nach oben

Current Infectious Disease Reports

Erschienen in:

01.03.2010

The Role of Adenovirus in Respiratory Tract Infections

verfasst von: Anjali N. Kunz, Martin Ottolini

Erschienen in: Current Infectious Disease Reports | Ausgabe 2/2010

Einloggen, um Zugang zu erhalten

Abstract

Adenovirus plays a significant role in respiratory tract disease in pediatric and adult patients. It has been linked to outbreaks and epidemics in various patient populations, resulting in considerable morbidity and mortality. In this article, we discuss the epidemiology, pathogenesis, respiratory tract illnesses and complications, and roles of potential treatment options. The role of the past oral adenovirus vaccine and the military implications of its withdrawal from routine use in military recruits is discussed as well.

Woodward TE: The Armed Forces Epidemiological Board: Its First Fifty Years. Falls Church, VA: Center of Excellence in Military Medical Research and Education, Office of the Surgeon General, Department of the Army; 1994. Available at http://history.amedd.army.mil/booksdocs/itsfirst50yrs/fiftyyears.html.

Mandell GL, Bennett JE, Dolin R: Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, edn 7. Philadelphia: Elsevier; 2009.

Rowe WP, Huebner RJ, Gillmore LK, et al.: Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med 1953, 84:570–573.PubMed

Brandt CD, Kim HW, Vargosko AJ, et al.: Infections in 18,000 infants and children in a controlled study of respiratory tract disease. I. Adenovirus pathogenicity in relation to serologic type and illness syndrome. Am J Epidemol 1969, 90:484–500.

Hale, GA, Heslop HE, Krance RA, et al.: Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant 1999, 23:277–282.

Kolavic-Gray SA, Binn LN, Sanchez JL, et al.: Large epidemic of adenovirus type 14 infection among military trainees: epidemiological, clinical and laboratory studies. Clin Infect Dis 2002, 35:808–818.CrossRefPubMed

Van Der Veen J, Dijkman JH: Associations of type 21 Adenovirus with acute respiratory illness in military recruits. Am J Hyg 1962, 76:149–159.

Dudding BA, Wagner SC, Zeller JA, et al.: Fatal pneumonia associated with adenovirus type 7 in three military trainees. N Engl J Med 1972, 286:1289–1292.PubMedCrossRef

Klinger JR, Sanchez MP, Curtin LA, et al.: Multiple cases of life-threatening adenovirus pneumonia in a mental health care center. Am J Respir Crit Care Med 1998, 157:645–549.PubMed

10.

• Hakim FA, Tleyjeh IM: Severe adenovirus pneumonia in immunocompetent adults: a case report and review of the literature. Eur J Clin Microbiol Infect Dis 2008, 27:153–158. This article describes severe adenovirus pneumonia with ARDS in immunocompetent adults, which is an unusual clinical presentation.CrossRefPubMed

11.

Osamura T, Mizuta R, Yoshika H, et al.: Isolation of adenovirus type 11 from the brain of a neonate with pneumonia and encephalitis. Eur J Pediatr 1993, 152:496–499.CrossRefPubMed

12.

Pinto A, Beck R, Jadavji T: Fatal neonatal pneumonia caused by adenovirus type 35. Report of one case and review of the literature. Arch Pathol Lab Med 1992, 116:95–99.PubMed

13.

Wigger HJ, Blanc WA: Fatal hepatic and bronchial necrosis in adenovirus infection with thymic dysplasia. N Engl J Med 1964, 275:870–874.CrossRef

14.

Leen AM, Rooney CM: Adenovirus as an emerging pathogen in immunocompromised patients. Br J Haematol 2005, 128:135–144.CrossRefPubMed

15.

Kojaoghlanian T, Flomenberg P, Horwitz MS: The impact of adenovirus infection on the immunocompromised host. Rev Med Virol 2003, 13:155–171.CrossRefPubMed

16.

Krilov LR, Rubin LG, Frogel M, et al.: Disseminated adenovirus infection with hepatic necrosis in patients with HIV and other immunodeficiency states. Rev Infect Dis 1990, 12:303–307.PubMed

17.

Dingle JH, Langmuir AD: Epidemiology of acute respiratory disease in military recruits. Am Rev Respir Dis 1968, 97(Suppl):1–65.

18.

Top FH, Dudding BA, Russell PK, et al.: Control of respiratory disease in recruits with types 4 and 7 adenovirus vaccines. Am J Epidemiol 1971, 94:142–146.PubMed

19.

• Metzgar D, Osuna M, Kajon AE, et al.: Abrupt emergence of diverse species B adenoviruses at US military recruit training centers. J Infect Dis 2007, 196:1465–1473. This important article details the alarming rise in respiratory tract infections with adenovirus serotypes 4, 7, 14, and 21 in military recruits across the United States.CrossRefPubMed

20.

• Tate JE, Bunning ML, Lott L, et al.: Outbreak of severe respiratory disease associated with emergent human adenovirus serotype 14 at a US air force training facility in 2007. J Infect Dis May 2009, 199:1419–1426. This article focuses on the severity of adenovirus 14 in healthy military recruits, and its importance as an emerging pathogen in this population.CrossRef

21.

Laham FR, Jewell AM, Schoonover AL, et al.: The search for adenovirus 14 in children in Houston, Texas. Pediatr Infect Dis J 2008, 27:653–654.CrossRefPubMed

22.

•• Lewis, PF, Schmidt MA, Lu X, et al.: A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14. J Infect Dis May 2009, 199:1427–1434. This article describes the clinical presentation and impact of a community outbreak of adenovirus 14.CrossRef

23.

Shields A, Hackman R, Fife K, et al.: Adenovirus infection in patients undergoing bone-marrow transplantation. N Engl J Med 1985, 312:529–533.PubMed

24.

Flomenberg P, Babbit J, Drobyski W, et al.: Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis 1994, 169:775–781.PubMed

25.

Aronson B, Aronson S, Sobel G, et al.: Pharyngoconjunctival fevers; report of an epidemic outbreak. AMA J Dis Child 1956, 92:596–612.PubMed

26.

Bell JA: Clinical manifestation of pharyngoconjunctival fever. Am J Opthalmol 1957, 43:11–14.

27.

Chaberny IE, Schnitzler P, Geiss HK, Wendt C: An outbreak of epidemic keratoconjunctivitis in a pediatric unit due to adenovirus type 8. Infect Control Hosp Epidemiol 2003, 24:514–519.CrossRefPubMed

28.

Buffington J, Chapman LE, Stobierski MG, et al.: Epidemic keratoconjunctivitis in a chronic care facility: risk factors and measures for control. J Am Geriatr Soc 1993, 41:1177–1181.PubMed

29.

Usui N, Ookoshi H, Mori H, et al.: Clinical features of epidemic keratoconjunctivitis in 41 patients. Nippon Ganka Gakkai Zasshi 2001, 105:183–188.PubMed

30.

Engelmann I, Madisch I, Pommer H, Heim A: An outbreak of epidemic keratoconjuctivitis caused by a new intermediate adenovirus 22/H8 identified by molecular typing. Clin Infect Dis 2006, 43:e64–e66.CrossRefPubMed

31.

Murrah WF: Epidemic keratoconjunctivitis. Ann Ophthalmol 1988, 20:36–38.PubMed

32.

Damen M, Minnaar R, Glasius P, et al.: Real-time PCR with an internal control for detection of all known human adenovirus serotypes. J Clin Microbiol 2008, 46:3997–4003.CrossRefPubMed

33.

• Wong S, Pabbaraju K, Pang XL, et al.: Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real-time PCR assay. J Med Virol 2008, 80:856–865. This article shows the utility and sensitivity of real-time PCR in detecting most clinically relevant adenovirus serotypes.CrossRefPubMed

34.

Metzgar D, Skochko G, Gibbins C, et al.: Evaluation and validation of a real-time PCR assay for detection and quantitation of human adenovirus 14 from clinical samples. PLoS One 2009, 4:e7081.CrossRefPubMed

35.

Bruno B, Gooley T, Hackman RC, et al.: Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biol Blood Marrow Transplant 2003, 9:341–352.CrossRefPubMed

36.

Legrand F, Berrebi D, Houhou N, et al: Early diagnosis of adenovirus infection and treatment with cidofovir after bone marrow transplantation in children. Bone Marrow Transplant 2001, 27:621–626.CrossRefPubMed

37.

Saquib R, Melton LB, Chandrakantan A, et al.: Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin. Transpl Infect Dis 2009 (Epub ahead of print).

38.

Lessler J, Reich NG, Brookmeyer R, et al.: Incubation periods of acute respiratory viral infections: a systemic review. Lancet Infect Dis 2009, 9:291–300.CrossRefPubMed

39.

Russell KL, Hawksworth AW, Ryan MAK, et al.: Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004. Vaccine 2006, 24:2835–2842.CrossRefPubMed

40.

Hilleman MR: Efficacy of and indications for use of adenovirus vaccine. Am J Public Health Nations Health 1958, 48:153–158.PubMed

41.

Kolavic-Gray SA, Binn LN, Sanchez JL, et al: Large epidemic of adenovirus type 4 infection among military trainees: epidemiological, clinical and laboratory studies. Clin Infect Dis 2002, 35:808–818.CrossRefPubMed

42.

• Lyons A, Longfield J, Kuschner R, et al.: A double-blinded, placebo-controlled study of the safety and immunogenicity of live, oral type 4 and type 7 adenovirus vaccines in adults. Vaccine 2008, 26:2890–2898. This article discusses the results of the new live, oral adenovirus vaccines during their phase 1 clinical trials.CrossRefPubMed

Titel: The Role of Adenovirus in Respiratory Tract Infections
verfasst von: Anjali N. Kunz
Martin Ottolini
Publikationsdatum: 01.03.2010
Verlag: Current Science Inc.
Erschienen in: Current Infectious Disease Reports / Ausgabe 2/2010
Print ISSN: 1523-3847
Elektronische ISSN: 1534-3146
DOI: https://doi.org/10.1007/s11908-010-0084-5

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Schadet Ärger den Gefäßen?

14.05.2024 Arteriosklerose Nachrichten

In einer Studie aus New York wirkte sich Ärger kurzfristig deutlich negativ auf die Endothelfunktion gesunder Probanden aus. Möglicherweise hat dies Einfluss auf die kardiovaskuläre Gesundheit.

Intervallfasten zur Regeneration des Herzmuskels?

14.05.2024 Herzinfarkt Nachrichten

Die Nahrungsaufnahme auf wenige Stunden am Tag zu beschränken, hat möglicherweise einen günstigen Einfluss auf die Prognose nach akutem ST-Hebungsinfarkt. Darauf deutet eine Studie an der Uniklinik in Halle an der Saale hin.

Klimaschutz beginnt bei der Wahl des Inhalators

14.05.2024 Klimawandel Podcast

Auch kleine Entscheidungen im Alltag einer Praxis können einen großen Beitrag zum Klimaschutz leisten. Die neue Leitlinie zur "klimabewussten Verordnung von Inhalativa" geht mit gutem Beispiel voran, denn der Wechsel vom klimaschädlichen Dosieraerosol zum Pulverinhalator spart viele Tonnen CO₂. Leitlinienautor PD Dr. Guido Schmiemann erklärt, warum nicht nur die Umwelt, sondern auch Patientinnen und Patienten davon profitieren.

Typ-2-Diabetes und Depression folgen oft aufeinander

14.05.2024 Typ-2-Diabetes Nachrichten

Menschen mit Typ-2-Diabetes sind überdurchschnittlich gefährdet, in den nächsten Jahren auch noch eine Depression zu entwickeln – und umgekehrt. Besonders ausgeprägt ist die Wechselbeziehung laut GKV-Daten bei jüngeren Erwachsenen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2010

Evaluation and Management of Anal Intraepithelial Neoplasia in HIV-Negative and HIV-Positive Men Who Have Sex with Men

Topical Antibiotic Therapy of Chronic Rhinosinusitis

Evaluation and Management of Syphilis in the HIV-Infected Patient

β-Lactamase–Producing Bacteria in Upper Respiratory Tract Infections

Epidemic of Sexually Transmitted Hepatitis C Virus Infection Among HIV-Infected Men