Introduction
The optimal type of internal fixation for treatment of a distal radius fracture is still under debate. The tibia is an important weight bearing bone in the lower limb, which articulates proximally with the femur at the knee and distally with the talus at the ankle. Fractures of the distal tibial metaphysis, diaphysis, and adjacent diaphysis are commonly seen in road traffic accidents or sports injuries. These metadiaphyseal fractures are distinct in terms of their management from articular impaction “pilon” type fractures and middle third diaphyseal injuries [
1]. The overall incidence of tibial fractures is 51.7 per 100,000 a year, and the incidence of diaphyseal and distal tibia fractures is 15.7 and 9.1 respectively per 100,000 a year [
2]. Common definitions of distal tibial fractures include distal extra-articular tibial fractures which are located between 4 and 12 cm from the tibial plafond (AO 42A1 and 43A1). Further subdivisions are made on the basis of the morphology and degree of comminution of the fracture: 43-A1 are non-comminuted extra-articular fractures, 43-A2 are wedge fractures, and 43-A3 are comminuted extra-articular fractures. Simple extension of the fracture into the joint without depression of the joint surface are classified as 43-B1 and are often treated in the same way as 43-A fractures [
3‐
5].
Use of IMN for fracture fixation has been shown that there is limited interference of the device with the soft tissue around the fracture, but the technique of placement is difficult and the learning curve is long. In addition, it has been shown to be linked to complications such as malunion and knee pain after surgery [
6‐
9]. Common surgical procedures for internal fixation of the plate include open reduction and internal fixation and bridge fixation (MIPPO). Open reduction and internal fixation is an anatomical reduction under direct vision, but it is very disturbing to the soft tissue surrounding the fracture. In severe soft tissue injury cases, it is often necessary to extend the preoperative preparation time to optimize soft tissue recovery. Compared with open reduction and internal fixation, MIPPO technology requires fixation with a steel plate, but it also indirect bridge fixation. It is more likely to lead to soft tissue injury than open reduction, but also has a higher rate of fracture malformation and increased local soft tissue pressure possibility [
10‐
13].
The aim of this systematic review and meta-analysis was to compare the efficacy of two fixation methods, plate fixation, and intramedullary nail fixation, in the treatment of distal metadiaphyseal tibial fractures with or without articular involvement.
Materials and methods
Search strategy
The databases searched were PubMed, MEDLINE, Embase, the Cochrane Library, SpringerLink, Clinical Trials.gov, and OVID from inception to August 2018. The following search terms were used: distal tibial fracture; intramedullary nail; plate; internal fixation.
Data selection
To evaluate inclusion eligibility, two investigators independently screened the title and abstracts of all articles. Any disagreements were resolved with discussion between the authors. A third researcher was the adjudicator when there was disagreement between the two investigators. The included studies had to meet the following criteria: (1) must be designed as RCTs; (2) participants must be at least 16 years old; (3) the articles compare intramedullary nail fixation and plate fixation.
Two authors independently extracted the following data from each eligible study: study design, type of study population, age, number of participants, and interventions. Any discrepancies in data extraction were resolved by a third investigator.
Quality and risk of bias assessments
The modified Jadad scale was used to assess the methodological quality of each study. A score of ≥ 4 indicated high quality. The Cochrane Handbook for Reviews of Interventions (RevMan Version 5.3) was used to assess the risk of bias. Two independent authors subjectively reviewed all articles and assigned a value of “high,” “low,” or “unclear” based on the following items: selection bias; performance bias; detection bias; attrition bias; reporting bias and other bias. Any disagreements were resolved with discussion to reach a consensus. If a consensus could not be reached a third investigator was consulted.
Statistical analysis
The RevMan software was used to analyze the numerical data from the included studies. For binary data, the risk ratios (RR), and 95% confidence intervals (CI) were assessed (ɑ = 0.05 for the inspection standards). For continuous data, means and standard deviations (SD) were pooled to a weighted mean difference (WMD) and a 95% confidence internal (CI) in the meta-analysis. Heterogeneity was tested using the I2 statistic. Studies with an I2 statistic of 25 to 50% were considered to have low heterogeneity, those with an I2 statistic of 50 to 75% were considered to have moderate heterogeneity and those with an I2 statistic > 75% were considered to have high heterogeneity. When the I2 statistic was > 50%, sensitivity analyses were performed to identify potential sources of heterogeneity. Statistical significance was indicated by a P value < 0.05.
Discussion
The earliest PubMed record describing the use of intramedullary nails in the treatment of fractures was a 1946 paper by Otoole reporting the treatment of femoral fractures [
23]; use was later reported in the treatment of tibiofibular fractures [
24], and subsequently widely applied in limb lengthening. Even in irregular bones such as clavicle fractures, the bone is characterized by highest protection of periosteal blood supply and lowest soft tissue irritation at the fracture end, thus providing a favorable soft tissue environment for fracture healing. IMN can be either reamed or non-reamed, where reaming is more beneficial for reduction. Animal studies have confirmed that there is no significant increase in blood perfusion and osteophyte strength at the fracture end when comparing reamed with unreamed IMN [
25]. However, stress occlusion of the fracture end can lead to destruction of local fracture integrity and lead to negative clinical outcomes, occurrences which are expected to decrease with improvement of instrument design techniques and surgery [
26]. After the fracture end is reset, the locking nail is locked and pressurized, and the fracture end micro-motion is provided to promote fracture healing, however, if fixed too firmly, the alignment may be poor, the rotation is deformed, or the nail broken [
27]. In contrast, open reduction and internal fixation is direct reduction and fixation, so contralateral alignment of the fracture end is superior to IMN fixation. MIPPO is similar to IMN fixation but does not require alignment of the fracture end under direct vision. In addition, it does not require strong fixation and emphasizes soft tissue and blood around the fracture. Limiting the disruption of the blood supply ensures adequate perfusion and maintenance of the biological environment at the fracture ends [
28‐
30]. In addition, treatment of distal radius fractures includes external fixation, external fixation combined with limited open reduction and internal fixation, intramedullary nail and steel plate fixation, but these are not included in the scope of this meta-analysis.
To our knowledge, this is the first meta-analysis looking at the most recent randomized controlled trials comparing the efficacy of IMN and PL in distal tibial fractures and distal metadiaphyseal tibial fractures. This meta-analysis was based on 11 RCTs that included 526 patients treated with IMN and 571 patients treated with PL fixation. The main outcomes investigated were union time, operation time, nonunion, and delay union, superficial infection, deep infection, malunion, and knee pain. In our meta-analysis, when IMN is compared with the PL group, there was no significant difference in AOFAS, delayed union time, deep infection, operation time, and radiation time. However, the IMN group was superior to the PL group in terms of the FFI, knee pain, and malunion. In terms of superficial infection occurrence, the PL group was significantly higher than the IMN group. These results highlight that IMN and PL are effective fixation methods for distal tibial fractures, with no significant differences in fracture healing time and operative time. But the INM group was shown to recover better than the PL group, and the superficial infection rate was lower. However, the malunion and postoperative knee pain in the IMN group were higher than those in the PL group. The operation time, fracture healing time, and intraoperative fluoroscopy time showed no statistically significant difference.
Prior studies [
13,
31‐
33] and several meta-analyses [
34‐
37] investigating the efficacy of IMN have shown that IMN has no superiority over PL when the two methods are compared in well-designed double-blinded trials. The reported beneficial effects of IMN in most trials may have been due to insufficient blinding methods. Our results showed that there was a statistically significant difference in malunion between the IMN and the PL group, with a higher rate of malunion in the IMN group. This is consistent with the results of a prior meta-analysis where no significant difference in operation time and radiation time between INM and PL group was seen (
P = 0.07,
P = 0.29, respectively) [
34]. This is not consistent with our conclusions. In addition, the limited number of RCTs and patients may also affect these results.
As is the case of many meta-analyses, our study is not devoid of limitations. First, the current meta-analysis focuses only on papers that have been previously published. Inclusion of unpublished research may have increased heterogeneity and changed the current results. Second, the frequency of follow-up varied between studies, with five studies following up for more than 18 months, five studies limited to a year, and one study following up for only 6 months. This variation may affect heterogeneity and hence the results. Furthermore, the type of incision and plate were not consistent across the different studies. There exist several different types of surgical incisions in the use of steel plate fixation, four studies used the MIPPO technique, whereas the rest used open reduction and internal fixation. In terms of type of steel plate, two studies used non-locking steel plates, five used compression-type steel plates, one used an anatomical steel plate, two used a bridge steel plate, and one used ordinary steel plates. Further rigorously designed RCTs, with larger sample sizes, are necessary to better compare the efficacy of IMN and PL fixation.