Introduction
Methods
Subjects
Total HIV-1 DNA quantitation
Statistical methods
Results
Baseline characteristics
Characteristics | Training cohort (n = 490) | Validation cohort (n = 117) |
---|---|---|
Median age (years, IQR) | 35 (28–44) | 32 (28–43) |
Gender (n, %) | ||
Male | 342 (69.8) | 108 (92.3) |
Female | 148 (30.2) | 9 (7.7) |
Transmission category (n, %) | ||
MSM | 154 (31.4) | 84 (71.8) |
Heterosexual | 258 (52.7) | 18 (15.4) |
Bisexual | 14 (2.9) | 4 (3.4) |
Blood | 7 (1.4) | 0 (0) |
Others/Unknown | 57 (11.6) | 11 (9.4) |
Subtype (n, %) | NA | |
CRF01_AE | 218 (44.5) | |
C/CRF07_BC/CRF08_BC | 123 (25.1) | |
B/B′ | 55 (11.2) | |
URF | 18 (3.7) | |
Unknown | 76 (15.5) | |
Median CD4 cell count (cells/μL, IQR) | 226 (159–344) | 189 (50–293) |
Median CD8 cell count (cells/μL, IQR) | 809 (590–1181) | 627 (449–925) |
Median CD4/CD8 ratio (IQR) | 0.25 (0.18–0.40) | 0.27 (0.13–0.45) |
Median HIV-1 plasma RNA (log copies/mL, IQR) | 4.66 (4.34–5.14) | 4.48 (2.90–4.96) |
Median total HIV-1 DNA (log copies/106 PBMCs, IQR) | 3.00 (2.66–3.33) | 3.01 (2.74–3.29) |
Total HIV-1 DNA decay during 288 weeks of cART
Contribution of baseline factors to the total HIV-1 DNA decay
Variables | Univariate Analysis | Multivariate Analysis | ||
---|---|---|---|---|
RR (95% CI) | P | RR (95% CI) | P | |
Sex | 0.921 | 0.921 | ||
Male | 1 | 1 | ||
Female | 0.96 (0.46–2.04) | 0.96 (0.46–2.04) | ||
Age-per 10 years increase | 1.02 (0.76–1.37) | 0.891 | 1.02 (0.76–1.37) | 0.889 |
Transmission route | 0.359 | 0.305 | ||
MSM | 1 | 1 | ||
Heterosexual | 1.06 (0.49–2.30) | 0.885 | 1.15 (0.62–2.13) | 0.650 |
Bisexual | 0.24 (0.03–2.19) | 0.203 | 0.27 (0.03–2.39) | 0.241 |
Blood | 1.33 (0.10–17.37) | 0.826 | 0.85 (0.08–8.97) | 0.895 |
Others/Unknown | 0.35 (0.09–1.41) | 0.140 | 0.35 (0.09–1.31) | 0.120 |
Subtype | 0.549 | 0.550 | ||
CRF01_AE | 1 | 1 | ||
C/CRF07_BC/CRF08_BC | 1.47 (0.75–2.86) | 0.264 | 1.47 (0.75–2.86) | 0.263 |
B/B′ | 0.71 (0.23–2.21) | 0.557 | 0.72 (0.23–2.22) | 0.562 |
Others/Unknown | 1.12 (0.31–4.01) | 0.863 | 1.12 (0.31–4.00) | 0.864 |
Baseline total HIV-1 DNA -per 1 log copies/106 PBMCs | 0.07 (0.03–0.16) | < 0.001 | 0.08 (0.04–0.16) | < 0.001 |
Baseline HIV-1 plasma RNA-per 1 log copies/mL | 1.20 (0.74–1.96) | 0.463 | 1.12 (0.70–1.77) | 0.641 |
Baseline CD4 cell count-per 100 cells/μL | 2.11 (1.28–3.48) | 0.003 | 1.72 (1.35–2.20) | < 0.001 |
Baseline CD8 cell count-per 100 cells/μL | 0.92 (0.81–1.05) | 0.211 | 0.97 (0.90–1.04) | 0.389 |
Baseline CD4/CD8 ratio-per 0.1 increase | 0.87 (0.64–1.19) | 0.391 | 0.86 (0.63–1.17) | 0.340 |