nach oben

European Journal of Applied Physiology

Erschienen in:

01.03.2009 | Original Article

Particulate matter inhalation during hay storing activity induces systemic inflammation and platelet aggregation

verfasst von: B. Schicker, M. Kuhn, R. Fehr, L. M. Asmis, C. Karagiannidis, W. H. Reinhart

Erschienen in: European Journal of Applied Physiology | Ausgabe 5/2009

Einloggen, um Zugang zu erhalten

Abstract

The aim of this study was to investigate possible pathomechanisms behind the cardiovascular morbidity caused by inhalation of particulate matter (PM₁₀). For that purpose, healthy volunteers were exposed to high PM₁₀ concentrations during a 2 h hay storing activity. Blood was drawn in the evening before and after PM₁₀ exposure and in the morning and evening of the day after exposure. The leukocyte count increased after PM₁₀ exposure with an initial increase of segmented neutrophils followed by banded forms. C-reactive protein increased over time. Fibrinogen and plasma viscosity became increased in the evening of the day after PM₁₀ exposure. Platelet aggregation was increased in the evening after PM₁₀ exposure. At the same time von Willebrand factor and factor VIII were increased, reflecting endothelial activation. These results confirm that acute inhalative exposure to high PM₁₀ concentrations during hay storage activity leads to a systemic inflammatory reaction, endothelial activation, and platelet aggregation.

Ahmadizad S, El-Sayed MS, MacLaren DP (2006) Responses of platelet activation and function to a single bout of resistance exercise and recovery. Clin Hemorheol Microcirc 35:159–168PubMed

Barnett AG, Williams GM, Schwartz J et al (2006) The effects of air pollution on hospitalizations for cardiovascular disease in elderly people in Australian and New Zealand cities. Environ Health Perspect 114:1018–1023PubMedCrossRef

Brook RD, Franklin B, Cascio W et al (2004) Air pollution and cardiovascular disease: a statement for healthcare professionals from the expert panel on population and prevention science of the American heart association. Circulation 109:2655–2671. doi:10.1161/01.CIR.0000128587.30041.C8 PubMedCrossRef

Bünger J, Westphal G, Mönnich A et al (2004) Cytotoxicity of occupationally and environmentally relevant mycotoxins. Toxicology 202:199–211. doi:10.1016/j.tox.2004.05.007 PubMedCrossRef

Cathomas RL, Bruesch H, Fehr R et al (2002) Organic dust exposure in dairy farmers in an alpine region. Swiss Med Wkly 132:174–178PubMed

Dalby MC, Davidson SJ, Burman JF et al (2000) Diurnal variation in platelet aggregation with the PFA-100 platelet function analyser. Platelets 11:320–324. doi:10.1080/09537100050144731 PubMedCrossRef

Danesh J, Whincup P, Walker M et al (2000) Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ 321:199–204. doi:10.1136/bmj.321.7255.199 PubMedCrossRef

Dockery DW, Pope CAIII, Xu X et al (1993) An association between air pollution and mortality in six U.S. cities. N Engl J Med 329:1753–1759. doi:10.1056/NEJM199312093292401 PubMedCrossRef

Dominici F, McDermott A, Daniels M et al (2005) Revised analyses of the National Morbidity, Mortality, and Air Pollution Study: mortality among residents of 90 cities. J Toxicol Environ Health A 68:1071–1092. doi:10.1080/15287390590935932 PubMedCrossRef

Ghio AJ, Kim C, Devlin RB (2000) Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Respir Crit Care Med 162:981–988PubMed

Gray MR, Thrasher JD, Crago R et al (2003) Mixed mold mycotoxicosis: immunological changes in humans following exposure in water-damaged buildings. Arch Environ Health 58:410–420PubMed

Hoek G, Brunekreef B, Fischer P, van Wijnen J et al (2001) The association between air pollution and heart failure, arrhythmia, embolism, thrombosis, and other cardiovascular causes of death in a time series study. Epidemiology 12:355–357. doi:10.1097/00001648-200105000-00017 PubMedCrossRef

Ishii H, Hayashi S, Hogg JC et al (2005) Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment. Respir Res 6:87. doi:10.1186/1465-9921-6-87 PubMedCrossRef

Jimenez LA, Drost EM, Gilmour PS et al (2002) PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha. Am J Physiol Lung Cell Mol Physiol 282:L237–L248PubMed

Lanki T, Pekkanen J, Aalto P et al (2006) Associations of traffic related air pollutants with hospitalisation for first acute myocardial infarction: the HEAPSS study. Occup Environ Med 63:844–851. doi:10.1136/oem.2005.023911 PubMedCrossRef

Lee KW, Blann AD, Lip GY (2005) Plasma markers of endothelial damage/dysfunction, inflammation and thrombogenesis in relation to TIMI risk stratification in acute coronary syndromes. Thromb Haemost 94:1077–1083PubMed

Lehmann T, Mairbäurl H, Pleisch B et al (2006) Platelet count and function at high altitude and in high-altitude pulmonary edema. J Appl Physiol 100:690–694. doi:10.1152/japplphysiol.00991.2005 PubMedCrossRef

Markovitch D, Tyrrell RM, Thompson D (2008) Acute moderate-intensity exercise in middle-aged men has neither an anti- nor proinflammatory effect. J Appl Physiol 105:260–265. doi:10.1152/japplphysiol.00096.2008 PubMedCrossRef

Mills NL, Amin N, Robinson SD et al (2006) Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am J Respir Crit Care Med 173:426–431. doi:10.1164/rccm.200506-865OC PubMedCrossRef

Morange PE, Simon C, Alessi MC et al (2004) Endothelial cell markers and the risk of coronary heart disease: the prospective epidemiological study of myocardial infarction (PRIME) study. Circulation 109:1343–1348. doi:10.1161/01.CIR.0000120705.55512.EC PubMedCrossRef

Nemmar A, Hoet PH, Vanquickenborne B et al (2002) Passage of inhaled particles into the blood circulation in humans. Circulation 105:411–414. doi:10.1161/hc0402.104118 PubMedCrossRef

Peters A (2005) Particulate matter and heart disease: evidence from epidemiological studies. Toxicol Appl Pharmacol 207:477–482. doi:10.1016/j.taap.2005.04.030 PubMedCrossRef

Peters A, Doring A, Wichmann HE et al (2000) Increased plasma viscosity during an air pollution episode: a link to mortality? Lancet 349:1582–1587. doi:10.1016/S0140-6736(97)01211-7 CrossRef

Peters A, Veronesi B, Calderon-Garciduenas L et al (2006) Translocation and potential neurological effects of fine and ultrafine particles a critical update. Part Fibre Toxicol 3:13. doi:10.1186/1743-8977-3-13 PubMedCrossRef

Petidis K, Douma S, Doumas M et al (2008) The interaction of vasoactive substances during exercise modulates platelet aggregation in hypertension and coronary artery disease. BMC Cardiovasc Disord 27:8–11

Pope CAIII, Thun MJ, Namboodiri MM et al (1995) Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Respir Crit Care Med 151:669–674PubMed

Pope CAIII, Burnett RT, Thurston GD et al (2004) Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation 109:71–77. doi:10.1161/01.CIR.0000108927.80044.7F PubMedCrossRef

Pope CAIII, Muhlestein JB, May HT et al (2006) Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution. Circulation 114:2443–2448. doi:10.1161/CIRCULATIONAHA.106.636977 PubMedCrossRef

Ruckerl R, Ibald-Mulli A, Koenig W et al (2006) Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med 173:432–441. doi:10.1164/rccm.200507-1123OC PubMedCrossRef

Salvi S, Blomberg A, Rudell B et al (1999) Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 159:702–709PubMed

Törnqvist H, Mills NL, Gonzalez M et al (2007) Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am J Respir Crit Care Med 176:395–400. doi:10.1164/rccm.200606-872OC PubMedCrossRef

Tozzi-Ciancarelli MG, Penco M, Di MC (2002) Influence of acute exercise on human platelet responsiveness: possible involvement of exercise-induced oxidative stress. Eur J Appl Physiol 86:266–272. doi:10.1007/s00421-001-0542-8 PubMedCrossRef

Van Eeden SF, Tan WC, Suwa T et al (2001) Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10)). Am J Respir Crit Care Med 164:826–830PubMed

Wang JS, Jen CJ, Kung HC (1994) Different effects of strenuous exercise and moderate exercise on platelet function in men. Circulation 90:2877–2885PubMed

Wellenius GA, Schwartz J, Mittleman MA (2005) Air pollution and hospital admissions for ischemic and hemorrhagic stroke among medicare beneficiaries. Stroke 36:2549–2553. doi:10.1161/01.STR.0000189687.78760.47 PubMedCrossRef

Winther K, Hillegass W, Tofler GH et al (1992) Effects on platelet aggregation and fibrinolytic activity during upright posture and exercise in healthy men. Am J Cardiol 70:1051–1055. doi:10.1016/0002-9149(92)90359-7 PubMedCrossRef

Zanobetti A, Schwartz J (2005) The effect of particulate air pollution on emergency admissions for myocardial infarction: a multicity case-crossover analysis. Environ Health Perspect 113:978–982PubMedCrossRef

Titel: Particulate matter inhalation during hay storing activity induces systemic inflammation and platelet aggregation
verfasst von: B. Schicker
M. Kuhn
R. Fehr
L. M. Asmis
C. Karagiannidis
W. H. Reinhart
Publikationsdatum: 01.03.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Applied Physiology / Ausgabe 5/2009
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-008-0962-9

Neu im Fachgebiet Arbeitsmedizin

Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Open Access Hüftgelenksbewegungseinschränkung Leitthema

Beginnend mit den 1920er-Jahren hat sich eine Vorstellung über die Geschlechterdifferenzen in Gesundheit und Mortalität etabliert, die von Lorber und Moore in dem einprägsamen Satz: „Women get sicker, but men die quicker“, zusammengefasst wurde [ 1 …, S. 13]. Tatsächlich erscheinen vor dem Hintergrund der höheren Lebenserwartung der Frauen die Studienergebnisse zu den Geschlechterdifferenzen in der Morbidität überraschend, wonach Frauen im Durchschnitt einen schlechteren Gesundheitszustand aufweisen als Männer [

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

Open Access Leitthema

Die demographische Alterung hat vielfältige gesellschaftliche Konsequenzen, deren Ausmaß wesentlich vom Gesundheitszustand der Bevölkerung abhängt. Um diesen analysieren und bewerten zu können, wurden spezielle Kennziffern entwickelt, die in …

Wie hat sich die Lebenserwartung ohne funktionelle Einschränkungen in Deutschland entwickelt? Eine Analyse mit Daten des Deutschen Alterssurveys (DEAS)

Open Access Hüftgelenksbewegungseinschränkung Leitthema

Deutschland erfährt, wie andere Hocheinkommensstaaten, aufgrund kontinuierlich rückläufiger Mortalität und niedriger Geburtenraten tiefgreifende demografische Veränderungen. Der demografische Wandel führt in Deutschland zu einem zunehmend höheren …

Hitzeschutz im Fokus der hessischen Betreuungs- und Pflegeaufsicht

Open Access Klimawandel Übersichtsartikel

Im Sommer 2023 kündigte das Bundesministerium für Gesundheit (BMG) einen nationalen Hitzeschutzplan an und forderte die Länder auf, zu prüfen, „ob die Warnstufen des [Deutschen Wetterdienstes] DWD mit der Durchführung von Akutmaßnahmen …

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2009

Effect of acute sprint interval exercise on central and peripheral artery distensibility in young healthy males

Relative importance of lean and fat mass on bone mineral density in a group of adolescent girls and boys

Changes in heart rate recovery after high-intensity training in well-trained cyclists

Effect of two durations of short-term intermittent hypoxia on ventilatory chemosensitivity in humans

Effect of high intensity intermittent training on heart rate variability in prepubescent children

A comparison of different two-dimensional approaches for the determination of the patellar tendon moment arm length

Neu im Fachgebiet Arbeitsmedizin

Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

Wie hat sich die Lebenserwartung ohne funktionelle Einschränkungen in Deutschland entwickelt? Eine Analyse mit Daten des Deutschen Alterssurveys (DEAS)

Hitzeschutz im Fokus der hessischen Betreuungs- und Pflegeaufsicht