Background
Gastric cancer (GC) is the fourth leading cause of cancer-related mortality worldwide [
1] and remains a leading contributor to the global disability-adjusted life-year burden [
2]. Incidence progressively increases with age (from around 50 years old) [
3]. Considerable differences in risk are observed by sex [
4], with males showing higher incidence compared to females [
5,
6]. In Germany, the standardized incidence rate was 6.8 per 100,000 females and 14.3 per 100,000 males in 2018, while the standardized mortality rate was 4.1 per 100,000 females and 7.7 per 100,000 males in the same year [
7]. For decades, a steady decline in GC incidence and mortality rates has been observed in developed countries, including Germany [
7].
In 40% of the cases the disease is already metastasized at the time of Gastric cancer diagnosis [
7,
8]. Moreover, disease recurrence is observed in more than 30% of curatively treated patients [
9]. Metastatic spread is generally fatal, causing organ compromise and failure of physiological homeostasis [
8]. Treatment is mainly selected based on the stage of disease, the presence of biomarkers, and the physician's preferred regimen. In the metastatic setting, first-line treatment may consist of doublet or triplet chemotherapies including taxanes, platinum compounds, and a cytotoxic compound such as 5-fluorouracil with or without trastuzumab (if human epidermal growth factor receptor 2 (HER2) is overexpressed) [
10]. Taxanes (docetaxel, paclitaxel), irinotecan or ramucirumab (alone or in combination with paclitaxel) are recommended as second-line treatment options. The landscape in the latter lines of treatment is more challenging in terms of therapeutic algorithms and a poorer prognosis for patients.
The development of targeted therapies is crucial to improve patient care and to address the high unmet need by this innovative approach of treatment. For example, the monoclonal antibody Trastuzumab (target: HER2) has shown an improved response in HER2-positive disease compared to standard systemic chemotherapy [
11]. Therefore, HER2 testing is recommended by guidelines in all metastatic GC (mGC) patients [
12,
13]. Real-world data offers the opportunity to gain needed insights into the treatment approaches in clinical practice and related outcomes in mGC care. A retrospective analysis of German claims data was conducted aiming to generate evidence on treatment regimens and survival in mGC patients. In addition, HER2-positive mGC patients actively treated with targeted therapy were identified, and relevant outcomes were described.
Methods
Study design and data source
A retrospective analysis was conducted using anonymized German claims data provided by AOK PLUS covering the period from January 1, 2010, to December 31, 2021. AOK PLUS, the sixths-biggest German sickness fund, covers approximately 3.5 million insured persons in the regions of Saxony and Thuringia in central-eastern Germany. This corresponds to 50% of the local population and approximately 4.8% of the overall German Statutory Health Insurance (SHI) population. The analyzed dataset comprised anonymized patient-level data on claims for inpatient care, outpatient care, outpatient drug prescriptions, and additional relevant data, including demographic information and all-cause of death.
Study population
The study population consisted of newly diagnosed mGC cases identified using German Modification of the International Classification of Diseases Version 10 (ICD-10-GM) codes. A metastatic-free period of at least 12 months was established before the index date (to identify mGC incident cases). The index date was defined as the first documented diagnosis of metastasis on or after the date of GC diagnosis. The following selection criteria were applied to retrieve the mGC population:
First, the disease criterion: At least one inpatient diagnosis of GC (ICD-10-GM code: C16.-) and/or at least two confirmed outpatient GC diagnoses in two quarters within 12 months. Second, the metastatic criterion: Any inpatient or confirmed outpatient diagnosis of metastasis (ICD-10-GM codes: C77-80) on or after the date of GC diagnosis. Third, the incident metastatic criterion: A metastatic-free period of at least 12 months before the first observable claim related to metastatic diagnosis. Fourth, the insurance criterion: Continuously insured for at least 12 months prior to the first observable metastatic diagnosis. Fifth, the age criterion: Age ≥ 18 years on the date of the first metastatic diagnosis. Sixth, the non-breast cancer (BC) criterion: No breast cancer diagnosis (ICD-10-GM code: C50.-) before or on the date of the first metastatic diagnosis. Seventh, the non-GIST criterion: No treatment for malignant gastrointestinal stromal tumor with imatinib (Anatomical Therapeutic Chemical Classification System (ATC) code: L01EA01, L01XE01; operation and procedure classification system (OPS) code: 6–001.g) and/or sunitinib (ATC code: L01EX01, L01XE04; OPS code: 6–003.a) during the entire study period. In addition, HER2-positive mGC patients were identified by a treatment proxy [treatment with trastuzumab (ATC code: L01XC03; OPS codes:6–001.7, 6–001.k) at any time after the first observed metastatic diagnosis] for subgroup analyses.
Incident mGC patients were identified during a 10-year period (from 2011 to 2020) by applying the selection criteria. Ensuring a reasonable time to record therapy treatments and time-to-event outcomes, data were considered until December 31, 2021. An overview of the study period and inclusion period is shown in Supplementary Fig.
1.
Treatment line definitions
mGC therapies were identified through inpatient and outpatient codes. The treatment codes are listed in Supplementary Table
1. The first line of treatment (1LOT) was established considering the first prescription/application of any of the agents listed in Supplementary Table
1. All therapies documented within 28 days after starting a LOT were considered part of combination therapy. A new line of treatment was initiated if an additional active substance or combination of substances (that was not part of the current LOT) was prescribed after 28 days or more or if therapy was restarted after a gap of more than three months. When an unspecified OPS code was documented for inpatients (chemotherapy with unspecified substances code, OPS 8–54), it was assumed that the preceding LOT was continued during the period of hospitalization. No new treatment line was established for switching between platinum compounds (carboplatin, cisplatin, or oxaliplatin).
Statistical analysis
Qualitative variables were described as frequencies with percentages, and quantitative variables as mean ± standard deviation (SD). Baseline characteristics of mGC patients were stated at time of first mGC diagnosis, including age, sex, comorbidities identified through ICD-10 codes (Charlson Comorbidity Index (CCI) score [
14], Supplementary Table
2), and the number of all-cause hospitalizations.
The most frequent therapy regimens were described numerically overall and by treatment line. Real-world time-to-treatment initiation (rwTTI) and real-world time-to-next-treatment (rwTTNT) were assessed using Kaplan–Meier (KM) method. RwTTI was estimated from mGC diagnosis until the date of death or censoring at end of continuous insurance or end of the study, whichever occurs first. RwTTNT was estimated since the start of each treatment line among those who reached the next LOT.
Survival analyses were conducted from the date of mGC diagnosis until the date of death (all-cause) or censoring at end of continuous insurance or end of the study, whichever occurs first. KM method was used to estimate real-world overall survival (rwOS). Median survival time and survival probabilities were reported. KM curves were displayed along with the number of patients at risk. Analyses were performed in each treatment line and in the HER2-positive mGC patients subgroup.
All findings were reported using the guidelines of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) [
15] and Standardized Reporting of Secondary data Analyses (STROSA) [
16]. Descriptive and analytical statistical analyses were conducted using STATA software version 17 (STATA Corp., College Station, Texas).
Discussion
Our real-world study provides key data to assess the disease burden of mGC in Germany, which is highly relevant to support discussing healthcare planning and the allocation of resources. The findings on treatment patterns offer a clear picture of the therapy regimens and the sequential switching of treatment lines in clinical practice. Survival analysis showed that mGC remains a life-threatening disease, for which new treatment options are needed to improve prognosis.
Almost half of mGC patients remained without systemic therapy. Patients who received disease-specific therapy were more likely to be male, young, and had fewer comorbidities. Palliative care can effectively relieve symptoms as well as improve the quality of life [
17]. The decision to offer supportive care alone or with systemic therapy is dependent on the patient's performance status [
13]. It is necessary to individualize the approach, for instance in patients with a late diagnosis and poor prognosis. Other real-world studies have reported a relevant proportion of mGC without systemic therapy. For instance, a study using the Flatiron Health database showed that one-quarter of patients with mGC did not receive treatment and only approximately one-half of patients receiving 1LOT received subsequent treatment [
18]. Furthermore, the proportion of untreated patients in our findings is consistent with the estimations of a retrospective observational study described in the Trifluridin/Tipiracil (Lonsurf®) dossier in Germany [
19].
Treatment patterns observed in this study were generally in line with the guideline recommendations and the literature [
13,
20,
21]. In the first line of treatment, the two most frequent combinations used were the triplet chemotherapy (docetaxel + fluorouracil + platinum compound) and the doublet chemotherapy (fluorouracil + platinum compound). Both combinations are existing treatment options in this setting according to the German S3 gastric cancer guideline [
20]. In second and later-line treatment, ramucirumab-paclitaxel, ramucirumab monotherapy, or irinotecan were frequently prescribed. Here, a longitudinal analysis of treatment patterns in mGC is presented to understand the current therapeutic landscape. This is in contrast to previous studies that are restricted to a specific line of treatment [
22‐
24].
The presented estimates for survival appear to be consistent with the literature [
25‐
28]. The Munich cancer registry (TRM) showed a median OS of 7.3 months for German mGC patients (Stage IV) [
9]. The ToGA trial showed that trastuzumab combined with chemotherapy offers a benefit for patients with HER2-positive advanced gastric cancer. The median OS was 13.8 months (95% CI 12 months to 16 months) in those assigned to trastuzumab with chemotherapy compared with 11.1 months (95% CI 10 months to 13 months) in those assigned to chemotherapy alone [
11].
For the interpretation of rwOS since the start of therapy lines, it is necessary to consider that at the start of each treatment line, a specific subgroup of patients was analyzed (i.e., only those who were able to reach the further line of treatment).
Our study relies on certain strengths. First, the use of a structured administrative database for insurance claims considering a large sample size. Second, the long study period allowed us to include patients for a decade along with record treatments, interventions, and outcomes of interest during follow-up. Third, data was independently collected in terms of inpatient/outpatient diagnoses and complete records of outpatient prescriptions. It is, however, necessary to recognize that there are general limitations related to the use of claims data. First, our study aimed to describe therapies and survival in mGC patients, while also providing insights on HER2-positive mGC patients actively treated with targeted therapy. Consequently, mGC patients were identified excluding BC patients given that HER-2 is overexpressed in approximately 20% of BC patients and has been associated with poorer prognosis. We also excluded GIST patients with unresectable or metastatic disease using tyrosine kinase inhibitors as a treatment proxy for identification. The exclusion of these patients needs to be considered for the interpretation of the study. Second, clinical and laboratory data are not available in German claims data, which limited our capacity to identify the metastatic stage based on clinical assessment or determine HER2 status. For that reason, a specific algorithm was implemented, and a treatment proxy was used to mitigate these issues. Considering the latest, it is important to mention that HER2-positive patients without targeted treatment were not included in the subgroup analysis. Therefore, HER2-positive analysis described only patients treated with targeted therapy. Third, due to the inpatient chemotherapy with unspecified substances code available in Germany, it was not possible to identify specific treatments for a proportion of patients in the hospital setting. It is also important to consider the assumptions applied in the algorithm to define treatment lines for the interpretation of results. Among other things, it should be noted that combination regimens were only identified as such if the associated drugs were prescribed within a time window of 28 days, since a later prescription would otherwise be identified as a change in the line of therapy. Furthermore, claims databases contain data from routine practice for reimbursement purposes. Despite this, coding is generally considered to be of high quality in these databases. Fourth, patient selection and representativeness of the study are limited to subjects who are insured with German statutory health insurance in the study area. Nevertheless, uniform healthcare regulations with nearly universal coverage and access to health resources across Germany reduce concerns of possible bias, since around 88% of the German population is insured under the SHI system. Lastly, data from routine practice may exhibit coding errors or missing data.
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