Background
Methods
Design and patients
Data collection
Statistical analysis
Results
Patient characteristics
Characteristics | Total Mean (SD)/ Median (Q1-Q3) / N(%) | Without irAEs Mean (SD)/ Median (Q1-Q3) / N(%) | With irAEs Mean (SD)/ Median (Q1-Q3) / N(%) | P |
---|---|---|---|---|
Age (range)year | 65.00 (33.00–84.00) | 66.00 (60.00–70.00) | 64.00 (57.00–69.00) | 0.20 |
Age year
| 0.33 | |||
< 70 | 148 (76.68%) | 90 (74.38%) | 58 (80.56%) | |
≥70 | 45 (23.32%) | 31 (25.62%) | 14 (19.44%) | |
Sex
| 0.98 | |||
Female | 27 (13.99%) | 17 (14.05%) | 10 (13.89%) | |
Male | 166 (86.01%) | 104 (85.95%) | 62 (86.11%) | |
Comorbidities
| 0.51 | |||
No | 159 (82.38%) | 98 (80.99%) | 61 (84.72%) | |
Yes | 34 (17.62%) | 23 (19.01%) | 11 (15.28%) | |
ECOG PS
| 0.62 | |||
≤ 2 | 183 (94.82%) | 114 (94.21%) | 69 (95.83%) | |
≥ 3 | 10 (5.18%) | 7 (5.79%) | 3 (4.17%) | |
TNM stage
| 0.28 | |||
I-III | 43 (22.28%) | 30 (24.79%) | 13 (18.06%) | |
IV | 150 (77.72%) | 91 (75.21%) | 59 (81.94%) | |
Chemotherapy
| 0.17 | |||
No | 24 (12.44%) | 12 (9.92%) | 12 (16.67%) | |
Yes | 169 (87.56%) | 109 (90.08%) | 60 (83.33%) | |
Radiotherapy
| 0.18 | |||
No | 111 (57.51%) | 74 (61.16%) | 37 (51.39%) | |
Yes | 82 (42.49%) | 47 (38.84%) | 35 (48.61%) | |
Targeted therapy
| 0.37 | |||
No | 123 (63.73%) | 80 (66.12%) | 43 (59.72%) | |
Yes | 70 (36.27%) | 41 (33.88%) | 29 (40.28%) | |
Anti-angiogenic therapy
| 0.04 | |||
No | 120 (62.18%) | 82 (67.77%) | 38 (52.78%) | |
Yes | 73 (37.82%) | 39 (32.23%) | 34 (47.22%) | |
COVID-19 pneumonia
| < 0.01 | |||
No | 167 (86.53%) | 115 (95.04%) | 52 (72.22%) | |
Yes | 26 (13.47%) | 6 (4.96%) | 20 (27.78%) | |
COVID-19 pneumonia grade
| < 0.01 | |||
No | 167 (86.53%) | 115 (95.04%) | 52 (72.22%) | |
1–2 | 20 (10.36%) | 3 (2.48%) | 17 (23.61%) | |
3–4 | 6 (3.11%) | 3 (2.48%) | 3 (4.17%) | |
WBC (10
9
/L)
| 5.66 (4.58–7.13) | 5.66 (4.51–7.17) | 5.69 (4.71–7.02) | 0.95 |
Neutrophil(10
9
/L)
| 3.67 (2.87–5.03) | 3.65 (2.75–4.97) | 3.74 (3.13–5.05) | 0.68 |
Lymphocyte (10
9
/L)
| 1.09 (0.81–1.53) | 1.13 (0.81–1.50) | 1.08 (0.83–1.57) | 0.66 |
Profiles of irAEs
Types of irAEs | Grade 1 | Grade2 | Grade 3 | Grade 4 | Total |
---|---|---|---|---|---|
Pneumonitis | 7 | 6 | 4 | 6 | 23 (22.12%) |
Hepatitis | 4 | 3 | 1 | 1 | 9(8.65%) |
Thyroiditis | 13 | 8 | 3 | — | 24(23.08%) |
Dermatitis/rash | 19 | 11 | 2 | 3 | 35(33.65%) |
Colitis | 5 | 2 | 1 | — | 8 (7.69%) |
Myocarditis | 1 | — | — | — | 1(0. 96%) |
others | 3 | 1 | — | — | 4(3.85%) |
Total
| 52(50.00%) | 31 (29.80%) | 11 (10.58%) | 10 (9.62%) | 104(100%) |
Association between irAEs and COVID-19 pneumonia
Variate | COVID- 19 Pneumonia | |||||
---|---|---|---|---|---|---|
Patients n (%) | Univariate | Multivariate | ||||
OR (95%CI) | P | OR (95%CI) | P | |||
Age(years)
| 0.98 | |||||
< 70 | 148 (76.68%) | 1 | ||||
≥ 70 | 45 (23.32%) | 0.98 (0.37, 2.62) | ||||
Sex
| 0.33 | |||||
Female | 27 (13.99%) | 1 | ||||
Male | 166 (86.01%) | 2.11 (0.47,9.50) | ||||
Comorbidities
| 0.06 | |||||
No | 159 (82.38%) | 1 | 1 | |||
Yes | 34 (17.62%) | 2.41 (0.95, 6.12) | 2.38 (0.76, 7.49) | 0.14 | ||
ECOG PS
| 0.74 | |||||
≤ 2 | 183 (94.82%) | 1 | ||||
≥ 3 | 10 (5.18%) | 0.70 (0.09,5.78) | ||||
TNM stage
| 0.69 | |||||
I-III | 43 (22.28%) | 1 | ||||
IV | 150 (77.72%) | 1.24 (0.44, 3.50) | ||||
irAEs
| < 0.01 | |||||
No | 121 (62.69%) | 1 | 1 | |||
Yes | 72(37.31%) | 7.37(2.80,19.43) | 9.56 (2.21,41.33) | 0.0025 | ||
IrAEs Grade
| ||||||
G 0 | 121 (62.69%) | 1 | 1 | |||
G 1–2 | 54 (27.98%) | 7.37 (2.67, 0.32) | 0.0001 | 0.79 (0.20, 3.11) | 0.74 | |
G 3–4 | 8 (9.33%) | 7.37 (1.9,27.54) | 0.003 | 1.0 | ||
Chemotherapy
| 0.09 | |||||
No | 24(12.44%) | 1 | 1 | |||
Yes | 169(87.56%) | 0.40 (0.14, 1.13) | 0.64 (0.18, 2.28) | 0.49 | ||
Radiotherapy
| 0.38 | |||||
No | 111(57.51%) | 1 | ||||
Yes | 82 (42.49%) | 0.68 (0.29, 1.62) | ||||
Targeted therapy
| 0.05 | |||||
No | 123 (63.73%) | 1 | 1 | |||
Yes | 70 (36.27%) | 2.31 (1.00, 5.33) | 2.24 (0.46,10.84) | 0.32 | ||
Anti-angiogenic
therapy
| 0.08 | |||||
No | 120 (62.18%) | 1 | 1 | |||
Yes | 73 (37.82%) | 2.14 (0.93, 4.92) | 0.73 (0.15, 3.54) | 0.70 | ||
WBC
(10
9
/L)
| 5.66 (4.58,7.13) | 1.08 (0.97, 1.19) | 0.16 | |||
Neutrophil
(10
9
/L)
| 3.67 (2.87,5.03) | 1.03 (0.97, 1.09) | 0.37 | |||
Lymphocyte
(10
9
/L)
| 1.09 (0.81,1.53) | 0.37 (0.15, 0.89) | 0.03 | 0.35 (0.14, 0.92) | 0.033 |