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18.05.2024

NEUT-RI, a surrogate marker of NETosis is lower in patients with strong IgM antiphospholipid antibodies

verfasst von: Sylvie Bouvier, Mathieu Fortier, Eva Nouvellon, Ariane Olivan, Mathias Chéa, Jean-Christophe Gris

Erschienen in: Journal of Thrombosis and Thrombolysis

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Abstract

Background

Antiphospholipid antibody syndrome (APS) is an acquired autoimmune disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy complications. Recently, thrombotic APS was linked to increased neutrophil extracellular traps (NET) formation, suggesting an association between NETs and the severity of APS-related thrombosis.

Methods

We performed a retrospective study on patients tested for presence of antiphospholipid antibodies (990 negative and 374 positive) to evaluate the association between the neutrophil activation state, estimated by the neutrophil reactive index (NEU-RI), a parameter routinely available from some haematology analysers, and antiphospholipid antibodies.

Results

We do not observe a difference in NEU-RI values between positive and negative patients globally. However, interestingly, we highlight an association between high titers of IgM and low NEU-RI values indicating a lower neutrophil activation.

Conclusion

Our data are in line with the recent questioning about the putative clinical consistency of positive solid-phase aPL IgM.

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10.

Chayoua W, Kelchtermans H, Gris JC, Moore GW, Musiał J, Wahl D, de Groot PG, de Laat B, Devreese KMJ (2020) The (non-)sense of detecting anti-cardiolipin and anti-β2glycoprotein I IgM antibodies in the antiphospholipid syndrome. J Thromb Haemost 18(1):169–179. https://doi.org/10.1111/jth.14633CrossRefPubMed

Titel: NEUT-RI, a surrogate marker of NETosis is lower in patients with strong IgM antiphospholipid antibodies
verfasst von: Sylvie Bouvier
Mathieu Fortier
Eva Nouvellon
Ariane Olivan
Mathias Chéa
Jean-Christophe Gris
Publikationsdatum: 18.05.2024
Verlag: Springer US
Erschienen in: Journal of Thrombosis and Thrombolysis
Print ISSN: 0929-5305
Elektronische ISSN: 1573-742X
DOI: https://doi.org/10.1007/s11239-024-03001-1

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NEUT-RI, a surrogate marker of NETosis is lower in patients with strong IgM antiphospholipid antibodies

Abstract

Background

Methods

Results

Conclusion

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Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

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Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Bei seelischem Stress sind Checkpoint-Hemmer weniger wirksam

Antikörper mobilisiert Neutrophile gegen Krebs

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

Update Innere Medizin