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Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 3/2007

01.03.2007 | Concise Article

Two outbreaks of acute hemorrhagic conjunctivitis in Africa due to genotype III coxsackievirus A24 variant

verfasst von: N. Lévêque, I. L. Amine, G. Cartet, A. B. Hammani, Y. C. Khazraji, B. Lina, J. J. Muyembe, H. Norder, J. J. Chomel

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 3/2007

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Abstract

Reported here are two outbreaks of acute hemorrhagic conjunctivitis that occurred in the Democratic Republic of the Congo and in Morocco in the summers of 2003 and 2004, respectively, with a large impact on public health. Virus was isolated from the conjunctival swabs of 30 Congolese and 20 Moroccan patients. Enterovirus-specific cytopathic effect was observed in all samples. None of the strains could be typed using a conventional neutralization assay with the Melnick intersecting pools; however, by sequencing the VP1 region, the viruses could be identified as coxsackie A24 variants. Phylogenetic analysis of the 3C protease region revealed that these strains were closely related to each other as well as to genotype III isolates detected in Korea in 2002, thus proving their worldwide spread. This is the first report of an epidemic of acute hemorrhagic conjunctivitis due to a coxsackievirus A24 variant in Africa since 1987 and the first ever from Morocco.
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Metadaten
Titel
Two outbreaks of acute hemorrhagic conjunctivitis in Africa due to genotype III coxsackievirus A24 variant
verfasst von
N. Lévêque
I. L. Amine
G. Cartet
A. B. Hammani
Y. C. Khazraji
B. Lina
J. J. Muyembe
H. Norder
J. J. Chomel
Publikationsdatum
01.03.2007
Verlag
Springer-Verlag
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 3/2007
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-007-0265-9

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