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06.05.2024 | Gynecologic Oncology
The challenge of survivors of gynecological carcinomas: a retrospective study on occurrence of second tumors
Erschienen in: Archives of Gynecology and Obstetrics
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Objective
To clarify the epidemiologic characteristics and risk of other tumors in survivors of gynecological tumors.
Materials and methods
This is a retrospective study based on the Surveillance, Epidemiology, and End Results database (SEER).
Results
The morbidity of other malignant tumors in patients with gynecological cancer was 8.07%. The most common subsequent tumors are breast, lung, colorectal, thyroid, and bladder cancers. Taking the incidence rate of the general population as reference, the second tumor with the highest relative risk in patients with cervical cancer is vulvar cancer. Bladder cancer is the second tumor with the highest relative risk value both in patients with corpus and ovarian cancer. The median period from the diagnosis of the initial tumor to the diagnosis of the second tumor was 5 years. Most patients with other tumors following gynecological cancer showed worse prognosis than patients with gynecological tumors only. However, thyroid cancer following ovarian cancer is a protective factor in survival.
Conclusion
Patients with gynecological tumors have a significantly higher risk of malignant tumors in other systems compared to ordinary population. It is necessary to be vigilant against subsequent high-risk tumors and tumors with poor prognosis within 5 years of initial diagnosis.