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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 12/2022

08.11.2022 | Allergic Skin Diseases (L Fonacier, Section Editor)

Biologics and Small Molecule Inhibitors: an Update in Therapies for Allergic and Immunologic Skin Diseases

verfasst von: Joseph Dodson, Peter A. Lio

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 12/2022

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Abstract

Purpose of Review

Biologics and small molecule inhibitors (SMIs) are a rapidly growing class of highly efficacious therapies in the treatment of chronic immunologic and allergic conditions. With precision targeting of inflammatory signaling molecules, these new agents selectively modulate the immune system to treat a variety of conditions. Dermatologic diseases, including atopic dermatitis and psoriasis, are of particular interest due to the growing number of new biologics and SMIs in recent years. This review serves to summarize and evaluate the recent literature regarding biologics and SMIs.

Recent Findings

Currently approved biologics for AD achieve clear or almost clear skin in less than 40% of patients treated. Several biologics that are still under investigation for AD have shown better efficacy in phase III trials with similar safety profiles. Recently approved SMIs for AD also demonstrate a high degree of efficacy, but safety profiles may limit their use. Psoriasis has several highly efficacious biologics on the market; however, only one SMI is currently available. Additional SMIs for psoriasis have completed phase III trials and demonstrated high efficacy.

Summary

This article evaluates recent literature on biologics and small molecule inhibitors for AD and psoriasis.
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Metadaten
Titel
Biologics and Small Molecule Inhibitors: an Update in Therapies for Allergic and Immunologic Skin Diseases
verfasst von
Joseph Dodson
Peter A. Lio
Publikationsdatum
08.11.2022
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 12/2022
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-022-01047-w

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