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03.04.2023 | Original Article

Association between metabolic syndrome and gastric cancer risk: results from the Health Examinees Study

verfasst von: Dan Huang, Woo-Kyoung Shin, Katherine De la Torre, Hwi-Won Lee, Sukhong Min, Aesun Shin, Jong-Koo Lee, Daehee Kang

Erschienen in: Gastric Cancer | Ausgabe 4/2023

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Abstract

Background

Previous studies suggested that metabolic syndrome (MetS) might create a pro-cancer environment and increase cancer incidence. However, evidence on the risk of gastric cancer (GC) was limited. This study aimed to evaluate the association between MetS and its components and GC in the Korean population.

Methods

Included were 108,397 individuals who participated in the large-scale prospective cohort study, the Health Examinees-Gem study during 2004–2017. The multivariable Cox proportional was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) on the association between MetS and its components with GC risk. Age was used as the time scale in the analyses. The stratified analysis was performed to determine the joint effect of lifestyle factors and MetS on GC risk in different groups.

Results

During the mean follow-up of 9.1 years, 759 cases of newly diagnosed cancer (408 men and 351 women) were identified. Overall, participants with MetS had a 26% increased risk of GC than those without MetS (HR 1.26; 95% CI 1.07–1.47); the risk increased with the number of MetS components (p for trend 0.01). Hypertriglyceridemia, low HDL-cholesterol, and hyperglycemia were independently associated with the risk of GC. The potential joint effect of MetS and current smokers (p for interaction 0.02) and obesity (BMI ≥ 25.0) (p for interaction 0.03) in GC.

Conclusions

In this prospective cohort study, we found that MetS were associated with an increased risk of GC in the Korean population. Our findings suggest that MetS may be a potentially modifiable risk factor for GC risk.

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Titel: Association between metabolic syndrome and gastric cancer risk: results from the Health Examinees Study
verfasst von: Dan Huang
Woo-Kyoung Shin
Katherine De la Torre
Hwi-Won Lee
Sukhong Min
Aesun Shin
Jong-Koo Lee
Daehee Kang
Publikationsdatum: 03.04.2023
Verlag: Springer Nature Singapore
Erschienen in: Gastric Cancer / Ausgabe 4/2023
Print ISSN: 1436-3291
Elektronische ISSN: 1436-3305
DOI: https://doi.org/10.1007/s10120-023-01382-5

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