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Pulmonary Hypertension 

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  1. Open Access 01.12.2024 | OriginalPaper

    Fractional exhaled nitric oxide in idiopathic pulmonary arterial hypertension and mixed connective tissue disease complicating pulmonary hypertension

    PH is a rare and progressive disease that can have several potential etiologies and is associated with respiratory and cardiovascular diseases. It is characterized by elevated lung vascular resistance, ultimately leading to premature death [ 1 ].

  2. Open Access 01.12.2024 | OriginalPaper

    Neutrophil extracellular traps promote proliferation of pulmonary smooth muscle cells mediated by CCDC25 in pulmonary arterial hypertension

    Pulmonary arterial hypertension (PAH) is a common clinical disease that affects at least 1% of the global population [ 1 , 2 ]. PAH is a heterogeneous clinical disease characterized by abnormally elevated pulmonary arterial pressure, which is …

  3. 24.04.2024 | Online First

    miR-210-5p Promotes Pulmonary Hypertension by Blocking ATP2A2

    Pulmonary hypertension is a chronic progressive and fatal disease. It is extremely disabling and lethal, with 1-, 3-, and 5-year survival rates of 88.2%, 72.2%, and 59.4%, respectively, and severely affects patients’ quality of life [ 1 ]. Despite …

  4. 15.04.2024 | Online First

    Is pulmonary hypertension protective against cardiac tamponade? A systematic review

    The presence of pulmonary hypertension (PH) may affect whether cardiac tamponade physiology develops from a pericardial effusion. Specifically, the increased intracardiac pressure and right ventricular hypertrophy associated with PH would …

  5. Open Access 01.12.2024 | Letter

    Effects of right ventricular remodeling in chronic thromboembolic pulmonary hypertension on the outcomes of balloon pulmonary angioplasty: a 2D-speckle tracking echocardiography study

    Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe disease characterized by obstructive pulmonary artery remodeling due to insoluble embolus or repeated embolization of a thrombus in proximal or distal arteries [ 1 ]. Long-term …

  6. Open Access 01.12.2024 | OriginalPaper

    Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in pulmonary arterial hypertension

    Pulmonary arterial hypertension (PAH) is a fatal pulmonary vascular disease which is marked by elevated pressure and the failure of the right ventricle [ 1 , 2 ]. Despite the significant progress in enhancing survival through the advancement of …

  7. Open Access 22.03.2024 | ReviewPaper

    Future Perspectives of Pulmonary Arterial Hypertension: A Review of Novel Pipeline Treatments and Indications

    Pulmonary arterial hypertension is characterized by elevated blood pressure and pathological changes in the pulmonary arterioles, leading to the development of right-heart failure and potentially fatal outcomes if left untreated. This review aims …

  8. 27.03.2024 | Online First

    Echocardiographic estimation of right ventricular diastolic stiffness based on pulmonary regurgitant velocity waveform analysis in precapillary pulmonary hypertension

    Right ventricular (RV) diastolic stiffness is an independent predictor of survival and is strongly associated with disease severity in patients with precapillary pulmonary hypertension (PH). Therefore, a fully validated echocardiographic method …

  9. Open Access 01.12.2024 | ReviewPaper

    Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension

    Inflammation and immune processes underlie pulmonary hypertension progression. Two main different activated phenotypes of macrophages, classically activated M1 macrophages and alternatively activated M2 macrophages, are both involved in …

  10. Open Access 15.04.2024 | Online First

    Frequency, characteristics and risk assessment of pulmonary arterial hypertension with a left heart disease phenotype

    A growing number of patients diagnosed with pulmonary arterial hypertension (PAH) has features suggestive of concomitant left heart disease (LHD), albeit not clinically overt, nor sufficient to cause an elevation in pulmonary artery wedge pressure …

  11. Open Access 01.12.2024 | OriginalPaper

    Causal impact of gut microbiota and associated metabolites on pulmonary arterial hypertension: a bidirectional Mendelian randomization study

  12. 22.03.2024 | Online First

    Semi-Quantitative Analysis of Lung Perfusion SPECT/CT for Evaluation of Response to Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension

    Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pre-capillary pulmonary hypertension classified as a World Health Organization (WHO) group IV pulmonary hypertension, and is considered to be the only curable form of pulmonary

  13. 13.03.2024 | ReviewPaper

    Improvement in Pulmonary Hypertension Following Metabolic and Bariatric Surgery: a Brief Review and Meta-analysis

    We reviewed the available evidence on the outcome of metabolic and bariatric surgery (MBS) in patients with pulmonary hypertension (PH). Five studies examining 174 patients were included; the mean age was 54.5 ± 9.27 years; the mean BMI before …

  14. Open Access 12.03.2024 | OriginalPaper

    Occurrence of hyperoxia during iNO treatment for persistent pulmonary hypertension of the newborn: a cohort study

    High concentrations of oxygen are often needed to optimize oxygenation in infants with persistent pulmonary hypertension (PPHN), but this can also increase the risk of hyperoxemia. We determined the occurrence of hyperoxemia in infants treated for …

  15. Open Access 01.12.2024 | OriginalPaper

    Serum PM20D1 levels in patients with idiopathic pulmonary arterial hypertension and its clinical significance

    Pulmonary Arterial Hypertension (PAH) is a serious pulmonary vascular disease characterized by elevated resting mean pulmonary arterial pressure (mPAP) [ 1 ]. PAH affects the function of pulmonary arteries and pulmonary capillaries, leading to …

  16. 18.04.2024 | Online First

    When pulmonary arterial hypertension complicates connective tissue diseases: we still have not found what we are looking for

  17. Open Access 20.02.2024 | OriginalPaper

    Treatment of pulmonary arterial hypertension in patients with connective tissue diseases: a systematic review and meta-analysis

    The evidence for the treatment of connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) mostly depends on subgroup or post hoc analysis of randomized controlled trials (RCTs). Thus, we performed a meta-analysis of RCTs …

  18. Open Access 02.04.2024 | Online First

    Impact of pulmonary hypertension on outcomes after TEER in patients suffering from mitral regurgitation

    Transcatheter edge-to-edge repair of the mitral valve (M-TEER) has emerged as a safe and less invasive therapeutic alternative in patients with severe mitral regurgitation and at high-risk for surgical mitral valve repair [ 1 – 4 ]. M-TEER is an …

  19. 01.04.2024 | Online First

    Management of Pulmonary Hypertension in the Context of Heart Failure with Preserved Ejection Fraction

    Heart failure with preserved ejection fraction (HFpEF) is at least as common as heart failure with reduced ejection fraction (HFrEF) and generally carries a similar prognosis with a high burden of morbidity and mortality [ 1 ]. The prevalence of …

  20. Open Access 01.12.2024 | OriginalPaper

    Unusual cause of muscle weakness, type II respiratory failure and pulmonary hypertension: a case report of ryanodine receptor type 1(RYR1)-related myopathy

    Congenital myopathies, a group of rare inherited muscle diseases characterized by abnormalities in the structure of muscle fibers, vary in their clinical presentation, histopathology, and genetic causes [ 1 ]. Common clinical features of congenital …

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Cor pulmonale (akut und chronisch) – Begutachtung

Die Ärztliche Begutachtung
Das chronische Cor pulmonale ist definiert als kardiale Dysfunktion bei pulmonaler Hypertonie. Eine pulmonale Hypertonie liegt nach der Definition der European Society of Cardiology vor, wenn ein pulmonaler Mitteldruck in Ruhe von 25 mmHg oder bei Belastung von 30 mmHg überschritten wird. Ätiologie und Pathophysiologie sind heterogen: Bei Vorliegen von Erkrankungen der Lungen oder des Thorax sowie von Störungen der pulmonalen Ventilation oder des Lungenkreislaufs entwickeln sich sekundär morphologische (Vergrößerung, Hypertrophie) und funktionelle Veränderungen (u. U. eingeschränkte Wandbewegungen) des rechten Ventrikels. Primäre Linksherzerkrankung und Herzklappenfehler sind definitionsgemäß ausgeschlossen.

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