nach oben

Pediatric Radiology

Erschienen in:

01.02.2013 | Original Article

Cerebral ultrasound findings in infants exposed to crack cocaine during gestation

verfasst von: Juliane Lucca, Matteo Baldisserotto

Erschienen in: Pediatric Radiology | Ausgabe 2/2013

Einloggen, um Zugang zu erhalten

Abstract

Background

Prenatal exposure to cocaine has been associated with a wide spectrum of structural abnormalities in infant brains. The growing use of crack, a smokable and extremely addictive form of cocaine, could exacerbate the situation.

Objective

The purpose of this study was to determine the frequency, type and severity of cerebral lesions detected by transfontanellar US in newborns exposed to crack during gestation.

Materials and methods

This was a retrospective study, involving a review of the medical records of children who were born to crack-using women and who were subjected to transfontanellar US imaging during their first days of life.

Results

Transfontanellar US revealed abnormalities in 45/129 newborns examined (34.9%). The changes detected were subependymal cysts in 24 infants (18.6%), lenticulostriate vasculopathy in 18 infants (14%), subependymal hemorrhage in 9 infants (7%), and choroid plexus cysts in 9 infants (7%).

Conclusion

All of the abnormalities found by US examination were discrete and likely without clinical significance for the babies. However, prospective studies with a long period of tracking are needed to determine whether there are later consequences on the neurodevelopment of children with prenatal exposure to crack.

UNODC (2011) World drug report 2011. United Nations Publication, sales No. E11.XI.10

Cornish JW, O’Brien CP (1996) Crack cocaine abuse: an epidemic with many public health consequences. Annu Rev Public Health 17:259–273PubMedCrossRef

Wagner CL, Katikaneni LD, Cox TH et al (1998) Substance abuse in pregnancy: the impact of prenatal drug exposure on the neonate. Obstet Gynecol Clin North Am 25:169–194PubMedCrossRef

Chasnoff IJ, Bussey ME, Savich R et al (1986) Perinatal cerebral infarction and maternal cocaine use. J Pediatr 108:456–459PubMedCrossRef

Dixon SD, Bejar R (1989) Echoencephalographic findings in neonates associated with maternal cocaine and methamphetamine use: incidence and clinical correlations. J Pediatr 115:770–778PubMedCrossRef

Heier LA, Carpanzano CR, Mast J et al (1991) Maternal cocaine abuse: the spectrum of radiologic abnormalities in the neonatal CNS. AJNR 12:951–956PubMed

Droga VS, Shyken JM, Menon PA et al (1994) Neurosonographic abnormalities associated with maternal history of cocaine use in neonates of appropriate size for their gestational age. AJNR 15:697–702

Cohen HL, Sloves JH, Laungani S et al (1994) Neurosonographic findings in full-term infants born to maternal cocaine abusers: visualization of subependymal and periventricular cysts. J Clin Ultrasound 22:327–333PubMedCrossRef

Smith LM, Qureshi N, Renslo R et al (2001) Prenatal cocaine exposure and cranial sonographic findings in preterm infants. J Clin Ultrasound 29:72–77PubMedCrossRef

10.

King TA, Perlman JM, Laptook AR et al (1995) Neurologic manifestations of in utero cocaine exposure in near-term and term infants. Pediatrics 96:259–264PubMed

11.

Behnke M, Eyler FD, Conlon M et al (1998) Incidence and description of structural brain abnormalities in newborns exposed to cocaine. J Pediatr 132:291–294PubMedCrossRef

12.

Bauer CR, Langer JC, Shankaran S et al (2005) Acute neonatal effects of cocaine exposure during pregnancy. Arch Pediatr Adolesc Med 159:824–834PubMedCrossRef

13.

Frank DA, Augustyn M, Knight WG et al (2001) Growth, development, and behavior in early childhood following prenatal cocaine exposure: a systematic review. JAMA 285:1613–1625PubMedCrossRef

14.

van Huis M, van Kempen AA, Peelen M et al (2009) Brain ultrasonography findings in neonates with exposure to cocaine during pregnancy. Pediatr Radiol 39:232–238PubMedCrossRef

15.

Chao CP, Zaleski CG, Patton AC (2006) Neonatal hypoxic-ischemic encephalopathy: multimodality imaging findings. Radiographics 26:S159–S172PubMedCrossRef

16.

Rademaker KJ, Uiterwaal CS, Beek FJ et al (2005) Neonatal cranial ultrasound versus MRI and neurodevelopmental outcome at school age in children born preterm. Arch Dis Child Fetal Neonatal Ed 90:F489–F493PubMedCrossRef

17.

Hayden CK, Shattuck KE, Richardson CJ et al (1985) Subependymal germinal matrix hemorrhage in full-term neonates. Pediatrics 75:714–718PubMed

18.

Frank DA, McCarten KM, Robson CD et al (1999) Level of in utero cocaine exposure and neonatal ultrasound findings. Pediatrics 104:1101–1105PubMedCrossRef

19.

Shackelford GD, Fulling KH, Glasier CM (1983) Cysts of the subependymal germinal matrix: sonographic demonstration with pathologic correlation. Radiology 149:117–121PubMed

20.

Behnke M, Eyler FD, Garvan CW et al (1999) Cranial ultrasound abnormalities identified at birth: their relationship to perinatal risk and neurobehavioral outcome. Pediatrics 103:e41PubMedCrossRef

21.

Fernandez Alvarez JR, Amess PN, Gandhi RS et al (2009) Diagnostic value of subependymal pseudocysts and choroid plexus cysts on neonatal cerebral ultrasound: a meta-analysis. Arch Dis Child Fetal Neonatal Ed 94:F443–F446PubMedCrossRef

22.

Coley BD, Rusin JA, Boue DR (2000) Importance of hypoxic/ischemic conditions in the development of cerebral lenticulostriate vasculopathy. Pediatr Radiol 30:846–855PubMedCrossRef

23.

El Ayoubi M, de Bethmann O, Monset-Couchard M (2003) Lenticulostriate echogenic vessels: clinical and sonographic study of 70 neonatal cases. Pediatr Radiol 33:697–703PubMedCrossRef

24.

Riebel T, Nasir R, Weber K (1992) Choroid plexus cysts: a normal finding on ultrasound. Pediatr Radiol 22:410–412PubMedCrossRef

25.

Thompson BL, Levitt P, Stanwood GD (2009) Prenatal exposure to drugs: effects on brain development and implications for policy and education. Nat Rev Neurosci 10:303–312PubMedCrossRef

26.

Bendersky M, Lewis M (1995) Effects of intraventricular hemorrhage and other medical and environmental risks on multiple outcomes at age three years. J Dev Behav Pediatr 16:89–96PubMedCrossRef

27.

Datta-Bhutada S, Johnson HL, Rosen TS (1998) Intrauterine cocaine and crack exposure: neonatal outcome. J Perinatol 18:183–188PubMed

Titel: Cerebral ultrasound findings in infants exposed to crack cocaine during gestation
verfasst von: Juliane Lucca
Matteo Baldisserotto
Publikationsdatum: 01.02.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Radiology / Ausgabe 2/2013
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-012-2528-6

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Cerebral ultrasound findings in infants exposed to crack cocaine during gestation

Abstract

Background

Objective

Materials and methods

Results

Conclusion

Neu im Fachgebiet Radiologie

Darf man die Behandlung eines Neonazis ablehnen?

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Akuter Schwindel: Wann lohnt sich eine MRT?

Update Radiologie

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Background

Objective

Materials and methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2013

Challenging topics in child abuse imaging: improving our understanding

Hermes

Cerebral sinovenous thrombosis in pediatric practice

What do pediatric healthcare experts really need to know about Daubert and the rules of evidence?

Infantile osteopetrosis with superimposed rickets

Ligaments of the tarsal sinus: improved detection, characterisation and significance in the paediatric ankle with 3-D proton density MR imaging

Neu im Fachgebiet Radiologie

Darf man die Behandlung eines Neonazis ablehnen?

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Akuter Schwindel: Wann lohnt sich eine MRT?

Update Radiologie