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Inflammation Research

Erschienen in:

01.08.2011 | Original Research Paper

Simplified detection of eosinophils in induced sputum

verfasst von: Elizabeth Fireman, Brenda Toledano, Nina Buchner, Moshe Stark, Yehuda Schwarz

Erschienen in: Inflammation Research | Ausgabe 8/2011

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Abstract

Objective and design

The induction of sputum is a safe, noninvasive method of studying airway inflammation in asthma, but the method of analyzing the samples is laborious and requires well-trained technicians using highly specialized laboratory equipment. We introduce a shorter and simpler modification of the process for identifying eosinophilic inflammation from induced sputum (IS) samples.

Material

Samples of 81 patients referred for IS assessment of respiratory diseases were studied. Four different assessment approaches were studied in comparison with the conventional method of selecting plugs proposed by the European Respiratory Society/American Thoracic Society task force.

Results

One modification of the conventional method of IS processing emerged as simpler to execute and less technologically demanding than the original one (13.0 ± 18.2 vs. 15.4 ± 22.4% eosinophils, P = 0.19).

Conclusion

The simpler approach should now encourage the use of IS as a convenient procedure for evaluating eosinophilic inflammation in less sophisticated laboratories.

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Titel: Simplified detection of eosinophils in induced sputum
verfasst von: Elizabeth Fireman
Brenda Toledano
Nina Buchner
Moshe Stark
Yehuda Schwarz
Publikationsdatum: 01.08.2011
Verlag: SP Birkhäuser Verlag Basel
Erschienen in: Inflammation Research / Ausgabe 8/2011
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-011-0328-3

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Abstract

Objective and design

Material

Results

Conclusion

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