Pregnancy Outcome After Surgical Anastomosis of Oviduct—a Multivariate Analysis

This study aimed at developing an effective pregnancy outcome prediction nomogram after surgical anastomosis of the oviduct. This was a retrospective cohort study involving hospitalized women who underwent oviduct anastomosis between January 2008 and January 2019. Socio-demographic and clinical characteristics data of patients were extracted from online records. Univariate and multivariate Cox analyses were performed on selected variables after which multivariate Cox regression analyses used to construct a nomogram for prediction of pregnancy outcomes. C-statistics (C-index) and calibration curves were used to validate the nomogram. A total of 247 women were enrolled in the study. Among them, 67.2% (167 women) had successful live intrauterine pregnancy and 50.6% had at least one live birth. Univariate Cox analysis revealed that patients older than 35 years (HR 0.56; 95% CI 0.41–0.76), post-operative tubal length less than 7 cm (HR 0.36; 95% CI 0.21–0.63), sterilization reversal by laparoscopy (HR 1.38; 95% CI 1.01–1.87), and pelvic environment (HR 0.80; 95% CI 0.68–0.94) were significantly associated with post-surgical intrauterine pregnancy. Based on multivariate Cox analysis, the independent prognostic factors were established to be age > 35 years, post-operative tubal length < 7 cm, sterilization reversal by laparoscopy, and pelvic environment. The constructed predictive model exhibited a good discrimination and predictive ability for intrauterine pregnancy after surgery (C-index 0.74). Sterilization reversal by laparoscopy, post-operative tubal length ≥ 7 cm, age ≤ 35 years, and normal pelvic environment were associated with better pregnancy outcomes after surgical anastomosis of the oviduct. Surgical repair of the fallopian tube partially reverses and restores the anterior natural fertility of women.