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01.02.2023 | Original Paper

Relationship Between Worst Pattern of Invasion and Extranodal Extension in Oral Tongue Squamous Cell Carcinomas

verfasst von: Mayuri Yasuda, Celina Chiodo, Cullen Lilley, Swati Mehrotra, Vijayalakshmi Ananthanarayanan, Andrea Ziegler, Eric Thorpe

Erschienen in: Head and Neck Pathology | Ausgabe 2/2023

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Abstract

Background

Oral tongue squamous cell carcinoma (OTSCC) is a common malignancy of the oral cavity with poor survival rates. The aim of this project is to investigate the relationship between certain histopathological factors such as Worst Pattern of Invasion (WPOI) and Extranodal Extension (ENE) in patients with oral tongue squamous cell carcinoma (OTSCC) who underwent surgical resection at Loyola University Medical Center.

Methods

This was a retrospective cohort study at a tertiary care academic medical center. All patients that underwent primary surgical resection of OTSCC between 1/1/2015 and 1/1/2022 were reviewed. Patients were identified using the Cerner CoPath Laboratory Information System.

Results

A total of 82 patients met inclusion criteria and were included in the study. Higher grades of WPOI (WPOI 5) were not significantly associated with the presence of ENE in our study (P = 0.82), regardless of the presence of major or minor ENE. WPOI 5 was associated with a higher incidence of local recurrence (P = 0.011).

Conclusions

Higher grades of WPOI were not found to correlate with the presence of ENE, a common histopathological factor that is used as an important prognostic indicator in OTSCC. It is important for clinicians to consider these factors separately when determining whether a patient is high-risk and would benefit from aggressive multimodal treatment.

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Titel: Relationship Between Worst Pattern of Invasion and Extranodal Extension in Oral Tongue Squamous Cell Carcinomas
verfasst von: Mayuri Yasuda
Celina Chiodo
Cullen Lilley
Swati Mehrotra
Vijayalakshmi Ananthanarayanan
Andrea Ziegler
Eric Thorpe
Publikationsdatum: 01.02.2023
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2023
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-023-01531-3

Springer Medizin

Relationship Between Worst Pattern of Invasion and Extranodal Extension in Oral Tongue Squamous Cell Carcinomas

Abstract

Background

Methods

Results

Conclusions

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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