Introduction
Methods
Data selection
Data collection
Endpoints of interest
Statistical analysis
Results
Baseline characteristics
Variables | Overall | Q1 | Q2 | Q3 | Q4 | P value |
---|---|---|---|---|---|---|
Number of patients | 1393 | 349 | 348 | 348 | 348 | |
Male,n(%) | 822 (59.0) | 208 (59.6) | 204 (58.6) | 211 (60.6) | 199 (57.2) | 0.818 |
Age,years,(median [IQR]) | 71.00 [60.00, 81.00] | 75.00 [63.00, 84.00] | 73.50 [61.75, 82.00] | 70.00 [59.75, 80.00] | 66.00 [57.00, 75.00] | < 0.001 |
Race,n(%) | 0.069 | |||||
White | 915 (65.7) | 222 (63.6) | 230 (66.1) | 232 (66.7) | 231 (66.4) | |
Black | 97 (7.0) | 38 (10.9) | 22 (6.3) | 20 (5.7) | 17 (4.9) | |
Asian | 32 (2.3) | 11 (3.2) | 9 (2.6) | 4 (1.1) | 8 (2.3) | |
Others | 349 (25.1) | 78 (22.3) | 87 (25.0) | 92 (26.4) | 92 (26.4) | |
BMI,kg/m2,n(%) | 0.001 | |||||
<30 | 415 (29.8) | 117 (33.5) | 114 (32.8) | 97 (27.9) | 87 (25.0) | |
>=30 | 244 (17.5) | 47 (13.5) | 57 (16.4) | 54 (15.5) | 86 (24.7) | |
Missing | 734 (52.7) | 185 (53.0) | 177 (50.9) | 197 (56.6) | 175 (50.3) | |
ASPIII (median [IQR]) | 43.00 [32.00, 55.00] | 41.00 [31.00, 52.00] | 42.00 [32.00, 54.25] | 43.00 [33.00, 55.00] | 49.00 [35.00, 62.00] | < 0.001 |
SAPIII (median [IQR]) | 36.00 [29.00, 45.00] | 35.00 [28.00, 43.00] | 35.00 [30.00, 44.00] | 37.00 [29.00, 46.00] | 37.50 [29.00, 47.00] | 0.11 |
SIRS score (median [IQR]) | 3.00 [2.00, 3.00] | 2.00 [2.00, 3.00] | 2.00 [2.00, 3.00] | 3.00 [2.00, 3.00] | 3.00 [2.00, 3.00] | < 0.001 |
SOFA score (median [IQR]) | 4.00 [2.00, 7.00] | 4.00 [2.00, 7.00] | 4.00 [2.00, 7.00] | 4.00 [2.00, 7.00] | 5.00 [3.00, 8.00] | < 0.001 |
Vital Signs | ||||||
HR (median [IQR]) | 87.00 [75.00, 101.00] | 85.00 [75.00, 100.00] | 87.00 [75.00, 102.25] | 87.00 [75.00, 99.00] | 88.00 [78.00, 103.00] | 0.183 |
SBP,mmhg,n(%) | 0.268 | |||||
< 90 | 13 (0.9) | 4 (1.1) | 3 (0.9) | 4 (1.1) | 2 (0.6) | |
>140 | 158 (11.3) | 37 (10.6) | 32 (9.2) | 37 (10.6) | 52 (14.9) | |
90–140 | 496 (35.6) | 124 (35.5) | 124 (35.6) | 115 (33.0) | 133 (38.2) | |
Missing | 726 (52.1) | 184 (52.7) | 189 (54.3) | 192 (55.2) | 161 (46.3) | |
DBP,mmhg,n(%) | 0.367 | |||||
< 60 | 94 (6.7) | 28 (8.0) | 24 (6.9) | 19 (5.5) | 23 (6.6) | |
> 90 | 53 (3.8) | 13 (3.7) | 11 (3.2) | 15 (4.3) | 14 (4.0) | |
60–90 | 520 (37.3) | 124 (35.5) | 124 (35.6) | 122 (35.1) | 150 (43.1) | |
Missing | 726 (52.1) | 184 (52.7) | 189 (54.3) | 192 (55.2) | 161 (46.3) | |
Laboratory tests | ||||||
Lymphocyte,%,n(%) | < 0.001 | |||||
<7 | 281 (20.2) | 49 (14.0) | 74 (21.3) | 76 (21.8) | 82 (23.6) | |
> 18.8 | 202 (14.5) | 51 (14.6) | 42 (12.1) | 49 (14.1) | 60 (17.2) | |
11.50–18.80 | 253 (18.2) | 74 (21.2) | 63 (18.1) | 65 (18.7) | 51 (14.7) | |
7–11.50 | 274 (19.7) | 54 (15.5) | 59 (17.0) | 72 (20.7) | 89 (25.6) | |
Missing | 383 (27.5) | 121 (34.7) | 110 (31.6) | 86 (24.7) | 66 (19.0) | |
Neutrophils,%,n(%) | < 0.001 | |||||
<69.8 | 211 (15.1) | 58 (16.6) | 50 (14.4) | 46 (13.2) | 57 (16.4) | |
> 85.9 | 277 (19.9) | 53 (15.2) | 67 (19.3) | 76 (21.8) | 81 (23.3) | |
69.8–79.60 | 251 (18.0) | 68 (19.5) | 55 (15.8) | 71 (20.4) | 57 (16.4) | |
79.60–85.90 | 271 (19.5) | 49 (14.0) | 66 (19.0) | 69 (19.8) | 87 (25.0) | |
Missing | 383 (27.5) | 121 (34.7) | 110 (31.6) | 86 (24.7) | 66 (19.0) | |
Platelets,(K/uL),(median [IQR]) | 209.00 [161.00, 268.00] | 198.00 [151.00, 254.00] | 208.00 [165.00, 262.00] | 212.00 [164.00, 273.50] | 214.50 [165.75, 282.00] | 0.03 |
WBC (median [IQR]) | 10.30 [7.60, 13.80] | 8.40 [6.70, 11.40] | 9.80 [7.70, 12.65] | 11.60 [8.15, 14.60] | 11.75 [8.60, 16.50] | < 0.001 |
RBC,m/uL,(median [IQR]) | 3.92 [3.41, 4.43] | 3.91 [3.47, 4.40] | 3.95 [3.41, 4.41] | 3.96 [3.42, 4.44] | 3.86 [3.35, 4.44] | 0.825 |
Hemoglobin,g/dL,(median [IQR]) | 11.70 [10.10, 13.20] | 11.70 [10.40, 13.20] | 11.70 [10.10, 13.28] | 11.80 [10.25, 13.25] | 11.30 [9.80, 13.20] | 0.312 |
PCO2,mmhg,(median [IQR]) | 41.00 [35.00, 48.00] | 40.00 [34.00, 46.00] | 40.00 [34.00, 48.00] | 41.00 [35.50, 49.00] | 41.00 [36.00, 49.00] | 0.029 |
PH (median [IQR]) | 7.39 [7.33, 7.44] | 7.41 [7.35, 7.44] | 7.40 [7.36, 7.45] | 7.39 [7.33, 7.44] | 7.37 [7.30, 7.42] | < 0.001 |
PO2,mmhg,(median [IQR]) | 99.00 [63.25, 190.75] | 102.00 [66.00, 241.00] | 98.50 [67.00, 199.75] | 89.00 [56.00, 161.50] | 104.50 [65.75, 187.25] | 0.073 |
Albumin,g/dL(median [IQR]) | 3.30 [2.80, 3.70] | 3.50 [3.00, 3.80] | 3.40 [2.90, 3.70] | 3.20 [2.80, 3.70] | 3.20 [2.70, 3.60] | < 0.001 |
BUN,mg/dL(median [IQR]) | 22.00 [16.00, 35.00] | 21.00 [16.00, 31.00] | 21.00 [16.00, 34.25] | 23.00 [17.00, 37.00] | 23.00 [16.00, 40.00] | 0.022 |
SCR, mg/dL,(median [IQR]) | 1.10 [0.80, 1.50] | 1.00 [0.80, 1.40] | 1.00 [0.80, 1.40] | 1.10 [0.90, 1.63] | 1.10 [0.90, 1.80] | 0.001 |
UCR,mg/dL,n(%) | 0.058 | |||||
< 48 | 134 (9.6) | 35 (10.0) | 29 (8.3) | 28 (8.0) | 42 (12.1) | |
> 122 | 135 (9.7) | 30 (8.6) | 30 (8.6) | 42 (12.1) | 33 (9.5) | |
48–78 | 127 (9.1) | 33 (9.5) | 24 (6.9) | 38 (10.9) | 32 (9.2) | |
78–122 | 132 (9.5) | 22 (6.3) | 33 (9.5) | 43 (12.4) | 34 (9.8) | |
Missing | 865 (62.1) | 229 (65.6) | 232 (66.7) | 197 (56.6) | 207 (59.5) | |
HDL,mg/dL,n(%) | < 0.001 | |||||
< 33 | 248 (17.8) | 40 (11.5) | 67 (19.3) | 71 (20.4) | 70 (20.1) | |
> 53 | 238 (17.1) | 98 (28.1) | 71 (20.4) | 40 (11.5) | 29 (8.3) | |
33–42 | 272 (19.5) | 64 (18.3) | 74 (21.3) | 72 (20.7) | 62 (17.8) | |
42–53 | 258 (18.5) | 87 (24.9) | 61 (17.5) | 61 (17.5) | 49 (14.1) | |
Missing | 377 (27.1) | 60 (17.2) | 75 (21.6) | 104 (29.9) | 138 (39.7) | |
LDL,mg/dL,n(%) | < 0.001 | |||||
< 55 | 249 (17.9) | 80 (22.9) | 65 (18.7) | 55 (15.8) | 49 (14.1) | |
> 103 | 245 (17.6) | 52 (14.9) | 58 (16.7) | 74 (21.3) | 61 (17.5) | |
55–76 | 255 (18.3) | 85 (24.4) | 67 (19.3) | 62 (17.8) | 41 (11.8) | |
76–103 | 250 (17.9) | 71 (20.3) | 82 (23.6) | 53 (15.2) | 44 (12.6) | |
Missing | 394 (28.3) | 61 (17.5) | 76 (21.8) | 104 (29.9) | 153 (44.0) | |
TG,mg/dL,(median [IQR]) | 113.00 [84.00, 164.00] | 70.00 [57.00, 85.00] | 104.00 [86.00, 119.25] | 138.00 [108.00, 168.25] | 209.50 [154.00, 290.25] | < 0.001 |
TC,mg/dL,n(%) | < 0.001 | |||||
<116 | 257 (18.4) | 89 (25.5) | 70 (20.1) | 56 (16.1) | 42 (12.1) | |
>174 | 259 (18.6) | 51 (14.6) | 59 (17.0) | 68 (19.5) | 81 (23.3) | |
116–145 | 275 (19.7) | 92 (26.4) | 77 (22.1) | 59 (17.0) | 47 (13.5) | |
145–174 | 253 (18.2) | 60 (17.2) | 72 (20.7) | 70 (20.1) | 51 (14.7) | |
Missing | 349 (25.1) | 57 (16.3) | 70 (20.1) | 95 (27.3) | 127 (36.5) | |
Glucose,mg/dL,(median [IQR]) | 129.00 [106.00, 172.00] | 104.00 [92.00, 120.00] | 121.50 [104.00, 143.00] | 141.50 [114.00, 173.00] | 202.00 [147.00, 263.25] | < 0.001 |
HbA1c%,n(%) | < 0.001 | |||||
< 5.7 | 275 (19.7) | 98 (28.1) | 86 (24.7) | 61 (17.5) | 30 (8.6) | |
> 6.4 | 261 (18.7) | 27 (7.7) | 53 (15.2) | 62 (17.8) | 119 (34.2) | |
5.7–6.4 | 287 (20.6) | 93 (26.6) | 78 (22.4) | 67 (19.3) | 49 (14.1) | |
Missing | 570 (40.9) | 131 (37.5) | 131 (37.6) | 158 (45.4) | 150 (43.1) | |
TNTµg/L,n(%) | 0.001 | |||||
<0.06 | 202 (14.5) | 60 (17.2) | 51 (14.7) | 49 (14.1) | 42 (12.1) | |
>0.975 | 203 (14.6) | 34 (9.7) | 45 (12.9) | 54 (15.5) | 70 (20.1) | |
0.06–0.25 | 208 (14.9) | 45 (12.9) | 55 (15.8) | 52 (14.9) | 56 (16.1) | |
0.25–0.975 | 198 (14.2) | 36 (10.3) | 61 (17.5) | 56 (16.1) | 45 (12.9) | |
Missing | 582 (41.8) | 174 (49.9) | 136 (39.1) | 137 (39.4) | 135 (38.8) | |
CKMB(IU/L),n(%) | 0.299 | |||||
< 3 | 180 (12.9) | 49 (14.0) | 46 (13.2) | 45 (12.9) | 40 (11.5) | |
> 18 | 280 (20.1) | 66 (18.9) | 55 (15.8) | 84 (24.1) | 75 (21.6) | |
3–6 | 2 (0.1) | 0 (0.0) | 1 (0.3) | 0 (0.0) | 1 (0.3) | |
6–18 | 13 (0.9) | 2 (0.6) | 6 (1.7) | 2 (0.6) | 3 (0.9) | |
Missing | 918 (65.9) | 232 (66.5) | 240 (69.0) | 217 (62.4) | 229 (65.8) | |
NT-proBNP,pg/mL,n(%) | 0.27 | |||||
<1632 | 78 (5.6) | 21 (6.0) | 16 (4.6) | 14 (4.0) | 27 (7.8) | |
>10,521 | 78 (5.6) | 20 (5.7) | 17 (4.9) | 23 (6.6) | 18 (5.2) | |
1632–3955 | 78 (5.6) | 14 (4.0) | 20 (5.7) | 21 (6.0) | 23 (6.6) | |
3955–10521 | 77 (5.5) | 13 (3.7) | 26 (7.5) | 22 (6.3) | 16 (4.6) | |
Missing | 1082 (77.7) | 281 (80.5) | 269 (77.3) | 268 (77.0) | 264 (75.9) | |
CRP(mg/L),n(%) | 0.295 | |||||
< 13.95 | 41 (2.9) | 15 (4.3) | 13 (3.7) | 8 (2.3) | 5 (1.4) | |
>134.4 | 41 (2.9) | 7 (2.0) | 9 (2.6) | 12 (3.4) | 13 (3.7) | |
13.95–57.90 | 41 (2.9) | 9 (2.6) | 10 (2.9) | 14 (4.0) | 8 (2.3) | |
57.90-134.4 | 40 (2.9) | 6 (1.7) | 14 (4.0) | 11 (3.2) | 9 (2.6) | |
Missing | 1230 (88.3) | 312 (89.4) | 302 (86.8) | 303 (87.1) | 313 (89.9) | |
Potassium,mmol/L,(median [IQR]) | 4.10 [3.80, 4.50] | 4.10 [3.70, 4.50] | 4.10 [3.80, 4.50] | 4.10 [3.80, 4.50] | 4.20 [3.80, 4.70] | 0.03 |
Sodium,mmol/L,(median [IQR]) | 139.00 [136.00, 141.00] | 140.00 [136.00, 142.00] | 139.00 [136.00, 142.00] | 139.00 [136.00, 141.00] | 138.00 [135.00, 141.00] | < 0.001 |
TyG index,(median [IQR]) | 4.82 [4.61, 5.07] | 4.47 [4.37, 4.55] | 4.71 [4.67, 4.78] | 4.94 [4.88, 5.00] | 5.28 [5.17, 5.48] | < 0.001 |
Comorbidities,n (%) | ||||||
AF,n(%) | 613 (44.0) | 185 (53.0) | 165 (47.4) | 132 (37.9) | 131 (37.6) | < 0.001 |
AMI,n(%) | 485 (34.8) | 82 (23.5) | 122 (35.1) | 137 (39.4) | 144 (41.4) | < 0.001 |
CKD,n(%) | 383 (27.5) | 96 (27.5) | 89 (25.6) | 96 (27.6) | 102 (29.3) | 0.748 |
COPD,n(%) | 164 (11.8) | 41 (11.7) | 47 (13.5) | 47 (13.5) | 29 (8.3) | 0.113 |
Dyslipidemia,n(%) | 658 (47.2) | 156 (44.7) | 168 (48.3) | 159 (45.7) | 175 (50.3) | 0.443 |
Diabetes,n(%) | 524 (37.6) | 65 (18.6) | 105 (30.2) | 135 (38.8) | 219 (62.9) | < 0.001 |
Hypertension,n(%) | 494 (35.5) | 130 (37.2) | 121 (34.8) | 123 (35.3) | 120 (34.5) | 0.871 |
PCI,n(%) | 189 (13.6) | 29 (8.3) | 45 (12.9) | 55 (15.8) | 60 (17.2) | 0.003 |
CABG,n(%) | 69 (5.0) | 14 (4.0) | 11 (3.2) | 17 (4.9) | 27 (7.8) | 0.031 |
Medications | ||||||
ARNI,n(%) | 11 (0.8) | 2 (0.6) | 4 (1.1) | 3 (0.9) | 2 (0.6) | 0.798 |
ACEI,n(%) | 634 (45.5) | 164 (47.0) | 164 (47.1) | 172 (49.4) | 134 (38.5) | 0.021 |
ARB,n(%) | 135 (9.7) | 25 (7.2) | 40 (11.5) | 38 (10.9) | 32 (9.2) | 0.209 |
Beta blocker,n(%) | 1090 (78.2) | 267 (76.5) | 276 (79.3) | 287 (82.5) | 260 (74.7) | 0.07 |
Digoxin, n(%) | 165 (11.8) | 48 (13.8) | 53 (15.2) | 34 (9.8) | 30 (8.6) | 0.019 |
Loop diuretics,n(%),n(%) | 1129 (81.0) | 277 (79.4) | 284 (81.6) | 282 (81.0) | 286 (82.2) | 0.8 |
Events | ||||||
AKIb,n(%) | 1154 (82.8) | 277 (79.4) | 287 (82.5) | 294 (84.5) | 296 (85.1) | 0.183 |
Variables | Overall | non-AKI | AKI | p value |
---|---|---|---|---|
Number of patients | 1393 | 239 | 1154 | |
Male,n(%) | 822 (59.0) | 123 (51.5) | 699 (60.6) | 0.011 |
Age,years,(median [IQR]) | 71.00 [60.00, 81.00] | 71.00 [59.00, 82.00] | 71.00 [60.00, 81.00] | 0.417 |
Race,n(%) | 0.1 | |||
White | 915 (65.7) | 156 (65.3) | 759 (65.8) | |
Black | 97 (7.0) | 20 (8.4) | 77 (6.7) | |
Asian | 32 (2.3) | 10 (4.2) | 22 (1.9) | |
Others | 349 (25.1) | 53 (22.2) | 296 (25.6) | |
BMI,kg/m2,n(%) | 0.037 | |||
<30 | 415 (29.8) | 87 (36.4) | 328 (28.4) | |
>=30 | 244 (17.5) | 34 (14.2) | 210 (18.2) | |
Missing | 734 (52.7) | 118 (49.4) | 616 (53.4) | |
ASPIII (median [IQR]) | 43.00 [32.00, 55.00] | 34.00 [26.00, 45.00] | 45.00 [34.00, 58.00] | < 0.001 |
SAPIII (median [IQR]) | 36.00 [29.00, 45.00] | 31.00 [24.50, 37.00] | 37.00 [30.00, 46.00] | < 0.001 |
SIRS score (median [IQR]) | 3.00 [2.00, 3.00] | 2.00 [2.00, 3.00] | 3.00 [2.00, 3.00] | 0.02 |
SOFA score (median [IQR]) | 4.00 [2.00, 7.00] | 3.00 [1.00, 4.50] | 5.00 [3.00, 8.00] | < 0.001 |
Vital Signs | ||||
HR (median [IQR]) | 87.00 [75.00, 101.00] | 86.00 [74.50, 101.50] | 87.00 [76.00, 101.00] | 0.403 |
SBP,mmhg,n(%) | 0.714 | |||
< 90 | 13 (0.9) | 1 (0.4) | 12 (1.0) | |
>140 | 158 (11.3) | 30 (12.6) | 128 (11.1) | |
90–140 | 496 (35.6) | 87 (36.4) | 409 (35.4) | |
Missing | 726 (52.1) | 121 (50.6) | 605 (52.4) | |
DBP,mmhg,n(%) | 0.768 | |||
< 60 | 94 (6.7) | 14 (5.9) | 80 (6.9) | |
> 90 | 53 (3.8) | 11 (4.6) | 42 (3.6) | |
60–90 | 520 (37.3) | 93 (38.9) | 427 (37.0) | |
Missing | 726 (52.1) | 121 (50.6) | 605 (52.4) | |
Laboratory tests | ||||
Lymphocyte,%,n(%) | < 0.001 | |||
<7 | 281 (20.2) | 32 (13.4) | 249 (21.6) | |
> 18.8 | 202 (14.5) | 40 (16.7) | 162 (14.0) | |
11.50–18.80 | 253 (18.2) | 42 (17.6) | 211 (18.3) | |
7–11.50 | 274 (19.7) | 28 (11.7) | 246 (21.3) | |
Missing | 383 (27.5) | 97 (40.6) | 286 (24.8) | |
Neutrophils,%,n(%) | < 0.001 | |||
<69.8 | 211 (15.1) | 41 (17.2) | 170 (14.7) | |
> 85.9 | 277 (19.9) | 35 (14.6) | 242 (21.0) | |
69.8–79.60 | 251 (18.0) | 33 (13.8) | 218 (18.9) | |
79.60–85.90 | 271 (19.5) | 33 (13.8) | 238 (20.6) | |
Missing | 383 (27.5) | 97 (40.6) | 286 (24.8) | |
Platelets,(K/uL),(median [IQR]) | 209.00 [161.00, 268.00] | 215.00 [167.00, 272.25] | 208.00 [160.00, 268.00] | 0.237 |
WBC (median [IQR]) | 10.30 [7.60, 13.80] | 10.10 [7.30, 12.88] | 10.40 [7.70, 14.00] | 0.052 |
RBC,m/uL,(median [IQR]) | 3.92 [3.41, 4.43] | 3.93 [3.40, 4.42] | 3.91 [3.41, 4.43] | 0.939 |
Hemoglobin,g/dL,(median [IQR]) | 11.70 [10.10, 13.20] | 11.90 [10.20, 13.20] | 11.60 [10.10, 13.30] | 0.352 |
PCO2,mmhg,(median [IQR]) | 41.00 [35.00, 48.00] | 41.00 [35.00, 48.00] | 40.00 [35.00, 48.00] | 0.721 |
PH (median [IQR]) | 7.39 [7.33, 7.44] | 7.39 [7.34, 7.42] | 7.39 [7.33, 7.44] | 0.996 |
PO2,mmhg,(median [IQR]) | 41.00 [35.00, 48.00] | 41.00 [35.00, 48.00] | 40.00 [35.00, 48.00] | 0.721 |
Albumin,g/dL(median [IQR]) | 3.30 [2.80, 3.70] | 3.50 [3.10, 3.82] | 3.30 [2.80, 3.70] | < 0.001 |
BUN,mg/dL(median [IQR]) | 22.00 [16.00, 35.00] | 20.00 [15.00, 30.50] | 22.00 [16.25, 36.00] | < 0.001 |
SCR, mg/dL,(median [IQR]) | 1.10 [0.80, 1.50] | 1.00 [0.80, 1.30] | 1.10 [0.80, 1.60] | < 0.001 |
UCR,mg/dL,n(%) | < 0.001 | |||
< 48 | 134 (9.6) | 16 (6.7) | 118 (10.2) | |
> 122 | 135 (9.7) | 11 (4.6) | 124 (10.7) | |
48–78 | 127 (9.1) | 16 (6.7) | 111 (9.6) | |
78–122 | 132 (9.5) | 9 (3.8) | 123 (10.7) | |
Missing | 865 (62.1) | 187 (78.2) | 678 (58.8) | |
HDL,mg/dL,n(%) | < 0.001 | |||
< 33 | 248 (17.8) | 31 (13.0) | 217 (18.8) | |
> 53 | 238 (17.1) | 63 (26.4) | 175 (15.2) | |
33–42 | 272 (19.5) | 57 (23.8) | 215 (18.6) | |
42–53 | 258 (18.5) | 51 (21.3) | 207 (17.9) | |
Missing | 377 (27.1) | 37 (15.5) | 340 (29.5) | |
LDL,mg/dL,n(%) | < 0.001 | |||
< 55 | 249 (17.9) | 32 (13.4) | 217 (18.8) | |
> 103 | 245 (17.6) | 54 (22.6) | 191 (16.6) | |
55–76 | 255 (18.3) | 56 (23.4) | 199 (17.2) | |
76–103 | 250 (17.9) | 58 (24.3) | 192 (16.6) | |
Missing | 394 (28.3) | 39 (16.3) | 355 (30.8) | |
TG,mg/dL,(median [IQR]) | 113.00 [84.00, 164.00] | 105.00 [80.50, 155.50] | 114.00 [84.25, 166.00] | 0.046 |
TC,mg/dL,n(%) | < 0.001 | |||
<116 | 257 (18.4) | 30 (12.6) | 227 (19.7) | |
>174 | 259 (18.6) | 59 (24.7) | 200 (17.3) | |
116–145 | 275 (19.7) | 62 (25.9) | 213 (18.5) | |
145–174 | 253 (18.2) | 55 (23.0) | 198 (17.2) | |
Missing | 349 (25.1) | 33 (13.8) | 316 (27.4) | |
Glucose,mg/dL,(median [IQR]) | 129.00 [106.00, 172.00] | 126.00 [103.00, 164.00] | 130.00 [107.00, 173.00] | 0.117 |
HbA1c%,n(%) | 0.105 | |||
< 5.7 | 275 (19.7) | 57 (23.8) | 218 (18.9) | |
> 6.4 | 261 (18.7) | 46 (19.2) | 215 (18.6) | |
5.7–6.4 | 287 (20.6) | 54 (22.6) | 233 (20.2) | |
Missing | 570 (40.9) | 82 (34.3) | 488 (42.3) | |
TNTµg/L,n(%) | 0.286 | |||
<0.06 | 202 (14.5) | 33 (13.8) | 169 (14.6) | |
>0.975 | 203 (14.6) | 32 (13.4) | 171 (14.8) | |
0.06–0.25 | 208 (14.9) | 27 (11.3) | 181 (15.7) | |
0.25–0.975 | 198 (14.2) | 34 (14.2) | 164 (14.2) | |
Missing | 582 (41.8) | 113 (47.3) | 469 (40.6) | |
CKMB(IU/L),n(%) | < 0.001 | |||
< 3 | 180 (12.9) | 33 (13.8) | 147 (12.7) | |
> 18 | 280 (20.1) | 24 (10.0) | 256 (22.2) | |
3–6 | 2 (0.1) | 0 (0.0) | 2 (0.2) | |
6–18 | 13 (0.9) | 1 (0.4) | 12 (1.0) | |
Missing | 918 (65.9) | 181 (75.7) | 737 (63.9) | |
NT-proBNP,pg/mL,n(%) | 0.401 | |||
<1632 | 78 (5.6) | 17 (7.1) | 61 (5.3) | |
>10521 | 78 (5.6) | 8 (3.3) | 70 (6.1) | |
1632–3955 | 78 (5.6) | 15 (6.3) | 63 (5.5) | |
3955–10,521 | 77 (5.5) | 13 (5.4) | 64 (5.5) | |
Missing | 1082 (77.7) | 186 (77.8) | 896 (77.6) | |
CRP(mg/L),n(%) | 0.241 | |||
< 13.95 | 41 (2.9) | 8 (3.3) | 33 (2.9) | |
>134.4 | 41 (2.9) | 5 (2.1) | 36 (3.1) | |
13.95–57.90 | 41 (2.9) | 6 (2.5) | 35 (3.0) | |
57.90–134.4 | 40 (2.9) | 2 (0.8) | 38 (3.3) | |
Missing | 1230 (88.3) | 218 (91.2) | 1012 (87.7) | |
Potassium,mmol/L,(median [IQR]) | 4.10 [3.80, 4.50] | 4.00 [3.70, 4.40] | 4.20 [3.80, 4.60] | 0.016 |
Sodium,mmol/L,(median [IQR]) | 139.00 [136.00, 141.00] | 139.00 [136.00, 141.00] | 139.00 [136.00, 142.00] | 0.69 |
TyG index,(median [IQR]) | 4.82 [4.61, 5.07] | 4.78 [4.57, 5.01] | 4.83 [4.63, 5.08] | 0.016 |
Comorbidities,n (%) | ||||
AF,n(%) | 613 (44.0) | 82 (34.3) | 531 (46.0) | 0.001 |
AMI,n(%) | 485 (34.8) | 80 (33.5) | 405 (35.1) | 0.686 |
CKD,n(%) | 383 (27.5) | 43 (18.0) | 340 (29.5) | < 0.001 |
COPD,n(%) | 164 (11.8) | 26 (10.9) | 138 (12.0) | 0.718 |
Dyslipidemia,n(%) | 658 (47.2) | 117 (49.0) | 541 (46.9) | 0.608 |
Diabetes,n(%) | 524 (37.6) | 77 (32.2) | 447 (38.7) | 0.069 |
Hypertension,n(%) | 494 (35.5) | 103 (43.1) | 391 (33.9) | 0.008 |
PCI,n(%) | 189 (13.6) | 41 (17.2) | 148 (12.8) | 0.094 |
CABG,n(%) | 69 (5.0) | 10 (4.2) | 59 (5.1) | 0.661 |
Medications | ||||
ARNI,n(%) | 11 (0.8) | 1 (0.4) | 10 (0.9) | 0.756 |
ACEI,n(%) | 634 (45.5) | 120 (50.2) | 514 (44.5) | 0.126 |
ARB,n(%) | 135 (9.7) | 28 (11.7) | 107 (9.3) | 0.297 |
Beta blocker,n(%) | 1090 (78.2) | 183 (76.6) | 907 (78.6) | 0.545 |
Digoxin ,n(%) | 165 (11.8) | 22 (9.2) | 143 (12.4) | 0.201 |
Loop diuretics,n(%) | 1129 (81.0) | 154 (64.4) | 975 (84.5) | < 0.001 |
Primary endpoint
Categories | Model 1 | Model 2 | Model 3 | |||
---|---|---|---|---|---|---|
h (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
AKI incidence | ||||||
Continuous variable per 1 unit | 1.57 [95% CI 1.34–1.84] | < 0.001 | 1.58 [95% CI 1.34–1.86] | < 0.001 | 1.58 [95%CI 1.22–2.04] | 0.0006 |
Quartilea | ||||||
Q1(N = 349) | Ref. | Ref. | Ref. | |||
Q2(N = 348) | 1.11 [95% CI 0.94–1.31] | 0.226 | 1.10 [95% CI 0.93–1.30] | 0.26 | 1.04 [95% CI 0.88–1.24] | 0.655 |
Q3(N = 348) | 1.27 [95% CI1.08–1.50] | 0.004 | 1.24 [95% CI1.06–1.47] | 0.009 | 1.16 [95% CI 0.96–1.39] | 0.122 |
Q4(N = 348) | 1.42 [95% CI 1.20–1.67] | <0.001 | 1.42 [95% CI1.20–1.67] | <0.001 | 1.32 [95% CI 1.06–1.65] | 0.012 |