Skip to main content
Erschienen in: Langenbeck's Archives of Surgery 1/2024

01.12.2024 | Brief Report

Anal incontinence after obstetrical anal sphincter injury significantly impacts quality of life for women: a cohort study

verfasst von: Emeline Rebmann, Jean-Francois Hamel, Candice Helbert, Florine Lemasson, Guillaume Legendre, Aurélien Venara

Erschienen in: Langenbeck's Archives of Surgery | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To assess the prevalence of anal incontinence (AI) after obstetrical anal sphincter injuries (OASIS) and its severity, as well as the risk factors for AI and AI episodes ≥ 6 months.

Methods

This prospective and observational monocentric cohort study included all the women who had an OASIS between 1 January 2005 and 31 December 2019. Information was collected by using a letter informing for the fecal incontinence quality of life (FIQL) questionnaire and by a phone interview. The main outcome measure was “1 passed or ongoing episode of AI”.

Results

Among the 227 patients included, 19.8% had ongoing AI, and 35.2% had AI passed or ongoing episodes. A total of 46.7% of women with AI reported a change in their quality of life in all fields of the FIQL. Excluding a history of inflammatory bowel disease, no factor was associated with the incidence of an AI episode.
Post-obstetrical AI ≥ 6 months (POAI ≥ 6) represented 63.7% of AI cases. This incontinence began with significant incidence in the immediate postpartum period but increased over time, unlike AI < 6 months, which appeared primarily in the immediate postpartum period. Instrumental birth was a protective factor for POAI ≥ 6 (OR = 0.24; CI 95% [0.08–0.78]; p = 0.016), while an increase in parity and BMI were risk factors for POAI ≥ 6 (OR = 4.21; CI 95% [1.01–17.71]; p = 0.05 and OR = 1.15; CI 95% [1.03–1.30]; p = 0.016, respectively).

Conclusion

The prevalence of AI after OASIS is not underestimated. Despite the fact that women do not seek care, the impact of AI on the quality of life is significant. A case of AI that lasts for 6 months after giving birth risks becoming chronic. Therefore, specialist advice should be recommended in this case.

Clinical trial registry

NCT04940494.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Ng KS, Sivakumaran Y, Nassar N, Gladman MA (2015) Fecal incontinence: community prevalence and associated factors–a systematic review. Dis Colon Rectum 58:1194–1209CrossRefPubMed Ng KS, Sivakumaran Y, Nassar N, Gladman MA (2015) Fecal incontinence: community prevalence and associated factors–a systematic review. Dis Colon Rectum 58:1194–1209CrossRefPubMed
2.
Zurück zum Zitat Pretlove SJ, Radley S, Toozs-Hobson PM, Thompson PJ, Coomarasamy A, Khan KS (2006) Prevalence of anal incontinence according to age and gender: a systematic review and meta-regression analysis. Int Urogynecol J Pelvic Floor Dysfunct 17(4):407–417CrossRefPubMed Pretlove SJ, Radley S, Toozs-Hobson PM, Thompson PJ, Coomarasamy A, Khan KS (2006) Prevalence of anal incontinence according to age and gender: a systematic review and meta-regression analysis. Int Urogynecol J Pelvic Floor Dysfunct 17(4):407–417CrossRefPubMed
3.
Zurück zum Zitat Sharma A, Yuan L, Marshall RJ, Merrie AE, Bissett IP (2016) Systematic review of the prevalence of faecal incontinence. Br J Surg 103:1589–1597CrossRefPubMed Sharma A, Yuan L, Marshall RJ, Merrie AE, Bissett IP (2016) Systematic review of the prevalence of faecal incontinence. Br J Surg 103:1589–1597CrossRefPubMed
4.
Zurück zum Zitat Richter HE, Nager CW, Burgio KL, Whitworth R, Weidner AC, Schaffer J, Zyczynski HM, Norton P, Jelovsek JE, Meikle SF, Spino C, Gantz M, Graziano S, Brubaker L, Pelvic Floor Disorders Network NICHD (2015) Incidence and predictors of anal incontinence after obstetric anal sphincter injury in primiparous women. Female Pelvic Med Reconstr Surg 21(4):182–189CrossRefPubMedPubMedCentral Richter HE, Nager CW, Burgio KL, Whitworth R, Weidner AC, Schaffer J, Zyczynski HM, Norton P, Jelovsek JE, Meikle SF, Spino C, Gantz M, Graziano S, Brubaker L, Pelvic Floor Disorders Network NICHD (2015) Incidence and predictors of anal incontinence after obstetric anal sphincter injury in primiparous women. Female Pelvic Med Reconstr Surg 21(4):182–189CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Desseauve D, Proust S, Carlier-Guerin C, Rutten C, Pierre F, Fritel X (2016) Evaluation of long-term pelvic floor symptoms after an obstetric anal sphincter injury (OASI) at least one year after delivery: a retrospective cohort study of 159 cases. Gynecol Obstet Fertil 44(7–8):385–390CrossRefPubMed Desseauve D, Proust S, Carlier-Guerin C, Rutten C, Pierre F, Fritel X (2016) Evaluation of long-term pelvic floor symptoms after an obstetric anal sphincter injury (OASI) at least one year after delivery: a retrospective cohort study of 159 cases. Gynecol Obstet Fertil 44(7–8):385–390CrossRefPubMed
6.
Zurück zum Zitat Jangö H, Langhoff-Roos J, Rosthøj S, Saske A (2018) Long-term anal incontinence after obstetric anal sphincter injury-does grade of tear matter? Am J Obstet Gynecol 218:232.e1-232.e10CrossRefPubMed Jangö H, Langhoff-Roos J, Rosthøj S, Saske A (2018) Long-term anal incontinence after obstetric anal sphincter injury-does grade of tear matter? Am J Obstet Gynecol 218:232.e1-232.e10CrossRefPubMed
7.
Zurück zum Zitat Mous M, Muller SA, de Leeuw JW (2008) Long-term effects of anal sphincter rupture during vaginal delivery: faecal incontinence and sexual complaints. BJOG 115(2):234–238CrossRefPubMed Mous M, Muller SA, de Leeuw JW (2008) Long-term effects of anal sphincter rupture during vaginal delivery: faecal incontinence and sexual complaints. BJOG 115(2):234–238CrossRefPubMed
8.
Zurück zum Zitat Viannay P, de la Codre F, Brochard C, Thubert T, Meurette G, Legendre G, Venara A (2021) Management and consequences of obstetrical anal sphincter injuries: review. J Visc Surg 158:231–241CrossRefPubMed Viannay P, de la Codre F, Brochard C, Thubert T, Meurette G, Legendre G, Venara A (2021) Management and consequences of obstetrical anal sphincter injuries: review. J Visc Surg 158:231–241CrossRefPubMed
9.
Zurück zum Zitat Faltin DL, Sangalli MR, Curtin F, Morabia A, Weil A (2001) Prevalence of anal incontinence and other anorectal symptoms in women. Int Urogynecol J Pelvic Floor Dysfunct 12:117–120 (discussion 121)CrossRefPubMed Faltin DL, Sangalli MR, Curtin F, Morabia A, Weil A (2001) Prevalence of anal incontinence and other anorectal symptoms in women. Int Urogynecol J Pelvic Floor Dysfunct 12:117–120 (discussion 121)CrossRefPubMed
10.
Zurück zum Zitat Blondel B, Alexander S, Bjarnadóttir RI, Gissler M, Langhoff-Roos J, Novak-Antolič Ž, Prunet C, Zhang WH, Hindori-Mohangoo AD, Zeitlin J, Euro-peristat scientific committee, (2016) variations in rates of severe perineal tears and episiotomies in 20 European countries: a study based on routine national data in Euro-Peristat Project. Acta Obstet Gynecol Scand 95(7):746–754CrossRefPubMed Blondel B, Alexander S, Bjarnadóttir RI, Gissler M, Langhoff-Roos J, Novak-Antolič Ž, Prunet C, Zhang WH, Hindori-Mohangoo AD, Zeitlin J, Euro-peristat scientific committee, (2016) variations in rates of severe perineal tears and episiotomies in 20 European countries: a study based on routine national data in Euro-Peristat Project. Acta Obstet Gynecol Scand 95(7):746–754CrossRefPubMed
11.
Zurück zum Zitat McLeod NL, Gilmour DT, Joseph KS, Farrell SA, Luther ER (2003) Trends in major risk factors for anal sphincter lacerations: a 10-year study. J Obstet Gynaecol Can 25(7):586–593CrossRefPubMed McLeod NL, Gilmour DT, Joseph KS, Farrell SA, Luther ER (2003) Trends in major risk factors for anal sphincter lacerations: a 10-year study. J Obstet Gynaecol Can 25(7):586–593CrossRefPubMed
12.
Zurück zum Zitat Dudding TC, Vaizey CJ, Kamm MA (2008) Obstetric anal sphincter injury: incidence, risk factors, and management. Ann Surg 247:224–237CrossRefPubMed Dudding TC, Vaizey CJ, Kamm MA (2008) Obstetric anal sphincter injury: incidence, risk factors, and management. Ann Surg 247:224–237CrossRefPubMed
13.
Zurück zum Zitat Gurol-Urganci I, Cromwell DA, Edozien LC, Mahmood TA, Adams EJ, Richmond DH, Templeton A, van der Meulen JH (2013) Third- and fourth-degree perineal tears among primiparous women in England between 2000 and 2012: time trends and risk factors. BJOG 120:1516–1525CrossRefPubMed Gurol-Urganci I, Cromwell DA, Edozien LC, Mahmood TA, Adams EJ, Richmond DH, Templeton A, van der Meulen JH (2013) Third- and fourth-degree perineal tears among primiparous women in England between 2000 and 2012: time trends and risk factors. BJOG 120:1516–1525CrossRefPubMed
14.
Zurück zum Zitat de Vogel J, van der Leeuw-van BA, Gietelink D, Vujkovic M, de Leeuw JW, van Bavel J, Papatsonis D (2012) The effect of a mediolateral episiotomy during operative vaginal delivery on the risk of developing obstetrical anal sphincter injuries. Am J Obstet Gynecol 206(5):404.e1–5CrossRefPubMed de Vogel J, van der Leeuw-van BA, Gietelink D, Vujkovic M, de Leeuw JW, van Bavel J, Papatsonis D (2012) The effect of a mediolateral episiotomy during operative vaginal delivery on the risk of developing obstetrical anal sphincter injuries. Am J Obstet Gynecol 206(5):404.e1–5CrossRefPubMed
15.
Zurück zum Zitat Huebner M, Gramlich NK, Rothmund R, Nappi L, Abele H, Becker S (2013) Fecal incontinence after obstetric anal sphincter injuries. Int J Gynaecol Obstet 121(1):74–77CrossRefPubMed Huebner M, Gramlich NK, Rothmund R, Nappi L, Abele H, Becker S (2013) Fecal incontinence after obstetric anal sphincter injuries. Int J Gynaecol Obstet 121(1):74–77CrossRefPubMed
16.
Zurück zum Zitat Harvey MA, Pierce M, Alter JE, Chou Q, Diamond P, Epp A, Geoffrion R, Harvey MA, Larochelle A, Maslow K, Neustaedter G, Pascali D, Pierce M, Schulz J, Wilkie D, Sultan A, Thakar R, Society of Obstetricians and Gynaecologists of Canada (2015) Obstetrical anal sphincter injuries (OASIS): prevention, recognition, and repair. J Obstet Gynaecol Can 37(12):1131–48CrossRefPubMed Harvey MA, Pierce M, Alter JE, Chou Q, Diamond P, Epp A, Geoffrion R, Harvey MA, Larochelle A, Maslow K, Neustaedter G, Pascali D, Pierce M, Schulz J, Wilkie D, Sultan A, Thakar R, Society of Obstetricians and Gynaecologists of Canada (2015) Obstetrical anal sphincter injuries (OASIS): prevention, recognition, and repair. J Obstet Gynaecol Can 37(12):1131–48CrossRefPubMed
19.
Zurück zum Zitat Deutekom M, Terra MP, Dobben AC, Dijkgraaf MG, Felt-Bersma RJ, Stoker J, Bossuyt PM (2005) Selecting an outcome measure for evaluating treatment in fecal incontinence. Dis Colon Rectum 48(12):2294–2301CrossRefPubMed Deutekom M, Terra MP, Dobben AC, Dijkgraaf MG, Felt-Bersma RJ, Stoker J, Bossuyt PM (2005) Selecting an outcome measure for evaluating treatment in fecal incontinence. Dis Colon Rectum 48(12):2294–2301CrossRefPubMed
20.
Zurück zum Zitat Patton V, Chen CM, Lubowski D (2015) Long-term results of the cutting seton for high anal fistula. ANZ J Surg 85(10):720–727CrossRefPubMed Patton V, Chen CM, Lubowski D (2015) Long-term results of the cutting seton for high anal fistula. ANZ J Surg 85(10):720–727CrossRefPubMed
21.
Zurück zum Zitat Maeda Y, Parés D, Norton C, Vaizey CJ, Kamm MA (2008) Does the St. Mark’s incontinence score reflect patients’ perceptions? A review of 390 patients. Dis Colon Rectum 51(4):436–42CrossRefPubMed Maeda Y, Parés D, Norton C, Vaizey CJ, Kamm MA (2008) Does the St. Mark’s incontinence score reflect patients’ perceptions? A review of 390 patients. Dis Colon Rectum 51(4):436–42CrossRefPubMed
22.
Zurück zum Zitat Bols EM, Hendriks HJ, Berghmans LC, Baeten CG, de Bie RA (2013) Responsiveness and interpretability of incontinence severity scores and FIQL in patients with fecal incontinence: a secondary analysis from a randomized controlled trial. Int Urogynecol J 24(3):469–478CrossRefPubMed Bols EM, Hendriks HJ, Berghmans LC, Baeten CG, de Bie RA (2013) Responsiveness and interpretability of incontinence severity scores and FIQL in patients with fecal incontinence: a secondary analysis from a randomized controlled trial. Int Urogynecol J 24(3):469–478CrossRefPubMed
23.
Zurück zum Zitat Roos AM, Sultan AH, Thakar R (2009) St. Mark’s incontinence score for assessment of anal incontinence following obstetric anal sphincter injuries (OASIS). Int Urogynecol J Pelvic Floor Dysfunct 20(4):407–10CrossRefPubMed Roos AM, Sultan AH, Thakar R (2009) St. Mark’s incontinence score for assessment of anal incontinence following obstetric anal sphincter injuries (OASIS). Int Urogynecol J Pelvic Floor Dysfunct 20(4):407–10CrossRefPubMed
24.
Zurück zum Zitat Gu P, Kuenzig ME, Kaplan GG, Pimentel M, Rezaie A (2018) Fecal incontinence in inflammatory bowel disease: a systematic review and meta-analysis. Inflamm Bowel Dis 24(6):1280–1290CrossRefPubMed Gu P, Kuenzig ME, Kaplan GG, Pimentel M, Rezaie A (2018) Fecal incontinence in inflammatory bowel disease: a systematic review and meta-analysis. Inflamm Bowel Dis 24(6):1280–1290CrossRefPubMed
25.
Zurück zum Zitat Roos AM, Thakar R, Sultan AH (2010) Outcome of primary repair of obstetric anal sphincter injuries (OASIS): does the grade of tear matter? Ultrasound Obstet Gynecol 36(3):368–374CrossRefPubMed Roos AM, Thakar R, Sultan AH (2010) Outcome of primary repair of obstetric anal sphincter injuries (OASIS): does the grade of tear matter? Ultrasound Obstet Gynecol 36(3):368–374CrossRefPubMed
26.
Zurück zum Zitat Prager M, Andersson KL, Stephansson O, Marchionni M, Marions L (2008) The incidence of obstetric anal sphincter rupture in primiparous women: a comparison between two European delivery settings. Acta Obstet Gynecol Scand 87(2):209–215CrossRefPubMed Prager M, Andersson KL, Stephansson O, Marchionni M, Marions L (2008) The incidence of obstetric anal sphincter rupture in primiparous women: a comparison between two European delivery settings. Acta Obstet Gynecol Scand 87(2):209–215CrossRefPubMed
27.
Zurück zum Zitat Gommesen D, Nohr EA, Qvist N, Rasch V (2020) Obstetric perineal ruptures-risk of anal incontinence among primiparous women 12 months postpartum: a prospective cohort study. Am J Obstet Gynecol 222(2):165.e1-165.e11CrossRefPubMed Gommesen D, Nohr EA, Qvist N, Rasch V (2020) Obstetric perineal ruptures-risk of anal incontinence among primiparous women 12 months postpartum: a prospective cohort study. Am J Obstet Gynecol 222(2):165.e1-165.e11CrossRefPubMed
28.
Zurück zum Zitat Hjertberg L, Pihl S, Blomberg M, Uustal E (2022) Body mass index and complications after obstetric anal sphincter injury, 8 weeks postpartum. Int Urogynecol J 33:3465–3472CrossRefPubMedPubMedCentral Hjertberg L, Pihl S, Blomberg M, Uustal E (2022) Body mass index and complications after obstetric anal sphincter injury, 8 weeks postpartum. Int Urogynecol J 33:3465–3472CrossRefPubMedPubMedCentral
29.
Zurück zum Zitat Gabra MG, Tessier KM, Fok CS, Nakib N, Oestreich MC, Fischer J (2022) Pelvic organ prolapse and anal incontinence in women: screening with a validated epidemiology survey. Arch Gynecol Obstet 306(3):779–784CrossRefPubMedPubMedCentral Gabra MG, Tessier KM, Fok CS, Nakib N, Oestreich MC, Fischer J (2022) Pelvic organ prolapse and anal incontinence in women: screening with a validated epidemiology survey. Arch Gynecol Obstet 306(3):779–784CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Johannessen HH, Stafne SN, Falk RS, Stordahl A, Wibe A, Mørkved S (2019) Prevalence and predictors of anal incontinence 6 years after first delivery », Neurourol. Urodyn 38:310–319CrossRef Johannessen HH, Stafne SN, Falk RS, Stordahl A, Wibe A, Mørkved S (2019) Prevalence and predictors of anal incontinence 6 years after first delivery », Neurourol. Urodyn 38:310–319CrossRef
31.
Zurück zum Zitat Erekson EA, Sung SW, Myers DL (2008) Effect of body mass index on the risk of anal incontinence and defecatory dysfunction in women. Am J Obstet Gynecol 198:596.e1-596.e4CrossRefPubMed Erekson EA, Sung SW, Myers DL (2008) Effect of body mass index on the risk of anal incontinence and defecatory dysfunction in women. Am J Obstet Gynecol 198:596.e1-596.e4CrossRefPubMed
32.
Zurück zum Zitat Sideris M, McCaughey T, Hanrahan JG, Arroyo-Manzano D, Zamora J, Jha S et al (2020) Risk of obstetric anal sphincter injuries (OASIS) and anal incontinence: a meta-analysis. Eur J Obstet Gynecol Reprod Biol 252:303–312CrossRefPubMed Sideris M, McCaughey T, Hanrahan JG, Arroyo-Manzano D, Zamora J, Jha S et al (2020) Risk of obstetric anal sphincter injuries (OASIS) and anal incontinence: a meta-analysis. Eur J Obstet Gynecol Reprod Biol 252:303–312CrossRefPubMed
33.
Zurück zum Zitat Corbière L, Legendre G, Gaborieau L, Bedouet A, Corroënne R, Venara A (2022) Acceptabilité et résultats de la consultation proctologique du post-partum après une lésion obstétricale du sphincter anal [Acceptability and results of postpartum proctological consultation for women who have had an obstetric injury of the anal sphincter]. Gynecol Obstet Fertil Senol 50(4):291–297PubMed Corbière L, Legendre G, Gaborieau L, Bedouet A, Corroënne R, Venara A (2022) Acceptabilité et résultats de la consultation proctologique du post-partum après une lésion obstétricale du sphincter anal [Acceptability and results of postpartum proctological consultation for women who have had an obstetric injury of the anal sphincter]. Gynecol Obstet Fertil Senol 50(4):291–297PubMed
Metadaten
Titel
Anal incontinence after obstetrical anal sphincter injury significantly impacts quality of life for women: a cohort study
verfasst von
Emeline Rebmann
Jean-Francois Hamel
Candice Helbert
Florine Lemasson
Guillaume Legendre
Aurélien Venara
Publikationsdatum
01.12.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
Langenbeck's Archives of Surgery / Ausgabe 1/2024
Print ISSN: 1435-2443
Elektronische ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-024-03257-4

Weitere Artikel der Ausgabe 1/2024

Langenbeck's Archives of Surgery 1/2024 Zur Ausgabe

Vorsicht, erhöhte Blutungsgefahr nach PCI!

10.05.2024 Koronare Herzerkrankung Nachrichten

Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Deutlich weniger Infektionen: Wundprotektoren schützen!

08.05.2024 Postoperative Wundinfektion Nachrichten

Der Einsatz von Wundprotektoren bei offenen Eingriffen am unteren Gastrointestinaltrakt schützt vor Infektionen im Op.-Gebiet – und dient darüber hinaus der besseren Sicht. Das bestätigt mit großer Robustheit eine randomisierte Studie im Fachblatt JAMA Surgery.

Chirurginnen und Chirurgen sind stark suizidgefährdet

07.05.2024 Suizid Nachrichten

Der belastende Arbeitsalltag wirkt sich negativ auf die psychische Gesundheit der Angehörigen ärztlicher Berufsgruppen aus. Chirurginnen und Chirurgen bilden da keine Ausnahme, im Gegenteil.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.