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Pediatric Surgery International

Erschienen in:

01.12.2023 | Review Article

Surgical implications of HIV infection

verfasst von: Alastair J. W. Millar, Sharon G. Cox

Erschienen in: Pediatric Surgery International | Ausgabe 1/2023

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Abstract

According to the joint United Nations Programme on HIV/AIDS (UNAIDS), 37.7 million adults and children worldwide were estimated to be living with HIV or acquired immune deficiency syndrome (AIDS) at the end of 2020 [UNAIDS. (2022). http://www.unaids.org. Accessed 30 May 2022]. Most reside in low- and middle-income countries, with approximately 67% in sub-Saharan Africa (SSA). At the end of 2020, the total number of children less than 15 years of age living with HIV infection was 2.6 million, of whom 2.3 million (88%) were living in SSA. Aggressive interventions have reduced the annual number of incident (new) HIV infections among children to around 150,000 [UNAIDS. (2022). http://www.unaids.org. Accessed 30 May 2022]. However, paediatric HIV infection remains a pandemic affecting children predominantly in SSA but is also seen in Asia and sporadically elsewhere particularly in areas of civil strife such as is currently the case in Ukraine [War in Ukraine. (2022). https://www.unaids.org/en/War-Ukraine-special. Accessed Apr 2022]. New HIV infections among children declined by more than half (54%) from 2010 to 2020, due mainly to the increased provision of antiretroviral therapy to pregnant and breastfeeding women living with HIV [UNAIDS. (2022). http://www.unaids.org. Accessed 30 May 2022]. These programmes include early identification of HIV infection in pregnant or breastfeeding women through routine HIV testing, provision of antiretroviral therapy (ART) to all HIV-infected women who are pregnant or breastfeeding, provision of antiretroviral prophylaxis to their newborn infants during the first 6–12 weeks of life, delivery by elective Caesarean section when indicated, promotion of exclusive breastfeeding, early infancy screening for HIV infection, and initiation of ART in infants with HIV infection. HIV-infected children may require surgery either as an emergency to deal with a life-threatening incidental condition unrelated to HIV infection or for a complication of the disease such as tuberculosis or an aggressive soft tissue infection like necrotising fasciitis. Non-emergency surgical procedures may be required to assist in the diagnosis of an HIV-related condition or to correct a routine surgical problem electively. Surgical conditions associated with HIV infection are described under categories of soft tissue or organ-specific infections requiring drainage or debridement; gastrointestinal tract disease and complications; infections in the perineal area; malignancies and HIV-associated vasculitis. Although surgical outcomes are less favourable in HIV-infected children, pre-operative treatment of coinfections, administration of cotrimoxazole prophylaxis, nutritional support and antiretroviral therapy, together with peri-operative antibiotic prophylaxis have resulted in excellent short-term outcomes [World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: Recommendations for a public health approach, June 201 http://www.apps.who.int/iris/bitstream/10665/85321/1/9789241505727_eng.pdf?ua=1; World Health Organization Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV, September 2015. http://www.apps.who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf?ua=1;Eley et al. in BMC Infect Dis 2:3, 2002;Karpelowsky et al. in Pediatr Surg Int 28:1007–1014, 2012;].

UNAIDS. (2022). http://www.unaids.org. Accessed 30 May 2022

War in Ukraine. (2022). https://www.unaids.org/en/War-Ukraine-special. Accessed Apr 2022

World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: Recommendations for a public health approach, June 2013. http://www.apps.who.int/iris/bitstream/10665/85321/1/9789241505727_eng.pdf?ua=1. Accessed 6 June 2022

World Health Organization Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV, September 2015. http://www.apps.who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf?ua=1. Accessed 6 June 2022

Eley BS, Sive AA, Shuttleworth M, Hussey GD (2002) A prospective, cross-sectional study of anaemia and peripheral iron status in antiretroviral naive, HIV-1 infected children in Cape Town, South Africa. BMC Infect Dis 2:3CrossRefPubMedPubMedCentral

Karpelowsky JS, Millar AJ, van der Graaf N, van Bogerijen G, Zar HJ (2012) Comparison of in-hospital morbidity and mortality in HIV-infected and uninfected children after surgery. Pediatr Surg Int 28(10):1007–1014. https://doi.org/10.1007/s00383-012-3163-xCrossRefPubMed

Children, HIV and AIDS (2022). https://www.data.unicef.org. Accessed 6 June 2022

Horberg MA, Hurley LB, Klein DB, Follansbee SE, Quesenberry C, Flamm JA, Green GM, Luu T (2006) Surgical outcomes in human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy. Arch Surg 141(12):1238–1245. https://doi.org/10.1001/archsurg.141.12.1238CrossRefPubMed

Madiba TE, Muckart DJ, Thomson SR (2009) Human immunodeficiency disease: how should it affect surgical decision making? World J Surg 33(5):899–909. https://doi.org/10.1007/s00268-009-9969-6CrossRefPubMed

10.

Shelburne SA, Visnegarwala F, Darcourt J, Graviss EA, Giordano TP, White AC Jr, Hamill RJ (2005) Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS 19(4):399–406CrossRefPubMed

11.

Yii MK, Saunder A, Scott DF (1995) Abdominal surgery in HIV/AIDS patients: indications, operative management, pathology and outcome. Aust NZ J Surg 65(5):320–326CrossRef

12.

Bowley DM, Rogers TN, Meyers T, Pitcher G (2007) Surgeons are failing to recognize children with HIV infection. J Pediatr Surg 42(2):431–434. https://doi.org/10.1016/j.jpedsurg.2006.10.016CrossRefPubMed

13.

Hadley LLK (2011) HIV/AIDS and the Paediatric Surgeon. In: Ameh EABS, Lakhoo K, Nwomeh BC, Poenaru D (eds) Paediatric surgery: a comprehensive text for Africa, vol 1. Global Help, Seattle, pp 151–156

14.

Gabler TD, Loveland J, Theron A, Westgarth-Taylor C (2018) Anorectal malformations and the impact of HIV on surgical outcome. S Afr Med J 108(11):947–952. https://doi.org/10.7196/SAMJ.2018.v108i11.13168CrossRefPubMed

15.

Stefanaki C, Stratigos AJ, Stratigos JD (2002) Skin manifestations of HIV-1 infection in children. Clin Dermatol 20(1):74–86CrossRefPubMed

16.

Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. (2022). https://www.aidsinfo.nih.gov/.2017. Accessed 6 June 2022

17.

Prose NS (1991) Cutaneous manifestations of HIV infection in children. Dermatol Clin 9(3):543–550CrossRefPubMed

18.

Flores G, Stavola JJ, Noel GJ (1993) Bacteremia due to Pseudomonas aeruginosa in children with AIDS. Clin Infect Dis 16(5):706–708CrossRefPubMed

19.

Machoki S, Mugambi AT, Theron A, Cox S, Pillay K Numanoglu A, Millar A J W (2015) Ann Ped Surg 11:35–37

20.

Pijnenburg MW, Cotton MF (2001) Necrotising fasciitis in an HIV-1-infected infant. S Afr Med J 91(6):500–501PubMed

21.

Prose NS (1992) Cutaneous manifestations of pediatric HIV infection. Pediatr Dermatol 9(4):326–328CrossRefPubMed

22.

Alexander A, Rode H (2007) Adverse reactions to the Bacillus Calmette-Guerin vaccine in HIV-positive infants. J Pediatr Surg 42(3):549–552. https://doi.org/10.1016/j.jpedsurg.2006.10.059CrossRefPubMed

23.

Puthanakit T, Oberdorfer P, Ukarapol N, Akarathum N, Punjaisee S, Sirisanthana T, Sirisanthana V (2006) Immune reconstitution syndrome from nontuberculous mycobacterial infection after initiation of antiretroviral therapy in children with HIV infection. Pediatr Infect Dis J 25(7):645–648. https://doi.org/10.1097/01.inf.0000225786.00940.37CrossRefPubMedPubMedCentral

24.

Hesseling AC, Johnson LF, Jaspan H, Cotton MF, Whitelaw A, Schaaf HS, Fine PE, Eley BS, Marais BJ, Nuttall J, Beyers N, Godfrey-Faussett P (2009) Disseminated bacille Calmette-Guerin disease in HIV-infected South African infants. Bull World Health Organ 87(7):505–511CrossRefPubMedPubMedCentral

25.

Nuttall JJ, Davies MA, Hussey GD, Eley BS (2008) Bacillus Calmette-Guerin (BCG) vaccine-induced complications in children treated with highly active antiretroviral therapy. Int J Infect Dis 12(6):e99-105. https://doi.org/10.1016/j.ijid.2008.06.014CrossRefPubMed

26.

Fantry L (2003) Gastrointestinal infections in the immunocompromised host. Curr Opin Gastroenterol 19(1):37–41CrossRefPubMed

27.

Cooke ML, Goddard EA, Brown RA (2009) Endoscopy findings in HIV-infected children from sub-Saharan Africa. J Trop Pediatr 55(4):238–243. https://doi.org/10.1093/tropej/fmn114CrossRefPubMed

28.

Issa RA, Podbielski FJ, Fontaine JP, Connolly AE, Walsh WV, Fraire AE (2004) Esophagectomy in a patient with AIDS. Dis Esophagus 17(3):270–272. https://doi.org/10.1111/j.1442-2050.2004.00422.xCrossRefPubMed

29.

Balderas V, Spechler SJ (2006) Upper gastrointestinal bleeding in a patient with AIDS. Nat Clin Pract Gastroenterol Hepatol 3(6):349–353. https://doi.org/10.1038/ncpgasthep0497. (quiz following 353)CrossRefPubMed

30.

Zanolla G, Resener T, Knebel R, Verney Y (2001) Massive lower gastrointestinal hemorrhage caused by CMV disease as a presentation of HIV in an infant. Pediatr Surg Int 17(1):65–67. https://doi.org/10.1007/s003830000397CrossRefPubMed

31.

Cairncross LL, Davidson A, Millar AJ, Pillay K (2009) Kaposi sarcoma in children with HIV: a clinical series from Red Cross Children’s Hospital. J Pediatr Surg 44(2):373–376. https://doi.org/10.1016/j.jpedsurg.2008.10.087CrossRefPubMed

32.

Kahn E (1997) Gastrointestinal manifestations in pediatric AIDS. Pediatr Pathol Lab Med 17(2):171–208PubMed

33.

Karpelowsky JS, Millar AJ, van der Graaf N, van Bogerijen G, Zar HJ (2011) Outcome of HIV-exposed uninfected children undergoing surgery. BMC Pediatr 11:69. https://doi.org/10.1186/1471-2431-11-69CrossRefPubMedPubMedCentral

34.

Banieghbal B, Fonseca J (1997) Acquired rectovaginal fistulae in South Africa. Arch Dis Child 77(1):94CrossRefPubMed

35.

Johnson PJ, Mirzai TH, Bentz ML (1997) Carbon dioxide laser ablation of anogenital condyloma acuminata in pediatric patients. Ann Plast Surg 39(6):578–582CrossRefPubMed

36.

Hadley GP, Naude F (2009) Malignant solid tumour, HIV infection and tuberculosis in children: an unholy triad. Pediatr Surg Int 25(8):697–701. https://doi.org/10.1007/s00383-009-2409-8CrossRefPubMed

37.

Stefan DC, Wessels G, Poole J, Wainwright L, Stones D, Johnston WT, Newton R (2011) Infection with human immunodeficiency virus-1 (HIV) among children with cancer in South Africa. Pediatr Blood Cancer 56(1):77–79. https://doi.org/10.1002/pbc.22672CrossRefPubMed

38.

Bohlius J, Maxwell N, Spoerri A, Wainwright R, Sawry S, Poole J, Eley B, Prozesky H, Rabie H, Garone D, Technau KG, Maskew M, Davies MA, Davidson A, Stefan DC, Egger M, for Ie DEASA (2016) Incidence of AIDS-defining and Other cancers in HIV-positive children in South Africa: record linkage study. Pediatr Infect Dis J 35(6):e164-170. https://doi.org/10.1097/INF.0000000000001117CrossRefPubMedPubMedCentral

39.

Biggar RJ, Frisch M, Goedert JJ (2000) Risk of cancer in children with AIDS. AIDS-cancer match registry study group. JAMA 284(2):205–209CrossRefPubMed

40.

Caselli D, Klersy C, de Martino M, Gabiano C, Galli L, Tovo PA, Arico M (2000) Human immunodeficiency virus-related cancer in children: incidence and treatment outcome–report of the Italian register. J Clin Oncol 18(22):3854–3861CrossRefPubMed

41.

Chetty R (2001) Vasculitides associated with HIV infection. J Clin Pathol 54(4):275–278. https://doi.org/10.1136/jcp.54.4.275CrossRefPubMedPubMedCentral

42.

Joshi VV, Pawel B, Connor E, Sharer L, Oleske JM, Morrison S, Marin-Garcia J (1987) Arteriopathy in children with acquired immune deficiency syndrome. Pediatr Pathol 7(3):261–275. https://doi.org/10.1080/15513818709177129CrossRefPubMed

43.

Saif MW, Greenberg B (2001) HIV and thrombosis: a review. AIDS Patient Care STDS 15(1):15–24. https://doi.org/10.1089/108729101460065CrossRefPubMed

44.

George R, Andronikou S, Theron S, du Plessis J, Hayes M, Goussard P, Mapukata A, Gie R (2009) Pulmonary infections in HIV-positive children. Pediatr Radiol 39(6):545–554. https://doi.org/10.1007/s00247-009-1194-9CrossRefPubMed

45.

Zar HJ (2004) Pneumonia in HIV-infected and HIV-uninfected children in developing countries: epidemiology, clinical features, and management. Curr Opin Pulm Med 10(3):176–182CrossRefPubMed

46.

Bosenberg AT (2007) Pediatric anesthesia in developing countries. Curr Opin Anaesthesiol 20(3):204–210. https://doi.org/10.1097/ACO.0b013e3280c60c78CrossRefPubMed

47.

Leelanukrom R, Pancharoen C (2007) Anesthesia in HIV-infected children. Paediatr Anaesth 17(6):509–519. https://doi.org/10.1111/j.1460-9592.2006.02150.xCrossRefPubMed

48.

World Health Organization. Antiretroviral therapy of HIV infection in infants and children: towards universal access. Recommendations for a public health approach, 2010 revision. http://www.whqlibdoc.who.int/publications/2010/9789241599801_eng.pdf

49.

Calis JC, van Hensbroek MB, de Haan RJ, Moons P, Brabin BJ, Bates I (2008) HIV-associated anemia in children: a systematic review from a global perspective. AIDS 22(10):1099–1112. https://doi.org/10.1097/QAD.0b013e3282fa759fCrossRefPubMed

50.

Gsponer T, Weigel R, Davies MA, Bolton C, Moultrie H, Vaz P, Rabie H, Technau K, Ndirangu J, Eley B, Garone D, Wellington M, Giddy J, Ehmer J, Egger M, Keiser O, Ie DEASA (2012) Variability of growth in children starting antiretroviral treatment in southern Africa. Pediatrics 130(4):e966-977. https://doi.org/10.1542/peds.2011-3020CrossRefPubMedPubMedCentral

51.

Abuzaitoun OR, Hanson IC (2000) Organ-specific manifestations of HIV disease in children. Pediatr Clin North Am 47(1):109–125CrossRefPubMed

52.

Mattioli G, Avanzini S, Pini-Prato A, Buffa P, Guida E, Rapuzzi G, Torre M, Rossi V, Montobbio G, Rosati U, Jasonni V (2009) Risk management in pediatric surgery. Pediatr Surg Int 25(8):683–690. https://doi.org/10.1007/s00383-009-2407-xCrossRefPubMed

53.

Nelson L, Fried M, Stewart K (2009) HIV-infected patients: the risks of surgery. J Perioper Pract 19(1):24–30PubMed

54.

Beaver BL, Hill JL, Vachon DA, Moore VL, Hines SE, Seiden SW, Stone M, Hutton N, Johnson JP (1990) Surgical intervention in children with human immunodeficiency virus infection. J Pediatr Surg 25(1):79–82 (Discussion 82-74)CrossRefPubMed

55.

Kleinhaus S, Weinberg G, Sheran M, Boley SJ (1985) The management of surgery in infants and children with the acquired immune deficiency syndrome. J Pediatr Surg 20(5):497–498CrossRefPubMed

56.

Banieghbal B (2009) Minimally invasive surgery for children with HIV/AIDS. J Laparoendosc Adv Surg Tech A 19(1):97–101. https://doi.org/10.1089/lap.2008.0097CrossRefPubMed

57.

Karpelowsky JS, Leva E, Kelley B, Numanoglu A, Rode H, Millar AJ (2009) Outcomes of human immunodeficiency virus-infected and -exposed children undergoing surgery–a prospective study. J Pediatr Surg 44(4):681–687. https://doi.org/10.1016/j.jpedsurg.2008.08.036CrossRefPubMed

58.

Desfrere L, de Oliveira I, Goffinet F, El Ayoubi M, Firtion G, Bavoux F, Jarreau PH, Moriette G (2005) Increased incidence of necrotizing enterocolitis in premature infants born to HIV-positive mothers. AIDS 19(14):1487–1493CrossRefPubMed

59.

Davies MA, Keiser O, Technau K, Eley B, Rabie H, van Cutsem G, Giddy J, Wood R, Boulle A, Egger M, Moultrie H, International Epidemiologic Databases to Evaluate ASAC (2009) Outcomes of the South African national antiretroviral treatment programme for children: the IeDEA Southern Africa collaboration. S Afr Med J 99(10):730–737PubMedPubMedCentral

60.

Violari A, Cotton MF, Gibb DM, Babiker AG, Steyn J, Madhi SA, Jean-Philippe P, McIntyre JA, Team CS (2008) Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med 359(21):2233–2244. https://doi.org/10.1056/NEJMoa0800971CrossRefPubMedPubMedCentral

61.

Karpelowsky JS, Zar HJ, van Bogerijen G, van der Graaf N, Millar AJ (2011) Predictors of postoperative complications in HIV-infected children undergoing surgery. J Pediatr Surg 46(4):674–678. https://doi.org/10.1016/j.jpedsurg.2010.11.026CrossRefPubMed

62.

Lord RV (1997) Anorectal surgery in patients infected with human immunodeficiency virus: factors associated with delayed wound healing. Ann Surg 226(1):92–99CrossRefPubMedPubMedCentral

63.

Tran HS, Moncure M, Tarnoff M, Goodman M, Puc MM, Kroon D, Eydelman J, Ross SE (2000) Predictors of operative outcome in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. Am J Surg 180(3):228–233CrossRefPubMed

64.

Slogrove AL, Cotton MF, Esser MM (2010) Severe infections in HIV-exposed uninfected infants: clinical evidence of immunodeficiency. J Trop Pediatr 56(2):75–81. https://doi.org/10.1093/tropej/fmp057CrossRefPubMed

65.

von Mollendorf C, von Gottberg A, Tempia S, Meiring S, de Gouveia L, Quan V, Lengana S, Avenant T, du Plessis N, Eley B, Finlayson H, Reubenson G, Moshe M, O’Brien KL, Klugman KP, Whitney CG, Cohen C, Group for Enteric R, Meningeal Disease Surveillance in South A (2015) Increased risk for and mortality from invasive pneumococcal disease in HIV-exposed but uninfected infants aged <1 year in South Africa, 2009-2013. Clin Infect Dis 60(9):1346–1356. https://doi.org/10.1093/cid/civ059CrossRef

66.

Mofenson LM (2015) Editorial commentary: new challenges in the elimination of pediatric HIV infection: the expanding population of HIV-exposed but uninfected children. Clin Infect Dis 60(9):1357–1360. https://doi.org/10.1093/cid/civ064CrossRefPubMed

Titel: Surgical implications of HIV infection
verfasst von: Alastair J. W. Millar
Sharon G. Cox
Publikationsdatum: 01.12.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 1/2023
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-022-05333-6

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Surgical implications of HIV infection

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