Introduction
Asthma and miRNA
Childhood Asthma and miRNA
Adult/childhood | miRNA ID | Target gene | Function | Sample | Reference (PubMed ID) | Review/research |
---|---|---|---|---|---|---|
Childhood | miR-145-5p | NA | Associated with the early decline patterns of lung function growth leading to COPD in children with asthma and additionally increases airway smooth muscle cell proliferation | Serum | 33385444 | Research |
Childhood | miR-196a2 | ANXA1 | miR-196a2 expression and serum ANXA1 concentration may play a role in the pathogenesis of asthma | Serum | 32279913 | Research |
Childhood | miR-15a | NA | Role in the fetal origin of asthma | Fetal lung | 33291534 | Research |
Childhood | miR-146a, miR-106b | NA | Aberrant expression of immune-related microRNAs in pediatric patients with asthma | Plasma | 33688482 | Research |
Childhood | miR-33a, miR-495 | NA | lncRNAs correlated negatively with miR-33a and miR-495 and positively with inflammatory cytokines in asthmatic children | Blood | 34288494 | Research |
Childhood | miR-328-3p, let-7d-3p | NA | Seasonal variation in miR-328-3p and let-7d-3p are associated with seasonal allergies and asthma symptoms in children | Serum | 34212545 | Research |
Childhood | miR-103 | NA | Baicalin regulates the onset of asthma in children by up-regulating microRNA-103 and modulating the TLR4/NF-B pathway | Mouse | 33730981 | Research |
Childhood | miR-206 | CCL2 | Pro-inflammatory and pro-fibrotic role of lncRNA RMRP in pediatric asthma through targeting microRNA-206/CCL2 axis | Pulmonary tissue | 33511814 | Research |
Childhood | miRs:221-5p, 139-3p, 96-5p, 6641-5p, 199b-5p, 151b, 1307-3p, 148a-5p | NA | Childhood asthma remission | Serum | 32888944 | Research |
Childhood | miR-451a | ETS1 | Down-regulation of miRNA-451a promotes the differentiation of CD4+ T cells toward Th2 cells by up-regulating ETS1 in childhood asthma | Lymphocytes | 33271553 | Research |
Childhood | miR-192 | CXCR5 | Decreased miR-192 in blood of asthmatics | NA | 32777705 | Review |
Childhood | miR-27b-3p | SYK, EGFR, IL-12 | Modulation of PI3K-Akt signaling pathway | Blood | 33460581 | Review |
Childhood | miR-143a | NA | Regulation of polymorphonuclear neutrophil counts | Sputum | 33460581 | Review |
Childhood | miR-223a | NA | Attenuation of the airway neutrophil responses | Sputum | 33460581 | Review |
Childhood | miR-21 | IL-12p35 | Production and activation of inflammatory cells | Serum | 33460581 | Review |
Childhood | miR-221 | Spred | Regulation of mast cells functions | Blood | 33460581 | Review |
Childhood | miR-485-3p | NA | Regulation of airway hyperresponsiveness | Blood | 33460581 | Review |
Childhood | miR-21-5p | IL-12 | Dysregulation of Th1/Th2 production | Bronchial epithelial cells | 33460581 | Review |
Childhood | miR-146a-3p | NA | Up-regulation of small airway reversibility | Bronchial epithelial cells | 33460581 | Review |
Childhood | miR-155-5p | CCL11, CCL26, IL-13 | Inhibition of eosinophil production | Bronchial epithelial cells | 33460581 | Review |
Childhood | miR-485-3p | SPRED-2 | Airway remodeling by decreasing sprout-related EVH1 domain-containing protein (spred)-2 expression to promote growth factor-mediated Ras/ERK activation | ASMCs | 34359876 | Review |
Childhood | miR-155 | NA | A biomarker of worsened lung function | Serum/plasma | 33478047 | Review |
Childhood | miR-16 | NA | A significant negative correlation with FEV1 | Serum/plasma | 33478047 | Review |
Childhood | miR-199a-5p | NA | Increased in plasma and sputum of patients with neutrophilic asthma. Negative correlation with pulmonary function | Serum/plasma | 33478047 | Review |
Childhood | miR-146b, miR-206, miR-720 | NA | NF-kβ and GSK3/AKT pathways, might improve the accuracy of asthma exacerbation risk prediction in a pediatric asthma | Serum | 33214212 | Review |
Childhood | miR-15b, miR-126, miR-139, miR-142, miR-186, miR-191, miR-342, miR-374a, miR-409, miR-660, miR-942, miR-1290 | NA | Correlating to lung function parameters in children | Blood | 33128813 | Review |
Childhood | miR-16, miR-30d, miR-296 | NA | Correlating to bronchial hyper-responsiveness | Blood | 33128813 | Review |
Childhood | miR-146a, miR-206, miR-720 | NA | Potential asthma prediction markers | Blood | 33128813 | Review |
Childhood | miR-223, miR-513a, miR-625 | CBL, PPARGC1B, ESR1 | Dust mite allergic asthma associated | Blood | 33128813 | Review |
Childhood | miR-15a | VEGF | Low levels in CD4+ T cells in pediatric asthma | NA | 33128813 | Review |
Childhood | miR-21 | IL-12p35 | Predicts therapeutic response to ICS in asthma | NA | 32777705 | Review |
Childhood | miR-146a | EGFR | Up-regulation of miR‑146a inhibits proliferation and promotes apoptosis of ASMCs in asthma | NA | 32777705 | Review |
Childhood | miR-221 | SIRT1 | Overexpression of miR-221 by targeting SIRT1 induces apoptosis and inhibits proliferation in bronchial epithelial BEAS2B cells | NA | 32777705 | Review |
Childhood | miR-19a | PTEN, A20 | Increased in airway T cells Reduction in smooth muscle cells leads to enhanced remodeling | ASMCs | 33128813 | Review |
Childhood | miR-485-5p | SPRED2 | Pediatric asthma | NA | 33488613 | Review |
Childhood | miR-221 | SPRED, SIRT1 | Pediatric asthma | NA | 33488613 | Review |
Adult Asthma and miRNA
Adult/childhood | miRNA | Target gene | Function | Sample | Reference | Review/research |
---|---|---|---|---|---|---|
Adult | miR-21 | NA | Promotes oxidative stress and inflammatory responses in asthmatic mice via the DDAH1/Wnt/β-catenin signaling axis | ASMCs | 34377230 | Research |
Adult | miR-23b | Smad3 | Controlling TGF-β1-induced airway smooth muscle cell proliferation by regulating Smad3 and, thereby reducing airway remodeling | ASMCs | 33152094 | Review |
Adult | miR-140-3p | IL-13 | Down-regulation of miR-140-3p is a cause of the interlukin-13-induced up-regulation of RhoA protein in bronchial smooth muscle cells | ASMCs | 33427568, 33385215 | Research |
Adult | miR-143-3p | TGF-β1, CDK4, Cyclin D1 | Overexpression of miR-143-3p could decrease asthma airway remodeling by suppressing proliferation and ECM protein deposition in TGF-β1-mediated airway smooth muscle cells via the negative regulation of NFATc1 signaling | ASMCs | 33454598 | Review |
Adult | miR-223 | IGF-1R, TGF-β1 | Overexpression of miR-223 could decrease the expression of proteins involved in the extracellular matrix, such as α-SMA (ACTA2), and type I and III collagens | ASMCs | 33454598 | Review |
Adult | miR-21 | TGF-beta, Smad7 | miR-21-transforming growth factor β1-Smad7 axis modulates the pathogenesis of ovalbumin-induced chronic asthma in human bronchial smooth muscle cells | ASMCs | 33601867 | Research |
Adult | miR-149 | TRPM7 | miR-149 attenuates the proliferation and migration of TGF-β1-induced airway smooth muscle cells by targeting TRPM7 and affecting downstream MAPK signal pathway | ASMCs | 33284571 | Research |
Adult | miR-140-3p | CD38 | Down-regulation of miR-140-3p contributes to up-regulation of CD38 protein in bronchial smooth muscle cells | ASMCs | 33121100 | Research |
Adult | miR-204-5p | TGF-β1 | miR-204-5p could reduce ECM production of airway smooth muscle cells by regulating Six1 in asthma | ASMCs | 33454598 | Review |
Adult/Childhood | miR-19a | PTEN, A20 | Increased in airway T cells Reduction in smooth muscle cells leads to enhanced remodeling | ASMCs | 33128813 | Review |
Adult | miR-370 | FGF1 | Exosomes generated from M2 macrophages carry miR-370, which slows asthma progression by inhibiting FGF1 production and the MAPK/STAT1 signaling pathway | Bone marrow cells/exosomes | 33994863 | Research |
Adult | miR-126 and miR-133 | NA | c-kit + cells could reduce asthma-related pathologies, likely through modulating miRNA-126 and -133 production | Bone marrow–derived c-kit + cells/serum | 33995948 | Research |
Adult | miR-141-3p | NA | Epithelial miR-141 regulates IL-13-induced airway mucus production | Bronchial epithelial brushing/HBECs and mouse lung tissue | 33682796 | Research |
Adult | miR-206 | CD39 | Epithelial miR-206 targets CD39/extracellular ATP to up-regulate airway IL-25 and TSLP in type 2-high asthma | Bronchial epithelial brushings | 33945508 | Research |
Adult | miR-30a-3p, miR-30d-3p | NA | Potential role for epithelial circRNA-miRNA-mRNA network in the pathogenesis of asthma | Bronchial epithelial brushings | 34336929 | Research |
Adult | miR-146a | IRAK1 | Down-regulated in bronchial brushing samples of asthma patients, inhibits IL-8 and CXCL1 expression and neutrophil migration | Bronchial epithelial brushings | 33128813 | Review |
Adult | miR-629-3p, miR-223-3p, miR-142-3p | NA | Neutrophilic inflammation | Bronchoalveolar lavage fluid | 33478047 | Review |
Adult | miR-185 | NA | A potential predictor of asthma severity in blood sera | Circulating eosinophils | 33128813 | Review |
Adult | 18 pri-miRs. miRs: 1276, 29B2, 3175, 33B, 4308, 4523, 4673, 4785, 590, 638, 614, 142, 3064, 4434, 1304, 2355, 26A2, 645 | NA | Differentially expressed in eosinophil samples in cases of atopic dermatitis or asthmatic condition, or according to PC20 or IgE levels, compared to healthy person samples | Eosinophils | 33260893 | Research |
Adult | miR-221 | NA | Decreased levels in epithelial and sputum was associated with eosinophilic airway inflammation in asthma | Epithelial and sputum | 33128813 | Review |
Adult | miR-122-5p | NA | Plasma miR-122-5p can sub-differentiate different types of asthma, such as neutrophilic versus eosinophilic asthma, given its IPA-predicted role in lymphocyte differentiation and function | Extracellular vesicles from plasma | 32627209 | Research |
Adult | miR-200b-3p | SOCS1 | A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma | Human bronchial epithelial cells (HBECs) | 33446603 | Research |
Adult | let-7i, miR-423 | NA | PRMT1 as a coactivator for STAT1 or RUNX1, which is essential for the transcription of pri-let-7i and pri-miR-423 in epithelial cells and might be relevant to epithelium dysfunction in asthma | Human bronchial epithelial cells (HBECs) | 33239422 | Research |
Adult | miR-143-3p | NA | LncRNA OIP5‑AS1 aggravates house dust mite‑induced inflammatory responses in human bronchial epithelial cells via the miR‑143‑3p/HMGB1 axis | Human bronchial epithelial cells (HBECs) | 33174035 | Research |
Adult | miR-181b-5p | SPP1 | miR-181b-5p has been identified as a potential biomarker for airway eosinophilia, and controls pro-inflammatory cytokine release by targeting the secreted phosphoprotein 1 (SPP1) gene | Human bronchial epithelial cells (HBECs)/plasma | 33152094 | Review |
Adult | miR-146a-5p | TRAF6 | miR-146a-5p inhibits the inflammatory response and injury of airway epithelial cells via targeting TNF receptor-associated factor 6 | Human small airway epithelial cells (HSAECs) | 34002665 | Research |
Adult | miR-149 | NA | LncRNA PVT1 exacerbates the inflammation and cell-barrier injury during asthma by regulating miR-149 | Human small airway epithelial cells (HSAECs) | 32830409 | Research |
Adult | miR-221-3p | NA | miR-221-3p correlates with eosinophils | Induced sputum | 33478047 | Review |
Adult | miR-98 | NA | miR-98 reduces nerve growth factor expression in nicotine-induced airway remodeling | Lung fibroblasts | 3308240 | Research |
Adult | miR-20a-5p | ATG7 | miR-20a-5p targets ATG7-regulated cell death, fibrosis, and inflammation | Lung tissue | 33684878 | Research |
Adult | miR-135a | NA | miR-135a inhibits airway inflammatory response in asthmatic mice via regulating JAK/STAT signaling pathway | Lung tissue | 33470387 | Research |
Adult | miR-139 | NA | miR-139 can down-regulate the Notch pathway and promote bone marrow-derived mesenchymal stem cells homing in asthmatic lung tissues, thus suppressing the inflammatory response of Th2 cells through immune regulation | Lung tissue | 33504414 | Research |
Adult | let-7a | IL-13 | Abundant in the lungs and regulates IL-13 expression | Lung tissue | 33128813 | Review |
Adult | miR-155 | NA | Down-regulated in the lymphocytes of allergic asthmatics during pollen season | Lymphocytes | 33128813 | Review |
Adult | miR-210 | NA | Increases in human mast cells following IgE sensitization | Mast cells | 33128813 | Review |
Adult | miR-146a, miR-499 | NA | Association of two polymorphisms of miRNA-146a rs2910164 (G > C) and miRNA-499 rs3746444 (T > C) with asthma: a meta-analysis | Meta-analysis | 32308092 | Research |
Adult | miR-181b | HMGB1 | LncRNA TUG1 promotes airway remodeling and mucus production in asthmatic mice through the microRNA-181b/HMGB1 axis | Mouse model | 33640857 | Research |
Adult | miR‑106b‑5p | SIX1 | miR‑106b‑5p targeting SIX1 inhibits TGF‑β1‑induced pulmonary fibrosis and epithelial‑mesenchymal transition in asthma through regulation of E2F1 | Mouse model | 33495833 | Research |
Adult | miR-26a, miR-142-3p | NA | Borneol reduces asthma symptoms by inhibiting CD4+ T-cell proliferation by down-regulating miR-26a and miR-142-3p | Mouse model | 33272847 | Research |
Adult | miR-15a-5p/miR-29c-3p | NA | Exposure to ozone impacted Th1/Th2 imbalance of CD (4 +) T cells and apoptosis of ASMCs underlying asthmatic progression by activating lncRNA PVT1-miR-15a-5p/miR-29c-3p signaling | Mouse model | 33223504 | Research |
Adult | miR-21 | NA | miR-21 inhibition suppresses alveolar M2 macrophages in an ovalbumin-induced allergic asthma mice model | Mouse model | 33474864 | Research |
Adult | miR-21-5p | Smad7 | MiR-21-5p in macrophage-derived exosomes targets Smad7 to promote epithelial mesenchymal transition of airway epithelial cells | Mouse model | 34040396 | Research |
Adult | miR-155 | NA | TDI (toluene 2,4-diisocyanate)-induced airway inflammation and hyperresponsiveness in asthma | Mouse model/human cell lines | 32499335 | Research |
Adult | miR-21 | NA | Dysregulated in circulation and lungs in allergic experimental murine models and human allergic asthmatics | Murine model | 33128813 | Review |
Adult | let-7a, miR-21, miR-133a, miR-155, miR-328, miR-1248 | NA | Decreased in exhaled breath condensates from asthmatic compared to healthy subjects | NA | 33128813 | Review |
Adult | miR-16 | ADRB2 | Negatively correlates to lung function parameters | NA | 33128813 | Review |
Adult | miR-1248 | IL-5 | Interacts with the 3′UTR to promote IL-5 expression | NA | 33128813 | Review |
Adult | miR-150 | eIF4E/Akt | Malat1 up-regulated in airway smooth muscle cells stimulated with platelet-derived growth factor BB (PDGF-BB). Silencing of Malat1 using miR-150 and block of eIF4E/Akt signaling inhibits PDGF-BB-induced airway smooth muscle cells proliferation and migration | NA | 32777705 | Review |
Adult | miR125a | NA | Expression of ANRIL/miR-125a used to investigate the disease exacerbation, exacerbation severity, and inflammation for asthma has a discriminant value | NA | 32777705 | Review |
Adult | miR-1248 | IL-5 | Elevates Th2 cytokine levels | NA | 32777705 | Review |
Adult | miR-371, miR-138, miR-544, miR-145, miR-214 | Runx3 | miRNAs capable of combinatorial regulation of Runx3, modulates Th1/Th2 balance in asthma | NA | 32777705 | Review |
Adult | miR-98 | TSP1, IL-13 | miR-98 suppresses TSP1 expression in peripheral B cells of allergic asthmatics | NA | 32777705 | Review |
Adult | miR19a | TGFbR2 | miR-19a targets TGFbR2 gene in severe asthma enhances proliferation of bronchial epithelial cells | NA | 32777705 | Review |
Adult | miR-21, miR-126 | IL-13 | miRNAs increased in asthmatics compared to controls, expression in bronchial epithelia of asthmatics positively correlated with IL-13 | NA | 32777705 | Review |
Adult | miR-221 | NA | Asthmatics and OVA-induced allergic mice have miR-221 up-regulated, reduced airway inflammation | NA | 32777705 | Review |
Adult | miR-1165-3p | NA | Circulating miR-1165-3p useful as a biomarker of asthma | NA | 32777705 | Review |
Adult | miR-221-3p | CXCL17 | miR-221-3p up-regulates anti-inflammatory chemokine CXCL17, protective against airway eosinophilic inflammation | NA | 32777705 | Review |
Adult | miR-142-3p | NA | miR-142-3p regulates the balance between proliferation and differentiation of ASMCs | NA | 32777705 | Review |
Adult | miR-26a, Let-7a, Let-7d, mir-323, miR-21 | NA | Biomarkers for diagnosis of asthma | NA | 32777705 | Review |
Adult | miR-17 | NA | Biomarker for the diagnosis of asthma | NA | 32777705 | Review |
Adult | let-7a | IL-13 | let-7a useful as a biomarker to discriminate between asthma phenotypes. exogenous let-7 mimic by targeting IL-13 alleviates asthmatic phenotype in OVA allergic mice | NA | 32777705 | Review |
Adult | miR-200 | NA | Asthma biomarker | NA | 33488613 | Review |
Adult | miR-346 | IL13 | Airway inflammation, T helper cell differentiation | NA | 33488613 | Review |
Adult | miR-574-5p | IL5RA | NA | NA | 33488613 | Review |
Adult | miR-24 | IL-4 production pathway | Cytokine regulation | NA | 33488613 | Review |
Adult | miR-27 | GATA3 | NA | NA | 33488613 | Review |
Adult | miR-16 | NA | Asthma biomarker | NA | 33488613 | Review |
Adult | miR-125b | NA | NA | NA | 33488613 | Review |
Adult | miR-133b | NA | NA | NA | 33488613 | Review |
Adult | miR-206 | NA | NA | NA | 33488613 | Review |
Adult | miR-144-5p | NA | Asthma biomarker | NA | 33488613 | Review |
Adult | let-7 family | NA | Asthma biomarker | NA | 33488613 | Review |
Adult | miR-185-5p | NA | NA | NA | 33488613 | Review |
Adult | miR-320a | NA | NA | NA | 33488613 | Review |
Adult | miR-1246 | NA | NA | NA | 33488613 | Review |
Adult | miR-21 | IL12p3, IRF5, CSF1R | Imbalance Th1/Th2 response, macrophage M2 polarization | NA | 33488613 | Review |
Adult | miR-142-3p | MAPK, NOD-like receptor, Toll-like receptor, JAKSTAT, and the TGF-b signaling pathways | Neutrophilic asthma | NA | 33488613 | Review |
Adult | miR-223-3p | NA | NA | NA | 33488613 | Review |
Adult | miR-629-3p | NA | NA | NA | 33488613 | Review |
Adult | miR-221-3p | CXCL17 | Regulation of eosinophil counts and ROS production | NA | 33488613 | Review |
Adult/Childhood | miR-196a2 | NA | miR-196a2 polymorphisms have also been shown to be involved in controlling asthma | NA | 33152094 | Review |
Adult/Childhood | miR-21, miR-223, miR-146a, miR-146b, miR-15 | NA | Asthma-related diseases such as atopic dermatitis and allergic rhinitis suggesting a key role in the atopic march from childhood to adulthood | NA | 34134446 | Review |
Adult | miR-375 | KLF4 | circARRDC3 contributes to interleukin‑13‑induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR‑375/KLF4 axis | Nasal epithelial cells | 33313951 | Research |
Adult | miR-145 | RUNX3 | In maintaining the balance between Th1 and Th2 responses by targeting the runt-related transcription factor 3 (RUNX3) | Peripheral blood | 33152094 | Review |
Adult | miR-3934 | NA | miR-3934 was down-regulated in PBMCs of asthmatic patients and may function as a potential diagnosis biomarker | Peripheral blood mononuclear cells (PBMCs) and serum | 33506046 | Research |
Adult | miR-29c | NA | LncRNA TUG1 facilitates Th2 cell differentiation by targeting the miR-29c/B7-H3 axis on macrophages | Peripheral blood, monocyte | 34335559 | Research |
ACOs | miR-19b-3p, miR-125b-5p, miR-320c | NA | The plasma levels of hsa-miR-19b-3p, hsa-miR-125b-5p and hsa-miR-320c in patients with asthma, COPD and asthma–COPD overlap syndrome (ACOS) | Plasma | 34151771 | Research |
Adult | miR-122-5p | NA | Increased in plasma and sputum supernatant EVs derived from patients with (severe) asthma, and this miRNA correlated with immune cell types in the blood | Plasma | 32627209 | Research |
Adult | miR-19b-3p, miR-320c | NA | NA | Plasma | 33349226 | Research |
Adult | miR-574-5p | NA | Related to incident asthma prediction and vitamin D effect modification | Plasma | 33923455 | Research |
Adult | miR-206 | NA | Plasma miR-206, IL-4, IL-13, and INF-γ have potential significance for prognosis of asthma induced pulmonary arterial hypertension | Plasma | 33086901 | Research |
Adult | miR-16, miR-125b, miR-133b, miR-206, miR-299 | NA | Plasma miRNAs able to distinguish asthmatics from healthy individuals or those with allergic rhinitis | Plasma | 33128813 | Review |
Adult | miR-122-5p | NA | Levels of miR-122-5p higher in patients with (severe) asthma | Plasma/sputum | 34067156 | Review |
Adult | miR-223, miR-21 | NA | Biomarker | Plasma/exosome | 33904674 | Research |
Adult | miR-142-5p and miR-130a-3p | NA | miR-142-5p and miR-130a-3p regulate pulmonary macrophage polarization and asthma airway remodeling | Pulmonary macrophages | 32524675 | Research |
ACOS | miR-15b-5p | NA | Circulating microRNA-15b-5p as a biomarker for asthma–COPD overlap | Serum | 32713026 | Research |
Adult | miR‐28‐3p, miR‐16‐2‐3p, and miR‐210‐3p | NA | Differentially expressed in the serum of severe asthma patients | Serum | 34161666 | Research |
Adult | miR-21, miR-155 | NA | Biomarkers for bronchial asthma | Serum | 31986951 | Research |
Adult | miR-1246, miR-5100, miR-338-3p | NFKB2, NFATC3, DUSP1, DUSP2, DUSP5 and DUSP16 | Altered expression of miR-1246, miR-5100, and miR-338-3p after 8 weeks of benralizumab administration, which could be used as early response markers | Serum | 33525548 | Research |
Adult | miR-106a, miR-126a, miR-146a, miR-126a, miR-106a, miR-19b | NA | Serum miRNA (miRNA106a and miRNA126a, miRNA146a, 126a, 106a, and 19b) expression correlates with clinical characteristics of asthma and systemic inflammation in an age-dependent manner | Serum | 34112152 | Research |
Adult | miR-125b | NA | Overexpression of miR-125b in severe asthma which was associated with serum IgE and hs-CRP may suggest that this molecule is linked to inflammatory reactions | Serum | 34001212 | Research |
Adult | miR-338-3p | NA | Biomarker | Serum | 33808110 | Research |
Adult | miR-126 | NA | Levels of miRNA-126 higher in asthmatics | Serum | 34067156 | Review |
Adult | miR-125b | NA | Levels of miRNA-125b higher in patients and correlating with disease severity | Serum | 34067156 | Review |
Adult | miR-155, -146a, miR-223, -374a | NA | Serum miRNAs correlating to clinical parameters in asthma subgroups | Serum | 33128813 | Review |
Adult | miR-126 | DNMT1 | Asthma progression | Serum | 33488613 | Review |
Adult | miR-92a | MUC5AC | Up-regulation of miR-92a contributes to blocking goblet cell metaplasia by targeting MUC5AC in asthma | Serum/lung | 32571119 | Research |
Adult | miR-181-5p | NA | Strong inverse correlation between plasma miR-181b-5p and airway eosinophilia | Serum/plasma | 33478047 | Review |
Adult | miR-629-3p, miR-223-3p, miR-142-3p | NA | Associated with severe neutrophilic asthma | Sputum | 33214212 | Review |
Adult | miR-629-3p, miR-223-3p, and miR-142-3p | NA | Significant up-regulation of miR-629-3p, miR-223-3p, and miR-142-3p in sputum of severe asthmatics compared to healthy controls, with the highest levels in patients with neutrophilic asthma | Sputum | 32973742 | Review |
Circulating and Exosome-Derived miRNAs
Asthmatic Airways and Airway Remodeling
Type | miRNA | Target gene | Function | Sample | Reference | Review/research |
---|---|---|---|---|---|---|
ASMCs | miR-620 | NA | Promotes TGF-β1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway | ASMCs | 32583575 | Research |
ASMCs | miR-620 | NA | miR-620 promotes TGF-β1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway | ASMCs | 32583575 | Research |
ASMCs | miR-145 | MMP-2, MMP-9 | Binds KLF5 3ʹUTR | ASMCs | 34359876 | Review |
ASMCs | miR-143-3p | NFATc1 | Promotes collagen 1 and fibronectin expressions, leading to elevated ASM cell proliferation and up-regulation of CDK4 and cyclin D1 expressions | ASMCs | 34359876 | Review |
ASMCs | miR-378 | NA | miR-378 is elevated in ASM cells from asthmatic patients and, via MAPK and calcium signaling, can up-regulate collagen I and fibronectin expression | ASMCs | 34359876 | Review |
ASMCs | miR-204-5p | Six1 | miR-204-5p has also been shown to be down-regulated in ASM cells from asthmatic patients and promotes the expressions of fibronectin and collagen III via the Six1 gene (a TGF-β1 inducible gene) | ASMCs | 34359876 | Review |
ASMCs | miR-145 | KLF4 | miR-145 was significantly elevated and led to increased collagen I and myosin heavy chain expression through negative regulation of the transcription factor Krüppel-like factor 4 (KLF4) protein and downstream activation of MMP-2 and MMP-9 | ASMCs | 34359876 | Review |
ASMCs | miR-25 | Collagen XI | Inhibition of miR-25 in IL-1β, TNF-α and IFN-γ-stimulated ASM cells, had a greater than twofold down regulatory effect on collagen XI expression, and to a lesser extent the expressions of collagen (V and XV), fibronectin, MMP-9, and integrin (αm and β2), by stimulating KLF4 expression | ASMCs | 34359876 | Review |
ASMCs | miR-181a | Collagen I and fibronectin | miR-181a expression in ASM, leading to the overexpression of collagen I and fibronectin, via the Akt signaling pathway | ASMCs | 34359876 | Review |
ASMCs | miR-142 | NA | Overexpressed in ASM cells derived from an asthma rat model and inhibits TGF-β expression via epidermal growth factor receptor (EGFR) signaling | ASMCs | 34359876 | Review |
ASMCs | miR-146a, miR-221 | NA | Regulating airway smooth muscle (ASM) cell function | ASMCs | 34134446 | Review |
ASMCs | miR-140-3p, miR-708, miR-142-3p | NA | ASM cell hyperplasia and hypertrophy; Th2 responses and IgE production | ASMCs | 34134446 | Review |
ASMCs | miR-10a | NA | Regulating the proliferation of ASM cells via the PI3K pathway | ASMCs | 33152094 | Review |
ASMCs | miR-140-3p | CD38, CCL11, CXCL12, CXCL10, CCL5, CXCL8 | CD38 expression, chemokine regulation, inflammation, and ASMC proliferation in asthma | ASMCs | 33488613 | Review |
ASMCs | miR-145 | KLF4 | ASMC proliferation and migration | ASMCs | 33488613 | Review |
ASMCs | miR-146a-5p | UBD, CXCL10, CXCL8, CCL20, UCA1 | Mucus production | ASMCs | 33488613 | Review |
ASMCs | miR-638 | NR4A3, CCND1 | ASMC proliferation and migration | ASMCs | 33488613 | Review |
ASMCs | miR-708 | CD38, CCL11, CXCL10, CCL2, CXCL8, JNK, MAPK, PTEN/AKT signaling pathways | CD38 expression, chemokine regulation, inflammation and ASMC proliferation in asthma | ASMCs | 33488613 | Review |
ASMCs | miR-146a/b | PTGS2, IL1B, NOTCH5 | Regulation of inflammation, macrophage M2 Polarization | ASMCs | 33488613 | Review |
ASMCs | miR-19 | Collagen I, fibronectin | miR-19 is decreased in ASM cells from asthmatic patients and induces elevated expression of collagen I, fibronectin and arginine methyltransferase activity through the ERK1/MAPK signaling pathway | ASMCs | 34359876 | Review |
Benralizumab | miR-21-5p | HDAC2, NFE2L2, GLCCI1, PTEN, NR3C1 | Benralizumab restores gene and microRNA expression involved in steroid sensitivity in severe asthma | NA | 33738833 | Research |
ASMCs | miR-30b-5p | PTEN | miR-30b-5p activates the PI3K/AKT pathway by targeting PTEN to facilitate PDGF-induced dysfunction of ASM cells | ASMCs | 34251961 | Research |
Bronchial epithelial brushing (HBECs) tissue | miR-19a | TGFBR2 | miR-19a to enhance proliferation of BECs in severe asthma through targeting TGF-β receptor 2 gene (TGFBR2) mRNA | Bronchial epithelial brushing (HBECs) tissue | 32973742 | Review |
Mice | miR-590-5p | FGF1 | TUG1 via sponging miR590-5p/FGF1 promoted airway smooth muscle cells proliferation and migration in asthma | NA | 32777705 | Review |
Mice | miR-21 | IL-12, STAT4 | Axis of miR-22/IL-12/STAT4 participates in development of allergic asthma | NA | 32777705 | Review |
Mice | miR-21 | IL-12p35 | miR-21 through the IL-13Rα1-independent pathway overexpressed in mouse allergic asthma | NA | 32777705 | Review |
Mice | miR-20b | NA | Intranasal administration of miR-20b increased the percentage of Gr1 + CD11b + myeloid-derived suppressor cells (MDSCs) and increased TGF-β in the lung of asthmatic mice | NA | 32777705 | Review |
Mice | miR-20b | NA | miRNA-20b promotes accumulation of CD11b + Ly6G + Ly6Clow MDSCs in asthmatic mice | NA | 32777705 | Review |
Mice | miR-485 | Smurf2 | miR-485 targeting Smurf2 through the TGF-β/Smads signaling pathway, suppresses cell proliferation and promotes cell apoptosis in mice with chronic asthma | NA | 32777705 | Review |
Mice | miR-410 | IL-4, IL-13 | Intranasal miR‑410 targeting IL-4/IL-13 attenuates airway inflammation in OVA‑induced asthmatic mice | NA | 32777705 | Review |
Mice | let-7 | IL13 | Regulation of asthmatic hyper-response | Lung | 33488613 | Review |
Mice | miR-487b | NA | miR-487b in activating and regulating macrophages in innate immune responses including pro-inflammatory effects through the induction of IL-33 transcripts | NA | 33152094 | Review |
Murine model | miR-155 | IL-33 | miR-155 required for allergen-induced ILC2 expansion and IL-33 production, asthma mouse model | NA | 32777705 | Review |
Murine model | miR-21 | HDAC2 | miR-21 induced in the lung by infection, during steroid-insensitive allergic airway disease in BALB/c. miR-21. Amplifies PI3K–mediated suppression of HDAC2 driving severe steroid-insensitive experimental asthma | NA | 32777705 | Review |
NA | miR-146a | IL-5, IL-13 | miR-146a decreases influx of inflammatory cells into lung, suppresses OVA-specific IgE and Th2 cytokines, attenuating airway hyper-responsiveness and allergic inflammation | NA | 32777705 | Review |
NA | miR-21 | PTEN | miR-21 through PTEN/PI3K/Akt signaling pathway modulates human ASMC proliferation and migration in asthma | NA | 32777705 | Review |
NA | miR-155 | COX-2 | miR-155 assists overexpression of COX-2 in asthmatic ASMCs | NA | 32777705 | Review |
NA | miR-155 | chemokine expression (CCL5, CCL11, CCL26, CXCL8, and CXCL10) | miR-155 as a novel target in allergic asthma | Bronchial epithelial brushing (HBECs) tissue | 33152094 | Review |
NA | miR-3162-3p | CTNNB1 | NA | Mice | 33488613 | Review |
NA | miR-155 | IL-6, KRAS, IL-17, IL-21, IL-6, | Anti-inflammatory | NA | 33378051 | Review |
NA | miR-21a | IL-1beta | NA | NA | 33378051 | Review |
NA | miR-146a | IL-17, IL-21, IL-6 | NA | NA | 33378051 | Review |
Asthma–COPD Overlap Syndrome
miRNA and Virus-Induced Exacerbations in Asthma
miRNA ID | Target gene | Function | Sample | Reference (PubMed ID) | Review/research |
---|---|---|---|---|---|
miR-146a/b | CCL5, IL-8 and CXCL1, IFNL1 | Strong anti-inflammatory effect on RV infection and allergic airway inflammation | Human bronchial epithelial cells (HBECs)/mouse | 34185416 | Research |
miR-29, -29c, -136, 449b, and let-7c | NA | Increased expression in influenza A virus’s infection | A549 cells | 33255348 | Review |
miR-155 | NA | Inhibition of miR-155 in human bronchial epithelial cells resulted in an increased viral replication of RV-1B | Human bronchial epithelial cells (HBECs)/mouse | 33255348 | Review |
miR-18a, -27a, -128 and -155 | IL-6 and CXCL8 | NA | Human bronchial epithelial cells (HBECs)/mouse | 33255348 | Review |
miR-24, -124a, and -744 | NA | Antiviral effects on influenza A virus in the human lung epithelial cell line A549 | Human lung epithelial cell line A549 | 33255348 | Review |
miR-124a and -744 | NA | Antiviral effects in RSV infection | Human lung epithelial cell line A549 | 33255348 | Review |
miR-146a | TRAF6 | Down-regulation of miR-146a was shown to inhibit influenza A virus replication by enhancing IFN type 1 responses by directly targeting the tumor necrosis factor receptor association factor 6 | NA | 33255348 | Review |
miR-223 | NA | STIM1 mediates IAV-induced inflammation of lung epithelial cells by regulating NLRP3 and inflammasome activation via targeting miR-223 | Human bronchial epithelial cells (HBECs)/mouse | 33278394 | Research |
miR-34b/c-5p | NA | Respiratory syncytial virus infection-induced mucus secretion by down-regulation of miR-34b/c-5p expression in airway epithelial cells | Human bronchial epithelial cells (HBECs)/mouse | 32939938 | Research |
miR-146 | TRAF6 | Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation | Human bronchial epithelial cells (HBECs)/mouse | 34185416 | Research |
miR-122 | SOCS1 | Promotes virus-induced lung disease by targeting SOCS1 | Lung tissue | 33830082 | Research |