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Erschienen in: Current Geriatrics Reports 4/2020

18.11.2020 | Geriatric Orthopedics (C Quatman and C Quatman-Yates, Section Editors)

Anticoagulation Management in Geriatric Orthopedic Trauma Patients

verfasst von: Jensa C. Morris, Mary I. O’Connor

Erschienen in: Current Geriatrics Reports | Ausgabe 4/2020

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Abstract

Purpose of Review

This article will review the perioperative management of geriatric patients on anticoagulants who present for non-elective orthopedic surgery.

Recent Findings

Our understanding of best practices in perioperative anticoagulation management has advanced significantly over the last 5 years. More patients are presenting for surgery on direct oral anticoagulants which require a different approach than the vitamin K antagonist, warfarin. We have come to better appreciate the importance of time to the operating room on outcomes, specifically in hip fracture surgery. Regional anesthesia now has standardized guidelines for preprocedure anticoagulation interruption. Prothrombin complex concentrate has increasing acceptance for warfarin reversal preoperatively. Reversal agents are now available for the direct oral anticoagulants but are not recommended for standard use preprocedure. And there has been a shift away from routine use of bridging anticoagulation periprocedure.

Summary

A team-based approach with input from the surgical, anesthesia, and internal medicine or geriatric team preoperatively is critical to the management of perioperative anticoagulation.
Literatur
1.
Zurück zum Zitat Peterson BE, Jiwanlal A, Della Rocca GJ, Crist BD. Orthopedic trauma and aging: it isn’t just about mortality. Geriatric Orthop Surg Rehab. 2015;6(1):33–6.CrossRef Peterson BE, Jiwanlal A, Della Rocca GJ, Crist BD. Orthopedic trauma and aging: it isn’t just about mortality. Geriatric Orthop Surg Rehab. 2015;6(1):33–6.CrossRef
2.
Zurück zum Zitat Ang D, Kurek S, McKenney M, Norwood S, Kimbrell B, Barquist E, et al. Outcomes of geriatric trauma patients on preinjury anticoagulation: a multicenter study. Am Surg. 2017;83:527–35.CrossRef Ang D, Kurek S, McKenney M, Norwood S, Kimbrell B, Barquist E, et al. Outcomes of geriatric trauma patients on preinjury anticoagulation: a multicenter study. Am Surg. 2017;83:527–35.CrossRef
3.
Zurück zum Zitat Dossett LA, Riesel JN, Griffin MR, Cotton BA. Prevalence and implications of preinjury warfarin use: an analysis of the National Trauma Databank. Arch Surg. 2011;146:565–70.CrossRef Dossett LA, Riesel JN, Griffin MR, Cotton BA. Prevalence and implications of preinjury warfarin use: an analysis of the National Trauma Databank. Arch Surg. 2011;146:565–70.CrossRef
4.
Zurück zum Zitat Caruso, G, Andreotti M, Tonon F, Corradi N, Rizzato D, Valentini A, Valpiani G, Massari L. The impact of warfarin on operative delay and 1-year mortality in elderly patients with hip fracture: a retrospective observational study. J Orthop Surg Res. 2019;14(169). https://doi.org/10.1186/s13018-019-1199-5. Caruso, G, Andreotti M, Tonon F, Corradi N, Rizzato D, Valentini A, Valpiani G, Massari L. The impact of warfarin on operative delay and 1-year mortality in elderly patients with hip fracture: a retrospective observational study. J Orthop Surg Res. 2019;14(169). https://​doi.​org/​10.​1186/​s13018-019-1199-5.
5.
Zurück zum Zitat Pincus D, Bheeshma R, Wasserstein D, Huang A, Paterson JM, Nathens AB, et al. Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA. 2017;318(20):1994–2003.CrossRef Pincus D, Bheeshma R, Wasserstein D, Huang A, Paterson JM, Nathens AB, et al. Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA. 2017;318(20):1994–2003.CrossRef
6.
Zurück zum Zitat Morrissey N, Iliopoulos E, Osmani AW, Newman K. Neck of femur fractures in the elderly: does every hour to surgery count. Injury. Int J Care Injured. 48:1155–8. Morrissey N, Iliopoulos E, Osmani AW, Newman K. Neck of femur fractures in the elderly: does every hour to surgery count. Injury. Int J Care Injured. 48:1155–8.
7.
Zurück zum Zitat Kim JL, Park JH, Han SB, Cho IY, Jang KM. Allogenic blood transfusion is a significant risk factor for surgical site infection following total hip and knee arthroplasty: a meta-analysis. Kim JL, Park JH, Han SB, Cho IY, Jang KM. Allogenic blood transfusion is a significant risk factor for surgical site infection following total hip and knee arthroplasty: a meta-analysis.
8.
Zurück zum Zitat Parvizi J, Azzam K, Rothman RH. Deep venous thrombosis prophylaxis for total joint arthroplasty: American Academy of Orthopaedic Surgeons guidelines. J Arthroplast. 2008;23(7 Suppl):2–5.CrossRef Parvizi J, Azzam K, Rothman RH. Deep venous thrombosis prophylaxis for total joint arthroplasty: American Academy of Orthopaedic Surgeons guidelines. J Arthroplast. 2008;23(7 Suppl):2–5.CrossRef
9.
Zurück zum Zitat Wellisz T. Management of bone bleeding during surgery and its impact on the incidence of post-operative osteomyelitis, osteomyelitis. In: Baptista, MS, Tardivo JP (eds) IntechOpen. 2012. https://doi.org/10.5772/31623 Wellisz T. Management of bone bleeding during surgery and its impact on the incidence of post-operative osteomyelitis, osteomyelitis. In: Baptista, MS, Tardivo JP (eds) IntechOpen. 2012. https://​doi.​org/​10.​5772/​31623
10.
Zurück zum Zitat Horlocker TT, Vandermeuelen E, Kopp SL, Gogarten W, Leffert LR, HT. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy. American Society of Regional Anesthesia and Pain Medicine evidence-based guidelines (fourth edition). Reg Anesth Pain Med. 2018;43:263–309.CrossRef Horlocker TT, Vandermeuelen E, Kopp SL, Gogarten W, Leffert LR, HT. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy. American Society of Regional Anesthesia and Pain Medicine evidence-based guidelines (fourth edition). Reg Anesth Pain Med. 2018;43:263–309.CrossRef
11.
Zurück zum Zitat Horlocker TT, Wedel DJ. Antcoagulation and neuraxial block: historical perspective, anesthetic implications, and risk management. Reg Anesth Pain Med. 1998;23:129–34.PubMed Horlocker TT, Wedel DJ. Antcoagulation and neuraxial block: historical perspective, anesthetic implications, and risk management. Reg Anesth Pain Med. 1998;23:129–34.PubMed
13.
Zurück zum Zitat Connolly SJ, Ezekowitz MD, Yusuf S, et al. RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(27):1139–51.CrossRef Connolly SJ, Ezekowitz MD, Yusuf S, et al. RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(27):1139–51.CrossRef
14.
Zurück zum Zitat Patel MR, Mahaffey KW, Garg J, et al. ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365(10):883–91.CrossRef Patel MR, Mahaffey KW, Garg J, et al. ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365(10):883–91.CrossRef
15.
Zurück zum Zitat Granger CB, Alexander JH, McMurray JJV, et al. ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981–92.CrossRef Granger CB, Alexander JH, McMurray JJV, et al. ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981–92.CrossRef
16.
Zurück zum Zitat Anderson M, Hassell K, Trujillo T, Wolfe B. When patients on target-specific oral anticoagulants need surgery. Cleve Clin J Med. 2014;81:629–39.CrossRef Anderson M, Hassell K, Trujillo T, Wolfe B. When patients on target-specific oral anticoagulants need surgery. Cleve Clin J Med. 2014;81:629–39.CrossRef
17.
Zurück zum Zitat Pabinger, I, Brenner B, Kalina U, Knaub S, Nagy A, Ostermann H. Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial. J Thromb Haemost. 2008; 6 (4):XXXX. Pabinger, I, Brenner B, Kalina U, Knaub S, Nagy A, Ostermann H. Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial. J Thromb Haemost. 2008; 6 (4):XXXX.
18.
Zurück zum Zitat Burk DR, Smith JL, Wild J. Prothrombin complex concentrates: an alternative to fresh frozen plasma. Orthopedics. 2017;40(2):e367–9.CrossRef Burk DR, Smith JL, Wild J. Prothrombin complex concentrates: an alternative to fresh frozen plasma. Orthopedics. 2017;40(2):e367–9.CrossRef
19.
Zurück zum Zitat Levy JH, Douketis J, Steiner T, Goldstein JN, Milling TJ. Prothrombin complex concentrates for perioperative vitamin K antagonist and non-vitamin K anticoagulant reversal. Anesthesiology. 2018;129(6):1171–84.CrossRef Levy JH, Douketis J, Steiner T, Goldstein JN, Milling TJ. Prothrombin complex concentrates for perioperative vitamin K antagonist and non-vitamin K anticoagulant reversal. Anesthesiology. 2018;129(6):1171–84.CrossRef
20.
Zurück zum Zitat Tao J, Bukanova EN, Akhtar S. Safety of 4-factor prothrombin complex concentrate (4F-PCC) for emergent reversal of factor Xa inhibitors. J Intensive Care. 2018;6:34.CrossRef Tao J, Bukanova EN, Akhtar S. Safety of 4-factor prothrombin complex concentrate (4F-PCC) for emergent reversal of factor Xa inhibitors. J Intensive Care. 2018;6:34.CrossRef
21.
Zurück zum Zitat Schulman S, Gross PL, Ritchie B, Nahirniak S, Lin Y, Lieberman L, et al. Prothrombin complex concentrate for major bleeding on factor Xa inhibitors: a prospective cohort study. Thromb Haemost. 2018;118(5):842–51.CrossRef Schulman S, Gross PL, Ritchie B, Nahirniak S, Lin Y, Lieberman L, et al. Prothrombin complex concentrate for major bleeding on factor Xa inhibitors: a prospective cohort study. Thromb Haemost. 2018;118(5):842–51.CrossRef
22.
Zurück zum Zitat Kim BH, Lee S, Yoo B, Lee WY, Lim Y, Kim MC, et al. Risk factors associated with outcomes of hip fracture surgery in elderly patients. Korean J Anaesthesiol. 2015;68(6):561–7.CrossRef Kim BH, Lee S, Yoo B, Lee WY, Lim Y, Kim MC, et al. Risk factors associated with outcomes of hip fracture surgery in elderly patients. Korean J Anaesthesiol. 2015;68(6):561–7.CrossRef
23.
Zurück zum Zitat Kilci O, Un C, Sacan O, Gamli M, Baskan S, Baydar M, et al. Postoperative mortality after hip gracture surgery: a 3 years follow up. PLoS One. 2016;11(10):e0162097.CrossRef Kilci O, Un C, Sacan O, Gamli M, Baskan S, Baydar M, et al. Postoperative mortality after hip gracture surgery: a 3 years follow up. PLoS One. 2016;11(10):e0162097.CrossRef
24.
Zurück zum Zitat Douketis JD, Spyropoulos AC, Kaatz SO, Becker RC, Caprini JA, Garcia DA, et al. Perioperative bridging anticoagulation in patients with atrial fibrillation. N Engl J Med. 2015;373:823–33.CrossRef Douketis JD, Spyropoulos AC, Kaatz SO, Becker RC, Caprini JA, Garcia DA, et al. Perioperative bridging anticoagulation in patients with atrial fibrillation. N Engl J Med. 2015;373:823–33.CrossRef
25.
Zurück zum Zitat Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, et al. Perioperative management of antithrombotic therapy: antithrombotic therapy and prevention of thrombosis. 9th edition: American College of Chest physicians evidence-based clinical practice guidelines. Chest. 2012;141:e326S–50S.CrossRef Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, et al. Perioperative management of antithrombotic therapy: antithrombotic therapy and prevention of thrombosis. 9th edition: American College of Chest physicians evidence-based clinical practice guidelines. Chest. 2012;141:e326S–50S.CrossRef
26.
Zurück zum Zitat Kearon C, Akl EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e419S–94S.CrossRef Kearon C, Akl EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e419S–94S.CrossRef
27.
Zurück zum Zitat Kaufman JA, Kinney TB, Streiff MB, Sing RF, Proctor MC, Becker D, et al. Guidelines for the use of retrievable and convertible vena cava filters: report from the Society of Interventional Radiology multidisciplinary consensus conference. J Vasc Interv Radiol. 2006;17:449–59.CrossRef Kaufman JA, Kinney TB, Streiff MB, Sing RF, Proctor MC, Becker D, et al. Guidelines for the use of retrievable and convertible vena cava filters: report from the Society of Interventional Radiology multidisciplinary consensus conference. J Vasc Interv Radiol. 2006;17:449–59.CrossRef
28.
Zurück zum Zitat Caplin DM, Nikolic B, Kalva SP, Ganguli S, Saad WE, Zuckerman DA, et al. Quality improvement guidelines for the performance of inferior vena cava filter placement for the prevention of pulmonary embolism. J Vasc Interv Radiol. 2011;22:1499–506.PubMed Caplin DM, Nikolic B, Kalva SP, Ganguli S, Saad WE, Zuckerman DA, et al. Quality improvement guidelines for the performance of inferior vena cava filter placement for the prevention of pulmonary embolism. J Vasc Interv Radiol. 2011;22:1499–506.PubMed
29.
Zurück zum Zitat Weinberg I, Abtahian F, Debiasi R, et al. Effect of delayed inferior vena cava filter retrieval after early initiation of anticoagulation. Am J Cardiol. 2014;113:389–94.CrossRef Weinberg I, Abtahian F, Debiasi R, et al. Effect of delayed inferior vena cava filter retrieval after early initiation of anticoagulation. Am J Cardiol. 2014;113:389–94.CrossRef
30.
Zurück zum Zitat Schulman S, Beyth RJ, Kearon C, Levine MN. Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):257S–98S.CrossRef Schulman S, Beyth RJ, Kearon C, Levine MN. Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):257S–98S.CrossRef
31.
Zurück zum Zitat Patti G, Lucerna M, De Caterina R, et al. Thromboembolic risk, bleeding outcomes and effect of different antithrombotic strategies in very elderly patients with atrial fibrillation: a sub- analysis from the PREFER in AF. Heart Assoc. 2017;e005657. https://doi.org/10.1161/JAHA.117.005657 Patti G, Lucerna M, De Caterina R, et al. Thromboembolic risk, bleeding outcomes and effect of different antithrombotic strategies in very elderly patients with atrial fibrillation: a sub- analysis from the PREFER in AF. Heart Assoc. 2017;e005657. https://​doi.​org/​10.​1161/​JAHA.​117.​005657
Metadaten
Titel
Anticoagulation Management in Geriatric Orthopedic Trauma Patients
verfasst von
Jensa C. Morris
Mary I. O’Connor
Publikationsdatum
18.11.2020
Verlag
Springer US
Erschienen in
Current Geriatrics Reports / Ausgabe 4/2020
Elektronische ISSN: 2196-7865
DOI
https://doi.org/10.1007/s13670-020-00345-3

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