Background
Methods
Study population
Definitions and endpoints
Statistics and analysis
Results
General information data
The event(n = 73) | non-the event(n = 251) | t/χ2/z | P value | |
---|---|---|---|---|
Gender,n(%) | ||||
Male | 60(82.19) | 191(76.10) | 1.204 | 0.273 |
Female | 13(17.81) | 60(23.90) | ||
Age (years) | 64(21) | 66(18) | −0.917 | 0.359 |
Chest pain period(h) | 4(5.00) | 5(4.00) | −1.603 | 0.109 |
Pain-to-balloon time(h) | 5(4.76) | 5.5(4.71) | −1.083 | 0.279 |
Door-to-balloon time(h) | 1(0.41) | 1(0.57) | −1.768 | 0.077 |
hospitalization day(d) | 6(3) | 6(2) | −0.355 | 0.722 |
History | ||||
Hypertension,n(%) | 31(42.47) | 104(41.43) | 0.025 | 0.875 |
Diabetes mellitus,n(%) | 11(15.07) | 54(21.51) | 1.465 | 0.226 |
Stroke or TIA,n(%) | 7(9.59) | 27(10.76) | 0.082 | 0.774 |
Previous MI/PCI/CABG,n(%) | 7(9.59) | 12(4.78) | 1.577 | 0.209 |
Heart Failure,n(%) | 4(5.48) | 6(2.39) | 0.919 | 0.338 |
Coronary heart disease,n(%) | 11(15.07) | 24(9.56) | 1.780 | 0.182 |
Current smoking status,n(%) | 24(32.88) | 87(34.66) | 0.080 | 0.777 |
Current drinking status,n(%) | 13(17.81) | 47(18.73) | 0.032 | 0.859 |
Admission medication | ||||
Aspirin,n(%) | 73(100.00) | 251(100.00) | – | – |
Clopidogrel or Tigrigrel,n(%) | 73(100.00) | 251(100.00) | – | – |
ACEIs or ARBs,n(%) | 41(56.16) | 142(56.57) | 0.004 | 0.950 |
CCB,n(%) | 38(52.05) | 113(45.02) | 1.125 | 0.289 |
Β-blocker,n(%) | 69(94.52) | 219(87.25) | 3.026 | 0.082 |
Statin,n(%) | 73(100.00) | 251(100.00) | – | – |
Diuretics,n(%) | 31(42.47) | 82(32.67) | 2.390 | 0.122 |
SBP (mmHg) | 121(26) | 123(29) | −0.385 | 0.700 |
DBP (mmHg) | 77(15) | 77(18) | −0.249 | 0.804 |
Heart-rate (beats-per-minute) | 82.40 ± 13.34 | 80.61 ± 14.43 | 0.003 | 0.343 |
Killip class,n(%) | ||||
1–2 | 65(89.04) | 228(90.84) | 0.211 | 0.646 |
3–4 | 8(10.96) | 23(9.16) | ||
Target Vessel,n(%) | ||||
LM | 4(5.48) | 5(1.99) | 1.419 | 0.234 |
LAD | 47(64.38) | 144(57.37) | 1.149 | 0.284 |
LCX | 7(9.59) | 30(11.95) | 0.312 | 0.576 |
RCA | 18(24.66) | 77(30.68) | 0.989 | 0.320 |
Simultaneous treatment of vascular situations,n(%) | ||||
1 | 70(95.89) | 246(98.01) | ||
> 1 | 3(4.11) | 5(1.99) | 0.357 | 0.550 |
Vessel-disease (stenosis > 50%) | ||||
1 vessel,n(%) | 21(28.77) | 69(27.49) | 0.046 | 0.830 |
2 vessels,n(%) | 25(34.25) | 56(22.31) | 4.297 | 0.038a |
3 vessels,n(%) | 27(36.99) | 126(50.20) | 3.961 | 0.047a |
PCI type,n(%) | ||||
Only PTCA | 8(10.96) | 27(10.76) | 0.002 | 0.961 |
PTCA and Stent | 65(89.04) | 224(89.24) | ||
Stent type,n(%) | ||||
Drug eluting stent | 24(32.88) | 105(41.83) | 1.893 | 0.169 |
Bare metal stent | 49(67.12) | 146(58.17) | ||
Number of stents inserted,n(%) | ||||
1 piece | 61(83.56) | 230(91.63) | 4.028 | 0.045a |
≥2 piece | 12(16.44) | 21(8.37) | ||
Stent length (mm) | 24(9) | 24(10) | −0.209 | 0.834 |
Stent Diameter (mm) | 3(0.5) | 3(0.5) | −0.156 | 0.876 |
IVUS Assist,n(%) | ||||
Yes | 7(9.59) | 6(2.39) | 5.855 | 0.016a |
No | 66(90.41) | 245(97.61) | ||
TIMI after PPCI n(%) | ||||
3 | 72(98.63) | 244(97.21) | 0.067 | 0.795 |
<3 | 1(1.37) | 7(2.79) | ||
Site of AMI n(%) | ||||
anterior | 42(57.53) | 128(51.00) | 1.759 | 0.799 |
antero-septal | 2(2.74) | 8(3.19) | ||
high side wall | 1(1.37) | 4(1.59) | ||
Inferior wall | 27(36.99) | 109(43.43) | ||
anterolateral | 1(1.37) | 2(0.80) | ||
Out-hospital medication,n(%) | ||||
Aspirin | 69(94.52) | 248(98.80) | 3.093 | 0.079 |
PY212 receptor inhibitors | 68(93.15) | 249(99.20) | 7.146 | 0.008a |
Β-blocker | 62(84.93) | 219(87.25) | 0.264 | 0.607 |
ACEIs or ARBs | 24(32.88) | 106(42.23) | 2.060 | 0.151 |
Statin | 69(94.52) | 243(96.81) | 0.314 | 0.575 |
Diuretics | 27(36.99) | 71(28.29) | 2.029 | 0.154 |
Insulin treatment | 4(5.48) | 9(3.59) | 0.150 | 0.699 |
the event(n = 73) | non-the event(n = 251) | t/χ2/z | P value | |
---|---|---|---|---|
Hemoglobin(g/L) | 137(18.5) | 135(21) | −1.849 | 0.064 |
Glycosylated hemoglobin(%) | 6.1(1.27) | 6.1(1.23) | −0.305 | 0.760 |
Glucose (mmol/L) | 6.43(2.78) | 6.23(2.62) | −1.122 | 0.262 |
eGFR (ml/min/1.73m2) | 104.80(26.58) | 104.76(29.96) | −0.362 | 0.718 |
Creatinine (μmol/L) | 62(21) | 59(23) | −1.140 | 0.254 |
UA (μmol/L) | 296.50(117) | 294.50(113) | −0.657 | 0.511 |
AST(U/L) | 191(327) | 169.50(215) | −1.461 | 0.144 |
ALT(U/L) | 49(43) | 45(36) | −1.637 | 0.102 |
Albumin(g/L) | 38.10(5.5) | 37.35(5.8) | −0.648 | 0.517 |
LDL-C (mmol/L) | 3.04(1.88) | 2.80(1.17) | −2.497 | 0.013a |
HDL-C (mmol/L) | 0.99(0.30) | 1.03(0.35) | −0.489 | 0.625 |
Triglycerides (mmol/L) | 1.18(0.99) | 1.18(0.85) | −0.562 | 0.574 |
Total cholesterol (mmol/L) | 4.31(1.53) | 4.32(1.34) | −0.339 | 0.734 |
Lp(a)(mg/L) | 261(207) | 242(234) | −0.188 | 0.851 |
Hs-TnT (ng/L) | 3433(4710.25) | 3155.50(5428.75) | −0.641 | 0.521 |
NT-proBNP (pg/ml) | 1091(2426.75) | 661.55(1483.93) | −2.841 | 0.004a |
SII (before PPCI)(T0) | 1334.58(1265.52) | 890(1011.97) | −3.378 | 0.001a |
SII(12 h after PPCI)(T1) | 1676.78(1661.00) | 1107.40(1147.42) | −4.031 | < 0.001a |
SII(24 h after PPCI) | 1212.70(730.09) | 842.06(673.34) | −4.637 | < 0.001a |
SII (48 h after PPCI) | 1044.06(601.88) | 632.12(429.28) | −5.871 | < 0.001a |
SII before discharge(T2) | 941.63(458.92) | 584.93(403.28) | −6.282 | < 0.001a |
SII (1 month discharge)(T1M) | 1005.48(580.87) | 489.63(252.03) | −10.187 | < 0.001a |
cTnImax (ng/ml) | 4.26(7.59) | 3.77(5.73) | −1.098 | 0.272 |
CK-MBmax (ng/ml) | 184.00(248) | 139.60(226) | −1.002 | 0.316 |
hs-CRPmax (mg/L) | 20.70(31.25) | 14.30(29.10) | −2.188 | 0.029a |
The event(n = 39) | non-the event(n = 285) | t/χ2/z | P value | |
---|---|---|---|---|
Gender | ||||
Male, n(%) | 33(84.62) | 218(76.49) | 1.297 | 0.255 |
Female, n(%) | 6(15.38) | 67(23.51) | ||
Age, n(%) | 69(20) | 66(17) | −0.382 | 0.702 |
Chest pain period(h) | 6(5.5) | 4(4) | −2.070 | 0.038a |
Pain-to-balloon time(h) | 7.1(6.5) | 5.35(4.43) | −2.283 | 0.022a |
Door-to-balloon time(h) | 1(0.58) | 1(0.61) | −0.785 | 0.433 |
hospitalization day(d) | 6(2) | 6(2) | −0.148 | 0.882 |
History | ||||
Hypertension,n(%) | 18(46.15) | 117(41.05) | 0.367 | 0.544 |
Diabetes mellitus,n(%) | 9(23.08) | 56(19.65) | 0.251 | 0.616 |
Stroke or TIA,n(%) | 6(15.38) | 28(9.82) | 0.615 | 0.433 |
Previous MI/PCI/CABG,n(%) | 3(7.69) | 16(5.61) | 0.024 | 0.877 |
Heart Failure,n(%) | 3(7.69) | 7(2.46) | 1.638 | 0.201 |
Coronary heart disease,n(%) | 6(15.38) | 29(10.18) | 0.501 | 0.479 |
Current smoking status,n(%) | 11(28.21) | 100(35.09) | 0.722 | 0.396 |
Current drinking status,n(%) | 8(20.51) | 52(18.25) | 0.117 | 0.732 |
Admission medication | ||||
Aspirin,n(%) | 39(100.00) | 285(100.00) | – | – |
Clopidogrel or Tigrigrel,n(%) | 39(100.00) | 285(100.00) | – | – |
ACEIs or ARBs,n(%) | 19(48.72) | 164(57.54) | 1.087 | 0.297 |
CCB,n(%) | 16(41.03) | 135(47.37) | 0.555 | 0.456 |
Β-blocker,n(%) | 34(87.18) | 254(89.12) | 0.008 | 0.928 |
Statin,n(%) | 39(100.00) | 285(100.00) | – | – |
Diuretics,n(%) | 18(46.15) | 95(33.33) | 2.483 | 0.115 |
SBP (mmHg) | 119(30) | 123(29) | −1.840 | 0.066 |
DBP (mmHg) | 72(14) | 78(18) | −1.544 | 0.123 |
Heart-rate (beats-per-minute) | 83.28 ± 14.84 | 80.70 ± 14.10 | 0.018 | 0.287 |
Killip class,n(%) | ||||
1–2 | 30(76.92) | 263(92.28) | 7.661 | 0.006a |
3–4 | 9(23.08) | 22(7.72) | ||
Target Vessel,n(%) | ||||
LM | 3(7.69) | 6(2.11) | 2.166 | 0.141 |
LAD | 25(64.10) | 166(58.25) | 0.486 | 0.486 |
LCX | 6(15.38) | 31(10.88) | 0.315 | 0.574 |
RCA | 7(17.95) | 88(30.88) | 2.767 | 0.096 |
Simultaneous treatment of vascular situations,n(%) | ||||
1 | 37(94.87) | 279(97.89) | 0.349 | 0.555 |
> 1 | 2(5.13) | 6(2.11) | ||
Vessel-disease (stenosis > 50%) | ||||
1 vessel,n(%) | 11(28.21) | 79(27.72) | 0.004 | 0.949 |
2 vessels,n(%) | 15(38.46) | 66(23.16) | 3.508 | 0.061 |
3 vessels,n(%) | 13(33.33) | 140(49.12) | 3.432 | 0.064 |
PCI type,n(%) | ||||
Only PTCA | 5(12.82) | 30(10.53) | 0.025 | 0.875 |
PTCA and Stent | 34(87.18) | 255(89.47) | ||
Stent type,n(%) | ||||
Drug eluting stent | 10(25.64) | 119(41.75) | 3.717 | 0.054 |
Bare metal stent | 29(74.36) | 166(58.25) | ||
Number of stents inserted,n(%) | ||||
1 piece | 32(82.05) | 261(91.58) | 2.582 | 0.108 |
≥2 piece | 7(17.95) | 24(8.42) | ||
Stent length (mm) | 28(6) | 23(11) | −1.995 | 0.046a |
Stent Diameter (mm) | 3(0.25) | 3(0.5) | −0.531 | 0.595 |
IVUS Assist,n(%) | ||||
Yes | 3(7.69) | 10(3.51) | 0.662 | 0.416 |
No | 36(92.31) | 275(96.49) | ||
TIMI after PPCI n(%) | ||||
3 | 37(94.87) | 279(97.89) | 0.349 | 0.555 |
<3 | 2(5.13) | 6(2.11) | ||
site of AMI n(%) | ||||
anterior | 25(64.10) | 145(50.88) | 6.695 | 0.112 |
antero-septal | 1(2.56) | 9(3.16) | ||
high side wall | 2(5.13) | 3(1.05) | ||
Inferior wall | 11(28.21) | 125(43.86) | ||
anterolateral | 0(0.00) | 3(1.05) |
The event(n = 39) | non-the event(n = 285) | t/χ2/z | P value | |
---|---|---|---|---|
Hemoglobin(g/L) | 138(31) | 135(20.50) | −0.460 | 0.645 |
Glycosylated hemoglobin(%) | 6.2(1.70) | 6.1(1.20) | −0.308 | 0.758 |
Glucose (mmol/L) | 6.49(2.96) | 6.20(2.64) | −2.034 | 0.042a |
eGFR (ml/min/1.73m2) | 104.89(34.78) | 104.71(28.31) | −0.445 | 0.656 |
Creatinine (μmol/L) | 60(17) | 59(23) | −0.742 | 0.458 |
UA (μmol/L) | 294(114) | 295(115) | −0.658 | 0.511 |
AST(U/L) | 238(365) | 173(211) | −1.359 | 0.174 |
ALT(U/L) | 53(45) | 46(37) | −1.939 | 0.053 |
Albumin(g/L) | 38.10(4.70) | 37.30(5.90) | −0.672 | 0.502 |
LDL-C (mmol/L) | 2.83(1.13) | 2.78(1.22) | −0.582 | 0.560 |
HDL-C (mmol/L) | 1.03(0.38) | 1.02(0.34) | −0.773 | 0.440 |
Triglycerides (mmol/L) | 1.26(0.99) | 1.17(0.88) | −0.699 | 0.485 |
Total cholesterol (mmol/L) | 4.34(1.10) | 4.29(1.43) | −0.442 | 0.658 |
Lp(a)(mg/L) | 215(258) | 246(217) | −0.136 | 0.892 |
Hs-TnT (ng/L) | 4622(8805) | 3150(4889) | −1.170 | 0.242 |
NT-proBNP (pg/ml) | 933.70(2264.30) | 729.30(1530.93) | −1.164 | 0.245 |
SII(before PPCI)(T0) | 1477.50(1500.91) | 901.28(996.63) | −3.375 | 0.001a |
SII(12 h after PPCI)(T1) | 2779.67(2189.23) | 1067.95(997.54) | −8.031 | < 0.001a |
SII(24 h after PPCI) | 1483.76(1834.28) | 872.23(664.46) | −4.295 | < 0.001a |
SII (48 h after PPCI) | 1074.46(891.21) | 679(466.88) | −4.622 | < 0.001a |
SII before discharge(T2) | 1000.53(501.99) | 624(448.04) | −5.461 | < 0.001a |
cTnImax (ng/ml) | 5.90(7.19) | 3.60(5.66) | −2.587 | 0.010a |
CK-MBmax (ng/ml) | 195.90(235) | 143.00(214) | −1.748 | 0.080 |
hs-CRPmax (mg/L) | 22.10(89.40) | 14.50(28.05) | −3.160 | 0.002a |
Variable | Univariate | Multivariate | ||
---|---|---|---|---|
OR (95%CI) | P value | OR (95%CI) | P value | |
2Vessal diseases(> 50%) | 0.551(0.313–0.973) | 0.040 | 0.854(0.297–2.457) | 0.769 |
3Vessal diseases(> 50%) | 1.717(1.005–2.934) | 0.048 | 1.612(0.620–4.189) | 0.327 |
Stent number | 0.306(0.143–0.657) | 0.002 | 0.462(0.125–1.703) | 0.246 |
IVUS assisted | 0.231(0.075–0.710) | 0.011 | 0.051(0.010–0.251) | < 0.001* |
P2Y12 receptor inhibitors | 9.154(1.738–48.223) | 0.009 | 2.844(0.296–27.287) | 0.365 |
LDL-C | 1.550(1.195–2.011) | 0.001 | 1.890(1.214–2.941) | 0.005* |
NT-proBNP | 1.000(1.000–1.001) | 0.569 | – | – |
SII(1 month discharge)(T1M) | 1.007(1.005–1.009) | < 0.001 | 1.008(1.006–1.010) | < 0.001* |
Age | 0.990(0.970–1.010) | 0.327 | – | – |
HDL-C | 0.795(0.280–2.257) | 0.666 | – | – |
cTnImax | 1.020(0.974–1.068) | 0.412 | – | – |
CK-MBmax | 1.001(0.999–1.003) | 0.318 | – | – |
hs-CRPmax | 1.005(1.000–1.010) | 0.037 | 1.006(0.998–1.015) | 0.145 |
Variable | Univariate | Multivariate | ||
---|---|---|---|---|
OR (95%CI) | P value | OR (95%CI) | P value | |
Age | 1.004(0.978–1.030) | 0.786 | – | – |
Chest pain period | 1.075(1.001–1.155) | 0.048 | 1.108(0.899–1.365) | 0.335 |
Pain-to-balloon time | 1.070(1.005–1.139) | 0.033 | 1.005(0.839–1.203) | 0.959 |
Killip class> 2 | 0.279(0.118–0.661) | 0.004 | 0.554(0.168–1.821) | 0.330 |
Stent length | 1.054(1.000–1.111) | 0.052 | – | – |
Glucose | 1.039(0.938–1.151) | 0.464 | – | – |
SII(12 h after PPCI)(T1) | 1.001(1.001–1.001) | < 0.001 | 1.001(1.001–1.001) | < 0.001* |
cTnImax | 1.053(1.001–1.109) | 0.045 | 1.075(1.008–1.148) | 0.029* |
CK-MBmax | 1.002(1.000–1.005) | 0.079 | – | – |
hs-CRPmax | 1.011(1.006–1.017) | <0.001 | 1.008(1.002–1.015) | 0.012* |
The overall levels of change in blood SII and hs-CRP levels at different onset times
Predictive value of ROC curve analysis of SII levels, hs-CRPmax, cTnImax, CK-MBmax for the occurrence of outcomes both hospitalization and discharge after PPCI in STEMI patients
Cut-off | Sensitivity | Specificity | AUC | 95%CI | P value | |
---|---|---|---|---|---|---|
SII before(T0) | 1264.15 | 0.641 | 0.667 | 0.667 | 0.575–0.758 | 0.001* |
SII12h after(T1) | 1915.77 | 0.897 | 0.814 | 0.896 | 0.852–0.941 | <0.001* |
SII24h after | 1282.53 | 0.615 | 0.765 | 0.712 | 0.620–0.804 | <0.001* |
SII48h after | 956.76 | 0.641 | 0.758 | 0.728 | 0.644–0.812 | <0.001* |
T2 | 779.79 | 0.821 | 0.653 | 0.770 | 0.697–0.843 | <0.001* |
hs-CRPmax | 9.050 | 0.872 | 0.358 | 0.656 | 0.566–0.746 | 0.002* |
cTnImax | 4.887 | 0.641 | 0.635 | 0.628 | 0.529–0.726 | 0.010* |
CK-MBmax | 276.11 | 0.487 | 0.758 | 0.586 | 0.488–0.685 | 0.080 |
Cut-off | Sensitivity | Specificity | AUC | 95%CI | P value | |
---|---|---|---|---|---|---|
SII before(T0) | 1278.35 | 0.534 | 0.681 | 0.630 | 0.558–0.702 | 0.001* |
SII12h after(T1) | 1361.13 | 0.671 | 0.602 | 0.655 | 0.587–0.723 | <0.001* |
SII24h after | 918.45 | 0.781 | 0.566 | 0.678 | 0.612–0.745 | <0.001* |
SII48h after | 1055.28 | 0.534 | 0.821 | 0.726 | 0.664–0.787 | <0.001* |
T2 | 735.32 | 0.753 | 0.645 | 0.742 | 0.679–0.804 | <0.001* |
SII1month(T1M) | 696.43 | 0.767 | 0.880 | 0.892 | 0.846–0.937 | <0.001* |
hs-CRPmax | 16.45 | 0.644 | 0.562 | 0.584 | 0.512–0.657 | 0.029* |
cTnImax | 5.668 | 0.438 | 0.681 | 0.542 | 0.465–0.619 | 0.272 |
CK-MBmax | 252.70 | 0.397 | 0.721 | 0.539 | 0.460–0.617 | 0.316 |
Correlation of high and low SII level groups with cumulative all-cause mortality in STEMI patients after PPCI
In-hospital course | n(%) |
---|---|
Cardiogenic shock | 4(1.23%) |
Acute respiratory failure | 2(0.62%) |
Acute kidney injury | 4(1.23%) |
Ventricular arrhythmia | 13(4.01%) |
Recurrent myocardial infarction | 5(1.54%) |
Repeat revascularization | 3(0.93%) |
All-cause mortality | 8(2.47%) |
Combined | 39(12.04%) |
Out-hospital course | n(%) |
---|---|
All-cause mortality | 16(4.94%) |
Recurrent myocardial infarction | 17(5.25%) |
Repeat revascularization | 28(8.64%) |
Ventricular arrhythmia | 12(3.70%) |
Combined | 73(22.53%) |