Background
Methods
Clinical patient enrollment
Group | Description | No | M/F | Age (year) | Size (cm) | Previous medication history | Lesion Location | Stage (I/II/IIIa/IIIb/IV) | MSS cases | |
---|---|---|---|---|---|---|---|---|---|---|
Calcification degree | Liquefaction degree | |||||||||
A | (-) | (-) | 12 | 6/6 | 36.8±8.0 | 9.7±4.7 | 0 | RTS (3), RL (4), LLL (2), LTS (1), LL(2), ML(1) | 0/3/2/2/5 | 7 |
B | (++) | (-) | 14 | 8/6 | 40.0±15.3 | 7.7±2.3 | 5 | RTS (3), RL (2), ML (4), LLL(3), RPL(1), LL(1) | 1/1/5/5/2 | 5 |
C | (+) | (+) | 16 | 7/9 | 34.4±12.5 | 14.0±5.2 | 2 | RTS (6), ML (3), LL (1), LLL (2), LTS (2), RPL (3) | 0/0/3/8/5 | 8 |
D | (++) | (+) | 12 | 3/9 | 34.9±13.0 | 10.8±4.3 | 3 | RTS (4), ML (2), RL(4), LTS(1), RPL(1) | 2/1/0/7/2 | 5 |
E | (+) | (++) | 12 | 4/8 | 39.0±10.1 | 10.4±4.7 | 1 | RTS (3), RL (5), LL(2), RPL(2) | 0/1/3/5/3 | 5 |
F | (++) | (++) | 9 | 4/5 | 34.6±9.8 | 13.8±7.6 | 3 | RTS (1), RL (3), LL (2), LTS (3) | 0/0/0/4/5 | 5 |
Sum | 75 | 32/43 | 36.7±11.8 | 11.0±5.2 | 14 | RTS (20), RL (18), ML (10), LL (8), LLL (7), LTS (7), RPL (7) | 3/6/13/31/22 | 35 |
Abdominal CT
18F-FDG-PET/CT, TBR and LME range indicated by PET/CT
Surgery and medical treatment
Pathology and LME range indicated by MSS method
Lesion categorization or grouping
Statistical analysis
Results
General baseline characteristics
Patient grouping
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Group A: 0% periphery calcified (−/non-calcified), 0% central liquefied (−);
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Group B: ≥50% periphery calcified (++/macro-calcified), 0% central liquefied (−);
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Group C: < 50% periphery calcified (+/micro-calcified), < 50% central liquefied (+);
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Group D: ≥50% periphery calcified (++/macro-calcified), < 50% central liquefied (+);
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Group E: < 50% periphery calcified (+/micro-calcified), 50 ~ 75% central liquefied (++);
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Group F: ≥50% periphery calcified (++/macro-calcified), ≥75% central liquefied (++).
TBR values, PET/CT or MSS indicated LME ranges between each groups (Fig. 4a ~ c, Table 2)
Group | Description | TBR value | PET/CT indicated LME range (mm) | MSS indicated LME range (mm) | ||||
---|---|---|---|---|---|---|---|---|
Calcification degree | Necrosis degree | Mean±SD | 95% CI | Mean±SD | 95% CI | Mean±SD | 95% CI | |
A | (-) | (-) | 5.1±1.9 | 3.9~6.4 | 14.9±3.9 | 12.5~17.4 | 17.9±4.9 | 13.3~22.4 |
B | (++) | (-) | 2.7±1.2 | 2.0~3.4 | 10.6±1.5 | 9.7~11.4 | 13.0±2.7 | 9.6~16.4 |
C | (+) | (+) | 4.2±1.2 | 3.6~4.9 | 12.3±1.1 | 11.7~12.9 | 11.9±2.6 | 9.7~14.0 |
D | (++) | (+) | 2.7±0.7 | 2.3~3.2 | 7.8±1.6 | 6.8~8.8 | 6.0±2.2 | 3.2~8.8 |
E | (+) | (++) | 4.6±1.2 | 3.8~5.3 | 11.1±2.3 | 9.6~12.6 | 11.0±4.1 | 5.8~16.2 |
F | (++) | (++) | 2.9±1.1 | 2.1~3.8 | 7.0±0.4 | 6.7~7.3 | 6.0±2.2 | 3.2~8.8 |
C+E | (+) | Not specified | 4.4±1.2 | 3.9~4.8 | 11.8±1.8 | 11.1~12.5 | 11.5±3.2 | 9.6~13.4 |
B+D+F | (++) | Not specified | 2.8±1.0 | 2.4~3.1 | 8.7±2.0 | 8.0~9.4 | 8.3±4.1 | 6.1~10.6 |
A+B | Not specified | (-) | 3.8±1.9 | 3.0~4.6 | 12.6±3.6 | 11.1~14.0 | 15.8±4.7 | 12.9~18.8 |
C+D | Not specified | (+) | 3.6±1.2 | 3.1~4.1 | 10.4±2.6 | 9.4~11.4 | 9.6±3.8 | 7.3~11.9 |
Sum (A~F) | 3.7±1.6 | 3.4~4.1 | 10.8±3.2 | 10.1~11.6 | 11.4±5.2 | 9.6~13.2 |