Background
Methods
Study population
Exposure and covariate assessment
Documentation of mortality endpoints
Statistical analyses
Results
Baseline characteristics
Total | Denmark | France | Germany | Greece | Italy | Norway | Spain | Sweden | The Netherlands | United Kingdom | |
---|---|---|---|---|---|---|---|---|---|---|---|
No. of participants | 322,972 | 27,887 | 66,878 | 26,766 | 13,893 | 30,008 | 35,215 | 23,828 | 19,930 | 26,223 | 52,344 |
Number of deaths | 14,383 | 1,879 | 2,913 | 671 | 527 | 834 | 756 | 625 | 1,583 | 1,419 | 3,176 |
Mean (SD) | |||||||||||
Age at recruitment, years | 50.3 (9.6) | 56.2 (4.4) | 52.1 (6.6) | 48.1 (8.9) | 51.6 (12.3) | 50.0 (8.0) | 47.6 (4.3) | 47.5 (8.3) | 54.9 (8.1) | 50.2 (11.6) | 47.1 (14.1) |
Duration OC use, yearsb,c | 7.7 (7.3) | 9.4 (6.4) | 7.4 (6.3) | 12.4 (8.5) | 2.5 (2.8) | 4.1 (4.8) | 5.0 (4.5) | 3.7 (3.6) | 9.7 (8.3) | 9.9 (7.3) | 7.6 (6.8) |
Number of FTPsc,d,e | 2.3 (1.0) | 2.2 (0.6) | 2.3 (0.9) | 2.0 (0.9) | 2.3 (1.0) | 2.1 (0.9) | 2.4 (0.8) | 2.8 (1.3) | 2.2 (0.9) | 2.6 (1.2) | 2.3 (1.0) |
Age at first FTPc,d | 24.9 (4.4) | 23.8 (3.1) | 24.9 (3.7) | 24.2 (4.4) | 24.1 (4.7) | 25.8 (4.3) | 24.0 (3.7) | 24.9 (3.8) | 24.6 (4.1) | 25.4 (4.3) | 25.6 (4.9) |
Breastfeeding, monthsc,f | 9.6 (10.6) | 9.4 (6.3) | 5.5 (5.2) | 5.4 (6.4) | 13.7 (16.3) | 9.1 (8.5) | 13.6 (9.5) | 13.1 (12.8) | 9.7 (7.3) | 6.6 (6.9) | 9.9 (12.9) |
Age at menarche, yearsc | 13.1 (1.5) | 13.7 (1.2) | 12.9 (1.3) | 13.2 (1.5) | 13.2 (1.6) | 12.6 (1.5) | 13.3 (1.1) | 13.0 (1.6) | 13.3 (1.5) | 13.3 (1.6) | 12.9 (1.6) |
Age at menopause, yearsc,g | 49.4 (4.4) | 49.9 (3.9) | 50.2 (4.3) | 50.1 (3.2) | 48.0 (4.7) | 49.2 (4.1) | 48.6 (3.3) | 48.8 (4.4) | – | 49.1 (4.5) | 49.2 (4.6) |
BMI, kg/m2 | 24.9 (4.4) | 25.5 (3.2) | 23.0 (3.2) | 25.7 (4.6) | 28.5 (5.2) | 25.6 (4.3) | 24.5 (3.1) | 28.5 (4.6) | 24.7 (4.2) | 25.1 (4.2) | 24.6 (4.2) |
Percentages | |||||||||||
Ever use OCsc | 59 | 58 | 60 | 80 | 11 | 40 | 60 | 36 | 61 | 76 | 68 |
Parousc | 85 | 88 | 90 | 86 | 90 | 87 | 92 | 89 | 86 | 81 | 78 |
Ever breastfedc,e | 85 | 93 | 72 | 84 | 88 | 84 | 94 | 89 | 95 | 81 | 83 |
Infertilityc,h | 5 | – | 6 | 1 | 4 | 6 | – | 4 | – | 3 | 5 |
Premenopausal | 35 | 7 | 27 | 37 | 38 | 38 | 23 | 42 | 27 | 37 | 38 |
Postmenopausal | 43 | 73 | 45 | 42 | 45 | 43 | 44 | 41 | 48 | 40 | 43 |
Surgical menopausei | 3 | 5 | 3 | 3 | 6 | 4 | 0 | 6 | 0 | 2 | 4 |
Perimenopausal/unknown menopause | 19 | 16 | 25 | 17 | 12 | 15 | 32 | 11 | 26 | 20 | 15 |
Hysterectomyc,j | 11 | 14 | 10 | 16 | 9 | 9 | 5 | 10 | – | 16 | 16 |
Oophorectomyc,j | 7 | 10 | 6 | 8 | 8 | 8 | 1 | 9 | – | 8 | 8 |
Current smokerc,k | 20 | 31 | 9 | 18 | 19 | 26 | 32 | 15 | 25 | 29 | 11 |
Marital status: single | 9 | 0 | 17 | 8 | 4 | 6 | 0 | 0 | 7 | 12 | 9 |
Ever marriedl | 72 | 0 | 80 | 92 | 96 | 93 | 81 | 0 | 92 | 87 | 90 |
Marital status: unknown | 19 | 100 | 4 | 0 | 0 | 1 | 19 | 100 | 0 | 0 | 0 |
Association of reproductive factors with all-cause mortality
Variable | Value | Cases / non-cases | Model 1 HRa (95 % CI) | Model 2 HRb (95 % CI) |
---|---|---|---|---|
Parous | No | 2,220 / 45,746 | 1.00 (reference) | 1.00 (reference) |
Yes | 11,757 / 254,871 | 0.80 (0.76–0.83) | 0.80 (0.76–0.84) | |
Number of FTPsc | 1 | 2,307 / 45,881 | 1.00 (reference) | 1.00 (reference) |
2 | 5,026 / 122,430 | 0.87 (0.83–0.91) | 0.91 (0.86–0.96) | |
3 | 2,529 / 56,316 | 0.83 (0.79–0.88) | 0.87 (0.82–0.92) | |
4 | 1,047 / 16,278 | 0.97 (0.90–1.04) | 0.98 (0.91–1.06) | |
5 | 350 / 4,448 | 0.97 (0.87–1.09) | 0.97 (0.86–1.09) | |
≥6 | 237 / 2,290 | 1.09 (0.95–1.25) | 1.08 (0.94–1.24) | |
P for trendd | 0.91 | 0.79 | ||
Age at first FTP, yearsc | ≤20 | 1,812 / 37,390 | 1.30 (1.23–1.38) | 1.10 (1.04–1.17) |
21–23 | 3,121 / 68,203 | 1.13 (1.07–1.19) | 1.05 (1.00–1.11) | |
24–25 | 2,173 / 49,889 | 1.02 (0.97–1.08) | 1.00 (0.95–1.06) | |
26–30 | 3,287 / 72,649 | 1.00 (reference) | 1.00 (reference) | |
≥31 | 1,281 / 25,749 | 1.08 (1.01–1.15) | 1.08 (1.01–1.16) | |
Breastfeedingc | Never | 1,721 / 36,691 | 1.00 (reference) | 1.00 (reference) |
Ever | 9,148 / 202,910 | 0.88 (0.83–0.93) | 0.92 (0.87–0.97) | |
Breastfeeding, monthse | ≤1 | 949 / 20,021 | 1.00 (reference) | 1.00 (reference) |
>1 to ≤3 | 1,753 / 39,935 | 1.01 (0.93–1.09) | 1.01 (0.93–1.09) | |
>3 to ≤6 | 1,846 / 41,685 | 0.94 (0.87–1.02) | 0.97 (0.89–1.05) | |
>6 to ≤12 | 2,224 / 47,802 | 0.90 (0.83–0.98) | 0.95 (0.88–1.03) | |
>12 to ≤18 | 986 / 23,319 | 0.81 (0.74–0.89) | 0.88 (0.80–0.97) | |
>18 | 1,276 / 27,949 | 0.88 (0.80–0.96) | 0.97 (0.89–1.07) | |
P for trendd | 0.013 | 0.85 | ||
Infertilityf | No | 8,958 / 199,770 | 1.00 (reference) | 1.00 (reference) |
Yes | 360 / 9,869 | 1.06 (0.95–1.18) | 1.06 (0.95–1.18) | |
OC use in never or former | Never | 6,379 / 100,292 | 1.00 (reference) | 1.00 (reference) |
smokers at baselineg | Ever | 3,736 / 140,642 | 0.90 (0.85–0.94) | 0.90 (0.86–0.95) |
Formerh | 3,475 / 122,414 | 0.89 (0.85–0.94) | 0.90 (0.86–0.95) | |
Currenth | 140 / 12,959 | 0.89 (0.74–1.07) | 0.92 (0.76–1.11) | |
Duration OC use, yearsg,i | ≤1 | 679 / 25,490 | 1.00 (reference) | 1.00 (reference) |
>1 to <5 | 721 / 30,600 | 0.99 (0.89–1.10) | 0.99 (0.89–1.11) | |
5 to <10 | 705 / 30,859 | 0.95 (0.85–1.06) | 0.96 (0.86–1.07) | |
10 to <15 | 616 / 21,267 | 1.05 (0.94–1.18) | 1.06 (0.94–1.18) | |
≥15 | 526 / 18,583 | 1.02 (0.90–1.15) | 1.02 (0.91–1.16) | |
P for trendd | 0.36 | 0.32 | ||
Age at menarche, years | <12 | 1,977 / 45,763 | 1.00 (reference) | 1.00 (reference) |
12 | 2,714 / 65,654 | 0.92 (0.86–0.97) | 0.95 (0.89–1.01) | |
13 | 3,378 / 79,701 | 0.88 (0.84–0.94) | 0.92 (0.87–0.98) | |
14 | 3,224 / 66,159 | 0.89 (0.84–0.95) | 0.93 (0.88–0.98) | |
≥15 | 2,774 / 47,743 | 0.88 (0.82–0.93) | 0.90 (0.85–0.96) | |
P for trendd | 0.004 | 0.038 | ||
Age at natural menopause, yearsj | ≤45 | 1,080 / 12,399 | 1.15 (1.07–1.24) | 1.09 (1.01–1.17) |
46–50 | 2,427 / 32,488 | 1.00 (reference) | 1.00 (reference) | |
51–52 | 1,064 / 14,537 | 0.88 (0.82–0.95) | 0.91 (0.85–0.99) | |
53–55 | 1,003 / 12,753 | 0.86 (0.80–0.93) | 0.92 (0.85–0.99) | |
>55 | 339 / 3,287 | 0.90 (0.80–1.01) | 0.95 (0.85–1.07) | |
P for trendd | <0.001 | <0.001 | ||
Total ovulatory lifespan, yearsk,l | 0–22 | 1,180 / 56,387 | 1.00 (reference) | 1.00 (reference) |
22–29 | 1,621 / 53,629 | 0.96 (0.89–1.05) | 0.99 (0.91–1.07) | |
29–34 | 2,148 / 52,270 | 0.92 (0.84–0.99) | 0.96 (0.89–1.04) | |
≥34 | 3,115 / 51,923 | 0.89 (0.82–0.97) | 0.98 (0.91–1.06) | |
P for trendd | 0.004 | 0.86 | ||
Oophorectomyl | No | 11,167 / 266,535 | 1.00 (reference) | 1.00 (reference) |
Yes | 1,202 / 18,603 | 1.05 (0.98–1.11) | 1.01 (0.93–1.10) | |
Hysterectomyl | No | 10,606 / 257,298 | 1.00 (reference) | 1.00 (reference) |
Yes | 1,972 / 30,608 | 1.01 (0.96–1.06) | 1.00 (0.94–1.05) |
Cancer mortality
Total cancer (n = 5,938) | Breast cancer (n = 749) | ||||
---|---|---|---|---|---|
ICD-10 code | C00–D48 | C50 | |||
Variable | Value | Cases/ non-cases | HRa (95 % CI) | Cases / non-cases | HRa (95 % CI) |
Parous | Yes | 4,973 / 261,634 | 0.87 (0.80–0.93) | 598 / 266,009 | 0.70 (0.58–0.85) |
Number of FTPsb,c | 1 | 944 / 47,240 | 1.00 (reference) | 135 / 48,049 | 1.00 (reference) |
2 | 2,164 / 125,284 | 0.91 (0.84–0.98) | 268 / 127,180 | 0.74 (0.60–0.92) | |
3 | 1,069 / 57,773 | 0.89 (0.81–0.97) | 119 / 58,723 | 0.70 (0.54–0.90) | |
4 | 442 / 16,880 | 1.05 (0.93–1.18) | 55 / 24,591 | 0.68 (0.49–0.95) | |
5 | 118 / 4,680 | 0.86 (0.71–1.05) | |||
≥6 | 88 / 2,438 | 1.11 (0.89–1.39) | |||
P for trendd | 0.85 | 0.012 | |||
Age at first FTP, yearsb | ≤20 | 781 / 38,420 | 1.03 (0.94–1.14) | 90 / 39,111 | 0.89 (0.68–1.16) |
21–23 | 1,267 / 70,055 | 0.97 (0.90–1.05) | 135 / 71,187 | 0.79 (0.63–0.99) | |
24–25 | 915 / 51,141 | 0.95 (0.87–1.03) | 114 / 51,942 | 0.91 (0.72–1.15) | |
26–30 | 1446 / 74,481 | 1.00 (reference) | 187 / 75,740 | 1.00 (reference) | |
≥31 | 531 / 26,496 | 1.06 (0.96–1.17) | 70 / 26,957 | 1.05 (0.79–1.39) | |
Breastfeedinge | Ever | 3,964 / 208,077 | 0.99 (0.91–1.08) | 484 / 211,557 | 1.01 (0.79–1.29) |
Breastfeeding, monthsf | ≤1 | 399 / 20,571 | 1.00 (reference) | 58 / 20,912 | 1.00 (reference) |
>1 to ≤3 | 768 / 40,917 | 0.96 (0.85–1.09) | 102 / 41,583 | 0.87 (0.62–1.21) | |
>3 to ≤6 | 783 / 42,744 | 0.92 (0.81–1.04) | 82 / 43,445 | 0.68 (0.48–0.96) | |
>6 to ≤12 | 965 / 49,056 | 0.93 (0.83–1.05) | 101 / 49,920 | 0.69 (0.49–0.97) | |
>12 to ≤18 | 434 / 23,868 | 0.87 (0.76–1.00) | 63 / 24,239 | 0.88 (0.60–1.27) | |
>18 | 579 / 28,644 | 1.04 (0.90–1.19) | 74 / 29,149 | 0.94 (0.65–1.37) | |
P for trendd | 0.23 | 0.35 | |||
OC use in never or former | Never | 2,376 / 104,288 | 1.00 (reference) | 257 / 106,407 | 1.00 (reference) |
smokers at baselineg | Ever | 1,775 / 142,587 | 0.91 (0.85–0.98) | 313 / 144,049 | 1.11 (0.91–1.35) |
Formerh | 1,656 / 124,219 | 0.91 (0.85–0.98) | 291 / 125,584 | 1.12 (0.92–1.36) | |
Currenth | 78 / 13,019 | 0.93 (0.73–1.20) | 18 / 13,079 | 0.87 (0.50–1.50) | |
Duration of OC use, yearsg,i | ≤1 | 325 / 25,843 | 1.00 (reference) | 53 / 26,115 | 1.00 (reference) |
>1 to <5 | 340 / 30,979 | 0.96 (0.82–1.12) | 64 / 31,255 | 1.00 (0.69–1.45) | |
5 to <10 | 372 / 31,188 | 1.06 (0.91–1.23) | 59 / 31,501 | 0.94 (0.64–1.37) | |
10 to <15 | 305 / 21,576 | 1.09 (0.92–1.28) | 63 / 21,818 | 1.33 (0.91–1.94) | |
≥15 | 277 / 18,825 | 1.07 (0.90–1.27) | 53 / 19,049 | 1.22 (0.81–1.83) | |
P for trendd | 0.195 | 0.106 | |||
Age at menarche, years | <12 | 811 / 46,926 | 1.00 (reference) | 98 / 47,639 | 1.00 (reference) |
12 | 1,147 / 67,220 | 0.97 (0.89–1.06) | 162 / 68,205 | 1.17 (0.91–1.51) | |
13 | 1,380 / 81,686 | 0.91 (0.83–0.99) | 164 / 82,902 | 0.93 (0.72–1.20) | |
14 | 1,365 / 68,009 | 0.95 (0.87–1.04) | 198 / 69,176 | 1.27 (0.99–1.63) | |
≥15 | 1,125 / 49,388 | 0.89 (0.81–0.98) | 114 / 50,399 | 0.89 (0.67–1.18) | |
P for trendd | 0.042 | 0.35 | |||
Age at natural menopause, yearsj | ≤45 | 371 / 13,105 | 0.97 (0.86–1.10) | 30 / 13,446 | 0.68 (0.45–1.03) |
46–50 | 988 / 33,921 | 1.00 (reference) | 120 / 34,789 | 1.00 (reference) | |
51–52 | 448 / 15,151 | 0.98 (0.88–1.10) | 43 / 15,556 | 0.80 (0.56–1.14) | |
53–55 | 448 / 13,307 | 1.08 (0.96–1.21) | 53 / 13,702 | 1.03 (0.73–1.45) | |
>55 | 141 / 3,483 | 1.12 (0.93–1.34) | 13 / 3,611 | 0.87 (0.47–1.61) | |
P for trendd | 0.080 | 0.37 |
Circulatory disease mortality
Circulatory disease (n = 2,404) | Cerebrovascular disease (n = 808) | Ischaemic heart disease (n = 732) | |||||
---|---|---|---|---|---|---|---|
ICD-10 codes | I00–I99 | I60–I69 | I20–I25 | ||||
Variable | Value | Cases / non-cases | HRa (95 % CI) | Cases / non-cases | HRa (95 % CI) | Cases / non-cases | HRa (95 % CI) |
Parous | Yes | 1,970 / 264,637 | 0.86 (0.76–0.96) | 655 / 265,952 | 0.93 (0.76–1.13) | 598 / 266,009 | 0.79 (0.65-0.97) |
Number of FTPsb | 1 | 374 / 47,810 | 1.00 (reference) | 114 / 48,070 | 1.00 (reference) | 117 / 48,067 | 1.00 (reference) |
2 | 799 / 126,649 | 0.92 (0.81–1.04) | 281 / 127,167 | 1.06 (0.85–1.32) | 240 / 127,208 | 0.91 (0.73-1.14) | |
3 | 431 / 58,411 | 0.88 (0.76–1.02) | 135 / 58,707 | 0.90 (0.70–1.17) | 139 / 58,703 | 0.93 (0.73-1.20) | |
4 | 198 / 17,124 | 0.95 (0.79–1.13) | 66 / 17,256 | 1.03 (0.75–1.41) | 48 / 17,274 | 0.74 (0.52-1.05) | |
5 | 63 / 4,735 | 0.85 (0.65–1.12) | 21 / 4,777 | 0.92 (0.57–1.48) | 18 / 4,780 | 0.78 (0.47-1.29) | |
≥6 | 62 / 2,464 | 1.13 (0.85–1.50) | 23 / 2,503 | 1.49 (0.93–2.39) | 19 / 2,507 | 1.12 (0.67-1.88) | |
P for trendc | 0.85 | 0.42 | 0.29 | ||||
Age at first FTP, yearsd | ≤20 | 304 / 38,897 | 1.15 (0.99–1.34) | 97 / 39,104 | 1.14 (0.86–1.50) | 105 / 39,096 | 1.14 (0.86-1.51) |
21–23 | 497 / 70,825 | 1.11 (0.98–1.26) | 150 / 71,172 | 0.96 (0.76–1.23) | 140 / 71,182 | 0.96 (0.74-1.24) | |
24–25 | 359 / 51,697 | 1.05 (0.92–1.20) | 122 / 51,934 | 1.00 (reference) | 106 / 51,950 | 1.00 (reference) | |
26–30 | 557 / 75,370 | 1.00 (reference) | 199 / 75,728 | 0.97 (0.78–1.23) | 166 / 75,761 | 0.99 (0.77-1.26) | |
≥31 | 237 / 26,790 | 1.06 (0.90–1.23) | 79 / 26,948 | 0.90 (0.67–1.21) | 74 / 26,953 | 1.10 (0.81-1.49) | |
Breastfeedingd | Ever | 1,534 / 210,507 | 0.80 (0.70–0.91) | 526 / 211,515 | 0.94 (0.74–1.21) | 445 / 211,596 | 0.69 (0.54-0.87) |
Breastfeeding, monthse | ≤1 | 135 / 20,835 | 1.00 (reference) | 38 / 20,932 | 1.00 (reference) | 41 / 20,929 | 1.00 (reference) |
>1 to ≤3 | 282 / 41,403 | 1.16 (0.94–1.43) | 101 / 41,584 | 1.47 (1.00–2.14) | 86 / 41,599 | 1.22 (0.83-1.79) | |
>3 to ≤6 | 276 / 43,251 | 1.05 (0.85–1.30) | 93 / 43,434 | 1.20 (0.82–1.77) | 91 / 43,436 | 1.22 (0.83-1.79) | |
>6 to ≤12 | 359 / 49,662 | 1.02 (0.83–1.26) | 115 / 49,906 | 1.10 (0.75–1.60) | 102 / 49,919 | 0.99 (0.68-1.45) | |
>12 to ≤18 | 184 / 24,118 | 0.98 (0.78–1.23) | 69 / 24,233 | 1.18 (0.78–1.77) | 51 / 24,251 | 0.94 (0.61-1.44) | |
>18 | 287 / 28,936 | 1.04 (0.83–1.31) | 110 / 29,113 | 1.28 (0.85–1.90) | 71 / 29,152 | 0.92 (0.60-1.40) | |
P for trendc | 0.48 | 0.076 | 0.153 | ||||
OC use in never or former | Never | 1,274 / 105,390 | 1.00 (reference) | 467 / 106,197 | 1.00 (reference) | 352 / 106,312 | 1.00 (reference) |
smokers at baselinef | Ever | 427 / 143,935 | 0.85 (0.75–0.97) | 144 / 144,218 | 0.80 (0.64–1.01) | 102 / 144,260 | 0.87 (0.67-1.12) |
Formerg | 397 / 125,478 | 0.84 (0.74–0.96) | 129 / 125,746 | 0.78 (0.62–0.98) | 100 / 125,775 | 0.87 (0.67-1.13) | |
Currentg,h | 22 / 13,075 | 1.48 (0.90–2.43) | 13 / 13,084 | 2.62 (1.30–5.26) | 2 / 13,095 | - | |
Duration of OC use, yearsf,i | ≤1 | 72 / 26,096 | 1.00 (reference) | 23 / 26,145 | 1.00 (reference) | 21 / 26,147 | 1.00 (reference) |
>1 to <5 | 72 / 31,247 | 0.95 (0.68–1.33) | 23 / 31,296 | 0.95 (0.52–1.73) | 21 / 31,298 | 0.97 (0.52-1.83) | |
5 to <10 | 80 / 31,480 | 0.98 (0.70–1.36) | 34 / 31,526 | 1.40 (0.80–2.44) | 14 / 31,546 | 0.58 (0.29-1.16) | |
10 to <15 | 84 / 21,797 | 1.22 (0.88–1.70) | 22 / 21,859 | 1.08 (0.59–2.00) | 22 / 21,859 | 1.09 (0.58-2.05) | |
≥15 | 70 / 19,032 | 1.14 (0.80–1.62) | 30 / 19,072 | 1.63 (0.91–2.94) | 15 / 19,087 | 0.96 (0.48-1.94) | |
P for trendc | 0.38 | 0.177 | 0.91 | ||||
Age at menarche, years | <12 | 325 / 47,412 | 1.00 (reference) | 105 / 47,632 | 1.00 (reference) | 107 / 47,630 | 1.00 (reference) |
12 | 411 / 67,956 | 0.84 (0.73–0.98) | 132 / 68,235 | 0.80 (0.62–1.04) | 123 / 68,244 | 0.80 (0.62-1.04) | |
13 | 555 / 82,511 | 0.89 (0.77–1.02) | 186 / 82,880 | 0.86 (0.67–1.09) | 165 / 82,901 | 0.81 (0.63-1.03) | |
14 | 559 / 68,815 | 0.91 (0.79–1.05) | 189 / 69,185 | 0.88 (0.69–1.12) | 164 / 69,210 | 0.80 (0.62-1.02) | |
≥15 | 494 / 50,019 | 0.83 (0.72–0.96) | 165 / 50,348 | 0.79 (0.61–1.02) | 160 / 50,353 | 0.80 (0.62-1.03) | |
P for trendc | 0.47 | 0.51 | 0.30 | ||||
Age at natural menopause, yearsj | ≤45 | 251 / 13,225 | 1.07 (0.91–1.25) | 78 / 13,398 | 1.00 (0.75–1.32) | 85 / 13,391 | 1.14 (0.86-1.50) |
46–50 | 499 / 34,410 | 1.00 (reference) | 163 / 34,746 | 1.00 (reference) | 157 / 34,752 | 1.00 (reference) | |
51–52 | 189 / 15,410 | 0.79 (0.67–0.94) | 68 / 15,531 | 0.83 (0.62–1.12) | 43 / 15,556 | 0.58 (0.41-0.82) | |
53–55 | 166 / 13,589 | 0.75 (0.63–0.90) | 54 / 13,701 | 0.71 (0.52–0.97) | 45 / 13,710 | 0.67 (0.48-0.94) | |
>55 | 64 / 3,560 | 0.85 (0.65–1.11) | 22 / 3,602 | 0.81 (0.51–1.28) | 17 / 3,607 | 0.71 (0.42-1.18) | |
P for trendc | <0.001 | 0.088 | <0.001 |