nach oben

Irish Journal of Medical Science (1971 -)

Erschienen in:

29.09.2021 | Original Article

Assessment of BNP and BDNF results in elective endovascular cerebral aneurysm treatment

verfasst von: Abdullah Sukun, Bulent Cekic

Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 4/2022

Einloggen, um Zugang zu erhalten

Abstract

Background

B-type natriuretic peptide (BNP) levels increase with an increase in intracranial pressure. A decrease in BNP levels has been found to be associated with patient positive prognosis. Brain-derived neurotrophic factor (BDNF) levels decrease in patients with acute stroke.

Aims

To compare the BNP and BDNF values in serum before and after elective endovascular cerebral aneurysm treatment (ECAT).

Methods

A total of 50 patients who underwent elective ECAT were included in the study. Exclusion criteria were determined to be history of heart failure or heart attack (n = 8), renal failure (n = 5), subarachnoid hemorrhage (n = 4), or previous aneurysm clip procedure (n = 3). Intravenous blood samples were obtained from 30 patients who underwent elective ECAT before and after treatment. After centrifugation, the BNP and BDNF values in serum were obtained with the ELISA method and compared.

Results

This study included 19 female and 11 male patients, aged between 24 and 75 years. The average age of the patients was 51.27 ± 13.31 years. The median BDNF values did not change significantly after ECAT (before the endovascular procedure: 3.1 ± 1.3 pg/dl; after the endovascular procedure: 2.8 ± 0.9 pg/dl, p = 0.16). Median BNP levels decreased significantly after ECAT (before the endovascular procedure: 617.50 ± 483.11 pg/ml; after the endovascular procedure: 395.00 ± 352.15 pg/ml, p < 0.001).

Conclusions

After elective endovascular cerebral aneurysm treatment, the BNP values in serum decreased significantly, and the BDNF values in serum did not change significantly.

As M, Jm D, Wettersten N (2018) Natriuretic peptides in heart failure: atrial and B-type natriuretic peptides. Heart Fail Clin 14(1):13–25. https://doi.org/10.1016/J.Hfc.2017.08.002CrossRef

Sonoda H, Ohte N, Goto T et al (2012) Plasma N-terminal pro-brain natriuretic peptide levels identifying left ventricular diastolic dysfunction in patients with preserved ejection fraction. Circ J 76(11):2599–2605. https://doi.org/10.1253/Circj.Cj-12-0406CrossRefPubMed

Mueller C, Mcdonald K, Ra DB et al (2019) Heart failure association of the European society of cardiology practical guidance on the use of natriuretic peptide concentrations. Eur J Heart Fail 21(6):715–731. https://doi.org/10.1002/Ejhf.1494CrossRefPubMed

Kawamura Y, Inoue K, Sakai H et al (2012) Brain natriuretic peptide in subarachnoid hemorrhage. No Shinkei Geka Neurological Surgery 40(12):1065–1070PubMed

Miranda M, Jf M, Mb Z et al (2019) Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Front Cell Neurosci 13:363. https://doi.org/10.3389/Fncel.2019.00363CrossRefPubMedPubMedCentral

Vm Ho, Ja L, Kc M (2011) The cell biology of synaptic plasticity. Science (New York, Ny) 334(6056):623–628. https://doi.org/10.1126/Science.1209236CrossRef

Ahmed Ao, Kramer S, Hofman N et al (2021) A meta-analysis of brain-derived neurotrophic factor effects on brain volume in schizophrenia: genotype and serum levels. Neuropsychobiology:1–14.https://doi.org/10.1159/000514126

Murakami S, Imbe H, Morikawa Y et al (2005) Chronic stress, as well as acute stress, reduces Bdnf Mrna expression in the rat hippocampus but less robustly. Neurosci Res 53(2):129–139. https://doi.org/10.1016/J.Neures.2005.06.008CrossRefPubMed

Arosio B, Fr G, Rco V et al (2021) Blood brain-derived neurotrophic factor (Bdnf) and major depression: do we have a translational perspective? Front Behav Neurosci 15:626906. https://doi.org/10.3389/Fnbeh.2021.626906CrossRefPubMedPubMedCentral

10.

Arazi H, Babaei P, Moghimi M et al (2021) Acute effects of strength and endurance exercise on serum Bdnf and Igf-1 levels in older men. BMC Geriatr 21(1):50. https://doi.org/10.1186/S12877-020-01937-6CrossRefPubMedPubMedCentral

11.

Ritter C, As M, Vr G et al (2012) Brain-derived neurotrophic factor plasma levels are associated with mortality in critically ill patients even in the absence of brain injury. Critical Care (London, England) 16(6):R234. https://doi.org/10.1186/Cc11902CrossRef

12.

King M, Lp K, Em W et al (2019) Serum levels of insulin-like growth factor-1 and brain-derived neurotrophic factor as potential recovery biomarkers in stroke. Neurol Res 41(4):354–363. https://doi.org/10.1080/01616412.2018.1564451CrossRefPubMed

13.

Yang L, Zhang Z, Sun D et al (2011) Low serum Bdnf may indicate the development of Psd in patients with acute ischemic stroke. Int J Geriatr Psychiatry 26(5):495–502. https://doi.org/10.1002/Gps.2552CrossRefPubMed

14.

Algin A, Mo E, Aydin I et al (2019) Clinical usefulness of brain-derived neurotrophic factor and visinin-like protein-1 in early diagnostic tests for acute stroke. Am J Emerg Med 37(11):2051–2054. https://doi.org/10.1016/J.Ajem.2019.02.037CrossRefPubMed

15.

Pikula A, As B, Tc C et al (2013) Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham study. Stroke 44(10):2768–2775. https://doi.org/10.1161/Strokeaha.113.001447CrossRefPubMed

16.

Hj Q, Zz Li, Lm W et al (2017) Association of lower serum brain-derived neurotrophic factor levels with larger infarct volumes in acute ischemic stroke. J Neuroimmunol 307:69–73. https://doi.org/10.1016/J.Jneuroim.2017.04.002CrossRef

17.

Gl S, Cc A, Ma S-C et al (2016) Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects. Journal Of Stroke And Cerebrovascular Diseases : The Official Journal Of National Stroke Association 25(12):2968–2974. https://doi.org/10.1016/J.Jstrokecerebrovasdis.2016.08.014CrossRef

18.

Am M, Lcc V, Mns A et al (2019) Plasma levels of brain-derived neurotrophic factor are associated with prognosis in the acute phase of ischemic stroke. Journal Of Stroke And Cerebrovascular Diseases : The Official Journal Of National Stroke Association 28(3):735–740. https://doi.org/10.1016/J.Jstrokecerebrovasdis.2018.11.013CrossRef

19.

Tsubokawa T, Shiokawa Y, Kurita H et al (2004) High plasma concentration of brain natriuretic peptide in patients with ruptured anterior communicating artery aneurysm. Neurol Res 26(8):893–896. https://doi.org/10.1179/016164104225017776CrossRefPubMed

20.

Gm R, Jackson V, Liska J et al (2010) Endothelin-1 and brain natriuretic peptide plasma levels decrease after aortic surgery. J Heart Valve Dis 19(6):724–730

21.

Sm DM, Rg H, Gj R et al (2011) Brain natriuretic peptide concentrations after aneurysmal subarachnoid hemorrhage: relationship with hypovolemia and hyponatremia. Neurocrit Care 14(2):176–181. https://doi.org/10.1007/S12028-011-9504-0CrossRef

22.

Pr T, Fields Jd, Wu Ah et al (2011) Elevated Bnp is associated with vasospasm-independent cerebral infarction following aneurysmal subarachnoid hemorrhage. Neurocrit Care 15(1):13–18. https://doi.org/10.1007/S12028-011-9535-6CrossRef

23.

Nyberg C, Karlsson T, Ronne-Engstrom E (2014) Predictors of increased cumulative serum levels of the N-terminal prohormone of brain natriuretic peptide 4 days after acute spontaneous subarachnoid hemorrhage. J Neurosurg 120(3):599–604. https://doi.org/10.3171/2013.8.Jns13625CrossRefPubMed

24.

Sakamoto D, Sakamoto S, Kanda T (2015) Validation of circulating Bnp level >1000 Pg/Ml in all-cause mortality: a retrospective study. J Int Med Res 43(4):583–591. https://doi.org/10.1177/0300060515583077CrossRefPubMed

25.

Chihi M, Gembruch O, Darkwah Oppong M et al (2020) Analysis of brain natriuretic peptide serum levels in patients with symptomatic chronic subdural hematoma: a potential reliable biomarker. J Neurotrauma 37(20):2211–2218. https://doi.org/10.1089/Neu.2020.7110CrossRefPubMedPubMedCentral

26.

Tanabe S, Shirakawa Y, Maeda N et al (2021) Paraesophageal hernia repair can decrease Bnp levels. Surg Endosc. https://doi.org/10.1007/S00464-020-08202-2CrossRefPubMed

27.

Fang N, Che M, Shi L et al (2021) B-type natriuretic peptide levels and volume status in twice-weekly hemodialysis patients. Ren Fail 43(1):1259–1265. https://doi.org/10.1080/0886022x.2021.1971091CrossRefPubMedPubMedCentral

Titel: Assessment of BNP and BDNF results in elective endovascular cerebral aneurysm treatment
verfasst von: Abdullah Sukun
Bulent Cekic
Publikationsdatum: 29.09.2021
Verlag: Springer International Publishing
Erschienen in: Irish Journal of Medical Science (1971 -) / Ausgabe 4/2022
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-021-02791-0

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Assessment of BNP and BDNF results in elective endovascular cerebral aneurysm treatment

Abstract

Background

Aims

Methods

Results

Conclusions

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Blutdrucksenkung könnte Uterusmyome verhindern

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

Update Innere Medizin

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Background

Aims

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2022

Anti-thrombotics and their impact on inpatient epistaxis management: a tertiary centre experience

Thiol level and total oxidant/antioxidant status in patients with COVID-19 infection

Implicit racial bias among medical graduates and students by an IAT measure: a systematic review and meta-analysis

JKAP, Th1 cells, and Th17 cells are dysregulated and inter-correlated, among them JKAP and Th17 cells relate to cognitive impairment progression in Alzheimer’s disease patients

Evaluation of hematological parameters and inflammatory markers in children with COVID-19

Novel phenotype and genotype spectrum of NARS2 and literature review of previous mutations

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Blutdrucksenkung könnte Uterusmyome verhindern

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

Update Innere Medizin