During the erythrocytic stage of the malaria parasite in humans, a fraction of asexual parasites differentiates into gametocytes [ 1 ]. Gametocytes are the sexual form of the parasite transmitted from humans to mosquitoes and are an important …

With almost 250 million infections and approximately 600 thousand deaths per year, malaria remains a global health priority. The renewed focus on malaria elimination has increased the priority of research into interventions to block malaria …

Novel vaccines and drugs are urgently needed to alleviate the burden of disease by malaria and reverse the recent resurgence of cases [ 1 – 3 ]. Plasmodium falciparum sporozoites (SPZ), the infective form of malaria, are considered a key target for …

Artemisinin-based combination therapy (ACT) remains a treatment of choice for uncomplicated Plasmodium falciparum malaria globally [ 1 , 2 ]. Six artemisinin-based combinations have been pre-qualified by the World Health Organization (WHO) for …

Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be …

Pathogen genomics is revolutionizing public health by providing a rich data source for informing real-time, actionable recommendations for public health programmes [ 1 ]. Each pathogen genome is a unique record of its previous transmission history …

Plasmodium falciparum presents a significant public health challenge in sub-Saharan Africa (SSA), constituting the majority of reported malaria cases. In 2022, out of the 249 million malaria cases recorded globally, 233 million occurred in SSA …

Anti-malarial drugs, particularly artemisinin-based combinations, are recommended and widely used for effective case management, but drug resistance is a major threat that has impacted their effectiveness for malaria control and elimination. The …

Malaria is one of the most important vector-borne diseases of humans with an estimated 241 million cases worldwide in 2020, being Africa the region that recorded the 95% of the malaria cases and the 96% of deaths worldwide [ 1 ]. A huge effort was …

Efficacious antimalarial drugs are mainstays of malaria control and elimination programs. Widespread resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) led to the adoption of artemisinin-based combination therapy (ACT) as the first- …

Malaria continues to be one of the most serious infectious diseases worldwide. There were an estimated 247 million cases of malaria and 619,000 malaria deaths worldwide in 2021, with sub-Saharan Africa bearing the highest proportions of cases [ 1 …

Malaria is a disease caused by infection with Plasmodium parasites, and global cases and deaths have declined substantially since 2000 [ 1 ], with 25 countries achieving zero locally acquired cases and many more approaching this significant …

Sri Lanka eliminated indigenous malaria in 2012, and was certified as a malaria free country in 2016. The conducive tropical environment still facilitates the perennial breeding of the major vector of malaria, Anopheles culicifacies , in many parts …

The emergence and spread of artemisinin partial resistance in East and Horn of Africa is alarming. However, artemisinin-based combination therapy (ACT) generally remains efficacious for the treatment of falciparum malaria. The emergence of partial …

Female Anopheles mosquitoes can carry Plasmodium protozoan parasites, some of which transmit to humans. The majority of malaria caused by Plasmodium falciparum and Plasmodium vivax occurs in Africa. Between 2010 and 2017, there was a noticeable …

Malaria is still a major cause of illness in about 85 countries worldwide, with an estimated 249 million cases in 2022 [ 1 ]. Globally, malaria cases have increased by 7.39% from the baseline year of the Global Technical Strategy for malaria …

Malaria continues to be a significant public health challenge in several parts of the world, where it is responsible for a high burden of morbidity and mortality [ 1 , 2 ]. Despite the impact of standard control interventions, asymptomatic …

One of the major obstacles to malaria elimination in the world is the resistance in Plasmodium falciparum to most antimalarial drugs. This study aimed to estimate the prevalence of molecular markers of antimalarial drugs resistance in Côte …

Malaria remains a public health problem in Uganda [ 1 ]. Transmission occurs throughout the year with peak transmission occurring between in May–June and November–December. Although the entire population remains at risk of malaria infections …