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Inflammation Research
Erschienen in: Inflammation Research 12/2015

01.12.2015 | Original Research Paper

Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo

verfasst von: Hyejin Kang, Sae-Kwang Ku, Byeongjin Jung, Jong-Sup Bae

Erschienen in: Inflammation Research | Ausgabe 12/2015

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Abstract

Aim and objective

Two structurally related flavonoids found in Cyclopia subternata, namely vicenin-2 and scolymoside, were examined for its effects on inflammatory responses by monitoring the effects of vicenin-2 and scolymoside on lipopolysaccharide (LPS)-mediated vascular inflammatory responses.

Methods

The anti-inflammatory activities of vicenin-2 and scolymoside were determined by measuring permeability, monocytes adhesion and migration, and activation of pro-inflammatory proteins in LPS-activated HUVECs and mice.

Results

We found that post-treatment of each compound inhibited LPS-induced barrier disruption, expression of cell adhesion molecules (CAMs), and adhesion/transendothelial migration of human neutrophils to human endothelial cells. Each compound induced potent inhibition of phorbol-12-myristate 13-acetate (PMA) and LPS-induced endothelial cell protein C receptor (EPCR) shedding. It also suppressed LPS-induced hyperpermeability and leukocytes migration in vivo. Furthermore, each compound suppressed the production of tumor necrosis factor-α (TNF-α) or Interleukin (IL)-6 and the activation of nuclear factor-κB (NF-κB) or extracellular regulated kinases (ERK) 1/2 by LPS. Moreover, post-treatment with each compound resulted in reduced LPS-induced lethal endotoxemia.

Conclusion

Vicenin-2 and scolymoside possess anti-inflammatory functions by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.
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Metadaten
Titel
Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo
verfasst von
Hyejin Kang
Sae-Kwang Ku
Byeongjin Jung
Jong-Sup Bae
Publikationsdatum
01.12.2015
Verlag
Springer Basel
Erschienen in
Inflammation Research / Ausgabe 12/2015
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-015-0886-x

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