Skip to main content
Erschienen in: European Journal of Applied Physiology 7/2017

03.05.2017 | Original Article

Sexual dimorphism in heart rate recovery from peak exercise

verfasst von: Goncalo Vilhena de Mendonca, Carolina Teodósio, Paula Marta Bruno

Erschienen in: European Journal of Applied Physiology | Ausgabe 7/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

There is lack of consensus on whether sex, per se, affects heart rate recovery (HRR). To discriminate between the role of sex and that of cardiovascular fitness on HRR, we compared two groups of male and female participants matched for age and peak oxygen uptake (VO2peak) percentile.

Methods

Forty healthy individuals with above-average cardiovascular fitness (VO2peak >50th percentile), aged 18–27 years (23 men; 17 women), performed maximal cycle-ergometer tests with cardiorespiratory measurements. HRR was obtained at 1 and 2 min of passive recovery. Multiple linear regression analysis was used to determine whether the relationship between VO2peak and HRR differed between sexes.

Results

Men attained greater peak values for VO2 and work rate (p < 0.05). Both groups of participants exhibited similar heart rate response to peak exercise and no sex differences were observed in VO2peak percentile or ventilatory threshold. HRR at 1 and 2 min of passive recovery was similar between sexes. In multiple linear models, VO2peak explained 11.2% of the variance in HRR1min both in men and women (p < 0.05). Most importantly, sex, VO2peak, and their interaction were all significant predictors of HRR2min (explained variance 29.2%) (p < 0.05).

Conclusions

This study shows that, for a given VO2peak percentile (>50th percentile), there is no sexual dimorphism in HRR obtained at 1 or 2 min of recovery. It also demonstrates that, in persons with similar VO2peak values, HRR obtained at 2 min of peak exercise cessation is affected by sex.
Literatur
Zurück zum Zitat ACSM (ed) (2009) ACSM’S guidelines for exercise testing and prescritpion, 8th edn. Lippincott Williams & Wilkins, Baltimore ACSM (ed) (2009) ACSM’S guidelines for exercise testing and prescritpion, 8th edn. Lippincott Williams & Wilkins, Baltimore
Zurück zum Zitat Antelmi I, Chuang EY, Grupi CJ, Latorre Mdo R, Mansur AJ (2008) Heart rate recovery after treadmill electrocardiographic exercise stress test and 24-hour heart rate variability in healthy individuals. Arq Bras Cardiol 90:380–385CrossRefPubMed Antelmi I, Chuang EY, Grupi CJ, Latorre Mdo R, Mansur AJ (2008) Heart rate recovery after treadmill electrocardiographic exercise stress test and 24-hour heart rate variability in healthy individuals. Arq Bras Cardiol 90:380–385CrossRefPubMed
Zurück zum Zitat Arena R, Guazzi M, Myers J, Peberdy MA (2006) Prognostic value of heart rate recovery in patients with heart failure. Am Heart J 151:851CrossRefPubMed Arena R, Guazzi M, Myers J, Peberdy MA (2006) Prognostic value of heart rate recovery in patients with heart failure. Am Heart J 151:851CrossRefPubMed
Zurück zum Zitat Arena R, Arrowood JA, Fei D, Shelar S, Helm S, Kraft KA (2010) The influence of sex on the relationship between heart rate recovery and other cardiovascular risk factors in apparently healthy subjects. Scand J Med Sci Sports 20:291–297CrossRefPubMed Arena R, Arrowood JA, Fei D, Shelar S, Helm S, Kraft KA (2010) The influence of sex on the relationship between heart rate recovery and other cardiovascular risk factors in apparently healthy subjects. Scand J Med Sci Sports 20:291–297CrossRefPubMed
Zurück zum Zitat Borresen J, Lambert MI (2008) Autonomic control of heart rate during and after exercise: measurements and implications for monitoring training status. Sports Med 38:633–646CrossRefPubMed Borresen J, Lambert MI (2008) Autonomic control of heart rate during and after exercise: measurements and implications for monitoring training status. Sports Med 38:633–646CrossRefPubMed
Zurück zum Zitat Bray MS, Hagberg JM, Perusse L, Rankinen T, Roth SM, Wolfarth B, Bouchard C (2009) The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc 41:35–73CrossRefPubMed Bray MS, Hagberg JM, Perusse L, Rankinen T, Roth SM, Wolfarth B, Bouchard C (2009) The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc 41:35–73CrossRefPubMed
Zurück zum Zitat Buchheit M, Gindre C (2006) Cardiac parasympathetic regulation: respective associations with cardiorespiratory fitness and training load. Am J Physiol Heart Circ Physiol 291:H451–H458CrossRefPubMed Buchheit M, Gindre C (2006) Cardiac parasympathetic regulation: respective associations with cardiorespiratory fitness and training load. Am J Physiol Heart Circ Physiol 291:H451–H458CrossRefPubMed
Zurück zum Zitat Carlson MD, Geha AS, Hsu J, Martin PJ, Levy MN, Jacobs G, Waldo AL (1992) Selective stimulation of parasympathetic nerve fibers to the human sinoatrial node. Circulation 85:1311–1317CrossRefPubMed Carlson MD, Geha AS, Hsu J, Martin PJ, Levy MN, Jacobs G, Waldo AL (1992) Selective stimulation of parasympathetic nerve fibers to the human sinoatrial node. Circulation 85:1311–1317CrossRefPubMed
Zurück zum Zitat Carnethon MR, Jacobs DR Jr, Sidney S, Sternfeld B, Gidding SS, Shoushtari C, Liu K (2005) A longitudinal study of physical activity and heart rate recovery: CARDIA, 1987–1993. Med Sci Sports Exerc 37:606–612CrossRefPubMed Carnethon MR, Jacobs DR Jr, Sidney S, Sternfeld B, Gidding SS, Shoushtari C, Liu K (2005) A longitudinal study of physical activity and heart rate recovery: CARDIA, 1987–1993. Med Sci Sports Exerc 37:606–612CrossRefPubMed
Zurück zum Zitat Cheng YJ, Lauer MS, Earnest CP, Church TS, Kampert JB, Gibbons LW, Blair SN (2003) Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. Diabetes Care 26:2052–2057CrossRefPubMed Cheng YJ, Lauer MS, Earnest CP, Church TS, Kampert JB, Gibbons LW, Blair SN (2003) Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. Diabetes Care 26:2052–2057CrossRefPubMed
Zurück zum Zitat Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS (1999) Heart-rate recovery immediately after exercise as a predictor of mortality. N Engl J Med 341:1351–1357CrossRefPubMed Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS (1999) Heart-rate recovery immediately after exercise as a predictor of mortality. N Engl J Med 341:1351–1357CrossRefPubMed
Zurück zum Zitat Cole CR, Foody JM, Blackstone EH, Lauer MS (2000) Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Ann Intern Med 132:552–555CrossRefPubMed Cole CR, Foody JM, Blackstone EH, Lauer MS (2000) Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Ann Intern Med 132:552–555CrossRefPubMed
Zurück zum Zitat Daanen HA, Lamberts RP, Kallen VL, Jin A, Van Meeteren NL (2012) A systematic review on heart-rate recovery to monitor changes in training status in athletes. Int J Sports Physiol Perform 7:251–260CrossRefPubMed Daanen HA, Lamberts RP, Kallen VL, Jin A, Van Meeteren NL (2012) A systematic review on heart-rate recovery to monitor changes in training status in athletes. Int J Sports Physiol Perform 7:251–260CrossRefPubMed
Zurück zum Zitat Darr KC, Bassett DR, Morgan BJ, Thomas DP (1988) Effects of age and training status on heart rate recovery after peak exercise. Am J Physiol 254:H340–H343PubMed Darr KC, Bassett DR, Morgan BJ, Thomas DP (1988) Effects of age and training status on heart rate recovery after peak exercise. Am J Physiol 254:H340–H343PubMed
Zurück zum Zitat Dewland TA, Androne AS, Lee FA, Lampert RJ, Katz SD (2007) Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes. Am J Physiol Heart Circ Physiol 293:H86–H92CrossRefPubMed Dewland TA, Androne AS, Lee FA, Lampert RJ, Katz SD (2007) Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes. Am J Physiol Heart Circ Physiol 293:H86–H92CrossRefPubMed
Zurück zum Zitat Gellish RL, Goslin BR, Olson RE, McDonald A, Russi GD, Moudgil VK (2007) Longitudinal modeling of the relationship between age and maximal heart rate. Med Sci Sports Exerc 39:822–829CrossRefPubMed Gellish RL, Goslin BR, Olson RE, McDonald A, Russi GD, Moudgil VK (2007) Longitudinal modeling of the relationship between age and maximal heart rate. Med Sci Sports Exerc 39:822–829CrossRefPubMed
Zurück zum Zitat Hautala AJ, Rankinen T, Kiviniemi AM, Makikallio TH, Huikuri HV, Bouchard C, Tulppo MP (2006) Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism. Am J Physiol Heart Circ Physiol 291:H459–H466CrossRefPubMed Hautala AJ, Rankinen T, Kiviniemi AM, Makikallio TH, Huikuri HV, Bouchard C, Tulppo MP (2006) Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism. Am J Physiol Heart Circ Physiol 291:H459–H466CrossRefPubMed
Zurück zum Zitat Howley ET, Bassett DR Jr, Welch HG (1995) Criteria for maximal oxygen uptake: review and commentary. Med Sci Sports Exerc 27:1292–1301CrossRefPubMed Howley ET, Bassett DR Jr, Welch HG (1995) Criteria for maximal oxygen uptake: review and commentary. Med Sci Sports Exerc 27:1292–1301CrossRefPubMed
Zurück zum Zitat Imai K, Sato H, Hori M, Kusuoka H, Ozaki H, Yokoyama H, Takeda H, Inoue M, Kamada T (1994) Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol 24:1529–1535CrossRefPubMed Imai K, Sato H, Hori M, Kusuoka H, Ozaki H, Yokoyama H, Takeda H, Inoue M, Kamada T (1994) Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol 24:1529–1535CrossRefPubMed
Zurück zum Zitat Ingelsson E, Larson MG, Vasan RS, O’Donnell CJ, Yin X, Hirschhorn JN, Newton-Cheh C, Drake JA, Musone SL, Heard-Costa NL, Benjamin EJ, Levy D, Atwood LD, Wang TJ, Kathiresan S (2007) Heritability, linkage, and genetic associations of exercise treadmill test responses. Circulation 115:2917–2924CrossRefPubMed Ingelsson E, Larson MG, Vasan RS, O’Donnell CJ, Yin X, Hirschhorn JN, Newton-Cheh C, Drake JA, Musone SL, Heard-Costa NL, Benjamin EJ, Levy D, Atwood LD, Wang TJ, Kathiresan S (2007) Heritability, linkage, and genetic associations of exercise treadmill test responses. Circulation 115:2917–2924CrossRefPubMed
Zurück zum Zitat Kilgour RD, Gariepy P, Rehel R (1993) Cardiovascular responses during recovery from exercise and thermal stress. Aviat Space Environ Med 64:224–229PubMed Kilgour RD, Gariepy P, Rehel R (1993) Cardiovascular responses during recovery from exercise and thermal stress. Aviat Space Environ Med 64:224–229PubMed
Zurück zum Zitat Kligfield P, McCormick A, Chai A, Jacobson A, Feuerstadt P, Hao SC (2003) Effect of age and gender on heart rate recovery after submaximal exercise during cardiac rehabilitation in patients with angina pectoris, recent acute myocardial infarction, or coronary bypass surgery. Am J Cardiol 92:600–603CrossRefPubMed Kligfield P, McCormick A, Chai A, Jacobson A, Feuerstadt P, Hao SC (2003) Effect of age and gender on heart rate recovery after submaximal exercise during cardiac rehabilitation in patients with angina pectoris, recent acute myocardial infarction, or coronary bypass surgery. Am J Cardiol 92:600–603CrossRefPubMed
Zurück zum Zitat Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D (2015) Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise. Physiol Genom 47:400–406CrossRef Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D (2015) Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise. Physiol Genom 47:400–406CrossRef
Zurück zum Zitat Lipinski MJ, Vetrovec GW, Gorelik D, Froelicher VF (2005) The importance of heart rate recovery in patients with heart failure or left ventricular systolic dysfunction. J Card Fail 11:624–630CrossRefPubMed Lipinski MJ, Vetrovec GW, Gorelik D, Froelicher VF (2005) The importance of heart rate recovery in patients with heart failure or left ventricular systolic dysfunction. J Card Fail 11:624–630CrossRefPubMed
Zurück zum Zitat Maeder MT, Ammann P, Rickli H, Brunner-La Rocca HP (2009) Impact of the exercise mode on heart rate recovery after maximal exercise. Eur J Appl Physiol 105:247–255CrossRefPubMed Maeder MT, Ammann P, Rickli H, Brunner-La Rocca HP (2009) Impact of the exercise mode on heart rate recovery after maximal exercise. Eur J Appl Physiol 105:247–255CrossRefPubMed
Zurück zum Zitat Mora S, Redberg RF, Sharrett AR, Blumenthal RS (2005) Enhanced risk assessment in asymptomatic individuals with exercise testing and Framingham risk scores. Circulation 112:1566–1572CrossRefPubMed Mora S, Redberg RF, Sharrett AR, Blumenthal RS (2005) Enhanced risk assessment in asymptomatic individuals with exercise testing and Framingham risk scores. Circulation 112:1566–1572CrossRefPubMed
Zurück zum Zitat Nilsson G, Hedberg P, Jonason T, Lonnberg I, Ohrvik J (2007) Heart rate recovery is more strongly associated with the metabolic syndrome, waist circumference, and insulin sensitivity in women than in men among the elderly in the general population. Am Heart J 154(460):e461–e467 Nilsson G, Hedberg P, Jonason T, Lonnberg I, Ohrvik J (2007) Heart rate recovery is more strongly associated with the metabolic syndrome, waist circumference, and insulin sensitivity in women than in men among the elderly in the general population. Am Heart J 154(460):e461–e467
Zurück zum Zitat Nunes RA, Barroso LP, Pereira Ada C, Krieger JE, Mansur AJ (2014) Gender-related associations of genetic polymorphisms of alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor with treadmill exercise test responses. Open Heart 1:e000132CrossRefPubMedPubMedCentral Nunes RA, Barroso LP, Pereira Ada C, Krieger JE, Mansur AJ (2014) Gender-related associations of genetic polymorphisms of alpha-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor with treadmill exercise test responses. Open Heart 1:e000132CrossRefPubMedPubMedCentral
Zurück zum Zitat Perini R, Orizio C, Comande A, Castellano M, Beschi M, Veicsteinas A (1989) Plasma norepinephrine and heart rate dynamics during recovery from submaximal exercise in man. Eur J Appl Physiol Occup Physiol 58:879–883CrossRefPubMed Perini R, Orizio C, Comande A, Castellano M, Beschi M, Veicsteinas A (1989) Plasma norepinephrine and heart rate dynamics during recovery from submaximal exercise in man. Eur J Appl Physiol Occup Physiol 58:879–883CrossRefPubMed
Zurück zum Zitat Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz T, Sheps SG, Roccella EJ, Subcommittee of P, Public Education of the American Heart Association Council on High Blood Pressure R (2005) Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension 45:142–161CrossRefPubMed Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz T, Sheps SG, Roccella EJ, Subcommittee of P, Public Education of the American Heart Association Council on High Blood Pressure R (2005) Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension 45:142–161CrossRefPubMed
Zurück zum Zitat Pierpont GL, Voth EJ (2004) Assessing autonomic function by analysis of heart rate recovery from exercise in healthy subjects. Am J Cardiol 94:64–68CrossRefPubMed Pierpont GL, Voth EJ (2004) Assessing autonomic function by analysis of heart rate recovery from exercise in healthy subjects. Am J Cardiol 94:64–68CrossRefPubMed
Zurück zum Zitat Shetler K, Marcus R, Froelicher VF, Vora S, Kalisetti D, Prakash M, Do D, Myers J (2001) Heart rate recovery: validation and methodologic issues. J Am Coll Cardiol 38:1980–1987CrossRefPubMed Shetler K, Marcus R, Froelicher VF, Vora S, Kalisetti D, Prakash M, Do D, Myers J (2001) Heart rate recovery: validation and methodologic issues. J Am Coll Cardiol 38:1980–1987CrossRefPubMed
Zurück zum Zitat Shvartz E, Reibold RC (1990) Aerobic fitness norms for males and females aged 6 to 75 years: a review. Aviat Space Environ Med 61:3–11PubMed Shvartz E, Reibold RC (1990) Aerobic fitness norms for males and females aged 6 to 75 years: a review. Aviat Space Environ Med 61:3–11PubMed
Zurück zum Zitat Singh TP, Rhodes J, Gauvreau K (2008) Determinants of heart rate recovery following exercise in children. Med Sci Sports Exerc 40:601–605CrossRefPubMed Singh TP, Rhodes J, Gauvreau K (2008) Determinants of heart rate recovery following exercise in children. Med Sci Sports Exerc 40:601–605CrossRefPubMed
Zurück zum Zitat Wasserman K, Whipp BJ, Koyl SN, Beaver WL (1973) Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol 35:236–243PubMed Wasserman K, Whipp BJ, Koyl SN, Beaver WL (1973) Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol 35:236–243PubMed
Zurück zum Zitat Watson RD, Hamilton CA, Jones DH, Reid JL, Stallard TJ, Littler WA (1980) Sequential changes in plasma noradrenaline during bicycle exercise. Clin Sci (Lond) 58:37–43CrossRef Watson RD, Hamilton CA, Jones DH, Reid JL, Stallard TJ, Littler WA (1980) Sequential changes in plasma noradrenaline during bicycle exercise. Clin Sci (Lond) 58:37–43CrossRef
Zurück zum Zitat Yazar S, Yazici M (2016) Impact of menstrual cycle on cardiac autonomic function assessed by heart rate variability and heart rate recovery. Med Princ Pract 25:374–377CrossRefPubMed Yazar S, Yazici M (2016) Impact of menstrual cycle on cardiac autonomic function assessed by heart rate variability and heart rate recovery. Med Princ Pract 25:374–377CrossRefPubMed
Metadaten
Titel
Sexual dimorphism in heart rate recovery from peak exercise
verfasst von
Goncalo Vilhena de Mendonca
Carolina Teodósio
Paula Marta Bruno
Publikationsdatum
03.05.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 7/2017
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-017-3627-8

Weitere Artikel der Ausgabe 7/2017

European Journal of Applied Physiology 7/2017 Zur Ausgabe

Neu im Fachgebiet Arbeitsmedizin

Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Beginnend mit den 1920er-Jahren hat sich eine Vorstellung über die Geschlechterdifferenzen in Gesundheit und Mortalität etabliert, die von Lorber und Moore in dem einprägsamen Satz: „Women get sicker, but men die quicker“, zusammengefasst wurde [ 1 …, S. 13]. Tatsächlich erscheinen vor dem Hintergrund der höheren Lebenserwartung der Frauen die Studienergebnisse zu den Geschlechterdifferenzen in der Morbidität überraschend, wonach Frauen im Durchschnitt einen schlechteren Gesundheitszustand aufweisen als Männer [

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

Open Access Leitthema

Die demographische Alterung hat vielfältige gesellschaftliche Konsequenzen, deren Ausmaß wesentlich vom Gesundheitszustand der Bevölkerung abhängt. Um diesen analysieren und bewerten zu können, wurden spezielle Kennziffern entwickelt, die in …

Wie hat sich die Lebenserwartung ohne funktionelle Einschränkungen in Deutschland entwickelt? Eine Analyse mit Daten des Deutschen Alterssurveys (DEAS)

Deutschland erfährt, wie andere Hocheinkommensstaaten, aufgrund kontinuierlich rückläufiger Mortalität und niedriger Geburtenraten tiefgreifende demografische Veränderungen. Der demografische Wandel führt in Deutschland zu einem zunehmend höheren …

Hitzeschutz im Fokus der hessischen Betreuungs- und Pflegeaufsicht

Open Access Klimawandel Übersichtsartikel

Im Sommer 2023 kündigte das Bundesministerium für Gesundheit (BMG) einen nationalen Hitzeschutzplan an und forderte die Länder auf, zu prüfen, „ob die Warnstufen des [Deutschen Wetterdienstes] DWD mit der Durchführung von Akutmaßnahmen …