AA, Taylor J, Manyonda I et al (2010) Does size really matter? Analysis of the effect of large fibroids and uterine volumes on complication rates of uterine artery embolisation. Cardiovasc Intervent Radiol 33:955–959PubMedCrossRef
13.
Zurück zum Zitat Razavi MK, Hwang G, Jahed A et al (2003) Abdominal myomectomy versus uterine fibroid embolization in the treatment of symptomatic uterine leiomyomas. Am J Roentgenol 180:1571–1575 Razavi MK, Hwang G, Jahed A et al (2003) Abdominal myomectomy versus uterine fibroid embolization in the treatment of symptomatic uterine leiomyomas. Am J Roentgenol 180:1571–1575
14.
Zurück zum Zitat Schüring AN, Garcia-Rocha GJ, Schlösser HW et al (2010) Perioperative complications in conventional and microsurgical abdominal myomectomy. Arch Gynecol Obstet Aug 1 [Epub ahead of print] Schüring AN, Garcia-Rocha GJ, Schlösser HW et al (2010) Perioperative complications in conventional and microsurgical abdominal myomectomy. Arch Gynecol Obstet Aug 1 [Epub ahead of print]
15.
Zurück zum Zitat LaMorte AI, Lalwani S, Diamond MP (1993) Morbidity associated with abdominal myomectomy. Obstet Gynecol 82:897–900PubMed LaMorte AI, Lalwani S, Diamond MP (1993) Morbidity associated with abdominal myomectomy. Obstet Gynecol 82:897–900PubMed
16.
Zurück zum Zitat Hutchins FL Jr (1995) Abdominal myomectomy as a treatment for symptomatic uterine fibroids. Obstet Gynecol Clin North Am 22:781–789PubMed Hutchins FL Jr (1995) Abdominal myomectomy as a treatment for symptomatic uterine fibroids. Obstet Gynecol Clin North Am 22:781–789PubMed
17.
Zurück zum Zitat Fauconnier A, Chapron C, Babaki-Fard K, Dubuisson JB (2000) Recurrence of leiomyomata after myomectomy. Hum Reprod Update 6:595–602PubMedCrossRef Fauconnier A, Chapron C, Babaki-Fard K, Dubuisson JB (2000) Recurrence of leiomyomata after myomectomy. Hum Reprod Update 6:595–602PubMedCrossRef
18.
Zurück zum Zitat Subramanian S, Clark MA, Isaacson K (2001) Outcome and resource use associated with myomectomy. Obstet Gynecol 98:583–587PubMedCrossRef Subramanian S, Clark MA, Isaacson K (2001) Outcome and resource use associated with myomectomy. Obstet Gynecol 98:583–587PubMedCrossRef
19.
Zurück zum Zitat Iverson RE Jr, Chelmow D, Strohbehn K et al (1996) Relative morbidity of abdominal hysterectomy and myomectomy for management of uterine leiomyomas. Obstet Gynecol 88:415–419PubMedCrossRef Iverson RE Jr, Chelmow D, Strohbehn K et al (1996) Relative morbidity of abdominal hysterectomy and myomectomy for management of uterine leiomyomas. Obstet Gynecol 88:415–419PubMedCrossRef
20.
Zurück zum Zitat Farhi J, Ashkenazi J, Feldberg D et al (1995) Effect of uterine leiomyomata on the results of in vitro fertilization treatment. Hum Reprod 10:2576–2578PubMedCrossRef Farhi J, Ashkenazi J, Feldberg D et al (1995) Effect of uterine leiomyomata on the results of in vitro fertilization treatment. Hum Reprod 10:2576–2578PubMedCrossRef
21.
Zurück zum Zitat Sinha R, Hegde A, Mahajan C et al (2008) Laparoscopic myomectomy: do size, number, and location of the myomas form limiting factors for laparoscopic myomectomy? J Minim Invasive Gynecol 15:292–300PubMedCrossRef Sinha R, Hegde A, Mahajan C et al (2008) Laparoscopic myomectomy: do size, number, and location of the myomas form limiting factors for laparoscopic myomectomy? J Minim Invasive Gynecol 15:292–300PubMedCrossRef
22.
Zurück zum Zitat Tinelli A, Malvasi A, Hudelist G et al (2010) Laparoscopic intracapsular myomectomy: comparison of single versus multiple fibroids removal. An institutional experience. J Laparoendosc Adv Surg Tech A 20:705–771PubMedCrossRef Tinelli A, Malvasi A, Hudelist G et al (2010) Laparoscopic intracapsular myomectomy: comparison of single versus multiple fibroids removal. An institutional experience. J Laparoendosc Adv Surg Tech A 20:705–771PubMedCrossRef
23.
Zurück zum Zitat Kirby JM, Burrows D, Haider E et al (2011) Utility of MRI before and after uterine fibroid embolization: why to do it and what to look for. Cardiovasc Intervent Radiol 34:705–716PubMedCrossRef Kirby JM, Burrows D, Haider E et al (2011) Utility of MRI before and after uterine fibroid embolization: why to do it and what to look for. Cardiovasc Intervent Radiol 34:705–716PubMedCrossRef
24.
Zurück zum Zitat Landi S, Zaccoletti R, Ferrari L et al (2001) Laparoscopic myomectomy: technique, complications, and ultrasound scan evaluations. J Am Assoc Gynecol Laparosc 8:231–240PubMedCrossRef Landi S, Zaccoletti R, Ferrari L et al (2001) Laparoscopic myomectomy: technique, complications, and ultrasound scan evaluations. J Am Assoc Gynecol Laparosc 8:231–240PubMedCrossRef
Metadaten
Titel
MR imaging evaluation of fibroid clearance following open myomectomy for massive/multiple symptomatic fibroids
verfasst von
Nevin T. Wijesekera
Giovanni Mauri
Sahana Gupta
Anna-Maria Belli
Isaac T. Manyonda
Publikationsdatum
01.11.2012
Verlag
Springer-Verlag
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 5/2012
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-012-2404-5

Weitere Artikel der Ausgabe 5/2012

Archives of Gynecology and Obstetrics 5/2012 Zur Ausgabe

Alter der Mutter beeinflusst Risiko für kongenitale Anomalie

28.05.2024 Kinder- und Jugendgynäkologie Nachrichten

Welchen Einfluss das Alter ihrer Mutter auf das Risiko hat, dass Kinder mit nicht chromosomal bedingter Malformation zur Welt kommen, hat eine ungarische Studie untersucht. Sie zeigt: Nicht nur fortgeschrittenes Alter ist riskant.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Fehlerkultur Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mammakarzinom: Brustdichte beeinflusst rezidivfreies Überleben

26.05.2024 Mammakarzinom Nachrichten

Frauen, die zum Zeitpunkt der Brustkrebsdiagnose eine hohe mammografische Brustdichte aufweisen, haben ein erhöhtes Risiko für ein baldiges Rezidiv, legen neue Daten nahe.

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.