Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant condition that leads to significant disability and morbidity, characterised by the formation of heterotopic hard tissues within connective tissues [ 1 , 2 ]. The disorder is …

Fibrodysplasia ossificans progressiva (FOP), as a rare, heritable and severely disabling genetic condition of connective tissue and progressive heterotopic ossification (HO), is the most catastrophic disorder of HO and a cause of extraskeletal …

Conducting clinical trials in rare diseases presents several challenges including small numbers of eligible participants, limited ability to conduct subsequent trials, heterogeneity across patient groups, understudied disease evolution, and a lack …

Verkrümmte oder verkürzte Großzehen scheinen nicht besorgniserregend. Wenn jedoch beulenartige Weichteilschwellungen hinzukommen, kann dies Hinweis auf die sehr seltene Erkrankung Fibrodysplasia ossificans progressiva sein. Daran sollte unbedingt gedacht werden, Fehldiagnosen können nämlich schwerwiegende Folgen haben.

Fibrodysplasia ossificans progressive (FOP) is an ultra-rare genetic disorder that is caused by a mutation in the ACVR1 gene and provokes severe heterotopic ossification. Since flares of the disease are associated with inflammation, it is assumed …

Fibrodysplasia ossificans progressiva (FOP) is an ultrarare and disabling genetic disorder of connective tissue that is characterized by congenital malformation of the great toes and progressive endochondral heterotopic ossification (HO) in soft …

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder associated with increased immune activity and severe, progressive heterotopic ossification. We previously described a cohort of 32 patients with FOP who were either exposed to …

Fibrodysplasia ossificans progressiva (FOP) is an ultrarare condition and one of the most impactful disorders associated with progressive heterotopic ossification events. It is estimated that there are 120–150 patients in Brazil; however …

Coronaviruses (CoVs) are a class of enveloped, single-stranded RNA viruses found globally in humans [ 1 ]. While coronavirus infections in humans are typically mild, several previous coronavirus outbreaks have been associated with significant …

Fibrodysplasia ossificans progressiva (FOP; OMIM #135100) is an ultra-rare, disabling genetic disorder characterized by congenital malformations of the great toes and progressive heterotopic ossification (HO) of soft and connective tissues [ 1 ].

Rare diseases are defined in Europe as disease with a prevalence of less than 1 in 2000. There are more than 7000 rare diseases, cumulatively affecting the lives of an estimated 3.5–5.9% of the global population [ 1 ]. Together, rare diseases …

With an estimated global prevalence of less than one birth per million[ 1 , 2 ], fibrodysplasia ossificans progressiva (FOP) is an ultra-rare, severely disabling, autosomal dominant, congenital disease characterized by progressive multi-focal …

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder that leads to heterotopic ossification (HO), resulting in progressive restriction of physical function. In this study, low-dose, whole-body computed tomography (WBCT) …

Fibrodysplasia ossificans progressiva (FOP; OMIM #135100) is an ultra-rare, progressive, and permanently disabling disorder of extraskeletal ossification. FOP is characterized by episodic flare-ups and irreversible heterotopic ossification (HO) in …

Fibrodyplasia ossificans progressiva (FOP) is a rare hereditary disease, which has a variable course characterized by occasional flare-ups of heterotopic ossification (HO) in soft tissues that are followed by swelling, stiffness, pain and warmth.