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Journal of Cardiovascular Translational Research
Erschienen in: Journal of Cardiovascular Translational Research 5/2023

27.03.2023 | Review

Targeting Vascular Smooth Muscle Cell Senescence: A Novel Strategy for Vascular Diseases

verfasst von: Meng-Juan Lin, Shi-Liang Hu, Ying Tian, Jing Zhang, Na Liang, Rong Sun, Shao-Xin Gong, Ai-Ping Wang

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 5/2023

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Abstract

Vascular diseases are a major threat to human health, characterized by high rates of morbidity, mortality, and disability. VSMC senescence contributes to dramatic changes in vascular morphology, structure, and function. A growing number of studies suggest that VSMC senescence is an important pathophysiological mechanism for the development of vascular diseases, including pulmonary hypertension, atherosclerosis, aneurysm, and hypertension. This review summarizes the important role of VSMC senescence and senescence-associated secretory phenotype (SASP) secreted by senescent VSMCs in the pathophysiological process of vascular diseases. Meanwhile, it concludes the progress of antisenescence therapy targeting VSMC senescence or SASP, which provides new strategies for the prevention and treatment of vascular diseases.
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Metadaten
Titel
Targeting Vascular Smooth Muscle Cell Senescence: A Novel Strategy for Vascular Diseases
verfasst von
Meng-Juan Lin
Shi-Liang Hu
Ying Tian
Jing Zhang
Na Liang
Rong Sun
Shao-Xin Gong
Ai-Ping Wang
Publikationsdatum
27.03.2023
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 5/2023
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-023-10377-7

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Kardiotoxische Nebenwirkungen einer Therapie mit Immuncheckpointhemmern mögen selten sein – wenn sie aber auftreten, wird es für Patienten oft lebensgefährlich. Voruntersuchung und Monitoring sind daher obligat.

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

24.05.2024 Diabetische Retinopathie Nachrichten

Möglicherweise hängt es von der Art der Diabetesmedikamente ab, wie hoch das Risiko der Betroffenen ist, dass sich sehkraftgefährdende Komplikationen verschlimmern.

TAVI versus Klappenchirurgie: Neue Vergleichsstudie sorgt für Erstaunen

21.05.2024 TAVI Nachrichten

Bei schwerer Aortenstenose und obstruktiver KHK empfehlen die Leitlinien derzeit eine chirurgische Kombi-Behandlung aus Klappenersatz plus Bypass-OP. Diese Empfehlung wird allerdings jetzt durch eine aktuelle Studie infrage gestellt – mit überraschender Deutlichkeit.

Update Kardiologie

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