Background
Methods
Data source
Study cohorts
Statistical analysis
Results
AUD | Comparison | Standardization difference | |||
---|---|---|---|---|---|
N = 60,590 | N = 60,590 | ||||
n | % | n | % | ||
Age, years | |||||
20–39 | 32,149 | 53.1 | 32,114 | 53.0 | 0.001 |
40–64 | 26,708 | 44.1 | 27,065 | 44.7 | 0.012 |
65+ | 1733 | 2.86 | 1411 | 2.33 | 0.033 |
Mean (SD) | 39.8 | 10.9 | 39.8 | 11.5 | 0.005 |
Gender | |||||
Men | 51,175 | 84.5 | 51,087 | 84.3 | 0.004 |
Women | 9415 | 15.5 | 9503 | 15.7 | 0.004 |
Urbanization | |||||
1 (highest) | 12,438 | 20.5 | 12,200 | 20.1 | 0.010 |
2 | 18,115 | 29.9 | 183.21 | 30.2 | 0.007 |
3 | 11,165 | 18.4 | 10,953 | 18.1 | 0.009 |
4–7 (lowest) | 18,872 | 31.2 | 19,116 | 31.6 | 0.009 |
Monthly income, NTD | |||||
$0–$10,000 | 21,406 | 35.3 | 21,320 | 35.2 | 0.003 |
$10,001–$20,000 | 26,767 | 44.2 | 27,413 | 45.2 | 0.021 |
>$20,001 | 12,417 | 20.5 | 11,857 | 19.6 | 0.023 |
Occupation | |||||
White collar | 16,994 | 28.1 | 16,740 | 27.6 | 0.009 |
Blue collar | 22,224 | 36.7 | 22,597 | 37.3 | 0.013 |
Others | 21,372 | 35.3 | 21,253 | 35.1 | 0.004 |
CCI score | |||||
0 | 49,856 | 82.6 | 50,256 | 82.9 | 0.017 |
≥ 1 | 10,734 | 17.4 | 10,334 | 17.1 | 0.017 |
Disorder | AUD | Comparison | Hazard ratio (95% confidence interval) | |||||
---|---|---|---|---|---|---|---|---|
Events, N | Person-years | Rate | Event no. | Person-years | Rate | Crude | Adjusted | |
Diabetes | ||||||||
Women | 1316 | 105,438 | 12.48 | 662 | 118,069 | 5.61 | 2.24 (2.04–2.45)*** | 2.48 (2.26–2.72)*** |
Men | 10,377 | 474,137 | 21.89 | 5862 | 579,043 | 10.12 | 2.15 (2.08–2.22)*** | 2.15 (2.09–2.22)*** |
Overall | 11,693 | 579,575 | 20.18 | 6524 | 697,111 | 9.36 | 2.14 (2.08–2.21)*** | 2.18 (2.11–2.24)*** |
Hypertension | ||||||||
Women | 2333 | 95,650 | 24.39 | 1440 | 111,810 | 12.88 | 1.87 (1.75–2.00)*** | 2.12 (1.98–2.26)*** |
Men | 15,962 | 425,433 | 37.52 | 11,893 | 533,850 | 22.28 | 1.66 (1.62–1.70)*** | 1.68 (1.64–1.72)*** |
Overall | 18,295 | 521,083 | 35.11 | 13,333 | 645,659 | 20.65 | 1.68 (1.64–1.71)*** | 1.72 (1.68–1.76)*** |
Both | ||||||||
Women | 730 | 109,548 | 6.66 | 378 | 120,200 | 3.14 | 2.16 (1.91–2.45)*** | 2.46 (2.17–2.79)*** |
Men | 5605 | 506,554 | 11.06 | 3477 | 596,147 | 5.83 | 1.96 (1.88–2.05)*** | 1.98 (1.90–2.07)*** |
Overall | 6335 | 616,102 | 10.28 | 3855 | 716,346 | 5.38 | 1.97 (1.89–2.05)*** | 2.02 (1.94–2.10)*** |
Disorder | Charlson comorbidity score | ||||||
---|---|---|---|---|---|---|---|
0 | ≥ 1 | ||||||
Events, N | Rate | HR (95% CI) | Events, n | Rate | HR (95% CI) | Interactions, p | |
Diabetes | < 0.0001 | ||||||
Comparison cohort | 5385 | 8.81 | Ref. | 1139 | 13.26 | 1.18 (1.11–1.26)*** | |
Alcohol use disorder | 9290 | 18.32 | 2.07 (2.00–2.14)*** | 2403 | 33.14 | 3.23 (3.08–3.40)*** | |
Hypertension | 0.0001 | ||||||
Comparison cohort | 10,941 | 19.23 | Ref. | 2392 | 31.17 | 1.15 (1.10–1.21)*** | |
Alcohol use disorder | 15,446 | 34.03 | 1.75 (1.71–1.80)*** | 2849 | 42.37 | 1.80 (1.73–1.88)*** | |
Both | < 0.0001 | ||||||
Comparison cohort | 3238 | 5.16 | Ref. | 617 | 6.91 | 1.04 (0.95–1.13) | |
Alcohol use disorder | 5208 | 9.72 | 1.94 (1.86–2.03)*** | 1127 | 14.08 | 2.54 (2.37–2.72)*** |