Erschienen in:
23.12.2023 | ASO Author Reflections
ASO Author Reflections: Cancer-Associated Fibroblasts with Decreased CD8+ T Cells are Associated with a Poor Prognosis in the Treatment of Breast Cancer Patients
verfasst von:
Hyung Suk Kim, MD, PhD, Kyueng-Whan Min, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 3/2024
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Excerpt
Despite remarkable advancements in early detection and treatment modalities, breast cancer remains the leading cause of cancer-related death due to its heterogeneity, aggressiveness, and variable treatment response. The decline in breast cancer mortality rates has slowed in recent years. The tumor microenvironment plays a critical role in breast cancer progression and therapeutic resistance. Among the various components of the tumor microenvironment, cancer-associated fibroblasts (CAFs) have emerged as critical regulators of tumor biology.
1 CAFs, a distinctive subset of fibroblastic cells within the tumor stroma, exhibit a unique ability to enhance cancer cell invasion, metastasis, and immune evasion.
2 However, the intricate molecular mechanisms underlying carcinogenesis and the clinicopathological variances associated with CAF expression in breast cancer remain incompletely elucidated. Understanding the complex interplay between CAFs and breast cancer cells is crucial for the development of novel therapeutic strategies to effectively target the tumor microenvironment. We investigated the correlation between survival outcomes and relevant clinicopathologic parameters according to the presence of CAF in breast cancer patients. …
