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Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

05.12.2023 | Original Article

Non-syndromic supernumerary teeth and association with a self-reported family history of cancer

verfasst von: Andrea Lips, Prof. Dr. Erika Calvano Küchler, Isabela Ribeiro Madalena, Patricia Nivoloni Tannure, Leonardo Santos Antunes, Livia Azeredo Alves Antunes, Marcelo Castro Costa, Peter Proff, Christian Kirschneck, Flares Baratto-Filho

Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

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Abstract

Background

Supernumerary teeth are an alteration of dental developmental and result in the formation of teeth above the usual number. Epidemiologic studies suggested that patients with dentofacial anomalies and their family members may present an increased risk of developing cancer, including female breast cancer and gynecologic cancers. These observations indicate that genetic alterations that result in dental anomalies may be related to cancer development. Thus, the aim of the present study was to evaluate the association between supernumerary teeth and a family history of female breast cancer and gynecologic cancers.

Methods

The diagnosis of supernumerary teeth was based on clinical and radiographic examinations. For data collection, a questionnaire asking for information regarding ethnicity, age, gender, and self-reported family history of cancer up to the second generation was used. Statistical analysis was performed using the Χ² test and Fisher’s exact test with an established α of 5%.

Results

A total of 344 patients were included; 47 of them had one or more non-syndromic supernumerary teeth (not associated with any syndrome or cleft lip and palate) and 297 were control patients. Age, ethnicity, and gender distribution were not statistically different between the group with supernumerary teeth and the control group (p > 0.05). The supernumerary teeth were most commonly observed in the incisors area. Breast cancer (n = 17) was the most commonly self-reported type of cancer, followed by uterine cervical (n = 10), endometrial (n = 2), and ovarian (n = 1) cancers. Endometrial cancer was significantly associated with the diagnosis of supernumerary teeth (p = 0.017).

Conclusion

This study suggests that patients with supernumerary teeth possess a higher risk of having family members with endometrial cancer.

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Titel: Non-syndromic supernumerary teeth and association with a self-reported family history of cancer
verfasst von: Andrea Lips
Prof. Dr. Erika Calvano Küchler
Isabela Ribeiro Madalena
Patricia Nivoloni Tannure
Leonardo Santos Antunes
Livia Azeredo Alves Antunes
Marcelo Castro Costa
Peter Proff
Christian Kirschneck
Flares Baratto-Filho
Publikationsdatum: 05.12.2023
Verlag: Springer Medizin
Erschienen in: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie
Print ISSN: 1434-5293
Elektronische ISSN: 1615-6714
DOI: https://doi.org/10.1007/s00056-023-00504-z

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