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01.09.2008 | Original Article

MRI of the fetal eyes: morphologic and biometric assessment for abnormal development with ultrasonographic and clinicopathologic correlation

verfasst von: Ashley J. Robinson, Susan Blaser, Ants Toi, David Chitayat, Sophie Pantazi, Sarah Keating, Sandra Viero, Greg Ryan

Erschienen in: Pediatric Radiology | Ausgabe 9/2008

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Abstract

Background

Currently ocular biometric measurements are defined by US and are measured from the orbital walls. These bony landmarks cannot be seen by MRI, and therefore these measurements cannot be directly applied.

Objective

To define measurements of normal growth of the fetal eyes using MRI.

Materials and methods

Transorbital views were analyzed in 198 fetal MR examinations. The ocular diameter (OD) and interocular and binocular distances (IOD and BOD) were measured and were plotted against gestational age. Fetuses with abnormalities affecting the eyes were evaluated separately.

Results

Of 198 scans, 146 had suitable images, 35 of which were abnormal. Normal growth of BOD, IOD and OD were determined, and compared with the respective already established US data.

Conclusion

Normal growth charts were derived from a cohort of 111 normal fetuses. Because the margins of the vitreous are inside the bony orbit, at the same gestational age measurements of the BOD and OD are always less than the corresponding measurements by US, and those of the IOD are always more. Normal growth charts for MRI can now be used to support suspected diagnoses of orbital and ocular pathologies and the syndromes that give rise to them, and many examples are demonstrated.

American Institute of Ultrasound in Medicine (2008) Practice guideline for the performance of obstetric ultrasound examinations. American Institute of Ultrasound in Medicine, Laurel, MD. http://www.aium.org/publications/clinical/obstetric.pdf. Accessed 20 June 2008

Dilmen G, Köktener A, Turhan NO et al (2002) Growth of the fetal lens and orbit. Int J Gynaecol Obstet 76:267–271PubMedCrossRef

Goldstein I, Tamir A, Zimmer EZ et al (1998) Growth of the fetal orbit and lens in normal pregnancies. Ultrasound Obstet Gynecol 12:175–179PubMedCrossRef

Rosati P, Guariglia L (2003) Early transvaginal fetal orbital measurements: a screening tool for aneuploidy? J Ultrasound Med 22:1201–1205PubMed

Trout T, Budorick NE, Pretorius DH et al (1994) Significance of orbital measurements in the fetus. J Ultrasound Med 13:937–943PubMed

Mayden KL, Tortora M, Berkowitz RL et al (1982) Orbital diameters: a new parameter for prenatal diagnosis and dating. Am J Obstet Gynecol 144:289–297PubMed

Babcook C (2000) The fetal face and neck. In: Callen P (ed) Ultrasonography in obstetrics and gynecology. Saunders, Philadelphia, pp 307–315

Stroustrup A, Levine D (2005) MR imaging of the fetal skull, face and neck. In: Levine D (ed) Atlas of fetal MRI. Taylor & Francis, Boca Raton, pp 73–90

Sonigo P, Simon I, Mahieu-Caputo D et al (2003) The role of MRI in the investigation of fetal ocular anomalies. Pediatr Radiol 33 [Suppl 2]:S25

10.

Robinson AJ, Blaser S, Toi A et al (2004) MR imaging of the fetal eyes: normal and abnormal development. Pediatr Radiol 34 [Suppl 2]:S136

11.

Bremond-Gignac D, Cussenot O, Deplus S et al (1994) Computation of eyeball growth by magnetic resonance imaging. Surg Radiol Anat 16:113–115PubMedCrossRef

12.

Bremond-Gignac DS, Benali K, Deplus S et al (1997) In utero eyeball development study by magnetic resonance imaging. Surg Radiol Anat 19:319–322PubMedCrossRef

13.

Jeanty P, Dramaix-Wilmet M, Van Gansbeke D et al (1982) Fetal ocular biometry by ultrasound. Radiology 143:513–516PubMed

14.

Romero R, Pilu G, Jeanty P et al (1988) Prenatal diagnosis of congenital anomalies. Appleton & Lange, Norwalk, p 83

15.

Achiron R, Gottlieb Z, Yaron Y et al (1995) The development of the fetal eye: in utero ultrasonographic measurements of the vitreous and lens. Prenat Diagn 15:155–160PubMedCrossRef

16.

Robson CD, Barnewolt CE (2004) MR imaging of fetal head and neck anomalies. Neuroimaging Clin N Am 14:273–291PubMedCrossRef

17.

Berg C, Geipel A, Germer U et al (2001) Prenatal detection of Fraser syndrome without cryptophthalmos: case report and review of the literature. Ultrasound Obstet Gynecol 18:76–80PubMedCrossRef

18.

Fryns JP, van Schoubroeck D, Vandenberghe K et al (1997) Diagnostic echographic findings in cryptophthalmos syndrome (Fraser syndrome). Prenat Diagn 17:582–584PubMedCrossRef

19.

Bardakjian T, Weiss A, Schneider A (2006) Anophthalmia/microphthalmia overview. GeneReviews, NCBI. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=gene.chapter.anophthalmia-ov Accessed 20 June 2008

20.

Chitayat D, Sroka H, Keating S et al (2007) The PDAC syndrome (pulmonary hypoplasia/agenesis, diaphragmatic hernia/eventration, anophthalmia/microphthalmia, and cardiac defect) (Spear syndrome, Matthew-Wood syndrome): report of eight cases including a living child and further evidence for autosomal recessive inheritance. Am J Med Genet A 143:1268–1281

21.

Achiron R, Kreiser D, Achiron A (2000) Axial growth of the fetal eye and evaluation of the hyaloid artery: in utero ultrasonographic study. Prenat Diagn 20:894–899PubMedCrossRef

22.

Birnholz JC, Farrell EE (1988) Fetal hyaloid artery: timing of regression with US. Radiology 166:781–783PubMed

23.

Ramji FG, Slovis TL, Baker JD (1996) Orbital sonography in children. Pediatr Radiol 26:245–258PubMedCrossRef

24.

Reches A, Yaron Y, Burdon K et al (2007) Prenatal detection of congenital bilateral cataract leading to the diagnosis of Nance-Horan syndrome in the extended family. Prenat Diagn 27:662–664PubMedCrossRef

25.

Fayol L, Garcia P, Denis D et al (2006) Adams-Oliver syndrome associated with cutis marmorata telangiectatica congenita and congenital cataract: a case report. Am J Perinatol 23:197–200PubMedCrossRef

26.

Başbuğ M, Serin IS, Ozçelik B et al (2005) Prenatal ultrasonographic diagnosis of rhizomelic chondrodysplasia punctata by detection of rhizomelic shortening and bilateral cataracts. Fetal Diagn Ther 20:171–174PubMedCrossRef

27.

Terhal P, Sakkers R, Hochstenbach R et al (2004) Cerebellar hypoplasia, zonular cataract, and peripheral neuropathy in trisomy 17 mosaicism. Am J Med Genet A 130:410–414CrossRef

28.

Vutova K, Peicheva Z, Popova A et al (2002) Congenital toxoplasmosis: eye manifestations in infants and children. Ann Trop Paediatr 22:213–218PubMedCrossRef

29.

Cengiz B, Baxi L (2001) Congenital cataract in triplet pregnancy after IVF with frozen embryos: prenatal diagnosis and management. Fetal Diagn Ther 16:234–236PubMedCrossRef

30.

Romain M, Awoust J, Dugauquier C et al (1999) Prenatal ultrasound detection of congenital cataract in trisomy 21. Prenat Diagn 19:780–782PubMedCrossRef

31.

Beinder EJ, Pfeiffer RA, Bornemann A et al (1997) Second-trimester diagnosis of fetal cataract in a fetus with Walker-Warburg syndrome. Fetal Diagn Ther 12:197–199PubMedCrossRef

32.

Shapiro I, Borochowitz Z, Degani S et al (1992) Neu-Laxova syndrome: prenatal ultrasonographic diagnosis, clinical and pathological studies, and new manifestations. Am J Med Genet 43:602–605PubMedCrossRef

33.

Brent RL (1984) The effects of ionizing radiation, microwaves, and ultrasound on the developing embryo: clinical interpretations and applications of the data. Curr Probl Pediatr 14:1–87PubMedCrossRef

34.

Milic A, Blaser S, Robinson A et al (2006) Prenatal detection of microtia by MRI in a fetus with trisomy 22. Pediatr Radiol 36:706–710PubMedCrossRef

35.

Hosseinzadeh K, Owens E (2005) Optimization of acquisition time for MRI of fetal head: the eyes have it. AJR 185:1060–1062PubMedCrossRef

36.

Demyer W, Zeman W, Palmer CG (1964) The face predicts the brain: diagnostic significance of median facial anomalies for holoprosencephaly (arrhinencephaly). Pediatrics 34:256–263PubMed

37.

Kusanovic J, Mittal P, Goncalves L et al (2005) 3D ultrasound evaluation of the fetal optic chiasm: a potential parameter for the differential diagnosis of developmental midline brain anomalies. Ultrasound Obstet Gynecol 26:311CrossRef

38.

Whitby E (2006) In utero magnetic resonance imaging of developmental abnormalities of the fetal CNS. In: Griffiths P, Paley M, Whitby E (eds) Imaging the central nervous system of the fetus and neonate. Taylor and Francis, New York, pp 99–110

39.

Cohen MM Jr, Richieri-Costa A, Guion-Almeida ML et al (1995) Hypertelorism: interorbital growth, measurements, and pathogenetic considerations. Int J Oral Maxillofac Surg 24:387–395PubMedCrossRef

40.

Slevin J, Blaser S, Chitayat D et al (2005) ‘Intraventricular fused fornices,’ a marker for complex midline anomalies. Ultrasound Obstet Gynecol 26:311CrossRef

Titel: MRI of the fetal eyes: morphologic and biometric assessment for abnormal development with ultrasonographic and clinicopathologic correlation
verfasst von: Ashley J. Robinson
Susan Blaser
Ants Toi
David Chitayat
Sophie Pantazi
Sarah Keating
Sandra Viero
Greg Ryan
Publikationsdatum: 01.09.2008
Verlag: Springer-Verlag
Erschienen in: Pediatric Radiology / Ausgabe 9/2008
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-008-0929-3

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MRI of the fetal eyes: morphologic and biometric assessment for abnormal development with ultrasonographic and clinicopathologic correlation