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17.05.2023 | Original Article

Comparison of the efficacies of triple, quadruple and sequential antibiotic therapy in eradicating Helicobacter pylori infection: A randomized controlled trial

verfasst von: Manas Kumar Panigrahi, Mohd Imran Chouhan, Vinay Kumar Hallur, Madhav Sameer Makashir, Chandan Kumar, Shivam Sethi, Hemanta Kumar Nayak, Biswa Mohan Padhy, Subash Chandra Samal

Erschienen in: Indian Journal of Gastroenterology | Ausgabe 4/2023

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Abstract

Background and Aim

There is regional variation in the eradication rates of Helicobacter pylori (H. pylori) regimens depending on the local antibiotic resistance patterns. The aim of this study was to compare the efficacies of triple, quadruple and sequential antibiotic therapy in eradicating H. pylori infection.

Methods

A total of 296 H. pylori-positive patients were randomized to receive one of the three regimens (triple, quadruple or sequential antibiotic therapy) and eradication rate was assessed by H. pylori stool antigen test.

Results

The eradication rates of standard triple therapy, sequential therapy and quadruple therapy were 93%, 92.9% and 96.4%, respectively (p = 0.57).

Conclusion

Fourteen days of standard triple therapy, 14 days of bismuth-based quadruple therapy and 10 days of sequential therapy are equally efficacious in eradicating H. pylori and all regimens have optimum H. pylori eradication rates.

Trial registration

ClinicalTrials.gov Identifier: CTRI/2020/04/024929

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Titel: Comparison of the efficacies of triple, quadruple and sequential antibiotic therapy in eradicating Helicobacter pylori infection: A randomized controlled trial
verfasst von: Manas Kumar Panigrahi
Mohd Imran Chouhan
Vinay Kumar Hallur
Madhav Sameer Makashir
Chandan Kumar
Shivam Sethi
Hemanta Kumar Nayak
Biswa Mohan Padhy
Subash Chandra Samal
Publikationsdatum: 17.05.2023
Verlag: Springer India
Erschienen in: Indian Journal of Gastroenterology / Ausgabe 4/2023
Print ISSN: 0254-8860
Elektronische ISSN: 0975-0711
DOI: https://doi.org/10.1007/s12664-022-01322-8

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Comparison of the efficacies of triple, quadruple and sequential antibiotic therapy in eradicating Helicobacter pylori infection: A randomized controlled trial